{"id":"https://openalex.org/W4225099284","doi":"https://doi.org/10.5281/zenodo.6502808","title":"Can the systemic immune-inflammatory index be a new indicator for the diagnosis and follow-up of alzheimer's disease?","display_name":"Can the systemic immune-inflammatory index be a new indicator for the diagnosis and follow-up of alzheimer's disease?","publication_year":2022,"publication_date":"2022-04-28","ids":{"openalex":"https://openalex.org/W4225099284","doi":"https://doi.org/10.5281/zenodo.6502808"},"language":"en","primary_location":{"id":"pmh:oai:acikerisim.ozal.edu.tr:20.500.12899/1221","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/tr/pub/jomtu/issue/69653/1099505","pdf_url":"https://dergipark.org.tr/tr/download/article-file/2357782","source":{"id":"https://openalex.org/S7407055283","display_name":"Malatya Turgut \u00d6zal University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dergipark.org.tr/tr/download/article-file/2357782","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005373127","display_name":"Asl\u0131 Bolay\u0131r","orcid":"https://orcid.org/0000-0001-6566-3751","observed_orcids":["https://orcid.org/0000-0001-6566-3751"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bolay\u0131r, Asl\u0131","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6566-3751","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074529579","display_name":"Tu\u011fba Raika K\u0131ran","orcid":"https://orcid.org/0000-0002-3724-0249","observed_orcids":["https://orcid.org/0000-0002-3724-0249"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raika K\u0131ran, Tu\u011fba","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3724-0249","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078556070","display_name":"Aysun Bay Karabulut","orcid":"https://orcid.org/0000-0002-7873-2805","observed_orcids":["https://orcid.org/0000-0002-7873-2805"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bay Karabulut, Aysun","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7873-2805","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1128,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.37288932,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.8090999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.8090999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.16130000352859497,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/systemic-immune-inflammation-index","display_name":"systemic immune-inflammation index","score":0.996999979019165},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.9700000286102295},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.6930000185966492},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8270000219345093},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.878000020980835},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.9959999918937683},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.722000002861023},{"id":"https://openalex.org/keywords/lymphocyte-count","display_name":"lymphocyte count","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6253350973129272},{"id":"https://openalex.org/C2777382242","wikidata":"https://www.wikidata.org/wiki/Q6017816","display_name":"Index (typography)","level":2,"score":0.5640199184417725},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5149767994880676},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5127816796302795},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4207141697406769},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.36733657121658325},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23568958044052124},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.185005784034729},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.05494391918182373}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:acikerisim.ozal.edu.tr:20.500.12899/1221","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/tr/pub/jomtu/issue/69653/1099505","pdf_url":"https://dergipark.org.tr/tr/download/article-file/2357782","source":{"id":"https://openalex.org/S7407055283","display_name":"Malatya Turgut \u00d6zal University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:zenodo.org:6502809","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/6502809","pdf_url":"https://zenodo.org/record/6502809","source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dergipark.org.tr:article/1099505","doi":null,"is_oa":false,"landing_page_url":"https://dergipark.org.tr/tr/pub/jomtu/issue/69653/1099505","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Medical Topics and Updates","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.5281/zenodo.6502808","doi":"https://doi.org/10.5281/zenodo.6502808","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.6502808","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.6502809","doi":"https://doi.org/10.5281/zenodo.6502809","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.6502809","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:acikerisim.ozal.edu.tr:20.500.12899/1221","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/tr/pub/jomtu/issue/69653/1099505","pdf_url":"https://dergipark.org.tr/tr/download/article-file/2357782","source":{"id":"https://openalex.org/S7407055283","display_name":"Malatya Turgut \u00d6zal University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321621","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4225099284.pdf","grobid_xml":"https://content.openalex.org/works/W4225099284.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7034160341","https://openalex.org/W4402545240","https://openalex.org/W7164663975","https://openalex.org/W7127318685","https://openalex.org/W4405863685","https://openalex.org/W7221780302","https://openalex.org/W4410832457","https://openalex.org/W3087415814","https://openalex.org/W4399997638","https://openalex.org/W2031405837"],"abstract_inverted_index":{"ABSTRACT":[0],"Background:":[1],"Alzheimer's":[2],"disease":[3,9,102,182,202,237],"(AD)":[4],"is":[5,28,39,54,241],"a":[6],"chronic":[7],"neurodegenerative":[8],"whose":[10],"prevalence":[11],"continues":[12],"to":[13,33,57,77,91,131],"increase":[14],"in":[15,30,42,68,73,83,149,221],"the":[16,24,34,43,46,58,79,84,93,144,196,201,209,224,231,236],"elderly":[17],"population.":[18,36],"It":[19],"has":[20],"been":[21],"shown":[22],"that":[23,217],"neutrophil/lymphocyte":[25],"ratio":[26],"(NLR),":[27],"increased":[29,179],"AD":[31,89],"compared":[32],"normal":[35],"However,":[37,223],"there":[38],"no":[40,141,187],"study":[41,75,116],"literature":[44],"regarding":[45],"role":[47,80],"of":[48,60,81,88,95,101,118,151,200,211,226,235],"systemic":[49],"immune-inflammatory":[50],"index":[51],"(SII),":[52],"which":[53],"calculated":[55],"according":[56],"formula":[59],"peripheral":[61],"platelet":[62,154],"count":[63,163],"X":[64],"neutrophil":[65,156],"count/lymphocyte":[66],"count,":[67],"AD.":[69,137,222],"Therefore,":[70],"our":[71,132,212],"aim":[72],"this":[74,96,227],"was":[76,140,164,191],"reveal":[78],"SII":[82,159,178],"diagnosis":[85],"and":[86,90,103,112,121,126,146,155,158,169,184,195,198,203,233,238],"follow-up":[87],"determine":[92],"relationship":[94,225],"value":[97],"with":[98,109,136,230],"severity,":[99],"duration":[100,183,199,234],"drug":[104,204,239],"use":[105,240],"by":[106],"comparing":[107],"it":[108],"NLR.":[110],"Materials":[111],"Methods:":[113],"Our":[114],"retrospective":[115],"consisted":[117],"94":[119],"gender":[120],"age":[122],"matched":[123],"healthy":[124],"volunteers":[125],"102":[127],"patients":[128],"who":[129],"applied":[130],"clinic":[133],"were":[134],"diagnosed":[135],"Results:":[138],"There":[139],"difference":[142],"between":[143,193],"patient":[145],"control":[147],"groups":[148],"terms":[150],"age,":[152],"gender,":[153],"counts,":[157],"values.":[160],"While":[161,177],"lymphocyte":[162],"lower":[165],"in-patient":[166],"group;":[167],"NLR":[168,194],"CRP":[170],"detected":[171],"higher":[172],"(p=0.001,":[173],"p=0.001,":[174,175],"respectively).":[176],"as":[180],"both":[181],"severity":[185,197,232],"elevated;":[186],"statistically":[188],"significant":[189],"correlation":[190],"found":[192],"use.":[205],"Conclusions:":[206],"Based":[207],"on":[208],"data":[210],"study,":[213],"we":[214],"can":[215],"suggest":[216],"inflammatory":[218,228],"process":[219,229],"increases":[220],"still":[242],"unknown.":[243]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-04-30T00:00:00"}
