{"id":"https://openalex.org/W4225422912","doi":"https://doi.org/10.1096/fasebj.2022.36.s1.0i192","title":"Orchestrated Intragranular Restructuring of Mucins During Secretory Granule Maturation","display_name":"Orchestrated Intragranular Restructuring of Mucins During Secretory Granule Maturation","publication_year":2022,"publication_date":"2022-05-01","ids":{"openalex":"https://openalex.org/W4225422912","doi":"https://doi.org/10.1096/fasebj.2022.36.s1.0i192"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.2022.36.s1.0i192","doi":"https://doi.org/10.1096/fasebj.2022.36.s1.0i192","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2022.36.s1.0i192","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039184400","display_name":"Kelly G. Ten Hagen","orcid":"https://orcid.org/0000-0002-2057-8120","observed_orcids":["https://orcid.org/0000-0002-2057-8120"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly G. Ten Hagen","raw_affiliation_strings":["NIDCR/NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIDCR/NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058752490","display_name":"Zulfeqhar Ali Syed","orcid":"https://orcid.org/0000-0002-5825-9782","observed_orcids":["https://orcid.org/0000-0002-5825-9782"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zulfeqhar A. Syed","raw_affiliation_strings":["NIDCR/NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIDCR/NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Liping Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liping Zhang","raw_affiliation_strings":["NIDCR/NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIDCR/NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065396975","display_name":"Duy T. Tran","orcid":"https://orcid.org/0009-0007-5098-8618","observed_orcids":["https://orcid.org/0009-0007-5098-8618"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duy T. Tran","raw_affiliation_strings":["NIDCR/NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIDCR/NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068287768","display_name":"Christopher K. E. Bleck","orcid":"https://orcid.org/0000-0003-1029-3444","observed_orcids":["https://orcid.org/0000-0003-1029-3444"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4388891757","display_name":"National Heart, Lung, and Blood Institute Division of Intramural Research","ror":"https://ror.org/023ny1p48","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4388891757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher K. E. Bleck","raw_affiliation_strings":["NHLBI/NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHLBI/NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4388891757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3200,"currency":"USD","value_usd":3200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05362421,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secretory-granule-maturation","display_name":"secretory granule maturation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mucin","display_name":"mucin","score":0.9160000085830688},{"id":"https://openalex.org/keywords/regulated-secretion","display_name":"regulated secretion","score":0.9660000205039978},{"id":"https://openalex.org/keywords/chloride-intracellular-channel","display_name":"CLIC","score":0.6769999861717224},{"id":"https://openalex.org/keywords/calcium","display_name":"calcium","score":0.5960000157356262},{"id":"https://openalex.org/keywords/chloride","display_name":"chloride","score":0.8399999737739563},{"id":"https://openalex.org/keywords/ph","display_name":"pH","score":0.6819999814033508},{"id":"https://openalex.org/keywords/multimodal-imaging","display_name":"multimodal imaging","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.7609959840774536},{"id":"https://openalex.org/C49760210","wikidata":"https://www.wikidata.org/wiki/Q5596727","display_name":"Granule (geology)","level":2,"score":0.7448126077651978},{"id":"https://openalex.org/C156399914","wikidata":"https://www.wikidata.org/wiki/Q7444454","display_name":"Secretory protein","level":3,"score":0.6781829595565796},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6676136255264282},{"id":"https://openalex.org/C6492254","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretory pathway","level":4,"score":0.5800846815109253},{"id":"https://openalex.org/C2909863526","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretory Vesicle","level":4,"score":0.5533668994903564},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.5188125967979431},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.5016846656799316},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.462527334690094},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.4288375973701477},{"id":"https://openalex.org/C45237549","wikidata":"https://www.wikidata.org/wiki/Q1376796","display_name":"Restructuring","level":2,"score":0.4248451590538025},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33397334814071655},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25037240982055664},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2351301908493042},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.19024962186813354},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.13982424139976501},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.13575050234794617},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.06911435723304749},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.2022.36.s1.0i192","doi":"https://doi.org/10.1096/fasebj.2022.36.s1.0i192","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.2022.36.s1.0i192","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3195716480","https://openalex.org/W4306641772","https://openalex.org/W1504648781","https://openalex.org/W2165493243","https://openalex.org/W2339438128","https://openalex.org/W1998843874","https://openalex.org/W2051473647","https://openalex.org/W2025047038","https://openalex.org/W1815456642","https://openalex.org/W2088182007"],"abstract_inverted_index":{"Regulated":[0],"secretion":[1],"is":[2],"an":[3],"essential":[4,80],"process":[5],"where":[6],"proteins":[7,33,153],"are":[8,24,79,154],"packaged":[9,156],"into":[10,157,168],"membranous":[11],"secretory":[12,21,39,122,146,163],"vesicles.":[13],"However,":[14],"the":[15,52,66,82,161],"details":[16],"of":[17,48,59,69,117,139],"cargo":[18,113,140],"packaging":[19],"and":[20,61,98,101,130,158],"granule":[22,40,123,147,164],"maturation":[23,41],"largely":[25],"unknown.":[26],"Here,":[27],"we":[28,64,109],"demonstrate":[29,65],"that":[30,78,111],"multiple":[31,151],"distinct":[32,49,71,152],"undergo":[34],"orchestrated":[35],"intragranular":[36,72],"restructuring":[37,84,143],"during":[38,145],"in":[42,133,173],"vivo,":[43],"to":[44],"allow":[45],"spatial":[46],"segregation":[47,138],"components":[50],"within":[51],"same":[53,162],"granule.":[54],"Furthermore,":[55],"through":[56,141],"a":[57],"combination":[58],"genetics":[60],"multimodality":[62],"imaging,":[63],"molecular":[67],"identity":[68],"each":[70],"structure.":[73],"We":[74],"further":[75],"identify":[76],"genes":[77],"for":[81],"temporally\u2010ordered":[83],"events,":[85],"including":[86],"those":[87],"controlling":[88],"pH":[89],"(":[90,96,105],"vha16.1":[91],"),":[92],"Cl":[93],"\u2010":[94],"ions":[95,104],"Clic":[97],"ClC\u2010c":[99],")":[100],"Ca":[102],"2+":[103],"fwe":[106],").":[107],"Finally,":[108],"show":[110],"altered":[112],"glycosylation":[114],"influences":[115],"dimensions":[116],"these":[118],"structures,":[119],"thereby":[120],"affecting":[121],"morphology.":[124],"This":[125],"study":[126],"elucidates":[127],"key":[128],"steps":[129],"factors":[131],"involved":[132],"intragranular,":[134],"rather":[135],"than":[136],"intergranular,":[137],"regulated":[142],"events":[144],"maturation.":[148],"Understanding":[149],"how":[150],"efficiently":[155],"secreted":[159],"from":[160,171],"may":[165],"provide":[166],"insight":[167],"diseases":[169],"resulting":[170],"defects":[172],"secretion.":[174]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-05T00:00:00"}
