{"id":"https://openalex.org/W4224930752","doi":"https://doi.org/10.1007/s13300-022-01253-9","title":"Reductions in HbA1c with Flash Glucose Monitoring Are Sustained for up to 24 Months: A Meta-Analysis of 75 Real-World Observational Studies","display_name":"Reductions in HbA1c with Flash Glucose Monitoring Are Sustained for up to 24 Months: A Meta-Analysis of 75 Real-World Observational Studies","publication_year":2022,"publication_date":"2022-04-27","ids":{"openalex":"https://openalex.org/W4224930752","doi":"https://doi.org/10.1007/s13300-022-01253-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/35476279","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9174370"},"language":"en","primary_location":{"id":"doi:10.1007/s13300-022-01253-9","doi":"https://doi.org/10.1007/s13300-022-01253-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13300-022-01253-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13300-022-01253-9.pdf","source":{"id":"https://openalex.org/S16535137","display_name":"Diabetes Therapy","issn_l":"1869-6953","issn":["1869-6953","1869-6961"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Therapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1007/s13300-022-01253-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059551923","display_name":"Mark L. Evans","orcid":"https://orcid.org/0000-0001-8122-8987","observed_orcids":["https://orcid.org/0000-0001-8122-8987"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Mark Evans","raw_affiliation_strings":["Wellcome Trust/MRC Institute of Metabolic Science, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Addenbrookes Hospital, Hills Road, IMS MRL Box 289, Cambridge, CB2 0QQ, UK. mle24@cam.ac.uk","Wellcome Trust/MRC Institute of Metabolic Science, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Addenbrookes Hospital, Hills Road, IMS MRL Box 289, Cambridge, CB2 0QQ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust/MRC Institute of Metabolic Science, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Addenbrookes Hospital, Hills Road, IMS MRL Box 289, Cambridge, CB2 0QQ, UK. mle24@cam.ac.uk","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210116691","https://openalex.org/I4210156194","https://openalex.org/I87048295"]},{"raw_affiliation_string":"Wellcome Trust/MRC Institute of Metabolic Science, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Addenbrookes Hospital, Hills Road, IMS MRL Box 289, Cambridge, CB2 0QQ, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210116691","https://openalex.org/I4210156194","https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067181560","display_name":"Zo\u00eb Welsh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zo\u00eb Welsh","raw_affiliation_strings":["Abbott Diabetes Care, Range Road, Witney, Oxfordshire, OX28 3FP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbott Diabetes Care, Range Road, Witney, Oxfordshire, OX28 3FP, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079463232","display_name":"Alexander Seibold","orcid":"https://orcid.org/0000-0002-2008-4593","observed_orcids":["https://orcid.org/0000-0002-2008-4593"]},"institutions":[{"id":"https://openalex.org/I4210126753","display_name":"Abbott (Germany)","ror":"https://ror.org/02x2gk324","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210088555","https://openalex.org/I4210126753"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Seibold","raw_affiliation_strings":["Abbott Diabetes Care, Max-Planck-Ring 2, 65205, Wiesbaden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbott Diabetes Care, Max-Planck-Ring 2, 65205, Wiesbaden, Germany","institution_ids":["https://openalex.org/I4210126753"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5059551923"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210116691","https://openalex.org/I4210156194","https://openalex.org/I87048295"],"apc_list":{"value":6000,"currency":"USD","value_usd":6000},"apc_paid":{"value":6000,"currency":"USD","value_usd":6000},"fwci":1.94,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.89576883,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"13","issue":"6","first_page":"1175","last_page":"1185"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10793","display_name":"Diabetes Management and Education","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/freestyle-libre","display_name":"FreeStyle Libre","score":0.828000009059906},{"id":"https://openalex.org/keywords/hba1c-reduction","display_name":"HbA1c reduction","score":0.9520000219345093},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8330000042915344},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.7760000228881836},{"id":"https://openalex.org/keywords/real-world-evidence","display_name":"real-world evidence","score":0.7900000214576721},{"id":"https://openalex.org/keywords/baseline-hba1c","display_name":"baseline HbA1c","score":0.8939999938011169},{"id":"https://openalex.org/keywords/continuous-glucose-monitoring","display_name":"continuous glucose monitoring","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.8534386157989502},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8253506422042847},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6433191895484924},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5867497324943542},{"id":"https://openalex.org/C2986379492","wikidata":"https://www.wikidata.org/wiki/Q1638492","display_name":"Continuous glucose monitoring","level":4,"score":0.4689226746559143},{"id":"https://openalex.org/C2777526259","wikidata":"https://www.wikidata.org/wiki/Q221836","display_name":"Flash (photography)","level":2,"score":0.4254688620567322},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.38128167390823364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3602454662322998},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24629783630371094},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.1755310297012329},{"id":"https://openalex.org/C153349607","wikidata":"https://www.wikidata.org/wiki/Q36649","display_name":"Visual arts","level":1,"score":0.0},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1007/s13300-022-01253-9","doi":"https://doi.org/10.1007/s13300-022-01253-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13300-022-01253-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13300-022-01253-9.pdf","source":{"id":"https://openalex.org/S16535137","display_name":"Diabetes Therapy","issn_l":"1869-6953","issn":["1869-6953","1869-6961"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9174370","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9174370","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Ther","raw_type":"Text"},{"id":"pmid:35476279","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35476279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes therapy : research, treatment and education of diabetes and related disorders","raw_type":"Journal Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/337873","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/337873","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.85279","doi":"https://doi.org/10.17863/cam.85279","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.85279","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1007/s13300-022-01253-9","doi":"https://doi.org/10.1007/s13300-022-01253-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13300-022-01253-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13300-022-01253-9.pdf","source":{"id":"https://openalex.org/S16535137","display_name":"Diabetes Therapy","issn_l":"1869-6953","issn":["1869-6953","1869-6961"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320333256","display_name":"Abbott Diabetes Care","ror":"https://ror.org/03vb88585"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4224930752.pdf","grobid_xml":"https://content.openalex.org/works/W4224930752.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1544940685","https://openalex.org/W1979423827","https://openalex.org/W2012079465","https://openalex.org/W2098432681","https://openalex.org/W2107572817","https://openalex.org/W2119066351","https://openalex.org/W2123946565","https://openalex.org/W2125435699","https://openalex.org/W2153043827","https://openalex.org/W2337454357","https://openalex.org/W2519526531","https://openalex.org/W2563731248","https://openalex.org/W2769264260","https://openalex.org/W2784276839","https://openalex.org/W2797188709","https://openalex.org/W2808881153","https://openalex.org/W2883680491","https://openalex.org/W2886078506","https://openalex.org/W2909166675","https://openalex.org/W2967436653","https://openalex.org/W2976205167","https://openalex.org/W2985334076","https://openalex.org/W3043197730","https://openalex.org/W3110786991","https://openalex.org/W3119134663","https://openalex.org/W3128076258","https://openalex.org/W3152935002","https://openalex.org/W3211824525","https://openalex.org/W4236126199","https://openalex.org/W4253996779","https://openalex.org/W4256370978","https://openalex.org/W4292229870","https://openalex.org/W4294116629","https://openalex.org/W6887914939","https://openalex.org/W7039317359"],"related_works":["https://openalex.org/W2985334076","https://openalex.org/W3110786991","https://openalex.org/W3175545062","https://openalex.org/W2948776981","https://openalex.org/W3017805503","https://openalex.org/W4318478697","https://openalex.org/W3035027712","https://openalex.org/W3035393026","https://openalex.org/W2808807312","https://openalex.org/W3199900085"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Real-world":[1],"evidence":[2],"(RWE)":[3],"confirms":[4,233],"that":[5,192,234],"reductions":[6,200,244],"in":[7,54,85,88,130,166,178,201,203,206,212,219,227,245,271],"HbA1c":[8,41,55,87,131,195,202,213,246,262],"for":[9,56,63,137,216,222,247,257,266],"children":[10],"and":[11,18,48,118,177,205,221,263,268,273],"adults":[12,19,138,248],"with":[13,20,27,66,91,139,151,198,242,249,252,259],"type":[14,21,92,100],"1":[15,93],"diabetes":[16,23,102],"(T1DM)":[17],"2":[22,101],"(T2DM)":[24],"are":[25,43,255,264],"associated":[26,241],"use":[28],"of":[29,52,58,210,231],"the":[30,59,109,236],"FreeStyle":[31,60,110,237],"Libre":[32,61,111,238],"system.":[33],"This":[34],"current":[35],"meta-analysis":[36],"aims":[37],"to":[38,49,75,147,159,174,186],"investigate":[39],"whether":[40],"benefits":[42],"sustained":[44,215,265],"over":[45],"24":[46,217,267],"months":[47,134,165,218,226,270],"identify":[50],"patterns":[51,209],"change":[53,84,211],"users":[57],"system":[62,239],"people":[64,258],"living":[65],"T1DM":[67,140,167,204,220,250,272],"or":[68,99,150,251],"T2DM.":[69,207,228,253],"METHODS:":[70],"A":[71],"bibliographic":[72],"search":[73],"up":[74],"December":[76],"2020":[77],"identified":[78],"75":[79],"studies":[80],"reporting":[81],"data":[82],"on":[83,115],"lab":[86],"30,478":[89],"participants":[90],"(n":[94,103],"=":[95,104],"28,063;":[96],"62":[97],"trials)":[98,107],"2415;":[105],"13":[106],"using":[108,123,235],"system,":[112],"including":[113],"observations":[114],"children,":[116],"adolescents":[117],"adults.":[119],"Meta-analysis":[120,230],"was":[121],"performed":[122],"a":[124],"random":[125],"effects":[126],"model.":[127],"RESULTS:":[128],"Reductions":[129,254],"at":[132,223],"3-4":[133],"were":[135,214],"similar":[136],"(-":[141,153,168,180],"0.53%,":[142],"95%":[143,155,170,182],"CI":[144,156,171,183],"-":[145,148,157,160,172,175,184,187],"0.69":[146],"0.38)":[149],"T2DM":[152,179],"0.45%,":[154],"0.57":[158],"0.33),":[161],"continuing":[162],"through":[163],"4.5-7.5":[164],"0.42%,":[169],"0.58":[173],"0.27)":[176],"0.59%,":[181],"0.80":[185],"0.39).":[188],"Meta-regression":[189],"analysis":[190],"shows":[191],"higher":[193,260],"starting":[194],"is":[196,240],"correlated":[197],"greater":[199,256],"These":[208],"least":[224],"12":[225,269],"CONCLUSIONS:":[229],"RWE":[232],"significant":[243],"baseline":[261],"TD2M":[274],"respectively.":[275]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-04-28T00:00:00"}