{"id":"https://openalex.org/W4224924595","doi":"https://doi.org/10.1016/j.cbpa.2022.102150","title":"Small-molecule discovery in the pancreatic beta cell","display_name":"Small-molecule discovery in the pancreatic beta cell","publication_year":2022,"publication_date":"2022-04-26","ids":{"openalex":"https://openalex.org/W4224924595","doi":"https://doi.org/10.1016/j.cbpa.2022.102150","pmid":"https://pubmed.ncbi.nlm.nih.gov/35487100","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9188675"},"language":"en","primary_location":{"id":"doi:10.1016/j.cbpa.2022.102150","doi":"https://doi.org/10.1016/j.cbpa.2022.102150","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cbpa.2022.102150","pdf_url":null,"source":{"id":"https://openalex.org/S35563517","display_name":"Current Opinion in Chemical Biology","issn_l":"1367-5931","issn":["1367-5931","1879-0402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9188675","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075249814","display_name":"Bridget K. Wagner","orcid":"https://orcid.org/0000-0002-2629-361X","observed_orcids":["https://orcid.org/0000-0002-2629-361X"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bridget K. Wagner","raw_affiliation_strings":["Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA. Electronic address: bwagner@broadinstitute.org","Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA"],"raw_orcid":"https://orcid.org/0000-0002-2629-361X","affiliations":[{"raw_affiliation_string":"Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA. Electronic address: bwagner@broadinstitute.org","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075249814"],"corresponding_institution_ids":["https://openalex.org/I107606265"],"apc_list":{"value":4660,"currency":"USD","value_usd":4660},"apc_paid":null,"fwci":0.2974,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.28790087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"68","issue":null,"first_page":"102150","last_page":"102150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/small-molecule-drug-discovery","display_name":"small molecule drug discovery","score":0.8159999847412109},{"id":"https://openalex.org/keywords/chemical-biology","display_name":"chemical biology","score":0.7570000290870667},{"id":"https://openalex.org/keywords/beta-cell-regeneration","display_name":"beta cell regeneration","score":0.8820000290870667},{"id":"https://openalex.org/keywords/beta-cell-proliferation","display_name":"beta-cell proliferation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/beta-cell-differentiation","display_name":"beta cell differentiation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/beta-cell-neogenesis","display_name":"beta-cell neogenesis","score":0.847000002861023},{"id":"https://openalex.org/keywords/beta-cell-death","display_name":"beta-cell death","score":0.7570000290870667},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.8029999732971191},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.7319999933242798},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9449999928474426},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9679999947547913},{"id":"https://openalex.org/keywords/diabetes-therapeutics","display_name":"diabetes therapeutics","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C2780093864","wikidata":"https://www.wikidata.org/wiki/Q10797618","display_name":"Neogenesis","level":4,"score":0.891696572303772},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.8014626502990723},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.6466935873031616},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6243532299995422},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.53987056016922},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.49967503547668457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47841840982437134},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.47233596444129944},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4472115635871887},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.42968714237213135},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.41983819007873535},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3803729712963104},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3521280288696289},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2118593454360962},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.2037298083305359},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18561440706253052},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.13980403542518616},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.061463356018066406},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.cbpa.2022.102150","doi":"https://doi.org/10.1016/j.cbpa.2022.102150","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cbpa.2022.102150","pdf_url":null,"source":{"id":"https://openalex.org/S35563517","display_name":"Current Opinion in Chemical Biology","issn_l":"1367-5931","issn":["1367-5931","1879-0402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Chemical Biology","raw_type":"journal-article"},{"id":"pmid:35487100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35487100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9188675","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9188675","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Chem Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9188675","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9188675","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Chem Biol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5400000214576721,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1035330972","display_name":"One-compound, one-islet: A high-throughput platform for small-molecule discovery","funder_award_id":"U01DK123717","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6550100078","display_name":"Interrogating the ubiquitin pathway to understand and treat cytokine-induced beta-cell death in type 1 diabetes","funder_award_id":"R01DK129464","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320309622","display_name":"Harvard University","ror":"https://ror.org/03vek6s52"},{"id":"https://openalex.org/F4320310820","display_name":"Juvenile Diabetes Research Foundation United States of America","ror":"https://ror.org/00vqxjy61"},{"id":"https://openalex.org/F4320314070","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W1509976269","https://openalex.org/W1552481166","https://openalex.org/W1971250081","https://openalex.org/W1972299138","https://openalex.org/W1977825723","https://openalex.org/W1982391086","https://openalex.org/W2003454094","https://openalex.org/W2017645161","https://openalex.org/W2024378513","https://openalex.org/W2027862526","https://openalex.org/W2028686926","https://openalex.org/W2035940741","https://openalex.org/W2036800308","https://openalex.org/W2041739600","https://openalex.org/W2061574308","https://openalex.org/W2065373825","https://openalex.org/W2081287291","https://openalex.org/W2081595122","https://openalex.org/W2090830096","https://openalex.org/W2105728643","https://openalex.org/W2112371420","https://openalex.org/W2112915315","https://openalex.org/W2125472394","https://openalex.org/W2128737073","https://openalex.org/W2131933743","https://openalex.org/W2133121517","https://openalex.org/W2147930426","https://openalex.org/W2148147368","https://openalex.org/W2155707987","https://openalex.org/W2157504181","https://openalex.org/W2167486844","https://openalex.org/W2171968212","https://openalex.org/W2180397054","https://openalex.org/W2234989637","https://openalex.org/W2258420810","https://openalex.org/W2260349684","https://openalex.org/W2270142843","https://openalex.org/W2285137452","https://openalex.org/W2314519609","https://openalex.org/W2322477027","https://openalex.org/W2402317064","https://openalex.org/W2415553457","https://openalex.org/W2418640715","https://openalex.org/W2512883383","https://openalex.org/W2518918481","https://openalex.org/W2530758423","https://openalex.org/W2604284862","https://openalex.org/W2605103173","https://openalex.org/W2614899983","https://openalex.org/W2730785100","https://openalex.org/W2733217812","https://openalex.org/W2743600157","https://openalex.org/W2750765370","https://openalex.org/W2790048311","https://openalex.org/W2797867047","https://openalex.org/W2808621054","https://openalex.org/W2851535791","https://openalex.org/W2885491801","https://openalex.org/W2902660337","https://openalex.org/W2906475498","https://openalex.org/W2911433225","https://openalex.org/W2915779410","https://openalex.org/W2947760229","https://openalex.org/W2947927825","https://openalex.org/W2949564787","https://openalex.org/W2981240954","https://openalex.org/W2995283269","https://openalex.org/W2995448053","https://openalex.org/W2997101184","https://openalex.org/W3005696213","https://openalex.org/W3007853433","https://openalex.org/W3010693554","https://openalex.org/W3028068117","https://openalex.org/W3045501927","https://openalex.org/W3077375981","https://openalex.org/W3121881487","https://openalex.org/W3158149336","https://openalex.org/W3160372846","https://openalex.org/W3165844927","https://openalex.org/W3168891401","https://openalex.org/W3195651404","https://openalex.org/W3198676490","https://openalex.org/W3200824716","https://openalex.org/W3207943086","https://openalex.org/W3215779200","https://openalex.org/W4200036848","https://openalex.org/W4248517419"],"related_works":["https://openalex.org/W2804537176","https://openalex.org/W4361801757","https://openalex.org/W4414040423","https://openalex.org/W4406931764","https://openalex.org/W2011736831","https://openalex.org/W7096631872","https://openalex.org/W2318974250","https://openalex.org/W2589866594","https://openalex.org/W2362148380","https://openalex.org/W2987386461"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-04-28T00:00:00"}