{"id":"https://openalex.org/W4224313453","doi":"https://doi.org/10.1038/s41698-022-00267-7","title":"Pre-treatment serum albumin and mutational burden as biomarkers of response to immune checkpoint blockade","display_name":"Pre-treatment serum albumin and mutational burden as biomarkers of response to immune checkpoint blockade","publication_year":2022,"publication_date":"2022-04-07","ids":{"openalex":"https://openalex.org/W4224313453","doi":"https://doi.org/10.1038/s41698-022-00267-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/35393553","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8990074"},"language":"en","primary_location":{"id":"doi:10.1038/s41698-022-00267-7","doi":"https://doi.org/10.1038/s41698-022-00267-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41698-022-00267-7","pdf_url":"https://www.nature.com/articles/s41698-022-00267-7.pdf","source":{"id":"https://openalex.org/S4210211538","display_name":"npj Precision Oncology","issn_l":"2397-768X","issn":["2397-768X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Precision Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41698-022-00267-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033460268","display_name":"Seong\u2010Keun Yoo","orcid":"https://orcid.org/0000-0002-8749-7050","observed_orcids":["https://orcid.org/0000-0002-8749-7050"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seong-Keun Yoo","raw_affiliation_strings":["Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, 44195, USA","The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA"],"raw_orcid":"https://orcid.org/0000-0002-8749-7050","affiliations":[{"raw_affiliation_string":"Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049504931","display_name":"Diego Chowell","orcid":"https://orcid.org/0000-0002-1355-5545","observed_orcids":["https://orcid.org/0000-0002-1355-5545"]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diego Chowell","raw_affiliation_strings":["Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075803345","display_name":"Cristina Valero","orcid":"https://orcid.org/0000-0003-3397-2888","observed_orcids":["https://orcid.org/0000-0003-3397-2888"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina Valero","raw_affiliation_strings":["Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084443648","display_name":"Luc G.T. Morris","orcid":"https://orcid.org/0000-0002-4417-2280","observed_orcids":["https://orcid.org/0000-0002-4417-2280"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luc G. T. Morris","raw_affiliation_strings":["Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA"],"raw_orcid":"https://orcid.org/0000-0002-4417-2280","affiliations":[{"raw_affiliation_string":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080223712","display_name":"Timothy An-thy Chan","orcid":"https://orcid.org/0000-0002-9265-0283","observed_orcids":["https://orcid.org/0000-0002-9265-0283"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Timothy A. Chan","raw_affiliation_strings":["Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, 44195, USA. chant2@ccf.org","Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA. chant2@ccf.org","Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, 44195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, 44195, USA. chant2@ccf.org","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA. chant2@ccf.org","institution_ids":["https://openalex.org/I36373038","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5080223712"],"corresponding_institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I36373038","https://openalex.org/I58956616"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":3.9735,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.9576974,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"6","issue":"1","first_page":"23","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-albumin","display_name":"serum albumin","score":0.9580000042915344},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.9470000267028809},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.9890000224113464},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9629999995231628},{"id":"https://openalex.org/keywords/tumor-response","display_name":"tumor response","score":0.49399998784065247},{"id":"https://openalex.org/keywords/radiological-response","display_name":"radiological response","score":0.6499999761581421},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.8617531061172485},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.683940052986145},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.6686915755271912},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6058516502380371},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5984416604042053},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5367933511734009},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4721636474132538},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4366682767868042},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40045762062072754},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3510444462299347},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29575207829475403},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16797223687171936},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11360204219818115},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06926727294921875}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41698-022-00267-7","doi":"https://doi.org/10.1038/s41698-022-00267-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41698-022-00267-7","pdf_url":"https://www.nature.com/articles/s41698-022-00267-7.pdf","source":{"id":"https://openalex.org/S4210211538","display_name":"npj Precision Oncology","issn_l":"2397-768X","issn":["2397-768X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Precision Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8990074","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8990074","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ Precis Oncol","raw_type":"Text"},{"id":"pmid:35393553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35393553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ precision oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b505c7d46c7b44c9a44fd0b4e106861d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b505c7d46c7b44c9a44fd0b4e106861d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Precision Oncology, Vol 6, Iss 1, Pp 1-5 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41698-022-00267-7","doi":"https://doi.org/10.1038/s41698-022-00267-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41698-022-00267-7","pdf_url":"https://www.nature.com/articles/s41698-022-00267-7.pdf","source":{"id":"https://openalex.org/S4210211538","display_name":"npj Precision Oncology","issn_l":"2397-768X","issn":["2397-768X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Precision Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2665966410","display_name":null,"funder_award_id":"Grant P30-CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2992418894","display_name":null,"funder_award_id":"R35 CA232097","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G3558678528","display_name":"Elucidating genetics of response to immune checkpoint blockade in lung cancer","funder_award_id":"R01CA205426","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4102770861","display_name":null,"funder_award_id":"CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4266131079","display_name":null,"funder_award_id":"NIH/NCI Cancer Center Support Grant P30 CA008748.","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6403603385","display_name":null,"funder_award_id":"Support Grant P30 CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G644517898","display_name":"Towards Precision Immuno-Oncology: Unraveling the Genomic Determinants and Mechanisms Underlying Immunotherapy Efficacy and Resistance","funder_award_id":"R35CA232097","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G874817191","display_name":null,"funder_award_id":"CA205426","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000003249","display_name":null,"funder_award_id":"CA008748","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000303076","display_name":null,"funder_award_id":"NIH/NCI Cancer Center Support Grant P30 CA008748","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320310212","display_name":"Fundaci\u00f3n Alfonso Mart\u00edn Escudero","ror":"https://ror.org/02897ye82"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4224313453.pdf","grobid_xml":"https://content.openalex.org/works/W4224313453.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W223909586","https://openalex.org/W1809056726","https://openalex.org/W2006617902","https://openalex.org/W2019607817","https://openalex.org/W2085458222","https://openalex.org/W2129191628","https://openalex.org/W2167064714","https://openalex.org/W2167127503","https://openalex.org/W2384032641","https://openalex.org/W2405513305","https://openalex.org/W2574604975","https://openalex.org/W2898946138","https://openalex.org/W2900661972","https://openalex.org/W2962917731","https://openalex.org/W2988620928","https://openalex.org/W2992331319","https://openalex.org/W3020886383","https://openalex.org/W3021646013","https://openalex.org/W3038009775","https://openalex.org/W3047253098","https://openalex.org/W3095767767","https://openalex.org/W3118913605","https://openalex.org/W3127371144","https://openalex.org/W3210650932"],"related_works":["https://openalex.org/W4312080410","https://openalex.org/W4388510380","https://openalex.org/W4206700113","https://openalex.org/W2952805319","https://openalex.org/W4296922672","https://openalex.org/W4390509618","https://openalex.org/W2913806219","https://openalex.org/W2945858728","https://openalex.org/W3136653115","https://openalex.org/W4294955051"],"abstract_inverted_index":{"The":[0],"effects":[1],"of":[2],"cytokine":[3],"and":[4,71],"protein":[5],"stabilizing":[6],"carriers,":[7],"such":[8],"as":[9],"serum":[10,37],"albumin,":[11],"on":[12],"tumor":[13,42,63,73],"response":[14,44,74],"to":[15,76],"immune":[16],"checkpoint":[17],"blockade":[18],"(ICB)":[19],"is":[20,54],"not":[21],"well":[22],"understood.":[23],"By":[24],"examining":[25],"1714":[26],"patients":[27],"across":[28],"16":[29],"cancer":[30],"types,":[31],"we":[32],"found":[33],"that":[34,58],"high":[35],"pretreatment":[36],"albumin":[38,53],"level":[39],"predicts":[40],"favorable":[41],"radiographic":[43],"following":[45],"ICB":[46,77],"treatment":[47],"in":[48,80],"a":[49,55],"dose-dependent":[50],"fashion.":[51],"Serum":[52],"candidate":[56],"biomarker":[57],"can":[59],"be":[60],"combined":[61],"with":[62],"mutational":[64],"burden":[65],"(TMB)":[66],"for":[67],"additional":[68],"predictive":[69],"capacity,":[70],"the":[72,81],"rate":[75],"was":[78],"~49%":[79],"albumin-high/TMB-high":[82],"group.":[83]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-04-26T00:00:00"}