{"id":"https://openalex.org/W4225856472","doi":"https://doi.org/10.21203/rs.3.rs-1274380/v2","title":"Epigenetic silencing of PTEN and epi-transcriptional silencing of MDM2 underlied resistance to hypomethylating agents in myelodysplastic syndrome","display_name":"Epigenetic silencing of PTEN and epi-transcriptional silencing of MDM2 underlied resistance to hypomethylating agents in myelodysplastic syndrome","publication_year":2022,"publication_date":"2022-04-19","ids":{"openalex":"https://openalex.org/W4225856472","doi":"https://doi.org/10.21203/rs.3.rs-1274380/v2"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-1274380/v2","doi":"https://doi.org/10.21203/rs.3.rs-1274380/v2","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1274380/v2","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.21203/rs.3.rs-1274380/v2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100717312","display_name":"Paul Lee","orcid":"https://orcid.org/0000-0002-4149-0435","observed_orcids":["https://orcid.org/0000-0002-4149-0435"]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]},{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Paul Lee","raw_affiliation_strings":["the University of Hong Kong","University of Hong Kong","the Chinese University of Hong Kong","the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","the University of Hong Kong Yok-Lam Kwong the University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","institution_ids":["https://openalex.org/I168719708","https://openalex.org/I177725633"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"the University of Hong Kong Yok-Lam Kwong the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020760738","display_name":"Rita Yim","orcid":"https://orcid.org/0000-0002-1754-1247","observed_orcids":["https://orcid.org/0000-0002-1754-1247"]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]},{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Rita Yim","raw_affiliation_strings":["the University of Hong Kong","University of Hong Kong","the Chinese University of Hong Kong","the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","the University of Hong Kong Yok-Lam Kwong the University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","institution_ids":["https://openalex.org/I168719708","https://openalex.org/I177725633"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"the University of Hong Kong Yok-Lam Kwong the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083685133","display_name":"Kai-Kei Miu","orcid":"https://orcid.org/0000-0001-9027-3333","observed_orcids":["https://orcid.org/0000-0001-9027-3333"]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]},{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Kai-Kei Miu","raw_affiliation_strings":["the Chinese University of Hong Kong","University of Hong Kong","the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","the University of Hong Kong","the University of Hong Kong Yok-Lam Kwong the University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","institution_ids":["https://openalex.org/I168719708","https://openalex.org/I177725633"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"the University of Hong Kong Yok-Lam Kwong the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009850351","display_name":"Sin-Hang Fung","orcid":"https://orcid.org/0000-0002-0847-4564","observed_orcids":["https://orcid.org/0000-0002-0847-4564"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Sin-Hang Fung","raw_affiliation_strings":["the Chinese University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072957014","display_name":"Jason Jinyue Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]},{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Jason Jinyue Liao","raw_affiliation_strings":["the Chinese University of Hong Kong","University of Hong Kong","the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","the University of Hong Kong","the University of Hong Kong Yok-Lam Kwong the University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","institution_ids":["https://openalex.org/I168719708","https://openalex.org/I177725633"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"the University of Hong Kong Yok-Lam Kwong the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086853104","display_name":"Zhangting Wang","orcid":"https://orcid.org/0000-0001-6040-0469","observed_orcids":["https://orcid.org/0000-0001-6040-0469"]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]},{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Zhangting Wang","raw_affiliation_strings":["the Chinese University of Hong Kong","University of Hong Kong","the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","the University of Hong Kong","the University of Hong Kong Yok-Lam Kwong the University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","institution_ids":["https://openalex.org/I168719708","https://openalex.org/I177725633"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"the University of Hong Kong Yok-Lam Kwong the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100361663","display_name":"Jun Li","orcid":"https://orcid.org/0000-0001-7218-429X","observed_orcids":["https://orcid.org/0000-0001-7218-429X","https://orcid.org/0000-0001-9880-1356"]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]},{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":["the City University of Hong Kong","University of Hong Kong","the Chinese University of Hong Kong","the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","the University of Hong Kong","the University of Hong Kong Yok-Lam Kwong the University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the City University of Hong Kong","institution_ids":["https://openalex.org/I168719708"]},{"raw_affiliation_string":"University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","institution_ids":["https://openalex.org/I168719708","https://openalex.org/I177725633"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"the University of Hong Kong Yok-Lam Kwong the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005752748","display_name":"Yammy Yung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yammy Yung","raw_affiliation_strings":["the University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113467699","display_name":"Hiu-Tung Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Hiu-Tung Chu","raw_affiliation_strings":["the University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110077023","display_name":"Pui-Kwan Yip","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]},{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Pui-Kwan Yip","raw_affiliation_strings":["the University of Hong Kong","University of Hong Kong","the Chinese University of Hong Kong","the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","the University of Hong Kong Yok-Lam Kwong the University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","institution_ids":["https://openalex.org/I168719708","https://openalex.org/I177725633"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"the University of Hong Kong Yok-Lam Kwong the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005983640","display_name":"Emily Lee","orcid":"https://orcid.org/0000-0002-7286-3441","observed_orcids":["https://orcid.org/0000-0002-7286-3441"]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]},{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Emily Lee","raw_affiliation_strings":["the University of Hong Kong","University of Hong Kong","the Chinese University of Hong Kong","the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","the University of Hong Kong Yok-Lam Kwong the University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","institution_ids":["https://openalex.org/I168719708","https://openalex.org/I177725633"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"the University of Hong Kong Yok-Lam Kwong the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006624497","display_name":"Eric Tse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]},{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Eric Tse","raw_affiliation_strings":["the University of Hong Kong","University of Hong Kong","the Chinese University of Hong Kong","the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","the University of Hong Kong Yok-Lam Kwong the University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","institution_ids":["https://openalex.org/I168719708","https://openalex.org/I177725633"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"the University of Hong Kong Yok-Lam Kwong the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062141909","display_name":"Yok-Lam Kwong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yok-Lam Kwong","raw_affiliation_strings":["the University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082583465","display_name":"Harinder Gill","orcid":"https://orcid.org/0000-0002-9551-4893","observed_orcids":["https://orcid.org/0000-0002-9551-4893"]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]},{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Harinder Gill","raw_affiliation_strings":["the University of Hong Kong","University of Hong Kong","the Chinese University of Hong Kong","the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","the University of Hong Kong Yok-Lam Kwong the University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Jun Li the City University of Hong Kong Yammy Yung the University of Hong Kong Hiu-Tung Chu the University of Hong Kong","institution_ids":["https://openalex.org/I168719708","https://openalex.org/I177725633"]},{"raw_affiliation_string":"the Chinese University of Hong Kong Sin-Hang Fung the Chinese University of Hong Kong","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"the University of Hong Kong Yok-Lam Kwong the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082583465"],"corresponding_institution_ids":["https://openalex.org/I168719708","https://openalex.org/I177725633","https://openalex.org/I889458895"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.26100000739097595,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hypomethylating-agent-resistance","display_name":"hypomethylating agent resistance","score":0.9110000133514404},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.8220000267028809},{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9559999704360962},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.9829999804496765},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/rna-methylation","display_name":"RNA methylation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.8059999942779541},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.843999981880188},{"id":"https://openalex.org/keywords/kasumi-1-cells","display_name":"Kasumi-1 cells","score":0.9860000014305115}],"concepts":[{"id":"https://openalex.org/C2780235182","wikidata":"https://www.wikidata.org/wiki/Q1181878","display_name":"Decitabine","level":5,"score":0.8081109523773193},{"id":"https://openalex.org/C2776239401","wikidata":"https://www.wikidata.org/wiki/Q416451","display_name":"Azacitidine","level":5,"score":0.7888795733451843},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.6661365032196045},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6592432260513306},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6335853934288025},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5310459733009338},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5278408527374268},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.49765899777412415},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.48766791820526123},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4820426404476166},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.45462846755981445},{"id":"https://openalex.org/C2776012956","wikidata":"https://www.wikidata.org/wiki/Q17125294","display_name":"Hypomethylating agent","level":5,"score":0.41922134160995483},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2594216465950012},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23372599482536316},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17762458324432373},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0880621075630188},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.06510484218597412},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.0},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-1274380/v2","doi":"https://doi.org/10.21203/rs.3.rs-1274380/v2","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1274380/v2","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-1274380/v2","doi":"https://doi.org/10.21203/rs.3.rs-1274380/v2","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1274380/v2","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"No poverty","id":"https://metadata.un.org/sdg/1","score":0.4399999976158142}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322170","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1255676896","https://openalex.org/W1519765314","https://openalex.org/W1566258855","https://openalex.org/W1972978471","https://openalex.org/W1985704394","https://openalex.org/W2015401701","https://openalex.org/W2017151158","https://openalex.org/W2027241628","https://openalex.org/W2028286076","https://openalex.org/W2034676880","https://openalex.org/W2051023783","https://openalex.org/W2081895311","https://openalex.org/W2087377443","https://openalex.org/W2104005232","https://openalex.org/W2129486980","https://openalex.org/W2145941456","https://openalex.org/W2148802388","https://openalex.org/W2157710603","https://openalex.org/W2157783208","https://openalex.org/W2158804744","https://openalex.org/W2159482845","https://openalex.org/W2170551349","https://openalex.org/W2192877027","https://openalex.org/W2471084888","https://openalex.org/W2561161989","https://openalex.org/W2774072836","https://openalex.org/W2789843538","https://openalex.org/W2889271227","https://openalex.org/W2900044275","https://openalex.org/W2904142799","https://openalex.org/W2911561283","https://openalex.org/W2950274377","https://openalex.org/W2998017678"],"related_works":["https://openalex.org/W2316427340","https://openalex.org/W2065576507","https://openalex.org/W2319910057","https://openalex.org/W2054507167","https://openalex.org/W2189342016","https://openalex.org/W2167485228","https://openalex.org/W1974512900","https://openalex.org/W4286817035","https://openalex.org/W1575781057","https://openalex.org/W2348621912"],"abstract_inverted_index":{"Abstract":[0],"BackgroundIn":[1],"myelodysplastic":[2],"syndrome":[3],"(MDS),":[4],"resistance":[5,155],"to":[6,23,65,156],"hypomethylating":[7,157],"agents":[8],"(HMA)":[9],"portends":[10],"a":[11,78,116],"poor":[12],"prognosis,":[13],"underscoring":[14],"the":[15,19],"importance":[16],"of":[17,54,71,80,88,94,107,115,126,148],"understanding":[18],"molecular":[20],"mechanisms":[21],"leading":[22],"HMA-resistance.":[24],"MethodsIn":[25],"this":[26,127],"study,":[27],"P39":[28,61,122],"and":[29,32,35,43,48,67,113,145,150],"Kasumi-1":[30],"cells":[31],"their":[33],"azacitidine-resistant":[34,121],"decitabine-resistant":[36],"sublines":[37],"were":[38,152],"evaluated":[39],"comparatively":[40],"with":[41,57,84,92,139,154],"transcriptomic":[42],"methylomic":[44],"analyses.":[45],"ResultsExpression":[46],"profiling":[47],"genome-wide":[49],"methylation":[50],"microarray":[51],"showed":[52],"downregulation":[53,93],"PTEN":[55,72,149],"associated":[56,153],"DNA":[58,86],"hypermethylation":[59],"in":[60,77,96,110,120,135],"cell":[62,99],"lines":[63],"resistant":[64,98],"azacitidine":[66],"decitabine.":[68],"This":[69],"pattern":[70],"dysregulation":[73,147],"was":[74,90,131],"also":[75,132],"confirmed":[76],"cohort":[79],"patients":[81,137],"failing":[82],"treatment":[83],"HMA.":[85],"hypomethylation":[87,106],"MDM2":[89,95,108,118,128,151],"detected":[91],"HMA":[97],"lines.":[100],"Long-read":[101],"sequencing":[102],"revealed":[103],"significant":[104],"RNA":[105],"resulting":[109],"alternative":[111],"splicing":[112],"production":[114],"truncated":[117,129],"transcript":[119,130],"cells.":[123],"The":[124],"expression":[125],"significantly":[133],"increased":[134],"HMA-resistant":[136],"compared":[138],"HMA-responsive":[140],"patients.":[141],"ConclusionsIn":[142],"conclusion,":[143],"epigenetic":[144],"epi-transcriptomic":[146],"agents.":[158]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}