{"id":"https://openalex.org/W4226024176","doi":"https://doi.org/10.1186/s12989-022-00448-z","title":"Inflammogenic effect of polyacrylic acid in rat lung following intratracheal instillation","display_name":"Inflammogenic effect of polyacrylic acid in rat lung following intratracheal instillation","publication_year":2022,"publication_date":"2022-01-21","ids":{"openalex":"https://openalex.org/W4226024176","doi":"https://doi.org/10.1186/s12989-022-00448-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/35062982","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8780717"},"language":"en","primary_location":{"id":"doi:10.1186/s12989-022-00448-z","doi":"https://doi.org/10.1186/s12989-022-00448-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12989-022-00448-z","pdf_url":"https://particleandfibretoxicology.biomedcentral.com/counter/pdf/10.1186/s12989-022-00448-z","source":{"id":"https://openalex.org/S189275214","display_name":"Particle and Fibre Toxicology","issn_l":"1743-8977","issn":["1743-8977"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and Fibre Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://particleandfibretoxicology.biomedcentral.com/counter/pdf/10.1186/s12989-022-00448-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071016788","display_name":"Chinatsu Nishida","orcid":"https://orcid.org/0000-0001-7694-6052","observed_orcids":["https://orcid.org/0000-0001-7694-6052"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chinatsu Nishida","raw_affiliation_strings":["Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan. 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan. 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062001983","display_name":"Taisuke Tomonaga","orcid":"https://orcid.org/0000-0003-3583-3785","observed_orcids":["https://orcid.org/0000-0003-3583-3785"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taisuke Tomonaga","raw_affiliation_strings":["Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan. 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan. 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014931636","display_name":"Hiroto Izumi","orcid":"https://orcid.org/0000-0003-0327-582X","observed_orcids":["https://orcid.org/0000-0003-0327-582X"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroto Izumi","raw_affiliation_strings":["Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan. 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan. 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008408753","display_name":"Ke\u2010Yong Wang","orcid":"https://orcid.org/0000-0001-8295-1229","observed_orcids":["https://orcid.org/0000-0001-8295-1229"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ke-Yong Wang","raw_affiliation_strings":["Shared-Use Research Center, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shared-Use Research Center, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079182220","display_name":"Hidenori Higashi","orcid":"https://orcid.org/0000-0002-6609-8472","observed_orcids":["https://orcid.org/0000-0002-6609-8472"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidenori Higashi","raw_affiliation_strings":["Department of Environmental Health Engineering, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Engineering, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113542585","display_name":"Toru Ishidao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Ishidao","raw_affiliation_strings":["Department of Environmental Management, School of Health Sciences, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Management, School of Health Sciences, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022279955","display_name":"Jun\u2010ichi Takeshita","orcid":"https://orcid.org/0000-0002-3471-1594","observed_orcids":["https://orcid.org/0000-0002-3471-1594"]},"institutions":[{"id":"https://openalex.org/I4405286475","display_name":"Research Institute of Science for Safety and Sustainability","ror":"https://ror.org/028e99p80","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286475","https://openalex.org/I73613424"]},{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun-ichi Takeshita","raw_affiliation_strings":["Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan. 16-1 Onogawa, Tsukuba, Ibaraki, 305-8569, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan. 16-1 Onogawa, Tsukuba, Ibaraki, 305-8569, Japan","institution_ids":["https://openalex.org/I4405286475","https://openalex.org/I73613424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011149735","display_name":"Ryohei Ono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17056963","display_name":"The University of Kitakyushu","ror":"https://ror.org/03mfefw72","country_code":"JP","type":"education","lineage":["https://openalex.org/I17056963"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryohei Ono","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The University of Kitakyushu, 1-1, Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka, 808-0135, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The University of Kitakyushu, 1-1, Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka, 808-0135, Japan","institution_ids":["https://openalex.org/I17056963"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048566286","display_name":"Kazuki Sumiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17056963","display_name":"The University of Kitakyushu","ror":"https://ror.org/03mfefw72","country_code":"JP","type":"education","lineage":["https://openalex.org/I17056963"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuki Sumiya","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The University of Kitakyushu, 1-1, Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka, 808-0135, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The University of Kitakyushu, 1-1, Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka, 808-0135, Japan","institution_ids":["https://openalex.org/I17056963"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063939653","display_name":"Shota Fujii","orcid":"https://orcid.org/0000-0002-6594-5211","observed_orcids":["https://orcid.org/0000-0002-6594-5211"]},"institutions":[{"id":"https://openalex.org/I17056963","display_name":"The University of Kitakyushu","ror":"https://ror.org/03mfefw72","country_code":"JP","type":"education","lineage":["https://openalex.org/I17056963"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shota Fujii","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The University of Kitakyushu, 1-1, Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka, 808-0135, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The University of Kitakyushu, 1-1, Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka, 808-0135, Japan","institution_ids":["https://openalex.org/I17056963"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004143066","display_name":"Shinichi Mochizuki","orcid":"https://orcid.org/0000-0001-9832-5070","observed_orcids":["https://orcid.org/0000-0001-9832-5070"]},"institutions":[{"id":"https://openalex.org/I17056963","display_name":"The University of Kitakyushu","ror":"https://ror.org/03mfefw72","country_code":"JP","type":"education","lineage":["https://openalex.org/I17056963"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinichi Mochizuki","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The University of Kitakyushu, 1-1, Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka, 808-0135, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The University of Kitakyushu, 1-1, Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka, 808-0135, Japan","institution_ids":["https://openalex.org/I17056963"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103198421","display_name":"Kazuo Sakurai","orcid":"https://orcid.org/0000-0002-9737-0061","observed_orcids":["https://orcid.org/0000-0002-9737-0061"]},"institutions":[{"id":"https://openalex.org/I17056963","display_name":"The University of Kitakyushu","ror":"https://ror.org/03mfefw72","country_code":"JP","type":"education","lineage":["https://openalex.org/I17056963"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuo Sakurai","raw_affiliation_strings":["Department of Chemistry and Biochemistry, The University of Kitakyushu, 1-1, Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka, 808-0135, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, The University of Kitakyushu, 1-1, Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka, 808-0135, Japan","institution_ids":["https://openalex.org/I17056963"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014459642","display_name":"Kei Yamasaki","orcid":"https://orcid.org/0000-0003-1876-3287","observed_orcids":["https://orcid.org/0000-0003-1876-3287"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kei Yamasaki","raw_affiliation_strings":["Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan. 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan. 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048500471","display_name":"Kazuhiro Yatera","orcid":"https://orcid.org/0000-0002-2955-4432","observed_orcids":["https://orcid.org/0000-0002-2955-4432"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiro Yatera","raw_affiliation_strings":["Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan. 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan. 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021890684","display_name":"Yasuo Morimoto","orcid":"https://orcid.org/0000-0002-5339-6905","observed_orcids":["https://orcid.org/0000-0002-5339-6905"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yasuo Morimoto","raw_affiliation_strings":["Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan. 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan. yasuom@med.uoeh-u.ac.jp","Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan. 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan"],"raw_orcid":"https://orcid.org/0000-0002-5339-6905","affiliations":[{"raw_affiliation_string":"Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan. 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan. yasuom@med.uoeh-u.ac.jp","institution_ids":["https://openalex.org/I188700360"]},{"raw_affiliation_string":"Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan. 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan","institution_ids":["https://openalex.org/I188700360"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021890684"],"corresponding_institution_ids":["https://openalex.org/I188700360"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":4.3386,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.95893582,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"19","issue":"1","first_page":"8","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intratracheal-instillation","display_name":"intratracheal instillation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.6669999957084656},{"id":"https://openalex.org/keywords/cxcl5","display_name":"CXCL5","score":0.9980000257492065},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/interstitial-lung-disease","display_name":"interstitial lung disease","score":0.7820000052452087},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.6819999814033508},{"id":"https://openalex.org/keywords/silica","display_name":"silica","score":0.5479999780654907},{"id":"https://openalex.org/keywords/chrysotile","display_name":"chrysotile","score":0.8130000233650208},{"id":"https://openalex.org/keywords/nio-nanoparticles","display_name":"nickel oxide nanoparticles","score":0.9079999923706055},{"id":"https://openalex.org/keywords/cerium-oxide-nanoparticles","display_name":"cerium oxide nanoparticles","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C2781047374","wikidata":"https://www.wikidata.org/wiki/Q2100012","display_name":"Pulmonary toxicity","level":3,"score":0.6891995668411255},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6734985709190369},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.648955762386322},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.6286993026733398},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5547366738319397},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5345895290374756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5143698453903198},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.474372923374176},{"id":"https://openalex.org/C2777134676","wikidata":"https://www.wikidata.org/wiki/Q35890","display_name":"Hypersensitivity pneumonitis","level":3,"score":0.46329084038734436},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.4446045756340027},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.43503665924072266},{"id":"https://openalex.org/C72673979","wikidata":"https://www.wikidata.org/wiki/Q17003157","display_name":"Bicinchoninic acid assay","level":2,"score":0.43102535605430603},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39783766865730286},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3871942162513733},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.29691940546035767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24925696849822998},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000180","descriptor_name":"Acrylic Resins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12989-022-00448-z","doi":"https://doi.org/10.1186/s12989-022-00448-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12989-022-00448-z","pdf_url":"https://particleandfibretoxicology.biomedcentral.com/counter/pdf/10.1186/s12989-022-00448-z","source":{"id":"https://openalex.org/S189275214","display_name":"Particle and Fibre Toxicology","issn_l":"1743-8977","issn":["1743-8977"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and Fibre Toxicology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-147025/v1","doi":"https://doi.org/10.21203/rs.3.rs-147025/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-147025/v1","pdf_url":"https://www.researchsquare.com/article/rs-147025/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:35062982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35062982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and fibre toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8780717","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8780717/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Part Fibre Toxicol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a7310acc785143c7b1466ed55340e3c3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a7310acc785143c7b1466ed55340e3c3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Particle and Fibre Toxicology, Vol 19, Iss 1, Pp 1-17 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12989-022-00448-z","doi":"https://doi.org/10.1186/s12989-022-00448-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12989-022-00448-z","pdf_url":"https://particleandfibretoxicology.biomedcentral.com/counter/pdf/10.1186/s12989-022-00448-z","source":{"id":"https://openalex.org/S189275214","display_name":"Particle and Fibre Toxicology","issn_l":"1743-8977","issn":["1743-8977"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and Fibre Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2467111453","display_name":"Mechanism of DNA Double Helix Cleavage by beta-Glucan: Transition Behaviors between Chemical Quantum States","funder_award_id":"20K20449","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3516496435","display_name":null,"funder_award_id":"20H05797","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5509742912","display_name":"Examination of Lung disorder by organic polymeric materials","funder_award_id":"18K10060","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G637481981","display_name":"Development of Next-Generation Drug Delivery System Using Quantized Polysaccharide-DNA Complex (qSDC)","funder_award_id":"20H00668","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4226024176.pdf","grobid_xml":"https://content.openalex.org/works/W4226024176.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W88511457","https://openalex.org/W195525803","https://openalex.org/W590971052","https://openalex.org/W1914698412","https://openalex.org/W1961573346","https://openalex.org/W1979912668","https://openalex.org/W1993021425","https://openalex.org/W1993151455","https://openalex.org/W2010930000","https://openalex.org/W2012447265","https://openalex.org/W2012471161","https://openalex.org/W2015610985","https://openalex.org/W2023429915","https://openalex.org/W2032942532","https://openalex.org/W2037971634","https://openalex.org/W2043706061","https://openalex.org/W2047653832","https://openalex.org/W2054282870","https://openalex.org/W2056067529","https://openalex.org/W2061182229","https://openalex.org/W2065991026","https://openalex.org/W2068848214","https://openalex.org/W2069641201","https://openalex.org/W2072488295","https://openalex.org/W2075400164","https://openalex.org/W2083288984","https://openalex.org/W2088295473","https://openalex.org/W2091780092","https://openalex.org/W2097036700","https://openalex.org/W2103752974","https://openalex.org/W2119816698","https://openalex.org/W2123517963","https://openalex.org/W2126763289","https://openalex.org/W2128685087","https://openalex.org/W2132598936","https://openalex.org/W2140551998","https://openalex.org/W2149587046","https://openalex.org/W2160336454","https://openalex.org/W2161693075","https://openalex.org/W2165468042","https://openalex.org/W2167383172","https://openalex.org/W2171528132","https://openalex.org/W2178606820","https://openalex.org/W2199924325","https://openalex.org/W2282813985","https://openalex.org/W2414781026","https://openalex.org/W2433551113","https://openalex.org/W2473109425","https://openalex.org/W2503785026","https://openalex.org/W2597632520","https://openalex.org/W2605536620","https://openalex.org/W2770670701","https://openalex.org/W2800806128","https://openalex.org/W2900578347","https://openalex.org/W2953846460","https://openalex.org/W2965192246","https://openalex.org/W2973131625","https://openalex.org/W3047793396","https://openalex.org/W3092902164","https://openalex.org/W3110016309","https://openalex.org/W3169507742","https://openalex.org/W4211262146","https://openalex.org/W4248573657","https://openalex.org/W4323062437"],"related_works":["https://openalex.org/W4310787840","https://openalex.org/W4404402792","https://openalex.org/W4308867205","https://openalex.org/W4388671527","https://openalex.org/W4399010155","https://openalex.org/W3110016309","https://openalex.org/W4406897987","https://openalex.org/W7157834059","https://openalex.org/W6939690480","https://openalex.org/W4320489806"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Some":[2],"organic":[3,43],"chemicals":[4],"are":[5],"known":[6],"to":[7,62,109,125,211,234,244],"cause":[8,27,46,68],"allergic":[9],"disorders":[10],"such":[11],"as":[12,138],"bronchial":[13],"asthma":[14],"and":[15,18,87,92,104,112,115,130,132,149,152,163,238,242,253,282],"hypersensitivity":[16],"pneumonitis,":[17],"it":[19],"has":[20,32],"been":[21,34],"considered":[22],"that":[23,37,222,231,248,272],"they":[24],"do":[25],"not":[26,58],"irreversible":[28],"pulmonary":[29,52],"fibrosis.":[30,53],"It":[31],"recently":[33],"reported,":[35],"however,":[36],"cross-linked":[38,63],"acrylic":[39],"acid-based":[40],"polymer,":[41],"an":[42],"chemical,":[44],"might":[45],"serious":[47],"interstitial":[48],"lung":[49,69,172,203],"diseases,":[50],"including":[51],"We":[54],"investigated":[55],"whether":[56],"or":[57,245],"intratracheal":[59,193],"instillation":[60],"exposure":[61,108,233],"polyacrylic":[64],"acid":[65],"(CL-PAA)":[66],"can":[67],"disorder":[70],"in":[71,119,143,153,178,197,201,232,249,279],"rats.":[72],"Methods":[73],"Male":[74],"F344":[75],"rats":[76],"were":[77,93,136,176,205],"intratracheally":[78],"instilled":[79],"with":[80,171],"dispersed":[81],"CL-PAA":[82,192,273],"at":[83,95,187,225],"low":[84],"(0.2":[85],"mg/rat)":[86,90],"high":[88],"(1.0":[89],"doses,":[91],"sacrificed":[94],"3":[96,102,184,209,226],"days,":[97],"1":[98,100,189,258,265],"week,":[99],"month,":[101],"months":[103,106,213],"6":[105,212],"after":[107,214,264],"examine":[110],"inflammatory":[111],"fibrotic":[113],"responses":[114],"related":[116],"gene":[117,174],"expressions":[118],"the":[120,154,157,202,219,254,280],"lungs.":[121],"Rat":[122],"lungs":[123,220],"exposed":[124],"crystalline":[126],"silica,":[127,235],"asbestos":[128,250],"(chrysotile),":[129],"NiO":[131,236],"CeO":[133,239],"2":[134,240],"nanoparticles":[135,237],"used":[137],"comparators.":[139],"Results":[140],"Persistent":[141,195],"increases":[142,196],"total":[144],"cell":[145],"count,":[146],"neutrophil":[147,150,159,277],"count":[148],"percentage,":[151],"concentration":[155],"of":[156,218],"cytokine-induced":[158],"chemoattractant":[160],"(CINC)-1,":[161],"CINC-2":[162],"C-X-C":[164],"motif":[165],"chemokine":[166],"5":[167],"(CXCL5),":[168],"which":[169],"correlated":[170],"tissue":[173,204],"expression,":[175],"observed":[177,207],"bronchoalveolar":[179],"lavage":[180],"fluid":[181],"(BALF)":[182],"from":[183,208],"days":[185,210,227],"until":[186,257],"least":[188],"month":[190,266],"following":[191],"instillation.":[194],"heme":[198],"oxygenase-1":[199],"(HO-1)":[200],"also":[206,262],"exposure.":[215],"Histopathological":[216],"findings":[217],"demonstrated":[221],"extensive":[223],"inflammation":[224,255,278],"was":[228],"greater":[229,246],"than":[230,247],"nanoparticles,":[241],"equal":[243],"(chrysotile)":[251],"exposure,":[252],"continued":[256],"month.":[259],"Fibrotic":[260],"changes":[261],"progressed":[263],"postexposure.":[267],"Conclusion":[268],"Our":[269],"results":[270],"suggested":[271],"potentially":[274],"causes":[275],"strong":[276],"rat":[281],"human":[283],"lung.":[284]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":11}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-05-05T00:00:00"}
