{"id":"https://openalex.org/W4225424166","doi":"https://doi.org/10.1096/fasebj.2022.36.s1.r3765","title":"Protease\u2010Activated Receptor\u20102 Differentially Regulates Vascular Smooth Muscle Cell Proliferation in Cyclic AMP\u2010Dependent Protein Kinase/Phosphoinositide 3\u2010Kinase\u2010Dependent Manner","display_name":"Protease\u2010Activated Receptor\u20102 Differentially Regulates Vascular Smooth Muscle Cell Proliferation in Cyclic AMP\u2010Dependent Protein Kinase/Phosphoinositide 3\u2010Kinase\u2010Dependent Manner","publication_year":2022,"publication_date":"2022-05-01","ids":{"openalex":"https://openalex.org/W4225424166","doi":"https://doi.org/10.1096/fasebj.2022.36.s1.r3765"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2022.36.s1.r3765","doi":"https://doi.org/10.1096/fasebj.2022.36.s1.r3765","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2022.36.s1.r3765","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067434743","display_name":"Madison D. Williams","orcid":"https://orcid.org/0009-0007-2955-5455","observed_orcids":["https://orcid.org/0009-0007-2955-5455"]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madison D. Williams","raw_affiliation_strings":["Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081993053","display_name":"Michael T. Bullock","orcid":"https://orcid.org/0009-0008-7237-6273","observed_orcids":["https://orcid.org/0009-0008-7237-6273","https://orcid.org/0000-0002-3103-1198"]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael T. Bullock","raw_affiliation_strings":["Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102950580","display_name":"Nathan A. Holland","orcid":"https://orcid.org/0000-0001-6268-4856","observed_orcids":["https://orcid.org/0000-0001-6268-4856"]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan A. Holland","raw_affiliation_strings":["Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sean C. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean C. Johnson","raw_affiliation_strings":["Department of Internal Medicine/Pediatrics, Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine/Pediatrics, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077791447","display_name":"Danielle M. Vuncannon","orcid":"https://orcid.org/0000-0002-2522-6677","observed_orcids":["https://orcid.org/0000-0002-2522-6677"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danielle M. Vuncannon","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028241279","display_name":"Joani Zary Oswald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joani Z. Oswald","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017892619","display_name":"Shaquria Adderley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaquria P. Adderley","raw_affiliation_strings":["Basic Science Department, Touro University, Henderson, NV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Science Department, Touro University, Henderson, NV","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005382945","display_name":"David A. Tulis","orcid":"https://orcid.org/0000-0003-3490-2283","observed_orcids":["https://orcid.org/0000-0003-3490-2283"]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Tulis","raw_affiliation_strings":["Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC","institution_ids":["https://openalex.org/I186335123"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3200,"currency":"USD","value_usd":3200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05685441,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protease-activated-receptor-2","display_name":"protease-activated receptor 2","score":0.9829999804496765},{"id":"https://openalex.org/keywords/protease-activated-receptor-4","display_name":"PAR4","score":0.9909999966621399},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cell-proliferation","display_name":"vascular smooth muscle cell proliferation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/phenotypic-switching","display_name":"phenotypic switching","score":0.8069999814033508},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.8930000066757202},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/vasp","display_name":"VASP","score":0.9580000042915344},{"id":"https://openalex.org/keywords/carotid-artery-injury","display_name":"carotid artery injury","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6242272853851318},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.542759120464325},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.5026423931121826},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.49372372031211853},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.48982951045036316},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4797462224960327},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4720664322376251},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.28693315386772156},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1405515968799591},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1096/fasebj.2022.36.s1.r3765","doi":"https://doi.org/10.1096/fasebj.2022.36.s1.r3765","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2022.36.s1.r3765","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmh:oai:touroscholar.touro.edu:tuncom_pubs-1221","doi":null,"is_oa":false,"landing_page_url":"https://touroscholar.touro.edu/tuncom_pubs/221","pdf_url":null,"source":{"id":"https://openalex.org/S4377196437","display_name":"Touro Scholar (Touro College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200437953","host_organization_name":"Touro College","host_organization_lineage":["https://openalex.org/I200437953"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"College of Osteopathic Medicine (TUN) Publications and Research","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1624897150","display_name":"Acid-sensing GPCRs in vascular inflammation and growth","funder_award_id":"1r15hl135699-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3758213330","display_name":"NO-independent cGMP regulation of vascular remodeling","funder_award_id":"R01HL081720","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387242075","https://openalex.org/W2990881576","https://openalex.org/W4412805636","https://openalex.org/W4407037421","https://openalex.org/W3016731081","https://openalex.org/W94263925","https://openalex.org/W4387270319","https://openalex.org/W2161543098","https://openalex.org/W4291130689","https://openalex.org/W2147666416"],"abstract_inverted_index":{"Cardiovascular":[0],"disease":[1],"(CVD)":[2],"remains":[3],"the":[4,24,69,75,166,276],"leading":[5],"cause":[6],"of":[7,14,27,47,68,77,159,226,250,270,278,288],"morbidity":[8],"and":[9,79,84,91,99,114,132,165,190,204,214,230,262,272,282],"mortality":[10],"worldwide,":[11],"despite":[12],"decades":[13],"extensive":[15],"research.":[16],"One":[17],"key":[18],"facet":[19],"in":[20,50,61,81,97,103,123,152,206,216,232,275,291],"CVD":[21,62],"pathogenesis":[22],"is":[23,63],"phenotypic":[25,58,82],"transition":[26],"affected":[28],"vascular":[29],"smooth":[30],"muscle":[31],"(VSM)":[32],"from":[33,174],"a":[34,39],"quiescent,":[35],"contractile":[36],"state":[37],"to":[38,73,108,140,154,194],"synthetic,":[40],"proliferative":[41],"state.":[42],"Protease\u2010activated":[43],"receptors":[44],"(PARs)":[45],"are":[46],"emerging":[48],"interest":[49],"CVD;":[51],"however,":[52],"their":[53],"potential":[54,267],"impact":[55],"on":[56],"VSM":[57,85,111,146,178,257,279,289],"switching":[59,83],"inherent":[60],"unclear.":[64],"The":[65],"overall":[66],"objective":[67],"current":[70],"study":[71,287],"was":[72],"determine":[74],"role":[76],"PAR2":[78,90,130,148,199,246,271,290],"PAR4":[80,92],"growth.":[86],"We":[87],"hypothesized":[88],"that":[89,105,115,245],"increase":[93],"following":[94,135],"arterial":[95],"injury":[96,138],"vivo":[98],"after":[100],"growth":[101,155,281],"stimulation":[102],"vitro,":[104],"they":[106,116],"serve":[107],"protect":[109],"against":[110],"cell":[112,280],"growth,":[113],"signal":[117],"primarily":[118],"through":[119,260],"specific":[120],"protein":[121,162,241],"kinases":[122],"phenotype\u2010specific":[124],"fashion.":[125],"In":[126,143],"rat":[127,144],"carotid":[128],"arteries,":[129],"expression":[131,149,158,225],"activity":[133],"increased":[134,151,224],"mechanical":[136],"distension":[137],"compared":[139,193],"uninjured":[141],"controls.":[142],"primary":[145],"cells,":[147,179],"also":[150],"response":[153],"stimulation.":[156],"Differential":[157],"cyclic":[160],"GMP\u2010dependent":[161],"kinase":[163,242],"PKG\u20101":[164],"PKG":[167],"target":[168],"VASP":[169,189,192],"distinguished":[170],"low":[171,181,207,233,253],"passage":[172],"(P3\u2010P6)":[173],"high":[175,195,217,237,255],"P":[176,182,196,208,218,234,238,256],"(P10\u2010P15)":[177],"with":[180],"cells":[183,209,235,258],"showing":[184],"elevated":[185],"PKG\u20101,":[186],"phosphorylated":[187],"(Ser239)":[188],"total":[191],"cells.":[197,219,239],"Pharmacologic":[198],"agonism":[200],"promoted":[201],"DNA":[202,212],"synthesis":[203,213],"proliferation":[205,215,249],"but":[210],"decreased":[211],"Western":[220],"blotting":[221],"analyses":[222],"showed":[223],"MEK1/2":[227],"MAPK,":[228],"PKA,":[229],"PI3K":[231],"versus":[236,254],"Specific":[240],"blockade":[243],"revealed":[244],"differentially":[247],"controls":[248],"phenotypically":[251],"distinct":[252],"predominantly":[259],"PKA":[261],"PI3K.":[263],"Our":[264],"findings":[265],"highlight":[266],"(patho)physiological":[268],"relevance":[269],"PAR2\u2010driven":[273],"PKA/PI3K":[274],"control":[277],"provide":[283],"evidence":[284],"for":[285],"continued":[286],"CVD.":[292]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-05T00:00:00"}
