{"id":"https://openalex.org/W4225868965","doi":"https://doi.org/10.3897/pharmacia.69.e81954","title":"The development of a novel ultrashort antimicrobial peptide nanoparticles with potent antimicrobial effect","display_name":"The development of a novel ultrashort antimicrobial peptide nanoparticles with potent antimicrobial effect","publication_year":2022,"publication_date":"2022-03-23","ids":{"openalex":"https://openalex.org/W4225868965","doi":"https://doi.org/10.3897/pharmacia.69.e81954"},"language":"en","primary_location":{"id":"doi:10.3897/pharmacia.69.e81954","doi":"https://doi.org/10.3897/pharmacia.69.e81954","is_oa":true,"landing_page_url":"https://doi.org/10.3897/pharmacia.69.e81954","pdf_url":"https://pharmacia.pensoft.net/article/81954/download/pdf/","source":{"id":"https://openalex.org/S4210231629","display_name":"Pharmacia","issn_l":"0428-0296","issn":["0428-0296","2603-557X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacia","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4225868965"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pharmacia.pensoft.net/article/81954/download/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005622789","display_name":"Ali H. Salama","orcid":"https://orcid.org/0000-0003-2141-5857","observed_orcids":["https://orcid.org/0000-0003-2141-5857"]},"institutions":[{"id":"https://openalex.org/I91633459","display_name":"Middle East University","ror":"https://ror.org/059bgad73","country_code":"JO","type":"education","lineage":["https://openalex.org/I91633459"]}],"countries":["JO"],"is_corresponding":true,"raw_author_name":"Ali Salama","raw_affiliation_strings":["Faculty of Pharmacy , Middle East University , Amman , Jordan","Middle East University, Amman, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy , Middle East University , Amman , Jordan","institution_ids":["https://openalex.org/I91633459"]},{"raw_affiliation_string":"Middle East University, Amman, Jordan","institution_ids":["https://openalex.org/I91633459"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005622789"],"corresponding_institution_ids":["https://openalex.org/I91633459"],"apc_list":{"value":100,"currency":"EUR","value_usd":107},"apc_paid":{"value":100,"currency":"EUR","value_usd":107},"fwci":1.0159,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.67347679,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"69","issue":"1","first_page":"255","last_page":"260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chitosan-nanoparticles","display_name":"chitosan nanoparticles","score":0.8370000123977661},{"id":"https://openalex.org/keywords/ionic-gelation","display_name":"ionic gelation","score":0.9589999914169312},{"id":"https://openalex.org/keywords/peptide-encapsulation","display_name":"peptide encapsulation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9200000166893005},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.9070000052452087},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.6850000023841858},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.6669999957084656},{"id":"https://openalex.org/keywords/biofilm-forming-bacteria","display_name":"biofilm-forming bacteria","score":0.8259999752044678},{"id":"https://openalex.org/keywords/multidrug-resistant-bacteria","display_name":"multidrug-resistant bacteria","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.892638087272644},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.674699068069458},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6735199689865112},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.578475832939148},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.5330867767333984},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.524999737739563},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.5173827409744263},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5102889537811279},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.5035602450370789},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.42222264409065247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2315588891506195},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1343906819820404},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3897/pharmacia.69.e81954","doi":"https://doi.org/10.3897/pharmacia.69.e81954","is_oa":true,"landing_page_url":"https://doi.org/10.3897/pharmacia.69.e81954","pdf_url":"https://pharmacia.pensoft.net/article/81954/download/pdf/","source":{"id":"https://openalex.org/S4210231629","display_name":"Pharmacia","issn_l":"0428-0296","issn":["0428-0296","2603-557X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacia","raw_type":"journal-article"},{"id":"pmh:10.3897/pharmacia.69.e81954","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.3897/pharmacia.69.e81954","pdf_url":null,"source":{"id":"https://openalex.org/S199213172","display_name":"ZooKeys","issn_l":"1313-2970","issn":["1313-2970","1313-2989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacia 69(1): 255-260","raw_type":"Research Article"},{"id":"pmh:oai:doaj.org/article:f78d86c1421941a0a15d1fe01c7feed4","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f78d86c1421941a0a15d1fe01c7feed4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacia, Vol 69, Iss 1, Pp 255-260 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3897/pharmacia.69.e81954","doi":"https://doi.org/10.3897/pharmacia.69.e81954","is_oa":true,"landing_page_url":"https://doi.org/10.3897/pharmacia.69.e81954","pdf_url":"https://pharmacia.pensoft.net/article/81954/download/pdf/","source":{"id":"https://openalex.org/S4210231629","display_name":"Pharmacia","issn_l":"0428-0296","issn":["0428-0296","2603-557X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4225868965.pdf","grobid_xml":"https://content.openalex.org/works/W4225868965.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1564553363","https://openalex.org/W1948545309","https://openalex.org/W1973990010","https://openalex.org/W1995634417","https://openalex.org/W1996998905","https://openalex.org/W2028593763","https://openalex.org/W2042752843","https://openalex.org/W2054602599","https://openalex.org/W2059521816","https://openalex.org/W2084845164","https://openalex.org/W2093029144","https://openalex.org/W2134205677","https://openalex.org/W2287921014","https://openalex.org/W2325908169","https://openalex.org/W2423450683","https://openalex.org/W2527973576","https://openalex.org/W2587346655","https://openalex.org/W2595688691"],"related_works":["https://openalex.org/W2766376540","https://openalex.org/W2067412807","https://openalex.org/W6990498712","https://openalex.org/W4317036542","https://openalex.org/W7212294284","https://openalex.org/W2287019289","https://openalex.org/W4389751540","https://openalex.org/W4311390789","https://openalex.org/W4212946488","https://openalex.org/W4411578704"],"abstract_inverted_index":{"Conventional":[0],"antibiotics":[1,50],"are":[2,60,186],"facing":[3],"significant":[4],"microbial":[5,55],"resistance,":[6],"which":[7],"has":[8],"recently":[9],"reached":[10],"previously":[11],"unnoticed":[12],"critical":[13],"levels.":[14],"As":[15],"a":[16,21,89,127,140],"result":[17],"of":[18,24,115,133,191],"this":[19,103],"situation,":[20],"large":[22],"proportion":[23],"antimicrobial":[25,74,95,168],"agents":[26],"currently":[27],"used":[28,86],"in":[29,51,102,130],"the":[30,42,52,122,131,188],"clinic":[31],"have":[32],"significantly":[33],"reduced":[34,182],"therapeutic":[35],"potential.":[36],"Antimicrobial":[37],"peptides":[38],"(AMPs)":[39],"may":[40,66],"offer":[41],"medical":[43],"community":[44],"an":[45,154],"alternative":[46],"strategy":[47],"to":[48,87,137,145,157],"traditional":[49],"fight":[53],"against":[54,112,170],"resistance.":[56],"Current":[57],"research":[58],"efforts":[59],"focused":[61],"on":[62,162],"developing":[63],"technologies":[64],"that":[65,185],"reduce":[67],"AMP":[68],"toxicity":[69,180],"while":[70],"retaining":[71],"their":[72,79],"potent":[73,93,167],"activity":[75],"and":[76,121,139,173,181],"possibly":[77],"improving":[78],"delivery.":[80],"The":[81],"ionotropic":[82],"gelation":[83],"method":[84],"was":[85],"encapsulate":[88],"novel":[90],"in-house":[91],"designed":[92],"ultrashort":[94],"peptide":[96],"(USAMP)":[97],"into":[98,150],"chitosan-based":[99],"nanoparticles":[100],"(CS-NPs)":[101],"study.":[104],"WRWRWR":[105,124,149],"-CS-NPs":[106,125],"were":[107],"tested":[108],"for":[109,118,165],"antibacterial":[110],"kinetics":[111],"two":[113],"strains":[114],"Staphylococcus":[116],"aureus":[117],"four":[119],"days,":[120],"developed":[123],"showed":[126],"3-log":[128],"decrease":[129,142],"number":[132],"colonies":[134],"when":[135,143],"compared":[136,144],"CS-NP":[138],"5-log":[141],"control":[146],"bacteria.":[147],"Loaded":[148],"CS-NPs":[151],"could":[152],"represent":[153],"innovative":[155],"approach":[156],"develop":[158],"delivery":[159],"systems":[160],"based":[161],"NPs":[163],"technology":[164],"achieving":[166],"effects":[169],"multi-drug":[171],"resistant":[172],"biofilm":[174],"forming":[175],"bacteria":[176],"with":[177],"negligible":[178],"systemic":[179],"synthetic":[183],"costs":[184],"obstructing":[187],"clinical":[189],"development":[190],"AMPs":[192],"generally.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-07T09:51:55.459714","created_date":"2022-05-05T00:00:00"}
