{"id":"https://openalex.org/W4224994142","doi":"https://doi.org/10.1111/biom.13680","title":"A Bayesian Model with Application for Adaptive Platform Trials Having Temporal Changes","display_name":"A Bayesian Model with Application for Adaptive Platform Trials Having Temporal Changes","publication_year":2022,"publication_date":"2022-04-27","ids":{"openalex":"https://openalex.org/W4224994142","doi":"https://doi.org/10.1111/biom.13680","pmid":"https://pubmed.ncbi.nlm.nih.gov/35476298"},"language":"en","primary_location":{"id":"doi:10.1111/biom.13680","doi":"https://doi.org/10.1111/biom.13680","is_oa":false,"landing_page_url":"https://doi.org/10.1111/biom.13680","pdf_url":null,"source":{"id":"https://openalex.org/S8265502","display_name":"Biometrics","issn_l":"0006-341X","issn":["0006-341X","1541-0420"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biometrics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038929034","display_name":"Chenguang Wang","orcid":"https://orcid.org/0000-0002-7085-3303","observed_orcids":["https://orcid.org/0000-0002-7085-3303","https://orcid.org/0009-0006-4205-771X","https://orcid.org/0009-0007-6271-4497"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chenguang Wang","raw_affiliation_strings":["Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University , Baltimore, Maryland , USA"],"raw_orcid":"https://orcid.org/0000-0002-7085-3303","affiliations":[{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University , Baltimore, Maryland , USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100616299","display_name":"Min Lin","orcid":"https://orcid.org/0000-0001-7042-9601","observed_orcids":["https://orcid.org/0000-0001-7042-9601"]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Lin","raw_affiliation_strings":["BioPharmaceuticals R&D, AstraZeneca , Gaithersburg, Maryland , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioPharmaceuticals R&D, AstraZeneca , Gaithersburg, Maryland , USA","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007801126","display_name":"Gary L. Rosner","orcid":"https://orcid.org/0000-0001-5566-6537","observed_orcids":["https://orcid.org/0000-0001-5566-6537"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary L. Rosner","raw_affiliation_strings":["Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University , Baltimore, Maryland , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University , Baltimore, Maryland , USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002854695","display_name":"Guoxing G Soon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1333606569","display_name":"Center for Drug Evaluation and Research","ror":"https://ror.org/00yf3tm42","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070","https://openalex.org/I1333606569"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Guoxing Soon","raw_affiliation_strings":["Center for Drug Evaluation and Research, Food and Drug Administration , Silver Spring, Maryland , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Drug Evaluation and Research, Food and Drug Administration , Silver Spring, Maryland , USA","institution_ids":["https://openalex.org/I1320320070","https://openalex.org/I1333606569"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5002854695"],"corresponding_institution_ids":["https://openalex.org/I1320320070","https://openalex.org/I1333606569"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":1.8438,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.86891877,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"79","issue":"2","first_page":"1446","last_page":"1458"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adaptive-platform-trial","display_name":"adaptive platform trial","score":0.972000002861023},{"id":"https://openalex.org/keywords/temporal-effects","display_name":"time effects","score":0.9020000100135803},{"id":"https://openalex.org/keywords/hidden-markov-models","display_name":"hidden Markov models","score":0.9980000257492065},{"id":"https://openalex.org/keywords/particle-filtering","display_name":"particle filter","score":0.9869999885559082},{"id":"https://openalex.org/keywords/clinical-trial-design","display_name":"clinical trial design","score":0.7429999709129333},{"id":"https://openalex.org/keywords/medical-product-development","display_name":"medical product development","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6908978819847107},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6778420805931091},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.5843005776405334},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4389249384403229},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4198642075061798},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2852681279182434},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09290096163749695}],"mesh":[{"descriptor_ui":"D000075522","descriptor_name":"Adaptive Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/biom.13680","doi":"https://doi.org/10.1111/biom.13680","is_oa":false,"landing_page_url":"https://doi.org/10.1111/biom.13680","pdf_url":null,"source":{"id":"https://openalex.org/S8265502","display_name":"Biometrics","issn_l":"0006-341X","issn":["0006-341X","1541-0420"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biometrics","raw_type":"journal-article"},{"id":"pmid:35476298","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35476298","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biometrics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000866064","display_name":"SPORE in Cervical Cancer","funder_award_id":"P50CA098252","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000911005","display_name":"Regional Oncology Research Center","funder_award_id":"P30CA006973","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1483307070","https://openalex.org/W1511524925","https://openalex.org/W1844985714","https://openalex.org/W1895243895","https://openalex.org/W1973521570","https://openalex.org/W1980501503","https://openalex.org/W2008964214","https://openalex.org/W2010622913","https://openalex.org/W2021609141","https://openalex.org/W2040749143","https://openalex.org/W2075095321","https://openalex.org/W2100950823","https://openalex.org/W2111787305","https://openalex.org/W2114361293","https://openalex.org/W2134306860","https://openalex.org/W2152878178","https://openalex.org/W2166992787","https://openalex.org/W2244666291","https://openalex.org/W2343362475","https://openalex.org/W2346987786","https://openalex.org/W2544612685","https://openalex.org/W2566492581","https://openalex.org/W2726405642","https://openalex.org/W2743122016","https://openalex.org/W2791402324","https://openalex.org/W2804946538","https://openalex.org/W2888632634","https://openalex.org/W2925249600","https://openalex.org/W2969790116","https://openalex.org/W2973459418","https://openalex.org/W2973709173","https://openalex.org/W2982812115","https://openalex.org/W2983727442","https://openalex.org/W3040508995","https://openalex.org/W3089510999","https://openalex.org/W3195119451","https://openalex.org/W4236654676","https://openalex.org/W4254966740"],"related_works":["https://openalex.org/W4292595864","https://openalex.org/W7081167724","https://openalex.org/W2903300857","https://openalex.org/W4389553541","https://openalex.org/W4415011081","https://openalex.org/W7125412690","https://openalex.org/W2520214602","https://openalex.org/W2124039397","https://openalex.org/W6901897316","https://openalex.org/W651652324"],"abstract_inverted_index":{"Temporal":[0],"changes":[1,36],"exist":[2],"in":[3,9,79,137],"clinical":[4,19,26,38,65],"trials.":[5],"Over":[6],"time,":[7],"shifts":[8],"patients'":[10],"characteristics,":[11],"trial":[12,20],"conduct,":[13],"and":[14,40,48,103,123,135],"other":[15],"features":[16],"of":[17,34,119,130],"a":[18,60,89,99,105],"may":[21],"occur.":[22],"In":[23,84],"typical":[24],"randomized":[25],"trials,":[27],"temporal":[28,35,56,95],"effects,":[29],"that":[30,75],"is,":[31],"the":[32,71,117,120],"impact":[33],"on":[37,98,128],"outcomes":[39],"study":[41],"analysis,":[42],"are":[43,76],"largely":[44],"mitigated":[45],"by":[46],"randomization":[47],"usually":[49],"need":[50],"not":[51],"be":[52,59],"explicitly":[53],"addressed.":[54],"However,":[55],"effects":[57,96],"can":[58],"serious":[61],"obstacle":[62],"for":[63,93,109],"conducting":[64],"trials":[66,74,129],"with":[67],"complex":[68],"designs,":[69],"including":[70],"adaptive":[72],"platform":[73],"gaining":[77],"popularity":[78],"recent":[80],"medical":[81],"product":[82],"development.":[83],"this":[85],"paper,":[86],"we":[87],"introduce":[88],"Bayesian":[90],"robust":[91],"prior":[92],"mitigating":[94],"based":[97,127],"hidden":[100],"Markov":[101],"model,":[102],"propose":[104],"particle":[106],"filtering":[107],"algorithm":[108],"computation.":[110],"We":[111],"conduct":[112],"simulation":[113],"studies":[114],"to":[115],"evaluate":[116],"performance":[118],"proposed":[121],"method":[122],"provide":[124],"illustration":[125],"examples":[126],"Ebola":[131],"virus":[132],"disease":[133],"therapeutics":[134],"hemostat":[136],"vascular":[138],"surgery.":[139]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-04-28T00:00:00"}