{"id":"https://openalex.org/W4225428147","doi":"https://doi.org/10.1002/btm2.10329","title":"Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasound","display_name":"Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasound","publication_year":2022,"publication_date":"2022-05-03","ids":{"openalex":"https://openalex.org/W4225428147","doi":"https://doi.org/10.1002/btm2.10329","pmid":"https://pubmed.ncbi.nlm.nih.gov/36684089","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9842024"},"language":"en","primary_location":{"id":"doi:10.1002/btm2.10329","doi":"https://doi.org/10.1002/btm2.10329","is_oa":true,"landing_page_url":"https://doi.org/10.1002/btm2.10329","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/btm2.10329","source":{"id":"https://openalex.org/S4210212656","display_name":"Bioengineering & Translational Medicine","issn_l":"2380-6761","issn":["2380-6761"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering &amp; Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/btm2.10329","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070673046","display_name":"Gerhard Leinenga","orcid":"https://orcid.org/0000-0002-3149-0909","observed_orcids":["https://orcid.org/0000-0002-3149-0909"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gerhard Leinenga","raw_affiliation_strings":["Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane (St Lucia Campus), Queensland, Australia"],"raw_orcid":"https://orcid.org/0000-0002-3149-0909","affiliations":[{"raw_affiliation_string":"Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane (St Lucia Campus), Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053165887","display_name":"Liviu\u2010Gabriel Bodea","orcid":"https://orcid.org/0000-0002-9604-9524","observed_orcids":["https://orcid.org/0000-0002-9604-9524"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Liviu\u2010Gabriel Bodea","raw_affiliation_strings":["Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane (St Lucia Campus), Queensland, Australia"],"raw_orcid":"https://orcid.org/0000-0002-9604-9524","affiliations":[{"raw_affiliation_string":"Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane (St Lucia Campus), Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108605263","display_name":"Jan Schr\u00f6der","orcid":"https://orcid.org/0000-0001-5270-0605","observed_orcids":["https://orcid.org/0000-0001-5270-0605"]},"institutions":[{"id":"https://openalex.org/I2801239119","display_name":"Australian Regenerative Medicine Institute","ror":"https://ror.org/02qa5kg76","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801037857","https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jan Schr\u00f6der","raw_affiliation_strings":["Department of Anatomy &amp; Developmental Biology and the Australian Regenerative Medicine Institute Monash University  Melbourne Victoria Australia","Department of Anatomy & Developmental Biology and the Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy &amp; Developmental Biology and the Australian Regenerative Medicine Institute Monash University  Melbourne Victoria Australia","institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"raw_affiliation_string":"Department of Anatomy & Developmental Biology and the Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043759736","display_name":"Giuzhi Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801239119","display_name":"Australian Regenerative Medicine Institute","ror":"https://ror.org/02qa5kg76","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801037857","https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Giuzhi Sun","raw_affiliation_strings":["Department of Anatomy &amp; Developmental Biology and the Australian Regenerative Medicine Institute Monash University  Melbourne Victoria Australia","Department of Anatomy & Developmental Biology and the Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy &amp; Developmental Biology and the Australian Regenerative Medicine Institute Monash University  Melbourne Victoria Australia","institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"raw_affiliation_string":"Department of Anatomy & Developmental Biology and the Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101033739","display_name":"Yichen Zhou","orcid":"https://orcid.org/0009-0001-4572-0090","observed_orcids":["https://orcid.org/0009-0001-4572-0090"]},"institutions":[{"id":"https://openalex.org/I2801239119","display_name":"Australian Regenerative Medicine Institute","ror":"https://ror.org/02qa5kg76","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801037857","https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yichen Zhou","raw_affiliation_strings":["Department of Anatomy &amp; Developmental Biology and the Australian Regenerative Medicine Institute Monash University  Melbourne Victoria Australia","Department of Anatomy & Developmental Biology and the Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy &amp; Developmental Biology and the Australian Regenerative Medicine Institute Monash University  Melbourne Victoria Australia","institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"raw_affiliation_string":"Department of Anatomy & Developmental Biology and the Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039982342","display_name":"Jae Hee Song","orcid":"https://orcid.org/0000-0002-6716-5681","observed_orcids":["https://orcid.org/0000-0002-6716-5681"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jae Song","raw_affiliation_strings":["Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane (St Lucia Campus), Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane (St Lucia Campus), Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082551254","display_name":"Alexandra Grubman","orcid":"https://orcid.org/0000-0003-4408-4499","observed_orcids":["https://orcid.org/0000-0003-4408-4499"]},"institutions":[{"id":"https://openalex.org/I2801239119","display_name":"Australian Regenerative Medicine Institute","ror":"https://ror.org/02qa5kg76","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801037857","https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Alexandra Grubman","raw_affiliation_strings":["Department of Anatomy &amp; Developmental Biology and the Australian Regenerative Medicine Institute Monash University  Melbourne Victoria Australia","Department of Anatomy & Developmental Biology and the Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0003-4408-4499","affiliations":[{"raw_affiliation_string":"Department of Anatomy &amp; Developmental Biology and the Australian Regenerative Medicine Institute Monash University  Melbourne Victoria Australia","institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"raw_affiliation_string":"Department of Anatomy & Developmental Biology and the Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012942304","display_name":"Jose Maria Polo","orcid":"https://orcid.org/0000-0002-2531-778X","observed_orcids":["https://orcid.org/0000-0002-2531-778X"]},"institutions":[{"id":"https://openalex.org/I2801239119","display_name":"Australian Regenerative Medicine Institute","ror":"https://ror.org/02qa5kg76","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801037857","https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Jose M. Polo","raw_affiliation_strings":["Department of Anatomy &amp; Developmental Biology and the Australian Regenerative Medicine Institute Monash University  Melbourne Victoria Australia","Department of Anatomy & Developmental Biology and the Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0002-2531-778X","affiliations":[{"raw_affiliation_string":"Department of Anatomy &amp; Developmental Biology and the Australian Regenerative Medicine Institute Monash University  Melbourne Victoria Australia","institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"raw_affiliation_string":"Department of Anatomy & Developmental Biology and the Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045325665","display_name":"J\u00fcrgen G\u00f6tz","orcid":"https://orcid.org/0000-0001-8501-7896","observed_orcids":["https://orcid.org/0000-0001-8501-7896","https://orcid.org/0000-0002-2003-9135"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"J\u00fcrgen G\u00f6tz","raw_affiliation_strings":["Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane (St Lucia Campus), Queensland, Australia"],"raw_orcid":"https://orcid.org/0000-0001-8501-7896","affiliations":[{"raw_affiliation_string":"Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane (St Lucia Campus), Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012942304","https://openalex.org/A5045325665","https://openalex.org/A5082551254"],"corresponding_institution_ids":["https://openalex.org/I165143802","https://openalex.org/I2801239119","https://openalex.org/I56590836"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":2.4145,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.8921565,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"e10329","last_page":"e10329"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5034000277519226,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5034000277519226,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.4480000138282776,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.025299999862909317,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9620000123977661},{"id":"https://openalex.org/keywords/microbubbles","display_name":"microbubbles","score":0.9660000205039978},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8930000066757202},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7229999899864197},{"id":"https://openalex.org/keywords/blood-brain-barrier-opening","display_name":"blood-brain barrier opening","score":0.8230000138282776},{"id":"https://openalex.org/keywords/microglial-transcriptome","display_name":"microglial transcriptome","score":0.7080000042915344},{"id":"https://openalex.org/keywords/phagosome-pathway","display_name":"phagosome pathway","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cell-cycle-genes","display_name":"cell cycle genes","score":0.8519999980926514},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.8194262981414795},{"id":"https://openalex.org/C64012434","wikidata":"https://www.wikidata.org/wiki/Q6839290","display_name":"Microbubbles","level":3,"score":0.6657472252845764},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.6553217768669128},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.6146377325057983},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.44535568356513977},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4367590546607971},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4283139705657959},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34708401560783386},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.32449227571487427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26748496294021606},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21082496643066406},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.20652765035629272},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.09295728802680969},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1002/btm2.10329","doi":"https://doi.org/10.1002/btm2.10329","is_oa":true,"landing_page_url":"https://doi.org/10.1002/btm2.10329","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/btm2.10329","source":{"id":"https://openalex.org/S4210212656","display_name":"Bioengineering & Translational Medicine","issn_l":"2380-6761","issn":["2380-6761"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering &amp; Translational Medicine","raw_type":"journal-article"},{"id":"doi:10.1101/2021.12.20.473590","doi":"https://doi.org/10.1101/2021.12.20.473590","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.12.20.473590","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/12/21/2021.12.20.473590.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9842024","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9842024","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioeng Transl Med","raw_type":"Text"},{"id":"pmid:36684089","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36684089","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering & translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/135457","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2440/135457","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dx.doi.org/10.1002/btm2.10329","raw_type":"Journal article"},{"id":"pmh:oai:doaj.org/article:4eada074200a42d6b53a82eee438c48a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4eada074200a42d6b53a82eee438c48a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioengineering & Translational Medicine, Vol 8, Iss 1, Pp n/a-n/a (2023)","raw_type":"article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/308317","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/308317","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/btm2.10329","doi":"https://doi.org/10.1002/btm2.10329","is_oa":true,"landing_page_url":"https://doi.org/10.1002/btm2.10329","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/btm2.10329","source":{"id":"https://openalex.org/S4210212656","display_name":"Bioengineering & Translational Medicine","issn_l":"2380-6761","issn":["2380-6761"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering &amp; Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4156275698","display_name":"Exploring Scanning Ultrasound (SUS), a novel method to treat and prevent neurodegenerative disease","funder_award_id":"1145580","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G8617808348","display_name":"Understanding signalling in the brain in neurons and at the blood-brain barrier in the context of Alzheimer\u2019s disease pathology and its treatment","funder_award_id":"1176326","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"},{"id":"https://openalex.org/F4320320971","display_name":"Monash University","ror":"https://ror.org/02bfwt286"},{"id":"https://openalex.org/F4320322858","display_name":"State Government of Victoria","ror":"https://ror.org/02xvc5r05"},{"id":"https://openalex.org/F4320325685","display_name":"Dementia Australia","ror":null},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320335348","display_name":"Department of Science, Information Technology and Innovation, Queensland Government","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4225428147.pdf","grobid_xml":"https://content.openalex.org/works/W4225428147.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1616122655","https://openalex.org/W1987735399","https://openalex.org/W2033105784","https://openalex.org/W2052652421","https://openalex.org/W2108277337","https://openalex.org/W2131358222","https://openalex.org/W2169076271","https://openalex.org/W2222356562","https://openalex.org/W2265799967","https://openalex.org/W2274959647","https://openalex.org/W2314634699","https://openalex.org/W2408084759","https://openalex.org/W2468438354","https://openalex.org/W2530322717","https://openalex.org/W2564088374","https://openalex.org/W2622807556","https://openalex.org/W2743727231","https://openalex.org/W2754309875","https://openalex.org/W2772202429","https://openalex.org/W2782455960","https://openalex.org/W2790961340","https://openalex.org/W2794408899","https://openalex.org/W2804685648","https://openalex.org/W2807207060","https://openalex.org/W2889808182","https://openalex.org/W2891710133","https://openalex.org/W2964544355","https://openalex.org/W2991414673","https://openalex.org/W3009304300","https://openalex.org/W3015035272","https://openalex.org/W3015813913","https://openalex.org/W3047911986","https://openalex.org/W3092195828","https://openalex.org/W3092432058","https://openalex.org/W3098995729","https://openalex.org/W3127469829","https://openalex.org/W3142848788","https://openalex.org/W3161784488","https://openalex.org/W3164578049","https://openalex.org/W3176585543","https://openalex.org/W3185072862","https://openalex.org/W3210243069","https://openalex.org/W3210405129"],"related_works":["https://openalex.org/W2897950021","https://openalex.org/W3161784488","https://openalex.org/W2169076271","https://openalex.org/W3092432058","https://openalex.org/W2946005609","https://openalex.org/W2790961340","https://openalex.org/W2964544355","https://openalex.org/W4210523407","https://openalex.org/W3014859431","https://openalex.org/W6939701452"],"abstract_inverted_index":{"Abstract":[0],"Rationale":[1],"Intracranial":[2],"scanning":[3],"ultrasound":[4,278],"combined":[5],"with":[6,89,316],"intravenously":[7],"injected":[8,88],"microbubbles":[9],"(SUS":[10,154],"+MB":[11,71,75,155,180,210,237,318],")":[12],"has":[13,37],"been":[14,38],"shown":[15],"to":[16,53,69,91,118,225,238,277,300],"transiently":[17],"open":[18],"the":[19,28,45,54,84,135,182,212,217,226,240,249,254,288],"blood-brain":[20],"barrier":[21],"and":[22,64,102,112,121,158,189,257],"reduce":[23],"amyloid-\u03b2":[24],"(A\u03b2)":[25],"pathology":[26],"in":[27,42,181,191,222,229,245,248,252,271,308],"APP23":[29,65,85,313],"mouse":[30,274],"model":[31,146,275],"of":[32,47,134,203,206,269,283,287,291,304],"Alzheimer\u2019s":[33],"disease":[34],"(AD).":[35],"This":[36],"accomplished,":[39],"at":[40],"least":[41],"part,":[43],"through":[44,126],"activation":[46,303],"microglial":[48,97,136,260,309],"cells;":[49],"however,":[50,233],"their":[51,122],"response":[52],"SUS":[55,70,179,209,236,317],"treatment":[56,153,218,279],"is":[57],"only":[58],"incompletely":[59],"understood.":[60],"Methods":[61],"Wild-type":[62],"(WT)":[63],"mice":[66,77,86,314],"were":[67,87,116,175],"subjected":[68,117,276],",":[72,211],"using":[73,106],"non-SUS":[74],"-treated":[76],"as":[78,150,152,280],"sham":[79],"controls.":[80],"After":[81],"48":[82],"hours,":[83],"methoxy-XO4":[90],"label":[92],"A\u03b2":[93,159,284],"aggregates,":[94],"followed":[95],"by":[96,178],"isolation":[98],"into":[99],"XO4":[100,103,110,113,164,183,230,255,258],"+":[101,111,162,184,231,256],"-":[104,114,165,193,259],"populations":[105],"flow":[107],"cytometry.":[108],"Both":[109],"cells":[115,137,185,194,310],"RNA":[119],"sequencing":[120],"transcriptome":[123],"was":[124],"analyzed":[125],"a":[127,139,266,281],"bioinformatics":[128],"pipeline.":[129],"Results":[130],"The":[131],"transcriptomic":[132],"analysis":[133,170,214,241,268],"revealed":[138,242],"clear":[140],"segregation":[141],"depending":[142],"on":[143],"genotype":[144],"(AD":[145],"versus":[147,156,163],"WT":[148],"mice),":[149],"well":[151],"sham)":[157],"internalization":[160],"(XO4":[161],"microglia).":[166],"Differential":[167],"gene":[168],"expression":[169],"detected":[171],"278":[172],"genes":[173,223,246,296],"that":[174,216],"significantly":[176],"changed":[177],"(248":[186],"up/30":[187],"down)":[188],"242":[190],"XO":[192],"(225":[195],"up/17":[196],"down).":[197],"Not":[198],"surprisingly":[199],"given":[200],"previous":[201],"findings":[202],"increased":[204],"phagocytosis":[205],"plaques":[207],"following":[208],"pathway":[213,228],"highlighted":[215],"induced":[219],"an":[220,243,272,301],"enrichment":[221,244],"related":[224],"phagosome":[227],"microglia;":[232],"when":[234],"comparing":[235],"sham,":[239],"involved":[247],"cell":[250,305],"cycle":[251,306],"both":[253],"population.":[261],"Conclusion":[262],"Our":[263],"data":[264],"provide":[265],"comprehensive":[267],"microglia":[270],"AD":[273],"function":[282],"internalization,":[285],"one":[286],"defining":[289],"hallmarks":[290],"AD.":[292],"Several":[293],"differentially":[294],"expressed":[295],"are":[297],"highlighted,":[298],"pointing":[299],"ultrasound-induced":[302],"mechanisms":[307],"isolated":[311],"from":[312],"treated":[315],".":[319],"Graphical":[320],"abstract":[321]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-05T00:00:00"}
