{"id":"https://openalex.org/W4224922650","doi":"https://doi.org/10.1016/j.jpsychires.2022.04.014","title":"Salvianolic acid B alleviates comorbid pain in depression induced by chronic restraint stress through inhibiting GABAergic neuron excitation via an ERK-CREB-BDNF axis-dependent mechanism","display_name":"Salvianolic acid B alleviates comorbid pain in depression induced by chronic restraint stress through inhibiting GABAergic neuron excitation via an ERK-CREB-BDNF axis-dependent mechanism","publication_year":2022,"publication_date":"2022-04-27","ids":{"openalex":"https://openalex.org/W4224922650","doi":"https://doi.org/10.1016/j.jpsychires.2022.04.014","pmid":"https://pubmed.ncbi.nlm.nih.gov/35500448"},"language":"en","primary_location":{"id":"doi:10.1016/j.jpsychires.2022.04.014","doi":"https://doi.org/10.1016/j.jpsychires.2022.04.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jpsychires.2022.04.014","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0022395622002175/pdf","source":{"id":"https://openalex.org/S160879026","display_name":"Journal of Psychiatric Research","issn_l":"0022-3956","issn":["0022-3956","1879-1379"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychiatric Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0022395622002175/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100379551","display_name":"Xinxin Liu","orcid":"https://orcid.org/0000-0002-7609-6198","observed_orcids":["https://orcid.org/0000-0002-7609-6198"]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinxin Liu","raw_affiliation_strings":["Department of Anesthesiology, Affiliated Huaihua Hospital, University of South China, Huaihua, 418000, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Affiliated Huaihua Hospital, University of South China, Huaihua, 418000, PR China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035232817","display_name":"Zixin Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143187","display_name":"First Affiliated Hospital of University of South China","ror":"https://ror.org/049z3cb60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143187"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zixin Hou","raw_affiliation_strings":["Department of Anesthesiology, The First Affiliated Hospital of University of South China, Hengyang, 421001, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The First Affiliated Hospital of University of South China, Hengyang, 421001, PR China","institution_ids":["https://openalex.org/I4210143187"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055211076","display_name":"Mingming Han","orcid":"https://orcid.org/0000-0002-5045-7274","observed_orcids":["https://orcid.org/0000-0002-5045-7274","https://orcid.org/0000-0001-5828-9079","https://orcid.org/0009-0006-1940-3119"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Mingming Han","raw_affiliation_strings":["Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230036, PR China; Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA","Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA","Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230036, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230036, PR China; Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA","institution_ids":["https://openalex.org/I126520041","https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230036, PR China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056859709","display_name":"Kemin Chen","orcid":"https://orcid.org/0000-0002-2778-3098","observed_orcids":["https://orcid.org/0000-0002-2778-3098","https://orcid.org/0009-0007-6999-9990"]},"institutions":[{"id":"https://openalex.org/I4210143187","display_name":"First Affiliated Hospital of University of South China","ror":"https://ror.org/049z3cb60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143187"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kemin Chen","raw_affiliation_strings":["Department of Anesthesiology, The First Affiliated Hospital of University of South China, Hengyang, 421001, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The First Affiliated Hospital of University of South China, Hengyang, 421001, PR China","institution_ids":["https://openalex.org/I4210143187"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100631222","display_name":"Yuxia Wang","orcid":"https://orcid.org/0000-0002-0020-0593","observed_orcids":["https://orcid.org/0000-0002-0020-0593"]},"institutions":[{"id":"https://openalex.org/I4210143187","display_name":"First Affiliated Hospital of University of South China","ror":"https://ror.org/049z3cb60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143187"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxia Wang","raw_affiliation_strings":["Department of Anesthesiology, The First Affiliated Hospital of University of South China, Hengyang, 421001, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The First Affiliated Hospital of University of South China, Hengyang, 421001, PR China","institution_ids":["https://openalex.org/I4210143187"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102063785","display_name":"Qing Jie","orcid":"https://orcid.org/0009-0001-6902-7477","observed_orcids":["https://orcid.org/0009-0001-6902-7477"]},"institutions":[{"id":"https://openalex.org/I4210143187","display_name":"First Affiliated Hospital of University of South China","ror":"https://ror.org/049z3cb60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143187"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Qing","raw_affiliation_strings":["Department of Anesthesiology, The First Affiliated Hospital of University of South China, Hengyang, 421001, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The First Affiliated Hospital of University of South China, Hengyang, 421001, PR China","institution_ids":["https://openalex.org/I4210143187"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034304131","display_name":"Fengrui Yang","orcid":"https://orcid.org/0000-0002-8558-1419","observed_orcids":["https://orcid.org/0000-0002-8558-1419"]},"institutions":[{"id":"https://openalex.org/I4210143187","display_name":"First Affiliated Hospital of University of South China","ror":"https://ror.org/049z3cb60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143187"]},{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fengrui Yang","raw_affiliation_strings":["Department of Anesthesiology, Affiliated Huaihua Hospital, University of South China, Huaihua, 418000, PR China; Department of Anesthesiology, The First Affiliated Hospital of University of South China, Hengyang, 421001, PR China. Electronic address: 332530935@qq.com","Department of Anesthesiology, Affiliated Huaihua Hospital, University of South China, Huaihua, 418000, PR China","Department of Anesthesiology, The First Affiliated Hospital of University of South China, Hengyang, 421001, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Affiliated Huaihua Hospital, University of South China, Huaihua, 418000, PR China; Department of Anesthesiology, The First Affiliated Hospital of University of South China, Hengyang, 421001, PR China. Electronic address: 332530935@qq.com","institution_ids":["https://openalex.org/I4210143187","https://openalex.org/I91935597"]},{"raw_affiliation_string":"Department of Anesthesiology, Affiliated Huaihua Hospital, University of South China, Huaihua, 418000, PR China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"Department of Anesthesiology, The First Affiliated Hospital of University of South China, Hengyang, 421001, PR China","institution_ids":["https://openalex.org/I4210143187"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5034304131"],"corresponding_institution_ids":["https://openalex.org/I4210143187","https://openalex.org/I91935597"],"apc_list":{"value":3170,"currency":"USD","value_usd":3170},"apc_paid":{"value":3170,"currency":"USD","value_usd":3170},"fwci":1.9226,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.83832415,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"151","issue":null,"first_page":"205","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.49070000648498535,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.49070000648498535,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.4318999946117401,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salvianolic-acid-b","display_name":"salvianolic acid B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pain-depression-comorbidity","display_name":"pain-depression comorbidity","score":0.7940000295639038},{"id":"https://openalex.org/keywords/chronic-restraint-stress","display_name":"chronic restraint stress","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gabaergic-neurons","display_name":"GABAergic neurons","score":0.8669999837875366},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.968999981880188},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9319999814033508},{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.6830000281333923},{"id":"https://openalex.org/keywords/analgesic-effect","display_name":"analgesic effect","score":0.9430000185966492}],"concepts":[{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.8711201548576355},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.6671290397644043},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5959633588790894},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4832195043563843},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.47300058603286743},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.4527013301849365},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.42476871609687805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.389425665140152},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3543519377708435},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34782588481903076},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33298173546791077},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33084776997566223},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.28812485933303833},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2568385601043701},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22965312004089355},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.21555498242378235},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09491589665412903},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08625379204750061},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.04979968070983887},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001572","descriptor_name":"Benzofurans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050882","descriptor_name":"CREB-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053630","descriptor_name":"Depsides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059330","descriptor_name":"GABAergic Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jpsychires.2022.04.014","doi":"https://doi.org/10.1016/j.jpsychires.2022.04.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jpsychires.2022.04.014","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0022395622002175/pdf","source":{"id":"https://openalex.org/S160879026","display_name":"Journal of Psychiatric Research","issn_l":"0022-3956","issn":["0022-3956","1879-1379"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychiatric Research","raw_type":"journal-article"},{"id":"pmid:35500448","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35500448","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of psychiatric research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jpsychires.2022.04.014","doi":"https://doi.org/10.1016/j.jpsychires.2022.04.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jpsychires.2022.04.014","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0022395622002175/pdf","source":{"id":"https://openalex.org/S160879026","display_name":"Journal of Psychiatric Research","issn_l":"0022-3956","issn":["0022-3956","1879-1379"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychiatric Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4224922650.pdf","grobid_xml":"https://content.openalex.org/works/W4224922650.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W49025511","https://openalex.org/W1973076339","https://openalex.org/W1977062227","https://openalex.org/W1989931235","https://openalex.org/W1995818832","https://openalex.org/W2002616166","https://openalex.org/W2014210756","https://openalex.org/W2037441307","https://openalex.org/W2059737837","https://openalex.org/W2070410958","https://openalex.org/W2122163450","https://openalex.org/W2132927067","https://openalex.org/W2324730741","https://openalex.org/W2409837131","https://openalex.org/W2491400549","https://openalex.org/W2512692201","https://openalex.org/W2581907223","https://openalex.org/W2602990635","https://openalex.org/W2702360522","https://openalex.org/W2737842237","https://openalex.org/W2762626802","https://openalex.org/W2891093122","https://openalex.org/W2910986368","https://openalex.org/W2945318718","https://openalex.org/W2946017999","https://openalex.org/W2954601620","https://openalex.org/W2970852449","https://openalex.org/W2990250457","https://openalex.org/W3001633359","https://openalex.org/W3003505716","https://openalex.org/W3003566286","https://openalex.org/W3004246797","https://openalex.org/W3012125399","https://openalex.org/W3021939227","https://openalex.org/W3037017657","https://openalex.org/W3041247018","https://openalex.org/W3047693933","https://openalex.org/W3118875038","https://openalex.org/W3118987048","https://openalex.org/W3120652163","https://openalex.org/W4212917819","https://openalex.org/W4231054479"],"related_works":["https://openalex.org/W4407034533","https://openalex.org/W4409223645","https://openalex.org/W2994837026","https://openalex.org/W4390499914","https://openalex.org/W4391952688","https://openalex.org/W2149909804","https://openalex.org/W7132854647","https://openalex.org/W7154692261","https://openalex.org/W4400874757","https://openalex.org/W4406317396"],"abstract_inverted_index":{"Pain":[0],"comorbid":[1,28,58,163,221],"with":[2,40,89,117],"depression":[3,31,62,225],"occurred":[4,150],"frequently":[5],"in":[6,27,30,44,60,78,111,139,151,165,179,204,223,226],"clinical":[7],"settings.":[8],"This":[9],"study":[10],"aims":[11],"to":[12,57,101,105,143,161],"explore":[13],"the":[14,45,48,96,107,112,140,152,173,184,199,205,209,214],"molecular":[15],"mechanism":[16],"underlying":[17],"antidepressant":[18],"and":[19,47,119,176,207],"analgetic":[20],"effect":[21],"of":[22,99,109,129,136,146,171,186,201,217],"salvianolic":[23],"acid":[24],"B":[25,86],"(SalB)":[26],"pain":[29,59,164,177,222],"induced":[32],"by":[33,133,191],"chronic":[34],"restraint":[35],"stress":[36],"(CRS),":[37],"which":[38,187],"associates":[39],"GABAergic":[41,103,137,202],"neuron":[42],"activation":[43],"amygdala":[46,141,206],"ERK-CREB-BDNF":[49,120,158,192,210],"signaling":[50,121,159,193,211],"pathway.":[51],"The":[52,81],"differentially":[53],"expressed":[54],"genes":[55],"related":[56],"CRS-induced":[61,166,224],"were":[63,76,182],"screened":[64],"through":[65,213],"bioinformatics":[66],"analysis.":[67],"After":[68,115,168],"CRS":[69,124,153,180],"treatment":[70,116],"for":[71],"3":[72],"weeks,":[73],"depression-like":[74,130,174],"behaviors":[75,175],"developed":[77],"GAD2-tdT":[79],"mice.":[80,154,227],"retrograde":[82,90],"tracer":[83,91],"cholera":[84],"toxin":[85],"subunit":[87],"combined":[88],"CTB-488":[92],"was":[93],"injected":[94],"into":[95],"parafascicular":[97,144,215],"nucleus":[98,145,216],"thalamus":[100],"project":[102],"neurons":[104,110,138,203],"observe":[106],"labeling":[108],"whole":[113],"brain.":[114],"SalB":[118,197],"pathway":[122,160,194,212],"inhibitor,":[123],"mice":[125,181],"showed":[126],"a":[127],"variety":[128],"behaviors,":[131],"accompanied":[132],"enhanced":[134],"activity":[135],"projecting":[142],"thalamus.":[147],"BDNF":[148,156],"underexpression":[149],"Overexpressed":[155],"activated":[157],"alleviate":[162],"depression.":[167],"intraperitoneal":[169],"injection":[170],"SalB,":[172],"threshold":[178],"alleviated,":[183],"effects":[185],"could":[188],"be":[189],"eliminated":[190],"antagonist.":[195],"Collectively,":[196],"inhibits":[198],"excitation":[200],"activates":[208],"thalamus,":[218],"whereby":[219],"alleviating":[220]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-04-28T00:00:00"}