{"id":"https://openalex.org/W4224980431","doi":"https://doi.org/10.3233/jad-215660","title":"Cancer History Is Associated with Slower Speed of Cognitive Decline in Patients with Amnestic Cognitive Impairment","display_name":"Cancer History Is Associated with Slower Speed of Cognitive Decline in Patients with Amnestic Cognitive Impairment","publication_year":2022,"publication_date":"2022-04-26","ids":{"openalex":"https://openalex.org/W4224980431","doi":"https://doi.org/10.3233/jad-215660","pmid":"https://pubmed.ncbi.nlm.nih.gov/35491784"},"language":"en","primary_location":{"id":"doi:10.3233/jad-215660","doi":"https://doi.org/10.3233/jad-215660","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-215660","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070600524","display_name":"Rolando I Castillo-Passi","orcid":"https://orcid.org/0000-0002-9446-074X","observed_orcids":["https://orcid.org/0000-0002-9446-074X"]},"institutions":[{"id":"https://openalex.org/I133599470","display_name":"Universidad del Desarrollo","ror":"https://ror.org/05y33vv83","country_code":"CL","type":"education","lineage":["https://openalex.org/I133599470"]},{"id":"https://openalex.org/I2801797538","display_name":"Cl\u00ednica Alemana","ror":"https://ror.org/028ynny55","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I2801797538"]},{"id":"https://openalex.org/I4210131012","display_name":"Hospital Cl\u00ednico de la Universidad de Chile","ror":"https://ror.org/02xtpdq88","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4210131012"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Rolando I. Castillo-Passi","raw_affiliation_strings":["Centro de Investigaci\u00f3n Cl\u00ednica Avanzada (CICA), Hospital Cl\u00ednico de la Universidad de Chile, Independencia, Santiago, RM, Chile","Departamento de Neurolog\u00eda y Psiquiatr\u00eda, CAS, Cl\u00ednica Alemana Universidad del Desarrollo, Santiago, RM, Chile","Laboratorio de Psiquiatr\u00eda Traslacional, Cl\u00ednica Psiqui\u00e1trica Universitaria, Universidad de Chile, Recoleta, Santiago, RM, Chile","Millennium Nucleus to Improve the Mental Health of Adolescents and Youths, Imhay, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Cl\u00ednica Avanzada (CICA), Hospital Cl\u00ednico de la Universidad de Chile, Independencia, Santiago, RM, Chile","institution_ids":["https://openalex.org/I4210131012"]},{"raw_affiliation_string":"Departamento de Neurolog\u00eda y Psiquiatr\u00eda, CAS, Cl\u00ednica Alemana Universidad del Desarrollo, Santiago, RM, Chile","institution_ids":["https://openalex.org/I133599470","https://openalex.org/I2801797538"]},{"raw_affiliation_string":"Laboratorio de Psiquiatr\u00eda Traslacional, Cl\u00ednica Psiqui\u00e1trica Universitaria, Universidad de Chile, Recoleta, Santiago, RM, Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Millennium Nucleus to Improve the Mental Health of Adolescents and Youths, Imhay, Chile","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059939654","display_name":"Rodrigo Clemente Vergara","orcid":"https://orcid.org/0000-0002-1943-2060","observed_orcids":["https://orcid.org/0000-0002-1943-2060"]},"institutions":[{"id":"https://openalex.org/I2802066150","display_name":"Metropolitan University of Educational Sciences","ror":"https://ror.org/057anza51","country_code":"CL","type":"education","lineage":["https://openalex.org/I2802066150"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Rodrigo C. Vergara","raw_affiliation_strings":["Centro Nacional de Inteligencia Artificial (CENIA), Macul, Santiago, RM, Chile","Departamento de Kinesiolog\u00eda, Facultad de Artes y Educaci\u00f3n F\u00edsica, Universidad Metropolitana de Ciencias de la Educaci\u00f3n, Santiago, RM, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de Inteligencia Artificial (CENIA), Macul, Santiago, RM, Chile","institution_ids":[]},{"raw_affiliation_string":"Departamento de Kinesiolog\u00eda, Facultad de Artes y Educaci\u00f3n F\u00edsica, Universidad Metropolitana de Ciencias de la Educaci\u00f3n, Santiago, RM, Chile","institution_ids":["https://openalex.org/I2802066150"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103938001","display_name":"Nicole K. Rogers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405284761","display_name":"Instituto de Neurocirug\u00eda Dr. Alfonso Asenjo","ror":"https://ror.org/045qz8528","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4405284761"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Nicole K. Rogers","raw_affiliation_strings":["Departamento de Neurociencia, Facultad de Medicina Universidad de Chile, Independencia Santiago, RM, Chile","Instituto de Neurocirug\u00eda Dr. Alfonso Asenjo, Providencia, Santiago, RM, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Neurociencia, Facultad de Medicina Universidad de Chile, Independencia Santiago, RM, Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Instituto de Neurocirug\u00eda Dr. Alfonso Asenjo, Providencia, Santiago, RM, Chile","institution_ids":["https://openalex.org/I4405284761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112960148","display_name":"Daniela P. Ponce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131012","display_name":"Hospital Cl\u00ednico de la Universidad de Chile","ror":"https://ror.org/02xtpdq88","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4210131012"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Daniela P. Ponce","raw_affiliation_strings":["Centro de Investigaci\u00f3n Cl\u00ednica Avanzada (CICA), Hospital Cl\u00ednico de la Universidad de Chile, Independencia, Santiago, RM, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Cl\u00ednica Avanzada (CICA), Hospital Cl\u00ednico de la Universidad de Chile, Independencia, Santiago, RM, Chile","institution_ids":["https://openalex.org/I4210131012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087252031","display_name":"Magdalena Bennett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Magdalena Bennett","raw_affiliation_strings":["IROM Department, McCombs School of Business, The University of Texas at Austin, Austin, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IROM Department, McCombs School of Business, The University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034268426","display_name":"Mar\u00eda Isabel Behrens","orcid":"https://orcid.org/0000-0003-0964-426X","observed_orcids":["https://orcid.org/0000-0003-0964-426X"]},"institutions":[{"id":"https://openalex.org/I133599470","display_name":"Universidad del Desarrollo","ror":"https://ror.org/05y33vv83","country_code":"CL","type":"education","lineage":["https://openalex.org/I133599470"]},{"id":"https://openalex.org/I2801797538","display_name":"Cl\u00ednica Alemana","ror":"https://ror.org/028ynny55","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I2801797538"]},{"id":"https://openalex.org/I4210131012","display_name":"Hospital Cl\u00ednico de la Universidad de Chile","ror":"https://ror.org/02xtpdq88","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4210131012"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Mar\u00eda Isabel Behrens","raw_affiliation_strings":["Centro de Investigaci\u00f3n Cl\u00ednica Avanzada (CICA), Hospital Cl\u00ednico de la Universidad de Chile, Independencia, Santiago, RM, Chile","Departamento de Neurociencia, Facultad de Medicina Universidad de Chile, Independencia Santiago, RM, Chile","Departamento de Neurolog\u00eda y Neurocirug\u00eda, Hospital Cl\u00ednico, Universidad de Chile, Independencia, Santiago, RM, Chile","Departamento de Neurolog\u00eda y Psiquiatr\u00eda, CAS, Cl\u00ednica Alemana Universidad del Desarrollo, Santiago, RM, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Cl\u00ednica Avanzada (CICA), Hospital Cl\u00ednico de la Universidad de Chile, Independencia, Santiago, RM, Chile","institution_ids":["https://openalex.org/I4210131012"]},{"raw_affiliation_string":"Departamento de Neurociencia, Facultad de Medicina Universidad de Chile, Independencia Santiago, RM, Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Departamento de Neurolog\u00eda y Neurocirug\u00eda, Hospital Cl\u00ednico, Universidad de Chile, Independencia, Santiago, RM, Chile","institution_ids":["https://openalex.org/I4210131012","https://openalex.org/I69737025"]},{"raw_affiliation_string":"Departamento de Neurolog\u00eda y Psiquiatr\u00eda, CAS, Cl\u00ednica Alemana Universidad del Desarrollo, Santiago, RM, Chile","institution_ids":["https://openalex.org/I133599470","https://openalex.org/I2801797538"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5034268426"],"corresponding_institution_ids":["https://openalex.org/I133599470","https://openalex.org/I2801797538","https://openalex.org/I4210131012","https://openalex.org/I69737025"],"apc_list":null,"apc_paid":null,"fwci":0.4093,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.54556321,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":96},"biblio":{"volume":"87","issue":"4","first_page":"1695","last_page":"1711"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/history-of-cancer","display_name":"cancer history","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C2776632958","wikidata":"https://www.wikidata.org/wiki/Q6906262","display_name":"Montreal Cognitive Assessment","level":4,"score":0.8338096141815186},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.7752487659454346},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6648816466331482},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.6014052033424377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5372967720031738},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.43189772963523865},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.42355653643608093},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.40049654245376587},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3498719334602356},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34330326318740845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34165695309638977},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.25472742319107056},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000073216","descriptor_name":"Mental Status and Dementia Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3233/jad-215660","doi":"https://doi.org/10.3233/jad-215660","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-215660","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},{"id":"pmid:35491784","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35491784","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's disease : JAD","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W202641607","https://openalex.org/W1096808295","https://openalex.org/W1609155228","https://openalex.org/W1963757800","https://openalex.org/W1976823440","https://openalex.org/W1992860945","https://openalex.org/W1995610796","https://openalex.org/W2009227687","https://openalex.org/W2017500142","https://openalex.org/W2019655958","https://openalex.org/W2019692765","https://openalex.org/W2036362469","https://openalex.org/W2041521913","https://openalex.org/W2049722644","https://openalex.org/W2049797841","https://openalex.org/W2054172272","https://openalex.org/W2060444352","https://openalex.org/W2061277292","https://openalex.org/W2066719062","https://openalex.org/W2099518031","https://openalex.org/W2106285225","https://openalex.org/W2114805009","https://openalex.org/W2115017507","https://openalex.org/W2132917208","https://openalex.org/W2151715350","https://openalex.org/W2155636825","https://openalex.org/W2165758561","https://openalex.org/W2170197381","https://openalex.org/W2337786458","https://openalex.org/W2519059622","https://openalex.org/W2597839143","https://openalex.org/W2610475829","https://openalex.org/W2655375924","https://openalex.org/W2734635135","https://openalex.org/W2792325398","https://openalex.org/W2802556468","https://openalex.org/W2887192861","https://openalex.org/W2936021011","https://openalex.org/W2937979781","https://openalex.org/W2946254369","https://openalex.org/W2952416899","https://openalex.org/W2952757700","https://openalex.org/W2955166598","https://openalex.org/W2973754816","https://openalex.org/W2982637342","https://openalex.org/W2996690250","https://openalex.org/W3003258168","https://openalex.org/W3004874663","https://openalex.org/W3006513902","https://openalex.org/W3036394325","https://openalex.org/W3101422350","https://openalex.org/W3156140067","https://openalex.org/W3169904864","https://openalex.org/W4240116026"],"related_works":["https://openalex.org/W2966282922","https://openalex.org/W4281853384","https://openalex.org/W2952416899","https://openalex.org/W2980884917","https://openalex.org/W4410813728","https://openalex.org/W4392051012","https://openalex.org/W2019692765","https://openalex.org/W2981151362","https://openalex.org/W3200492671","https://openalex.org/W4283746443"],"abstract_inverted_index":{"BACKGROUND:":[0],"Several":[1],"epidemiological":[2],"studies":[3],"report":[4],"a":[5,237,249],"negative":[6],"association":[7],"between":[8],"Cancer":[9,68,212,241],"and":[10,30,85,100,108,111,144,160,177,200,257],"Alzheimer's":[11],"disease":[12],"(AD).":[13],"OBJECTIVE:":[14],"To":[15],"characterize":[16],"the":[17,42,124],"trajectories":[18,218],"of":[19,33,67,77,123,126,191,219,239,251],"memory":[20,192],"loss":[21],"in":[22,53,129,248],"individuals":[23],"with":[24,29,55,87,94,132,253],"early":[25,56,133],"amnestic":[26,57,134,220,244],"cognitive":[27,58,96,118,127,135,202,221,245],"impairment":[28,59,136],"without":[31],"history":[32,213,238],"previous":[34,240],"cancer.":[35],"METHODS:":[36],"Cognitive":[37,44],"deterioration":[38,259],"was":[39,69,214],"assessed":[40],"using":[41],"Montreal":[43],"Assessment":[45],"(MoCA)":[46],"or":[47,230],"MoCA-Memory":[48],"Index":[49],"Score":[50],"(MoCA-MIS)":[51],"biannually":[52],"subjects":[54,131,252],"followed-up":[60],"retrospectively":[61],"from":[62,71,227],"2007":[63],"to":[64,91,116,196,206],"2021.":[65],"History":[66],"obtained":[70],"clinical":[72,231],"records.":[73],"Simple":[74],"linear":[75,114],"regressions":[76,115],"MoCA-MIS":[78,156,198],"scores":[79],"were":[80,103,223],"calculated":[81],"for":[82,105],"each":[83],"subject":[84],"analyzed":[86],"K-means":[88],"cluster":[89],"analysis":[90],"identify":[92],"subgroups":[93],"different":[95,228],"decline":[97,119,128,193,203,222],"trajectories.":[98],"\u03c72":[99],"t":[101],"tests":[102],"used":[104],"descriptive":[106],"categorical":[107],"continuous":[109],"variables":[110],"mixed":[112],"multiple":[113],"determine":[117],"covariates.":[120],"RESULTS:":[121],"Analysis":[122],"trajectory":[125],"141":[130],"identified":[137],"two":[138],"subgroups:":[139],"Fast":[140,152,186],"(n":[141,146],"=":[142,147,164,168,175,183],"60)":[143],"Slow":[145],"81)":[148],"progressors.":[149],"At":[150],"baseline":[151,256],"progressors":[153,187],"had":[154,178],"better":[155],"(p":[157,174,182],"<":[158],"0.001)":[159],"functionality":[161],"(CDR":[162],"p":[163,167],"0.02,":[165],"AD8":[166],"0.05),":[169],"took":[170],"less":[171],"anti-dementia":[172],"medications":[173],"0.005),":[176],"higher":[179],"depression":[180,254],"rates":[181],"0.02).":[184],"Interestingly,":[185],"slowed":[188],"their":[189],"speed":[190],"(from":[194,204],"1.6":[195],"1.1":[197],"points/year)":[199,210],"global":[201],"2.0":[205],"1.4":[207],"total":[208],"MoCA":[209],"when":[211],"present.":[215],"CONCLUSION:":[216],"Two":[217],"identified,":[224],"possibly":[225],"derived":[226],"neurophysiopathologies":[229],"stages.":[232],"This":[233],"study":[234],"suggests":[235],"that":[236],"slows":[242],"down":[243],"decline,":[246],"specifically":[247],"subgroup":[250],"at":[255,260],"accelerated":[258],"follow-up.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-04-28T00:00:00"}