{"id":"https://openalex.org/W4224255413","doi":"https://doi.org/10.1016/j.foodres.2022.111266","title":"Identification and molecular mechanisms of novel antioxidant peptides from two sources of eggshell membrane hydrolysates showing cytoprotection against oxidative stress: A combined in silico and in vitro study","display_name":"Identification and molecular mechanisms of novel antioxidant peptides from two sources of eggshell membrane hydrolysates showing cytoprotection against oxidative stress: A combined in silico and in vitro study","publication_year":2022,"publication_date":"2022-04-20","ids":{"openalex":"https://openalex.org/W4224255413","doi":"https://doi.org/10.1016/j.foodres.2022.111266","pmid":"https://pubmed.ncbi.nlm.nih.gov/35761579"},"language":"en","primary_location":{"id":"doi:10.1016/j.foodres.2022.111266","doi":"https://doi.org/10.1016/j.foodres.2022.111266","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.foodres.2022.111266","pdf_url":null,"source":{"id":"https://openalex.org/S38919146","display_name":"Food Research International","issn_l":"0963-9969","issn":["0963-9969","1873-7145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Research International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040899036","display_name":"Lingjiao Zhu","orcid":"https://orcid.org/0000-0003-4310-2181","observed_orcids":["https://orcid.org/0000-0003-4310-2181"]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingjiao Zhu","raw_affiliation_strings":["National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101828764","display_name":"Hanguo Xiong","orcid":"https://orcid.org/0000-0002-5799-9623","observed_orcids":["https://orcid.org/0000-0002-5799-9623"]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanguo Xiong","raw_affiliation_strings":["National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075542108","display_name":"Xi Huang","orcid":"https://orcid.org/0000-0001-7380-8236","observed_orcids":["https://orcid.org/0000-0001-7380-8236","https://orcid.org/0009-0003-9649-1114","https://orcid.org/0009-0004-3815-5486"]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Huang","raw_affiliation_strings":["National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056649796","display_name":"Vincent Guyonnet","orcid":"https://orcid.org/0000-0001-5576-4348","observed_orcids":["https://orcid.org/0000-0001-5576-4348"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vincent Guyonnet","raw_affiliation_strings":["FFI Consulting, Limited, 2488 Lyn Road, Brockville, Ontario K6V 5T3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FFI Consulting, Limited, 2488 Lyn Road, Brockville, Ontario K6V 5T3, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064201133","display_name":"Meihu Ma","orcid":"https://orcid.org/0000-0001-5640-3501","observed_orcids":["https://orcid.org/0000-0001-5640-3501"]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Meihu Ma","raw_affiliation_strings":["National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China. Electronic address: mameihuhn@163.com","National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China. Electronic address: mameihuhn@163.com","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100649521","display_name":"Xueqin Chen","orcid":"https://orcid.org/0000-0001-9444-5059","observed_orcids":["https://orcid.org/0000-0001-9444-5059"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xueqin Chen","raw_affiliation_strings":["Hubei Provincial Engineering Technology Research Center for Deep Processing of Eggs, Wuhan, Hubei 430070, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Provincial Engineering Technology Research Center for Deep Processing of Eggs, Wuhan, Hubei 430070, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004209704","display_name":"Yuting Zheng","orcid":"https://orcid.org/0000-0001-6112-8487","observed_orcids":["https://orcid.org/0000-0001-6112-8487"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuting Zheng","raw_affiliation_strings":["Hubei Provincial Engineering Technology Research Center for Deep Processing of Eggs, Wuhan, Hubei 430070, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Provincial Engineering Technology Research Center for Deep Processing of Eggs, Wuhan, Hubei 430070, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100695804","display_name":"Limei Wang","orcid":"https://orcid.org/0000-0002-5041-2287","observed_orcids":["https://orcid.org/0000-0002-5041-2287","https://orcid.org/0009-0001-1824-6020"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Limei Wang","raw_affiliation_strings":["Hubei Provincial Engineering Technology Research Center for Deep Processing of Eggs, Wuhan, Hubei 430070, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Provincial Engineering Technology Research Center for Deep Processing of Eggs, Wuhan, Hubei 430070, PR China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100928996","display_name":"Hu Gan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gan Hu","raw_affiliation_strings":["National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China","institution_ids":["https://openalex.org/I204823248"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064201133"],"corresponding_institution_ids":["https://openalex.org/I204823248"],"apc_list":{"value":3910,"currency":"USD","value_usd":3910},"apc_paid":null,"fwci":9.2573,"has_fulltext":false,"cited_by_count":105,"citation_normalized_percentile":{"value":0.99300252,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"157","issue":null,"first_page":"111266","last_page":"111266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eggshell-membrane","display_name":"eggshell membrane","score":0.878000020980835},{"id":"https://openalex.org/keywords/antioxidant-peptides","display_name":"antioxidant peptides","score":0.8880000114440918},{"id":"https://openalex.org/keywords/hydrolysate","display_name":"hydrolysate","score":0.6880000233650208},{"id":"https://openalex.org/keywords/keap1-nrf2-pathway","display_name":"Nrf2/Keap1 pathway","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.8450000286102295},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9900000095367432},{"id":"https://openalex.org/keywords/peptidomics","display_name":"peptidomics","score":0.7480000257492065},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.5040000081062317},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9129999876022339},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9490000009536743},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.734000027179718},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.4659999907016754},{"id":"https://openalex.org/keywords/functional-foods","display_name":"functional foods","score":0.5339999794960022},{"id":"https://openalex.org/keywords/agricultural-by-products","display_name":"agricultural by-products","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C2776352850","wikidata":"https://www.wikidata.org/wiki/Q18389506","display_name":"Eggshell membrane","level":3,"score":0.84437096118927},{"id":"https://openalex.org/C2780967304","wikidata":"https://www.wikidata.org/wiki/Q246156","display_name":"Cytoprotection","level":3,"score":0.7988318204879761},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7650927305221558},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.746761679649353},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6976227760314941},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6615443825721741},{"id":"https://openalex.org/C28800991","wikidata":"https://www.wikidata.org/wiki/Q15634405","display_name":"Hydrolysate","level":3,"score":0.5457742214202881},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5180245041847229},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4660103917121887},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3441218137741089},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.10954311490058899},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072019","descriptor_name":"Kelch-Like ECH-Associated Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004528","descriptor_name":"Egg Shell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.foodres.2022.111266","doi":"https://doi.org/10.1016/j.foodres.2022.111266","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.foodres.2022.111266","pdf_url":null,"source":{"id":"https://openalex.org/S38919146","display_name":"Food Research International","issn_l":"0963-9969","issn":["0963-9969","1873-7145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Research International","raw_type":"journal-article"},{"id":"pmid:35761579","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35761579","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food research international (Ottawa, Ont.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.4359000027179718,"id":"https://metadata.un.org/sdg/2"},{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2990362038","display_name":null,"funder_award_id":"2018YFD0400302","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G4443896695","display_name":null,"funder_award_id":"32072237","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W314933065","https://openalex.org/W840875033","https://openalex.org/W1489741616","https://openalex.org/W1966092834","https://openalex.org/W1976005221","https://openalex.org/W1992431983","https://openalex.org/W1998098449","https://openalex.org/W2048226075","https://openalex.org/W2090678272","https://openalex.org/W2138216052","https://openalex.org/W2192713486","https://openalex.org/W2256462479","https://openalex.org/W2313927775","https://openalex.org/W2401030213","https://openalex.org/W2496925402","https://openalex.org/W2503897961","https://openalex.org/W2594583518","https://openalex.org/W2622908978","https://openalex.org/W2730416833","https://openalex.org/W2734769589","https://openalex.org/W2761081861","https://openalex.org/W2804269048","https://openalex.org/W2884748382","https://openalex.org/W2888299914","https://openalex.org/W2901614104","https://openalex.org/W2901987854","https://openalex.org/W2903660774","https://openalex.org/W2943327232","https://openalex.org/W2947291861","https://openalex.org/W2967921691","https://openalex.org/W2979060808","https://openalex.org/W2981147350","https://openalex.org/W3002278749","https://openalex.org/W3004047855","https://openalex.org/W3004266191","https://openalex.org/W3009840168","https://openalex.org/W3010283997","https://openalex.org/W3011686755","https://openalex.org/W3020184563","https://openalex.org/W3025460259","https://openalex.org/W3036506516","https://openalex.org/W3036795917","https://openalex.org/W3088459654","https://openalex.org/W3092442543","https://openalex.org/W3116770645","https://openalex.org/W3132775553","https://openalex.org/W3136528674","https://openalex.org/W3173938493","https://openalex.org/W3182640006","https://openalex.org/W3199875557","https://openalex.org/W3202639823"],"related_works":["https://openalex.org/W4416518508","https://openalex.org/W4311975437","https://openalex.org/W2981147350","https://openalex.org/W2313927775","https://openalex.org/W7223449729","https://openalex.org/W4406774399","https://openalex.org/W2913263603","https://openalex.org/W7160775832","https://openalex.org/W4361010503","https://openalex.org/W7163166029"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":37},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":6}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-04-26T00:00:00"}
