{"id":"https://openalex.org/W4224255077","doi":"https://doi.org/10.1021/acsinfecdis.1c00628","title":"Structure-Based Design of \u03b1-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa","display_name":"Structure-Based Design of \u03b1-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa","publication_year":2022,"publication_date":"2022-04-22","ids":{"openalex":"https://openalex.org/W4224255077","doi":"https://doi.org/10.1021/acsinfecdis.1c00628","pmid":"https://pubmed.ncbi.nlm.nih.gov/35451824","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9112332"},"language":"en","primary_location":{"id":"doi:10.1021/acsinfecdis.1c00628","doi":"https://doi.org/10.1021/acsinfecdis.1c00628","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.1c00628","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acsinfecdis.1c00628","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048397252","display_name":"Cansu Kaya","orcid":"https://orcid.org/0000-0001-9269-7033","observed_orcids":["https://orcid.org/0000-0001-9269-7033","https://orcid.org/0000-0001-8746-7321"]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]},{"id":"https://openalex.org/I4210142777","display_name":"Helmholtz Institute for Pharmaceutical Research Saarland","ror":"https://ror.org/042dsac10","country_code":"DE","type":"government","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929","https://openalex.org/I4210142777"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Cansu Kaya","raw_affiliation_strings":["Department of Pharmacy, Saarland University, Campus E8.1, 66123 Saarbr\u00fccken, Germany","Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Saarland University, Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210124929","https://openalex.org/I4210142777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056609795","display_name":"Isabell Walter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]},{"id":"https://openalex.org/I4210142777","display_name":"Helmholtz Institute for Pharmaceutical Research Saarland","ror":"https://ror.org/042dsac10","country_code":"DE","type":"government","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929","https://openalex.org/I4210142777"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Isabell Walter","raw_affiliation_strings":["Department of Pharmacy, Saarland University, Campus E8.1, 66123 Saarbr\u00fccken, Germany","Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Saarland University, Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210124929","https://openalex.org/I4210142777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030819201","display_name":"Alaa Alhayek","orcid":"https://orcid.org/0000-0001-8192-6574","observed_orcids":["https://orcid.org/0000-0001-8192-6574"]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]},{"id":"https://openalex.org/I4210142777","display_name":"Helmholtz Institute for Pharmaceutical Research Saarland","ror":"https://ror.org/042dsac10","country_code":"DE","type":"government","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929","https://openalex.org/I4210142777"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alaa Alhayek","raw_affiliation_strings":["Department of Pharmacy, Saarland University, Campus E8.1, 66123 Saarbr\u00fccken, Germany","Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Saarland University, Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210124929","https://openalex.org/I4210142777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090839909","display_name":"Roya Shafiei","orcid":"https://orcid.org/0000-0001-9783-595X","observed_orcids":["https://orcid.org/0000-0001-9783-595X"]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]},{"id":"https://openalex.org/I4210142777","display_name":"Helmholtz Institute for Pharmaceutical Research Saarland","ror":"https://ror.org/042dsac10","country_code":"DE","type":"government","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929","https://openalex.org/I4210142777"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Roya Shafiei","raw_affiliation_strings":["Department of Pharmacy, Saarland University, Campus E8.1, 66123 Saarbr\u00fccken, Germany","Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9783-595X","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Saarland University, Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210124929","https://openalex.org/I4210142777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056312547","display_name":"Gwena\u00eblle J\u00e9z\u00e9quel","orcid":"https://orcid.org/0000-0001-8945-8680","observed_orcids":["https://orcid.org/0000-0001-8945-8680"]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]},{"id":"https://openalex.org/I4210142777","display_name":"Helmholtz Institute for Pharmaceutical Research Saarland","ror":"https://ror.org/042dsac10","country_code":"DE","type":"government","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929","https://openalex.org/I4210142777"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gwena\u00eblle J\u00e9z\u00e9quel","raw_affiliation_strings":["Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8945-8680","affiliations":[{"raw_affiliation_string":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210124929","https://openalex.org/I4210142777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080972979","display_name":"Anastasia Andreas","orcid":"https://orcid.org/0009-0006-8600-3158","observed_orcids":["https://orcid.org/0009-0006-8600-3158"]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]},{"id":"https://openalex.org/I4210142777","display_name":"Helmholtz Institute for Pharmaceutical Research Saarland","ror":"https://ror.org/042dsac10","country_code":"DE","type":"government","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929","https://openalex.org/I4210142777"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anastasia Andreas","raw_affiliation_strings":["Department of Pharmacy, Saarland University, Campus E8.1, 66123 Saarbr\u00fccken, Germany","Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Saarland University, Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210124929","https://openalex.org/I4210142777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057718680","display_name":"Jelena Konstantinovi\u0107","orcid":"https://orcid.org/0000-0002-2572-8538","observed_orcids":["https://orcid.org/0000-0002-2572-8538"]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]},{"id":"https://openalex.org/I4210142777","display_name":"Helmholtz Institute for Pharmaceutical Research Saarland","ror":"https://ror.org/042dsac10","country_code":"DE","type":"government","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929","https://openalex.org/I4210142777"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jelena Konstantinovi\u0107","raw_affiliation_strings":["Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210124929","https://openalex.org/I4210142777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005617800","display_name":"Esther Sch\u00f6nauer","orcid":"https://orcid.org/0000-0002-2625-9446","observed_orcids":["https://orcid.org/0000-0002-2625-9446"]},"institutions":[{"id":"https://openalex.org/I182212641","display_name":"University of Salzburg","ror":"https://ror.org/05gs8cd61","country_code":"AT","type":"education","lineage":["https://openalex.org/I182212641"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Esther Sch\u00f6nauer","raw_affiliation_strings":["Department of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Stra\u00dfe, 34, 5020 Salzburg, Austria"],"raw_orcid":"https://orcid.org/0000-0002-2625-9446","affiliations":[{"raw_affiliation_string":"Department of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Stra\u00dfe, 34, 5020 Salzburg, Austria","institution_ids":["https://openalex.org/I182212641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041119394","display_name":"Asfandyar Sikandar","orcid":"https://orcid.org/0000-0002-6566-4022","observed_orcids":["https://orcid.org/0000-0002-6566-4022"]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]},{"id":"https://openalex.org/I4210142777","display_name":"Helmholtz Institute for Pharmaceutical Research Saarland","ror":"https://ror.org/042dsac10","country_code":"DE","type":"government","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929","https://openalex.org/I4210142777"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Asfandyar Sikandar","raw_affiliation_strings":["Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210124929","https://openalex.org/I4210142777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075469040","display_name":"J\u00f6rg Haupenthal","orcid":"https://orcid.org/0000-0003-3991-2800","observed_orcids":["https://orcid.org/0000-0003-3991-2800"]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]},{"id":"https://openalex.org/I4210142777","display_name":"Helmholtz Institute for Pharmaceutical Research Saarland","ror":"https://ror.org/042dsac10","country_code":"DE","type":"government","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929","https://openalex.org/I4210142777"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Haupenthal","raw_affiliation_strings":["Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210124929","https://openalex.org/I4210142777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077818118","display_name":"Rolf M\u00fcller","orcid":"https://orcid.org/0000-0002-1042-5665","observed_orcids":["https://orcid.org/0000-0002-1042-5665","https://orcid.org/0000-0001-6571-6630"]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]},{"id":"https://openalex.org/I4210142777","display_name":"Helmholtz Institute for Pharmaceutical Research Saarland","ror":"https://ror.org/042dsac10","country_code":"DE","type":"government","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929","https://openalex.org/I4210142777"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rolf M\u00fcller","raw_affiliation_strings":["Department of Pharmacy, Saarland University, Campus E8.1, 66123 Saarbr\u00fccken, Germany","Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany","Helmholtz International Lab for Anti-Infectives, Campus E 8.1, 66123 Saarbr\u00fccken, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1042-5665","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Saarland University, Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210124929","https://openalex.org/I4210142777"]},{"raw_affiliation_string":"Helmholtz International Lab for Anti-Infectives, Campus E 8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023287358","display_name":"Hans Brandstetter","orcid":"https://orcid.org/0000-0002-6089-3045","observed_orcids":["https://orcid.org/0000-0002-6089-3045"]},"institutions":[{"id":"https://openalex.org/I182212641","display_name":"University of Salzburg","ror":"https://ror.org/05gs8cd61","country_code":"AT","type":"education","lineage":["https://openalex.org/I182212641"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Hans Brandstetter","raw_affiliation_strings":["Department of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Stra\u00dfe, 34, 5020 Salzburg, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Stra\u00dfe, 34, 5020 Salzburg, Austria","institution_ids":["https://openalex.org/I182212641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015608341","display_name":"Rolf W. Hartmann","orcid":"https://orcid.org/0000-0002-5871-5231","observed_orcids":["https://orcid.org/0000-0002-5871-5231"]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]},{"id":"https://openalex.org/I4210142777","display_name":"Helmholtz Institute for Pharmaceutical Research Saarland","ror":"https://ror.org/042dsac10","country_code":"DE","type":"government","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929","https://openalex.org/I4210142777"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rolf W. Hartmann","raw_affiliation_strings":["Department of Pharmacy, Saarland University, Campus E8.1, 66123 Saarbr\u00fccken, Germany","Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany"],"raw_orcid":"https://orcid.org/0000-0002-5871-5231","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Saarland University, Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210124929","https://openalex.org/I4210142777"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082528019","display_name":"Anna K. H. Hirsch","orcid":"https://orcid.org/0000-0001-8734-4663","observed_orcids":["https://orcid.org/0000-0001-8734-4663"]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]},{"id":"https://openalex.org/I4210142777","display_name":"Helmholtz Institute for Pharmaceutical Research Saarland","ror":"https://ror.org/042dsac10","country_code":"DE","type":"government","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929","https://openalex.org/I4210142777"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Anna K.H. Hirsch","raw_affiliation_strings":["Department of Pharmacy, Saarland University, Campus E8.1, 66123 Saarbr\u00fccken, Germany","Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany","Helmholtz International Lab for Anti-Infectives, Campus E 8.1, 66123 Saarbr\u00fccken, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8734-4663","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Saarland University, Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)\u2500Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210124929","https://openalex.org/I4210142777"]},{"raw_affiliation_string":"Helmholtz International Lab for Anti-Infectives, Campus E 8.1, 66123 Saarbr\u00fccken, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5082528019"],"corresponding_institution_ids":["https://openalex.org/I4210124929","https://openalex.org/I4210142777","https://openalex.org/I91712215"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":1.2317,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.76976653,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"8","issue":"5","first_page":"1010","last_page":"1021"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lasb-elastase","display_name":"LasB elastase","score":0.8830000162124634},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9950000047683716},{"id":"https://openalex.org/keywords/anti-virulence-therapy","display_name":"anti-virulence therapy","score":0.8149999976158142},{"id":"https://openalex.org/keywords/elastase-inhibitors","display_name":"elastase inhibitors","score":0.7509999871253967},{"id":"https://openalex.org/keywords/structure-based-drug-design","display_name":"structure-based drug design","score":0.7390000224113464},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.6990000009536743},{"id":"https://openalex.org/keywords/virulence-factor-inhibition","display_name":"virulence factor inhibition","score":0.7440000176429749},{"id":"https://openalex.org/keywords/multidrug-resistant-bacteria","display_name":"multidrug-resistant bacteria","score":0.7789999842643738},{"id":"https://openalex.org/keywords/hydrophilicity","display_name":"hydrophilicity","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.8614615201950073},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.8363564014434814},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.8022018074989319},{"id":"https://openalex.org/C2779032433","wikidata":"https://www.wikidata.org/wiki/Q761648","display_name":"Galleria mellonella","level":4,"score":0.7885534763336182},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.6503015756607056},{"id":"https://openalex.org/C2781090273","wikidata":"https://www.wikidata.org/wiki/Q1623405","display_name":"Virulence factor","level":4,"score":0.6325967311859131},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5682475566864014},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.5332533717155457},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5164780616760254},{"id":"https://openalex.org/C2778883795","wikidata":"https://www.wikidata.org/wiki/Q804517","display_name":"Pathogenic bacteria","level":3,"score":0.46086394786834717},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17048239707946777},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15197399258613586},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09534722566604614},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0913923978805542},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acsinfecdis.1c00628","doi":"https://doi.org/10.1021/acsinfecdis.1c00628","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.1c00628","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9112332","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9112332/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9112332/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infect Dis","raw_type":"Text"},{"id":"pmid:35451824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35451824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-04768125v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-04768125","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Infectious Diseases, 2022, 8, pp.1010 - 1021. ⟨10.1021/acsinfecdis.1c00628⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1021/acsinfecdis.1c00628","doi":"https://doi.org/10.1021/acsinfecdis.1c00628","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.1c00628","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3113548870","display_name":"Mechanism of bacterial collagenolysis","funder_award_id":"P31843","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"}],"funders":[{"id":"https://openalex.org/F4320308269","display_name":"Alexander von Humboldt-Stiftung","ror":"https://ror.org/012kf4317"},{"id":"https://openalex.org/F4320319116","display_name":"Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator","ror":"https://ror.org/0381dsh28"},{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"},{"id":"https://openalex.org/F4320323322","display_name":"Universit\u00e4t des Saarlandes","ror":"https://ror.org/01jdpyv68"},{"id":"https://openalex.org/F4320323345","display_name":"Universit\u00e4t Salzburg","ror":"https://ror.org/05gs8cd61"},{"id":"https://openalex.org/F4320325698","display_name":"Helmholtz Association","ror":null},{"id":"https://openalex.org/F4320334763","display_name":"Leibniz-Gemeinschaft","ror":"https://ror.org/01n6r0e97"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4224255077.pdf","grobid_xml":"https://content.openalex.org/works/W4224255077.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W4112642","https://openalex.org/W1530747269","https://openalex.org/W1615535881","https://openalex.org/W1751253656","https://openalex.org/W1793924104","https://openalex.org/W1859272595","https://openalex.org/W1870508787","https://openalex.org/W1915829691","https://openalex.org/W1969511733","https://openalex.org/W1973843350","https://openalex.org/W1980712809","https://openalex.org/W1989035014","https://openalex.org/W1994674290","https://openalex.org/W1999979510","https://openalex.org/W2001875667","https://openalex.org/W2005166974","https://openalex.org/W2010629864","https://openalex.org/W2011788706","https://openalex.org/W2031112158","https://openalex.org/W2038578669","https://openalex.org/W2040008652","https://openalex.org/W2051328671","https://openalex.org/W2053360373","https://openalex.org/W2056659809","https://openalex.org/W2060816398","https://openalex.org/W2064163165","https://openalex.org/W2065372703","https://openalex.org/W2090318684","https://openalex.org/W2100693319","https://openalex.org/W2114358145","https://openalex.org/W2128049766","https://openalex.org/W2134896733","https://openalex.org/W2134999596","https://openalex.org/W2137272233","https://openalex.org/W2138390226","https://openalex.org/W2146881880","https://openalex.org/W2155800098","https://openalex.org/W2165638033","https://openalex.org/W2291776655","https://openalex.org/W2507588877","https://openalex.org/W2524047578","https://openalex.org/W2582069104","https://openalex.org/W2598898392","https://openalex.org/W2615493985","https://openalex.org/W2750507304","https://openalex.org/W2792207297","https://openalex.org/W2833927071","https://openalex.org/W2887593704","https://openalex.org/W2903381708","https://openalex.org/W2949415506","https://openalex.org/W2990798082","https://openalex.org/W2992929975","https://openalex.org/W3032515986","https://openalex.org/W3123196133","https://openalex.org/W3212433274","https://openalex.org/W4245530044"],"related_works":["https://openalex.org/W2792207297","https://openalex.org/W2138390226","https://openalex.org/W4224827471","https://openalex.org/W2134896733","https://openalex.org/W3212433274","https://openalex.org/W4413163477","https://openalex.org/W6898867261","https://openalex.org/W7172517592","https://openalex.org/W2006790035","https://openalex.org/W4388188762"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"Antivirulence":[7],"therapy":[8],"has":[9],"become":[10],"a":[11,45],"widely":[12],"applicable":[13],"method":[14],"for":[15],"fighting":[16],"infections":[17],"caused":[18],"by":[19,28,77],"multidrug-resistant":[20],"bacteria.":[21],"Among":[22],"the":[23,29,49,52,58,66,79,85,105,108,113,121,130],"many":[24],"virulence":[25],"factors":[26],"produced":[27],"Gram-negative":[30],"bacterium":[31],"Pseudomonas":[32],"aeruginosa,":[33],"elastase":[34],"(LasB)":[35],"stands":[36],"out":[37],"as":[38,42],"an":[39],"important":[40],"target":[41],"it":[43],"plays":[44],"pivotal":[46],"role":[47],"in":[48,120],"invasion":[50],"of":[51,57,72,82,84,107,115,133],"host":[53],"tissue":[54],"and":[55,96,110,117],"evasion":[56],"immune":[59],"response.":[60],"In":[61],"this":[62],"work,":[63],"we":[64],"explored":[65],"recently":[67],"reported":[68],"LasB":[69],"inhibitor":[70],"class":[71],"\u03b1-benzyl-":[73],"N":[74],"-aryl":[75],"mercaptoacetamides":[76],"exploiting":[78],"crystal":[80],"structure":[81],"one":[83],"compounds.":[86],"Our":[87],"exploration":[88],"yielded":[89],"inhibitors":[90,100],"that":[91],"maintained":[92],"inhibitory":[93],"activity,":[94],"selectivity,":[95],"increased":[97,129],"hydrophilicity.":[98],"These":[99],"were":[101],"found":[102],"to":[103,111],"reduce":[104],"pathogenicity":[106],"bacteria":[109],"maintain":[112],"integrity":[114],"lung":[116],"skin":[118],"cells":[119],"diseased":[122],"state.":[123],"Furthermore,":[124],"two":[125],"most":[126],"promising":[127],"compounds":[128],"survival":[131],"rate":[132],"Galleria":[134],"mellonella":[135],"larvae":[136],"treated":[137],"with":[138],"P.":[139],"aeruginosa":[140],"culture":[141],"supernatant.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-04-26T00:00:00"}