{"id":"https://openalex.org/W4224255802","doi":"https://doi.org/10.1038/s41467-022-29902-4","title":"CMYA5 establishes cardiac dyad architecture and positioning","display_name":"CMYA5 establishes cardiac dyad architecture and positioning","publication_year":2022,"publication_date":"2022-04-21","ids":{"openalex":"https://openalex.org/W4224255802","doi":"https://doi.org/10.1038/s41467-022-29902-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/35449169","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9023524"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-022-29902-4","doi":"https://doi.org/10.1038/s41467-022-29902-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-29902-4","pdf_url":"https://www.nature.com/articles/s41467-022-29902-4.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-022-29902-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005371628","display_name":"Fujian Lu","orcid":"https://orcid.org/0000-0003-3605-3924","observed_orcids":["https://orcid.org/0000-0003-3605-3924"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fujian Lu","raw_affiliation_strings":["Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038266752","display_name":"Qing Ma","orcid":"https://orcid.org/0000-0002-5625-1330","observed_orcids":["https://orcid.org/0000-0002-5625-1330"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Ma","raw_affiliation_strings":["Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061307926","display_name":"Wenjun Xie","orcid":"https://orcid.org/0000-0003-0493-062X","observed_orcids":["https://orcid.org/0000-0003-0493-062X"]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjun Xie","raw_affiliation_strings":["The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, 710049, Xi'an, Shanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, 710049, Xi'an, Shanxi, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020288815","display_name":"Carter Liou","orcid":"https://orcid.org/0009-0000-2577-4350","observed_orcids":["https://orcid.org/0009-0000-2577-4350"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carter L. Liou","raw_affiliation_strings":["Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344036","display_name":"Donghui Zhang","orcid":"https://orcid.org/0000-0001-7258-8577","observed_orcids":["https://orcid.org/0000-0001-7258-8577"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I4405271183","display_name":"State Key Laboratory of Biocatalysis and Enzyme Engineering","ror":"https://ror.org/020tz4h34","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271183"]},{"id":"https://openalex.org/I75900474","display_name":"Hubei University","ror":"https://ror.org/03a60m280","country_code":"CN","type":"education","lineage":["https://openalex.org/I75900474"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Donghui Zhang","raw_affiliation_strings":["Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Science, Hubei University, 430062, Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Science, Hubei University, 430062, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I4405271183","https://openalex.org/I75900474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072707319","display_name":"Mason Sweat","orcid":"https://orcid.org/0000-0002-5400-1266","observed_orcids":["https://orcid.org/0000-0002-5400-1266"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mason E. Sweat","raw_affiliation_strings":["Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050357612","display_name":"Blake D. Jardin","orcid":"https://orcid.org/0000-0002-1376-5235","observed_orcids":["https://orcid.org/0000-0002-1376-5235"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blake D. Jardin","raw_affiliation_strings":["Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA"],"raw_orcid":"https://orcid.org/0000-0002-1376-5235","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003583561","display_name":"Francisco J. Naya","orcid":"https://orcid.org/0000-0001-5643-2345","observed_orcids":["https://orcid.org/0000-0001-5643-2345"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francisco J. Naya","raw_affiliation_strings":["Department of Biology, Program in Cell and Molecular Biology, Boston University, Boston, MA, 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Program in Cell and Molecular Biology, Boston University, Boston, MA, 02215, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084882105","display_name":"Yuxuan Guo","orcid":"https://orcid.org/0000-0002-6009-4403","observed_orcids":["https://orcid.org/0000-0002-6009-4403"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yuxuan Guo","raw_affiliation_strings":["Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","Peking University Health Science Center, School of Basic Medical Sciences, The Institute of Cardiovascular Sciences, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, 100191, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Peking University Health Science Center, School of Basic Medical Sciences, The Institute of Cardiovascular Sciences, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, 100191, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076736316","display_name":"Heping Cheng","orcid":"https://orcid.org/0000-0002-9604-6702","observed_orcids":["https://orcid.org/0000-0002-9604-6702"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I4391768054","display_name":"State Key Laboratory of Membrane Biology","ror":"https://ror.org/03mq8q210","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210167311","https://openalex.org/I4391768054","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Heping Cheng","raw_affiliation_strings":["State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Peking University, 100871, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-9604-6702","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Peking University, 100871, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I4391768054"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076662333","display_name":"William T. Pu","orcid":"https://orcid.org/0000-0002-4551-8079","observed_orcids":["https://orcid.org/0000-0002-4551-8079"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William T. Pu","raw_affiliation_strings":["Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA. william.pu@cardio.chboston.org","Harvard Stem Cell Institute, 7 Divinity Avenue, Cambridge, MA, 02138, USA. william.pu@cardio.chboston.org","Harvard Stem Cell Institute, 7 Divinity Avenue, Cambridge, MA, 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA. william.pu@cardio.chboston.org","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, 7 Divinity Avenue, Cambridge, MA, 02138, USA. william.pu@cardio.chboston.org","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, 7 Divinity Avenue, Cambridge, MA, 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5076662333"],"corresponding_institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I4210157861"],"apc_list":{"value":5890,"currency":"USD","value_usd":5890},"apc_paid":{"value":5890,"currency":"USD","value_usd":5890},"fwci":4.7968,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.96434106,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"2185","last_page":"2185"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/excitation-contraction-coupling","display_name":"excitation-contraction coupling","score":0.9769999980926514},{"id":"https://openalex.org/keywords/junctional-sarcoplasmic-reticulum","display_name":"junctional sarcoplasmic reticulum","score":0.9509999752044678},{"id":"https://openalex.org/keywords/z-line","display_name":"Z-line","score":0.765999972820282},{"id":"https://openalex.org/keywords/t-tubules","display_name":"T-tubules","score":0.9950000047683716},{"id":"https://openalex.org/keywords/heart-development","display_name":"heart development","score":0.6460000276565552},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.625},{"id":"https://openalex.org/keywords/calcium-release","display_name":"calcium release","score":0.8349999785423279},{"id":"https://openalex.org/keywords/pressure-overload","display_name":"pressure overload","score":0.7149999737739563},{"id":"https://openalex.org/keywords/proximity-proteomics","display_name":"proximity proteomics","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.8730735182762146},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.615795910358429},{"id":"https://openalex.org/C2777716012","wikidata":"https://www.wikidata.org/wiki/Q5318389","display_name":"Dyad","level":2,"score":0.5842866897583008},{"id":"https://openalex.org/C190712762","wikidata":"https://www.wikidata.org/wiki/Q18031341","display_name":"Ryanodine receptor 2","level":4,"score":0.47286176681518555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4528175890445709},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3620843291282654},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3335704207420349},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.2612264156341553},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08846312761306763},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012508","descriptor_name":"Sarcolemma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056966","descriptor_name":"Excitation Contraction Coupling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1038/s41467-022-29902-4","doi":"https://doi.org/10.1038/s41467-022-29902-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-29902-4","pdf_url":"https://www.nature.com/articles/s41467-022-29902-4.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9023524","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9023524","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:35449169","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35449169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:null:2144/46493","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pubmed/35449169","pdf_url":null,"source":{"id":"https://openalex.org/S4306402384","display_name":"OpenBU (Boston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I111088046","host_organization_name":"Boston University","host_organization_lineage":["https://openalex.org/I111088046"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29902-4","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-022-29902-4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:e12393a3286b484db96f093687dad036","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e12393a3286b484db96f093687dad036","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)","raw_type":"article"},{"id":"doi:10.60692/h0et5-k4866","doi":"https://doi.org/10.60692/h0et5-k4866","is_oa":true,"landing_page_url":"https://doi.org/10.60692/h0et5-k4866","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/jfd7h-72109","doi":"https://doi.org/10.60692/jfd7h-72109","is_oa":true,"landing_page_url":"https://doi.org/10.60692/jfd7h-72109","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1038/s41467-022-29902-4","doi":"https://doi.org/10.1038/s41467-022-29902-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-29902-4","pdf_url":"https://www.nature.com/articles/s41467-022-29902-4.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G339984688","display_name":"Development of MYBPC3-based gene therapy to regulate RYR2 activity","funder_award_id":"20POST35200233","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G4422234635","display_name":null,"funder_award_id":"R01 HL146634","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G5325870837","display_name":"Regulation of Cardiomyocyte Maturation","funder_award_id":"R01HL146634","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5699315463","display_name":null,"funder_award_id":"R21 HD094909","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7053818543","display_name":null,"funder_award_id":"R21 HD094909","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G7548702623","display_name":"Enabling mammalian in vivo forward genetic screens based on cell morphology","funder_award_id":"5r21hd094909-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000877371","display_name":"Research Methods in Pediatric Cardiovascular Disease","funder_award_id":"T32HL007572","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4224255802.pdf","grobid_xml":"https://content.openalex.org/works/W4224255802.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1517994259","https://openalex.org/W1699189198","https://openalex.org/W1969271357","https://openalex.org/W1972476556","https://openalex.org/W1978041489","https://openalex.org/W1989891419","https://openalex.org/W1992496728","https://openalex.org/W2003236418","https://openalex.org/W2011683654","https://openalex.org/W2018561717","https://openalex.org/W2018594419","https://openalex.org/W2023758830","https://openalex.org/W2026465178","https://openalex.org/W2027167256","https://openalex.org/W2046701128","https://openalex.org/W2065468928","https://openalex.org/W2067678773","https://openalex.org/W2078913751","https://openalex.org/W2098476525","https://openalex.org/W2105707485","https://openalex.org/W2106972592","https://openalex.org/W2112180900","https://openalex.org/W2123219150","https://openalex.org/W2127041759","https://openalex.org/W2129466238","https://openalex.org/W2130264694","https://openalex.org/W2134592641","https://openalex.org/W2134815855","https://openalex.org/W2135515146","https://openalex.org/W2140313980","https://openalex.org/W2147343486","https://openalex.org/W2155271904","https://openalex.org/W2164535593","https://openalex.org/W2401852324","https://openalex.org/W2588995004","https://openalex.org/W2593514961","https://openalex.org/W2602896452","https://openalex.org/W2738439325","https://openalex.org/W2889940320","https://openalex.org/W2904180818","https://openalex.org/W2909950349","https://openalex.org/W2999577865","https://openalex.org/W3043804763","https://openalex.org/W3082866380","https://openalex.org/W3092385612","https://openalex.org/W3164495245","https://openalex.org/W3165613911"],"related_works":["https://openalex.org/W4391642116","https://openalex.org/W4402276441","https://openalex.org/W4413028185","https://openalex.org/W3004883133","https://openalex.org/W7202395019","https://openalex.org/W2904180818","https://openalex.org/W3025744187","https://openalex.org/W2208897002","https://openalex.org/W4387620988","https://openalex.org/W1518540487"],"abstract_inverted_index":{"Abstract":[0],"Cardiac":[1],"excitation-contraction":[2],"coupling":[3],"requires":[4],"dyads,":[5],"the":[6,39],"nanoscopic":[7],"microdomains":[8],"formed":[9],"adjacent":[10,95],"to":[11,60,96,124,129,149],"Z-lines":[12,97],"by":[13,141],"apposition":[14],"of":[15,23,31],"transverse":[16,85,104],"tubules":[17,86],"and":[18,26,49,84,116,127,154],"junctional":[19,80,99,117,146],"sarcoplasmic":[20,81,100,118,147],"reticulum.":[21],"Disruption":[22],"dyad":[24,43,110,112,152,156],"architecture":[25],"function":[27],"are":[28],"common":[29],"features":[30],"diseased":[32],"cardiomyocytes.":[33,89],"However,":[34],"little":[35],"is":[36,69],"known":[37],"about":[38],"mechanisms":[40],"that":[41,76,143],"modulate":[42],"organization":[44],"during":[45],"cardiac":[46,91,125],"development,":[47,92],"homeostasis,":[48],"disease.":[50],"Here,":[51],"we":[52],"use":[53],"proximity":[54],"proteomics":[55],"in":[56,87],"intact,":[57],"living":[58],"hearts":[59],"identify":[61],"proteins":[62,68],"enriched":[63],"near":[64],"dyads.":[65],"Among":[66],"these":[67],"CMYA5,":[70],"an":[71],"under-studied":[72],"striated":[73],"muscle":[74],"protein":[75],"co-localizes":[77],"with":[78],"Z-lines,":[79,115,150],"reticulum":[82,101,119,148],"proteins,":[83],"mature":[88],"During":[90],"CMYA5":[93,107,144],"positioning":[94,102,113],"precedes":[98],"or":[103],"tubule":[105],"formation.":[106],"ablation":[108],"disrupts":[109],"architecture,":[111,153],"at":[114],"Ca":[120,157],"2+":[121,158],"release,":[122],"leading":[123],"dysfunction":[126],"inability":[128],"tolerate":[130],"pressure":[131],"overload.":[132],"These":[133],"data":[134],"provide":[135],"mechanistic":[136],"insights":[137],"into":[138],"cardiomyopathy":[139],"pathogenesis":[140],"demonstrating":[142],"anchors":[145],"establishes":[151],"regulates":[155],"release.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-04-26T00:00:00"}
