{"id":"https://openalex.org/W4224254844","doi":"https://doi.org/10.3389/fonc.2022.851572","title":"Case Report: Precision Medicine Target Revealed by In Vitro Modeling of Relapsed, Refractory Acute Lymphoblastic Leukemia From a Child With Neurofibromatosis","display_name":"Case Report: Precision Medicine Target Revealed by In Vitro Modeling of Relapsed, Refractory Acute Lymphoblastic Leukemia From a Child With Neurofibromatosis","publication_year":2022,"publication_date":"2022-04-20","ids":{"openalex":"https://openalex.org/W4224254844","doi":"https://doi.org/10.3389/fonc.2022.851572","pmid":"https://pubmed.ncbi.nlm.nih.gov/35515133","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9065550"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2022.851572","doi":"https://doi.org/10.3389/fonc.2022.851572","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.851572","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.851572/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.851572/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009176458","display_name":"Susan L. Heatley","orcid":"https://orcid.org/0000-0001-7497-6477","observed_orcids":["https://orcid.org/0000-0001-7497-6477"]},"institutions":[{"id":"https://openalex.org/I4210135240","display_name":"ANZCHOG","ror":"https://ror.org/03dfj7v30","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210135240"]},{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Susan L. Heatley","raw_affiliation_strings":["Australian & New Zealand Children's Haematology/Oncology Group, Clayton, VIC, Australia","Cancer Program, Precision Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia","Faculty of Health & Medical Science, University of Adelaide, Adelaide, SA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian & New Zealand Children's Haematology/Oncology Group, Clayton, VIC, Australia","institution_ids":["https://openalex.org/I4210135240"]},{"raw_affiliation_string":"Cancer Program, Precision Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I4210137740"]},{"raw_affiliation_string":"Faculty of Health & Medical Science, University of Adelaide, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069484473","display_name":"Elyse C. Page","orcid":"https://orcid.org/0000-0002-8990-2574","observed_orcids":["https://orcid.org/0000-0002-8990-2574"]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Elyse C. Page","raw_affiliation_strings":["Cancer Program, Precision Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia","Faculty of Science, University of Adelaide, Adelaide, SA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Program, Precision Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I4210137740"]},{"raw_affiliation_string":"Faculty of Science, University of Adelaide, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023254607","display_name":"Laura N Eadie","orcid":"https://orcid.org/0000-0003-1912-7602","observed_orcids":["https://orcid.org/0000-0003-1912-7602"]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Laura N. Eadie","raw_affiliation_strings":["Cancer Program, Precision Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia","Faculty of Health & Medical Science, University of Adelaide, Adelaide, SA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Program, Precision Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I4210137740"]},{"raw_affiliation_string":"Faculty of Health & Medical Science, University of Adelaide, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042140091","display_name":"Barbara J. McClure","orcid":"https://orcid.org/0000-0002-5201-4127","observed_orcids":["https://orcid.org/0000-0002-5201-4127"]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Barbara J. McClure","raw_affiliation_strings":["Cancer Program, Precision Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia","Faculty of Health & Medical Science, University of Adelaide, Adelaide, SA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Program, Precision Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I4210137740"]},{"raw_affiliation_string":"Faculty of Health & Medical Science, University of Adelaide, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016376415","display_name":"Jacqueline A. Rehn","orcid":"https://orcid.org/0000-0001-5043-6943","observed_orcids":["https://orcid.org/0000-0001-5043-6943"]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jacqueline Rehn","raw_affiliation_strings":["Cancer Program, Precision Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia","Faculty of Health & Medical Science, University of Adelaide, Adelaide, SA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Program, Precision Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I4210137740"]},{"raw_affiliation_string":"Faculty of Health & Medical Science, University of Adelaide, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002537433","display_name":"David T. O. Yeung","orcid":"https://orcid.org/0000-0002-7558-9927","observed_orcids":["https://orcid.org/0000-0002-7558-9927","https://orcid.org/0000-0002-1505-2001"]},"institutions":[{"id":"https://openalex.org/I1320133117","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320133117","https://openalex.org/I4392738059"]},{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]},{"id":"https://openalex.org/I4210150821","display_name":"Australasian Leukaemia and Lymphoma Group","ror":"https://ror.org/05t72y326","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210150821"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David T. Yeung","raw_affiliation_strings":["Australasian Leukaemia & Lymphoma Group, Richmond, VIC, Australia","Cancer Program, Precision Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia","Dept of Haematology, Royal Adelaide Hospital, Adelaide, SA, Australia","Faculty of Health & Medical Science, University of Adelaide, Adelaide, SA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australasian Leukaemia & Lymphoma Group, Richmond, VIC, Australia","institution_ids":["https://openalex.org/I4210150821"]},{"raw_affiliation_string":"Cancer Program, Precision Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I4210137740"]},{"raw_affiliation_string":"Dept of Haematology, Royal Adelaide Hospital, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I1320133117"]},{"raw_affiliation_string":"Faculty of Health & Medical Science, University of Adelaide, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001294228","display_name":"Michael Philip Osborn","orcid":"https://orcid.org/0000-0002-1288-9930","observed_orcids":["https://orcid.org/0000-0002-1288-9930"]},"institutions":[{"id":"https://openalex.org/I2801308011","display_name":"Women's and Children's Hospital","ror":"https://ror.org/03kwrfk72","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801308011"]},{"id":"https://openalex.org/I4210135240","display_name":"ANZCHOG","ror":"https://ror.org/03dfj7v30","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210135240"]},{"id":"https://openalex.org/I4210150821","display_name":"Australasian Leukaemia and Lymphoma Group","ror":"https://ror.org/05t72y326","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210150821"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael Osborn","raw_affiliation_strings":["Australasian Leukaemia & Lymphoma Group, Richmond, VIC, Australia","Australian & New Zealand Children's Haematology/Oncology Group, Clayton, VIC, Australia","Dept of Haematology & Oncology, Women's & Children's Hospital, Adelaide, SA, Australia","Faculty of Health & Medical Science, University of Adelaide, Adelaide, SA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australasian Leukaemia & Lymphoma Group, Richmond, VIC, Australia","institution_ids":["https://openalex.org/I4210150821"]},{"raw_affiliation_string":"Australian & New Zealand Children's Haematology/Oncology Group, Clayton, VIC, Australia","institution_ids":["https://openalex.org/I4210135240"]},{"raw_affiliation_string":"Dept of Haematology & Oncology, Women's & Children's Hospital, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I2801308011"]},{"raw_affiliation_string":"Faculty of Health & Medical Science, University of Adelaide, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101469407","display_name":"Tam\u00e1s R\u00e9v\u00e9sz","orcid":"https://orcid.org/0000-0002-6718-3222","observed_orcids":["https://orcid.org/0000-0002-6718-3222"]},"institutions":[{"id":"https://openalex.org/I2801308011","display_name":"Women's and Children's Hospital","ror":"https://ror.org/03kwrfk72","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801308011"]},{"id":"https://openalex.org/I4210135240","display_name":"ANZCHOG","ror":"https://ror.org/03dfj7v30","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210135240"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tamas Revesz","raw_affiliation_strings":["Australian & New Zealand Children's Haematology/Oncology Group, Clayton, VIC, Australia","Dept of Haematology & Oncology, Women's & Children's Hospital, Adelaide, SA, Australia","Faculty of Health & Medical Science, University of Adelaide, Adelaide, SA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian & New Zealand Children's Haematology/Oncology Group, Clayton, VIC, Australia","institution_ids":["https://openalex.org/I4210135240"]},{"raw_affiliation_string":"Dept of Haematology & Oncology, Women's & Children's Hospital, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I2801308011"]},{"raw_affiliation_string":"Faculty of Health & Medical Science, University of Adelaide, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078529390","display_name":"Maria L. Kirby","orcid":"https://orcid.org/0000-0002-8786-3532","observed_orcids":["https://orcid.org/0000-0002-8786-3532"]},"institutions":[{"id":"https://openalex.org/I2801308011","display_name":"Women's and Children's Hospital","ror":"https://ror.org/03kwrfk72","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801308011"]},{"id":"https://openalex.org/I4210135240","display_name":"ANZCHOG","ror":"https://ror.org/03dfj7v30","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210135240"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Maria Kirby","raw_affiliation_strings":["Australian & New Zealand Children's Haematology/Oncology Group, Clayton, VIC, Australia","Dept of Haematology & Oncology, Women's & Children's Hospital, Adelaide, SA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian & New Zealand Children's Haematology/Oncology Group, Clayton, VIC, Australia","institution_ids":["https://openalex.org/I4210135240"]},{"raw_affiliation_string":"Dept of Haematology & Oncology, Women's & Children's Hospital, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I2801308011"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026996624","display_name":"Deborah L. White","orcid":"https://orcid.org/0000-0003-4844-333X","observed_orcids":["https://orcid.org/0000-0003-4844-333X"]},"institutions":[{"id":"https://openalex.org/I4210135240","display_name":"ANZCHOG","ror":"https://ror.org/03dfj7v30","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210135240"]},{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]},{"id":"https://openalex.org/I4210150821","display_name":"Australasian Leukaemia and Lymphoma Group","ror":"https://ror.org/05t72y326","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210150821"]},{"id":"https://openalex.org/I4405269685","display_name":"Australian Genomics Health Alliance","ror":"https://ror.org/04y1rbh73","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4405269685"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Deborah L. White","raw_affiliation_strings":["Australasian Leukaemia & Lymphoma Group, Richmond, VIC, Australia","Australian & New Zealand Children's Haematology/Oncology Group, Clayton, VIC, Australia","Australian Genomics Health Alliance, Parkville, VIC, Australia","Cancer Program, Precision Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia","Faculty of Health & Medical Science, University of Adelaide, Adelaide, SA, Australia","Faculty of Science, University of Adelaide, Adelaide, SA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australasian Leukaemia & Lymphoma Group, Richmond, VIC, Australia","institution_ids":["https://openalex.org/I4210150821"]},{"raw_affiliation_string":"Australian & New Zealand Children's Haematology/Oncology Group, Clayton, VIC, Australia","institution_ids":["https://openalex.org/I4210135240"]},{"raw_affiliation_string":"Australian Genomics Health Alliance, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I4405269685"]},{"raw_affiliation_string":"Cancer Program, Precision Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I4210137740"]},{"raw_affiliation_string":"Faculty of Health & Medical Science, University of Adelaide, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I5681781"]},{"raw_affiliation_string":"Faculty of Science, University of Adelaide, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I5681781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5026996624"],"corresponding_institution_ids":["https://openalex.org/I4210135240","https://openalex.org/I4210137740","https://openalex.org/I4210150821","https://openalex.org/I4405269685","https://openalex.org/I5681781"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.539,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.62302603,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"12","issue":null,"first_page":"851572","last_page":"851572"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.6035000085830688,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.6035000085830688,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.35839998722076416,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurofibromatosis-type-1","display_name":"neurofibromatosis type 1","score":0.9570000171661377},{"id":"https://openalex.org/keywords/b-cell-acute-lymphoblastic-leukemia","display_name":"B-cell acute lymphoblastic leukemia","score":0.9679999947547913},{"id":"https://openalex.org/keywords/relapsed-refractory-leukemia","display_name":"relapsed/refractory leukemia","score":0.9330000281333923},{"id":"https://openalex.org/keywords/in-vitro-disease-model","display_name":"in vitro disease model","score":0.6520000100135803},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.8399999737739563},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.8849999904632568},{"id":"https://openalex.org/keywords/trametinib","display_name":"trametinib","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mirdametinib","display_name":"mirdametinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/leukemic-transformation","display_name":"leukemic transformation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/pediatric-leukemia","display_name":"pediatric leukemia","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C2778984943","wikidata":"https://www.wikidata.org/wiki/Q847605","display_name":"Neurofibromatosis","level":2,"score":0.8547621965408325},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7216045260429382},{"id":"https://openalex.org/C2778472372","wikidata":"https://www.wikidata.org/wiki/Q7833138","display_name":"Trametinib","level":4,"score":0.7049752473831177},{"id":"https://openalex.org/C2779157977","wikidata":"https://www.wikidata.org/wiki/Q2578247","display_name":"Juvenile myelomonocytic leukemia","level":4,"score":0.6678732633590698},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5489710569381714},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5066136121749878},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.48135071992874146},{"id":"https://openalex.org/C29906990","wikidata":"https://www.wikidata.org/wiki/Q1440688","display_name":"Frameshift mutation","level":4,"score":0.4437635540962219},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.44306498765945435},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40799063444137573},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.394269734621048},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34039267897605896},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.26386070251464844},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18732336163520813},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1628132164478302},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.12041899561882019},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.1199396550655365},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.11137798428535461},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.10000267624855042},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07125255465507507},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fonc.2022.851572","doi":"https://doi.org/10.3389/fonc.2022.851572","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.851572","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.851572/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmid:35515133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35515133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:9065550","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9065550/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/135799","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2440/135799","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.frontiersin.org/articles/10.3389/fonc.2022.851572/full","raw_type":"Journal article"},{"id":"pmh:oai:doaj.org/article:9f2434c287fe47c995543bb044e7f78d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9f2434c287fe47c995543bb044e7f78d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 12 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2022.851572","doi":"https://doi.org/10.3389/fonc.2022.851572","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.851572","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.851572/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G5216905525","display_name":"Improving risk evaluation and outcomes in paediatric acute lymphoblastic leukaemia","funder_award_id":"1057746","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G945039369","display_name":"Screening and targeting newly discovered genetic lesions in poor risk adult and childhood ALL","funder_award_id":"1044884","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320320369","display_name":"Leukaemia Foundation","ror":"https://ror.org/05kqz6183"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320334706","display_name":"Cancer Council South Australia","ror":"https://ror.org/03m5qkb69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4224254844.pdf","grobid_xml":"https://content.openalex.org/works/W4224254844.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1505052107","https://openalex.org/W1968174927","https://openalex.org/W1969979664","https://openalex.org/W1976453397","https://openalex.org/W1987186315","https://openalex.org/W2009757848","https://openalex.org/W2020059542","https://openalex.org/W2020231002","https://openalex.org/W2020898706","https://openalex.org/W2095617425","https://openalex.org/W2119240494","https://openalex.org/W2136942244","https://openalex.org/W2139969213","https://openalex.org/W2520188071","https://openalex.org/W2591172233","https://openalex.org/W2757339809","https://openalex.org/W2761653381","https://openalex.org/W2894522011","https://openalex.org/W3010907970","https://openalex.org/W3094349710","https://openalex.org/W3133867946"],"related_works":["https://openalex.org/W3213212101","https://openalex.org/W4366587948","https://openalex.org/W2126788747","https://openalex.org/W4287586739","https://openalex.org/W2315083258","https://openalex.org/W1984019158","https://openalex.org/W1985440313","https://openalex.org/W3044455534","https://openalex.org/W4372302060","https://openalex.org/W1798228598"],"abstract_inverted_index":{"Children":[0],"with":[1,41,79,96],"neurofibromatosis":[2,42,94],"have":[3],"a":[4,27,36,73,85],"higher":[5],"risk":[6],"of":[7,51,69,93],"developing":[8],"juvenile":[9],"myelomonocytic":[10],"leukemia":[11,22],"and":[12,46,64,78],"acute":[13,20],"myeloid":[14],"leukemia,":[15],"but":[16],"rarely":[17],"develop":[18],"B-cell":[19],"lymphoblastic":[21],"(B-ALL).":[23],"Through":[24],"in-vitro":[25],"modeling,":[26],"novel":[28,86],"NF1":[29,67],"p.L2467":[30],"frameshift":[31],"(fs)":[32],"mutation":[33],"identified":[34],"in":[35,90],"relapsed/refractory":[37],"Ph-like":[38],"B-ALL":[39],"patient":[40],"demonstrated":[43],"cytokine":[44],"independence":[45],"increased":[47],"RAS":[48],"signaling,":[49],"indicative":[50],"leukemic":[52],"transformation.":[53],"Furthermore,":[54],"these":[55],"cells":[56],"were":[57],"sensitive":[58],"to":[59,76,81],"the":[60,91],"MEK":[61,82],"inhibitors":[62],"trametinib":[63],"mirdametinib.":[65],"Bi-allelic":[66],"loss":[68],"function":[70],"may":[71],"be":[72],"contributing":[74],"factor":[75],"relapse":[77],"sensitivity":[80],"inhibitors,":[83],"suggests":[84],"precision":[87],"medicine":[88],"target":[89],"setting":[92],"patients":[95],"B-ALL.":[97]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-04-26T00:00:00"}
