{"id":"https://openalex.org/W4226063370","doi":"https://doi.org/10.21203/rs.3.rs-1037721/v1","title":"CYP2D6 Genotyping for Personalized Therapy of Tamoxifen in Indonesian Women with ER+ Breast Cancer","display_name":"CYP2D6 Genotyping for Personalized Therapy of Tamoxifen in Indonesian Women with ER+ Breast Cancer","publication_year":2022,"publication_date":"2022-01-05","ids":{"openalex":"https://openalex.org/W4226063370","doi":"https://doi.org/10.21203/rs.3.rs-1037721/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-1037721/v1","doi":"https://doi.org/10.21203/rs.3.rs-1037721/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1037721/v1","pdf_url":"https://www.researchsquare.com/article/rs-1037721/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-1037721/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000899053","display_name":"Baitha Palanggatan Maggadani","orcid":"https://orcid.org/0000-0002-7284-0338","observed_orcids":["https://orcid.org/0000-0002-7284-0338"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID","US"],"is_corresponding":false,"raw_author_name":"Baitha Palanggatan Maggadani","raw_affiliation_strings":["University of Indonesia Faculty of Pharmacy","MRCCC Siloam Hospitals Semanggi, SJH Initiative","University of California Irvine School of Pharmacy & Pharmaceutical Sciences Harmita Harmita University of Indonesia Faculty of Pharmacy Yahdiana Harahap University of Indonesia Faculty of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I29617571"]},{"raw_affiliation_string":"MRCCC Siloam Hospitals Semanggi, SJH Initiative","institution_ids":[]},{"raw_affiliation_string":"University of California Irvine School of Pharmacy & Pharmaceutical Sciences Harmita Harmita University of Indonesia Faculty of Pharmacy Yahdiana Harahap University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I29617571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034475609","display_name":"Kathleen Irena Junusmin","orcid":"https://orcid.org/0000-0002-2634-7921","observed_orcids":["https://orcid.org/0000-0002-2634-7921"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID","US"],"is_corresponding":false,"raw_author_name":"Kathleen Irena Junusmin","raw_affiliation_strings":["Nalagenetics Pte Ltd","MRCCC Siloam Hospitals Semanggi, SJH Initiative","University of California Irvine School of Pharmacy & Pharmaceutical Sciences Harmita Harmita University of Indonesia Faculty of Pharmacy Yahdiana Harahap University of Indonesia Faculty of Pharmacy","University of Indonesia Faculty of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nalagenetics Pte Ltd","institution_ids":[]},{"raw_affiliation_string":"MRCCC Siloam Hospitals Semanggi, SJH Initiative","institution_ids":[]},{"raw_affiliation_string":"University of California Irvine School of Pharmacy & Pharmaceutical Sciences Harmita Harmita University of Indonesia Faculty of Pharmacy Yahdiana Harahap University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I29617571"]},{"raw_affiliation_string":"University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I29617571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050323902","display_name":"Levana L. Sani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID","US"],"is_corresponding":false,"raw_author_name":"Levana L. Sani","raw_affiliation_strings":["Nalagenetics Pte Ltd","MRCCC Siloam Hospitals Semanggi, SJH Initiative","University of California Irvine School of Pharmacy & Pharmaceutical Sciences Harmita Harmita University of Indonesia Faculty of Pharmacy Yahdiana Harahap University of Indonesia Faculty of Pharmacy","University of Indonesia Faculty of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nalagenetics Pte Ltd","institution_ids":[]},{"raw_affiliation_string":"MRCCC Siloam Hospitals Semanggi, SJH Initiative","institution_ids":[]},{"raw_affiliation_string":"University of California Irvine School of Pharmacy & Pharmaceutical Sciences Harmita Harmita University of Indonesia Faculty of Pharmacy Yahdiana Harahap University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I29617571"]},{"raw_affiliation_string":"University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I29617571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103112422","display_name":"Caroline Mahendra","orcid":"https://orcid.org/0000-0002-5893-1305","observed_orcids":["https://orcid.org/0000-0002-5893-1305"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID","US"],"is_corresponding":false,"raw_author_name":"Caroline Mahendra","raw_affiliation_strings":["Nalagenetics Pte Ltd","MRCCC Siloam Hospitals Semanggi, SJH Initiative","University of California Irvine School of Pharmacy & Pharmaceutical Sciences Harmita Harmita University of Indonesia Faculty of Pharmacy Yahdiana Harahap University of Indonesia Faculty of Pharmacy","University of Indonesia Faculty of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nalagenetics Pte Ltd","institution_ids":[]},{"raw_affiliation_string":"MRCCC Siloam Hospitals Semanggi, SJH Initiative","institution_ids":[]},{"raw_affiliation_string":"University of California Irvine School of Pharmacy & Pharmaceutical Sciences Harmita Harmita University of Indonesia Faculty of Pharmacy Yahdiana Harahap University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I29617571"]},{"raw_affiliation_string":"University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I29617571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069722682","display_name":"Margareta Amelia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID","US"],"is_corresponding":false,"raw_author_name":"Margareta Amelia","raw_affiliation_strings":["Nalagenetics Pte Ltd","MRCCC Siloam Hospitals Semanggi, SJH Initiative","University of California Irvine School of Pharmacy & Pharmaceutical Sciences Harmita Harmita University of Indonesia Faculty of Pharmacy Yahdiana Harahap University of Indonesia Faculty of Pharmacy","University of Indonesia Faculty of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nalagenetics Pte Ltd","institution_ids":[]},{"raw_affiliation_string":"MRCCC Siloam Hospitals Semanggi, SJH Initiative","institution_ids":[]},{"raw_affiliation_string":"University of California Irvine School of Pharmacy & Pharmaceutical Sciences Harmita Harmita University of Indonesia Faculty of Pharmacy Yahdiana Harahap University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I29617571"]},{"raw_affiliation_string":"University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I29617571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042455203","display_name":"Gabriella Gabriella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID","US"],"is_corresponding":false,"raw_author_name":"Gabriella Gabriella","raw_affiliation_strings":["Nalagenetics Pte Ltd","MRCCC Siloam Hospitals Semanggi, SJH Initiative","University of California Irvine School of Pharmacy & Pharmaceutical Sciences Harmita Harmita University of Indonesia Faculty of Pharmacy Yahdiana Harahap University of Indonesia Faculty of Pharmacy","University of Indonesia Faculty of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nalagenetics Pte Ltd","institution_ids":[]},{"raw_affiliation_string":"MRCCC Siloam Hospitals Semanggi, SJH Initiative","institution_ids":[]},{"raw_affiliation_string":"University of California Irvine School of Pharmacy & Pharmaceutical Sciences Harmita Harmita University of Indonesia Faculty of Pharmacy Yahdiana Harahap University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I29617571"]},{"raw_affiliation_string":"University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I29617571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030052681","display_name":"Astrid K Irwanto","orcid":"https://orcid.org/0000-0003-1371-3862","observed_orcids":["https://orcid.org/0000-0003-1371-3862"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID","US"],"is_corresponding":false,"raw_author_name":"Astrid Irwanto","raw_affiliation_strings":["Nalagenetics Pte Ltd","MRCCC Siloam Hospitals Semanggi, SJH Initiative","University of California Irvine School of Pharmacy & Pharmaceutical Sciences Harmita Harmita University of Indonesia Faculty of Pharmacy Yahdiana Harahap University of Indonesia Faculty of Pharmacy","University of Indonesia Faculty of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nalagenetics Pte Ltd","institution_ids":[]},{"raw_affiliation_string":"MRCCC Siloam Hospitals Semanggi, SJH Initiative","institution_ids":[]},{"raw_affiliation_string":"University of California Irvine School of Pharmacy & Pharmaceutical Sciences Harmita Harmita University of Indonesia Faculty of Pharmacy Yahdiana Harahap University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I29617571"]},{"raw_affiliation_string":"University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I29617571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060981830","display_name":"Alexandre Chan","orcid":"https://orcid.org/0000-0003-4391-4219","observed_orcids":["https://orcid.org/0000-0003-4391-4219"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID","US"],"is_corresponding":false,"raw_author_name":"Alexandre Chan","raw_affiliation_strings":["University of California Irvine School of Pharmacy & Pharmaceutical Sciences","MRCCC Siloam Hospitals Semanggi, SJH Initiative","University of California Irvine School of Pharmacy & Pharmaceutical Sciences Harmita Harmita University of Indonesia Faculty of Pharmacy Yahdiana Harahap University of Indonesia Faculty of Pharmacy","University of Indonesia Faculty of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Irvine School of Pharmacy & Pharmaceutical Sciences","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"MRCCC Siloam Hospitals Semanggi, SJH Initiative","institution_ids":[]},{"raw_affiliation_string":"University of California Irvine School of Pharmacy & Pharmaceutical Sciences Harmita Harmita University of Indonesia Faculty of Pharmacy Yahdiana Harahap University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I29617571"]},{"raw_affiliation_string":"University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I29617571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061575955","display_name":"Harmita Harmita","orcid":"https://orcid.org/0000-0003-3392-2303","observed_orcids":["https://orcid.org/0000-0003-3392-2303"]},"institutions":[{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Harmita Harmita","raw_affiliation_strings":["University of Indonesia Faculty of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I29617571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049276027","display_name":"Yahdiana Harahap","orcid":"https://orcid.org/0000-0002-7217-7900","observed_orcids":["https://orcid.org/0000-0002-7217-7900"]},"institutions":[{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Yahdiana Harahap","raw_affiliation_strings":["University of Indonesia Faculty of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I29617571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057826493","display_name":"Samuel J. Haryono","orcid":"https://orcid.org/0000-0003-4045-347X","observed_orcids":["https://orcid.org/0000-0003-4045-347X"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID","US"],"is_corresponding":true,"raw_author_name":"Samuel J. Haryono","raw_affiliation_strings":["MRCCC Siloam Hospitals Semanggi, SJH Initiative","University of California Irvine School of Pharmacy & Pharmaceutical Sciences Harmita Harmita University of Indonesia Faculty of Pharmacy Yahdiana Harahap University of Indonesia Faculty of Pharmacy","University of Indonesia Faculty of Pharmacy"],"raw_orcid":"https://orcid.org/0000-0003-4045-347X","affiliations":[{"raw_affiliation_string":"MRCCC Siloam Hospitals Semanggi, SJH Initiative","institution_ids":[]},{"raw_affiliation_string":"University of California Irvine School of Pharmacy & Pharmaceutical Sciences Harmita Harmita University of Indonesia Faculty of Pharmacy Yahdiana Harahap University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I29617571"]},{"raw_affiliation_string":"University of Indonesia Faculty of Pharmacy","institution_ids":["https://openalex.org/I29617571"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057826493"],"corresponding_institution_ids":["https://openalex.org/I204250578","https://openalex.org/I29617571"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.8809999823570251},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.9890000224113464},{"id":"https://openalex.org/keywords/endoxifen","display_name":"endoxifen","score":0.9649999737739563},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.859000027179718},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"pharmacogenomics","score":0.8820000290870667},{"id":"https://openalex.org/keywords/intermediate-metabolizers","display_name":"intermediate metabolizers","score":0.9110000133514404},{"id":"https://openalex.org/keywords/poor-metabolizers","display_name":"poor metabolizers","score":0.8859999775886536},{"id":"https://openalex.org/keywords/indonesian-women","display_name":"Indonesian women","score":0.5320000052452087},{"id":"https://openalex.org/keywords/aromatase-inhibitors","display_name":"aromatase inhibitors","score":0.7239999771118164},{"id":"https://openalex.org/keywords/adjuvant-endocrine-therapy","display_name":"adjuvant endocrine therapy","score":0.7089999914169312},{"id":"https://openalex.org/keywords/cyp2d6-10-allele","display_name":"CYP2D6*10 allele","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2779207338","wikidata":"https://www.wikidata.org/wiki/Q9240","display_name":"Indonesian","level":2,"score":0.8484188318252563},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.8097811937332153},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.6974554061889648},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.646310031414032},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6064749956130981},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5554437041282654},{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.5533645749092102},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4473249614238739},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35647621750831604},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.18782839179039001},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1570388376712799},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15007880330085754},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.0},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-1037721/v1","doi":"https://doi.org/10.21203/rs.3.rs-1037721/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1037721/v1","pdf_url":"https://www.researchsquare.com/article/rs-1037721/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-1037721/v1","doi":"https://doi.org/10.21203/rs.3.rs-1037721/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1037721/v1","pdf_url":"https://www.researchsquare.com/article/rs-1037721/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323819","display_name":"Universitas Indonesia","ror":"https://ror.org/0116zj450"},{"id":"https://openalex.org/F4320330442","display_name":"Universitas Katolik Indonesia Atma Jaya","ror":"https://ror.org/02hd2zk59"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4226063370.pdf","grobid_xml":"https://content.openalex.org/works/W4226063370.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1819536321","https://openalex.org/W1836143067","https://openalex.org/W1966987047","https://openalex.org/W1978470279","https://openalex.org/W1980861196","https://openalex.org/W1999130958","https://openalex.org/W2009439253","https://openalex.org/W2079488149","https://openalex.org/W2079777965","https://openalex.org/W2089221571","https://openalex.org/W2098867544","https://openalex.org/W2106158413","https://openalex.org/W2108946787","https://openalex.org/W2135502243","https://openalex.org/W2164681558","https://openalex.org/W2407393655","https://openalex.org/W2462443690","https://openalex.org/W2570427206","https://openalex.org/W2768884428","https://openalex.org/W2921611274","https://openalex.org/W3044035800","https://openalex.org/W3047372839","https://openalex.org/W3167464043"],"related_works":["https://openalex.org/W4408052531","https://openalex.org/W2113225995","https://openalex.org/W2946069671","https://openalex.org/W2069469265","https://openalex.org/W3131226910","https://openalex.org/W4408176718","https://openalex.org/W2031743713","https://openalex.org/W2971549068","https://openalex.org/W2053639830","https://openalex.org/W2104019649"],"abstract_inverted_index":{"Abstract":[0],"PurposeTamoxifen,":[1],"common":[2],"adjuvant":[3],"therapy":[4,57,85],"prescribed":[5],"in":[6,46,51,74,212,239,243,263],"estrogen":[7],"receptor":[8],"positive":[9],"(ER+)":[10],"breast":[11,77,278],"cancer,":[12],"is":[13],"metabolized":[14],"by":[15],"CYP2D6":[16,44,67,123,143,233,275],"enzyme":[17],"into":[18],"endoxifen.":[19],"The":[20,230],"phenotypes":[21],"of":[22,66,154,159,171,206,228,253,274,288],"CYP2D6,":[23],"a":[24,215,224,266],"highly":[25],"polymorphic":[26],"gene,":[27],"vary":[28],"from":[29],"ultrarapid":[30],"(UM),":[31],"normal":[32],"(NM),":[33],"intermediate":[34],"(IM),":[35],"and":[36,48,69,93,101,183,198,203,235,249],"poor":[37],"metabolizers":[38],"(PM).":[39],"Studies":[40],"showed":[41],"that":[42,169],"reduced":[43],"activity":[45],"IMs":[47,213,264],"PMs":[49],"resulted":[50],"lower":[52],"endoxifen":[53,72,210,244,261],"level,":[54],"thereby":[55],"reducing":[56],"efficacy.":[58],"This":[59],"study":[60],"aims":[61],"to":[62,127,134,214,255,265],"observe":[63],"the":[64,109,178,186,195,240,286],"distribution":[65],"profiles":[68],"their":[70,129],"corresponding":[71],"levels":[73,153,193,211,245,262],"Indonesian":[75],"ER+":[76,277],"cancer":[78,279],"patients.Methods151":[79],"patients":[80,138,172],"who":[81],"have":[82,223],"received":[83],"tamoxifen":[84,130,160,207,254,282],"for":[86],"\u22658":[87],"weeks":[88,164],"were":[89,96,125,161,174,200],"recruited":[90,173],"prospectively.":[91],"DNA":[92],"blood":[94],"samples":[95],"collected":[97],"with":[98,121,139,218,304],"buccal":[99],"swab":[100],"finger-prick":[102],"methods,":[103],"respectively.":[104],"Genotyping":[105],"was":[106,115,177,185,237,295],"performed":[107,116],"using":[108,117],"qPCR":[110],"method":[111],"while":[112,137],"metabolites":[113,152],"measurement":[114],"HPLC-tandem":[118],"MS.":[119],"Patients":[120],"IM/PM":[122],"profile":[124,144],"advised":[126],"increase":[128,205,285],"dose":[131,166,204],"or":[132,141],"switch":[133],"aromatase":[135],"inhibitor,":[136],"UM":[140],"NM":[142],"remained":[145],"on":[146,276,300],"20":[147],"mg":[148,257],"daily":[149,258],"dose.":[150],"Tamoxifen":[151],"those":[155],"given":[156],"40":[157,256],"mg/day":[158],"measured":[162],"eight":[163],"post":[165],"adjustment.ResultsWe":[167],"found":[168],"40.7%":[170],"IM.":[175],"CYP2D6*10":[176],"most":[179,187],"abundant":[180],"allele":[181],"(28.8%)":[182],"*10/*36":[184],"frequently":[188],"observed":[189],"diplotype":[190],"(23.6%).":[191],"Endoxifen":[192],"between":[194,232],"NM-PM,":[196],"NM-IM,":[197],"IM-PM":[199],"statistically":[201],"significant,":[202],"successfully":[208],"increased":[209,260],"similar":[216,267],"level":[217,268],"NMs":[219],"at":[220,298],"baseline.ConclusionIndonesian":[221],"women":[222,280],"relatively":[225],"high":[226],"proportion":[227],"IMs.":[229],"correlation":[231],"genotype":[234],"phenotype":[236],"shown":[238],"significant":[241],"difference":[242],"among":[246],"NMs,":[247],"IMs,":[248],"PMs.":[250],"Dose":[251],"adjustment":[252],"positively":[259],"as":[269],"NMs.":[270],"Implementing":[271],"pharmacogenomics":[272],"testing":[273],"taking":[281],"can":[283],"potentially":[284],"likelihood":[287],"achieving":[289],"better":[290],"treatment":[291],"efficacy.Trial":[292],"RegistrationThe":[293],"trial":[294],"retrospectively":[296],"registered":[297],"ClinicalTrials.gov":[299],"18":[301],"March":[302],"2020":[303],"identifier":[305],"NCT04312347":[306],"(accessible":[307],"at:":[308],"https://clinicaltrials.gov/ct2/show/NCT04312347).":[309]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-05-05T00:00:00"}