{"id":"https://openalex.org/W4224251618","doi":"https://doi.org/10.3390/ijms23094633","title":"Non-Cytokine Protein Profile of the Mesenchymal Stem Cell Secretome That Regulates the Androgen Production Pathway","display_name":"Non-Cytokine Protein Profile of the Mesenchymal Stem Cell Secretome That Regulates the Androgen Production Pathway","publication_year":2022,"publication_date":"2022-04-22","ids":{"openalex":"https://openalex.org/W4224251618","doi":"https://doi.org/10.3390/ijms23094633","pmid":"https://pubmed.ncbi.nlm.nih.gov/35563028","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9101816"},"language":"en","primary_location":{"id":"doi:10.3390/ijms23094633","doi":"https://doi.org/10.3390/ijms23094633","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23094633","pdf_url":"https://www.mdpi.com/1422-0067/23/9/4633/pdf?version=1650765335","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/9/4633/pdf?version=1650765335","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013251005","display_name":"Hang-Soo Park","orcid":"https://orcid.org/0000-0002-9130-8478","observed_orcids":["https://orcid.org/0000-0002-9130-8478"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hang-Soo Park","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA"],"raw_orcid":"https://orcid.org/0000-0002-9130-8478","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051475223","display_name":"Rishi Man Chugh","orcid":"https://orcid.org/0000-0003-4036-6878","observed_orcids":["https://orcid.org/0000-0003-4036-6878"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rishi Man Chugh","raw_affiliation_strings":["Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, KS 66160, USA","Department of Surgery, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USA"],"raw_orcid":"https://orcid.org/0000-0003-4036-6878","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, KS 66160, USA","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Department of Surgery, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080420490","display_name":"Melissa R. Pergande","orcid":"https://orcid.org/0000-0003-1197-4057","observed_orcids":["https://orcid.org/0000-0003-1197-4057"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa R. Pergande","raw_affiliation_strings":["Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA"],"raw_orcid":"https://orcid.org/0000-0003-1197-4057","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038178667","display_name":"Esra Can Cetin","orcid":"https://orcid.org/0000-0003-0979-8402","observed_orcids":["https://orcid.org/0000-0003-0979-8402"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esra Cetin","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA"],"raw_orcid":"https://orcid.org/0000-0003-0979-8402","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046960443","display_name":"Hiba Siblini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiba Siblini","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008713652","display_name":"Sahar Esfandyari","orcid":"https://orcid.org/0000-0001-7346-5915","observed_orcids":["https://orcid.org/0000-0001-7346-5915"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sahar Esfandyari","raw_affiliation_strings":["Department of Surgery, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082245282","display_name":"Stephanie M. Cologna","orcid":"https://orcid.org/0000-0002-3541-3361","observed_orcids":["https://orcid.org/0000-0002-3541-3361"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie M. Cologna","raw_affiliation_strings":["Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA"],"raw_orcid":"https://orcid.org/0000-0002-3541-3361","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003343672","display_name":"Ayman A. Al-Hendy","orcid":"https://orcid.org/0000-0002-8778-4447","observed_orcids":["https://orcid.org/0000-0002-8778-4447"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ayman Al-Hendy","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA","Department of Surgery, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USA"],"raw_orcid":"https://orcid.org/0000-0002-8778-4447","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Surgery, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003343672"],"corresponding_institution_ids":["https://openalex.org/I39422238","https://openalex.org/I40347166"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":1.55,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.78496571,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"23","issue":"9","first_page":"4633","last_page":"4633"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.07760000228881836,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/bone-marrow-derived-stem-cells","display_name":"bone marrow-derived stem cells","score":0.765999972820282},{"id":"https://openalex.org/keywords/secretome","display_name":"secretome","score":0.9290000200271606},{"id":"https://openalex.org/keywords/androgen-biosynthesis","display_name":"androgen production","score":0.8349999785423279},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.6600000262260437},{"id":"https://openalex.org/keywords/protein-profile","display_name":"protein profile","score":0.5329999923706055},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7893320322036743},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.7137606143951416},{"id":"https://openalex.org/C156399914","wikidata":"https://www.wikidata.org/wiki/Q7444454","display_name":"Secretory protein","level":3,"score":0.6202570796012878},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5182466506958008},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5152061581611633},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.4888097941875458},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.4395647943019867},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24220529198646545},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.2390071153640747},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.20279589295387268},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.07157287001609802},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000089282","descriptor_name":"Secretome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms23094633","doi":"https://doi.org/10.3390/ijms23094633","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23094633","pdf_url":"https://www.mdpi.com/1422-0067/23/9/4633/pdf?version=1650765335","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:35563028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35563028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9101816","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9101816/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms23094633","doi":"https://doi.org/10.3390/ijms23094633","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23094633","pdf_url":"https://www.mdpi.com/1422-0067/23/9/4633/pdf?version=1650765335","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309626","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28"},{"id":"https://openalex.org/F4320310260","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43"},{"id":"https://openalex.org/F4320332222","display_name":"University of Illinois at Urbana-Champaign","ror":"https://ror.org/047426m28"},{"id":"https://openalex.org/F4320332697","display_name":"University of Illinois at Chicago","ror":"https://ror.org/02mpq6x41"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4224251618.pdf","grobid_xml":"https://content.openalex.org/works/W4224251618.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1813186957","https://openalex.org/W1908187771","https://openalex.org/W1984659394","https://openalex.org/W1988426085","https://openalex.org/W1990461498","https://openalex.org/W1996484645","https://openalex.org/W1999360673","https://openalex.org/W2001364132","https://openalex.org/W2029841039","https://openalex.org/W2031348353","https://openalex.org/W2031882974","https://openalex.org/W2034004034","https://openalex.org/W2042639777","https://openalex.org/W2059910219","https://openalex.org/W2062389660","https://openalex.org/W2067082722","https://openalex.org/W2096173332","https://openalex.org/W2099584640","https://openalex.org/W2104512123","https://openalex.org/W2122822855","https://openalex.org/W2125502478","https://openalex.org/W2143408624","https://openalex.org/W2170563191","https://openalex.org/W2171977523","https://openalex.org/W2528009933","https://openalex.org/W2601526802","https://openalex.org/W2736808007","https://openalex.org/W2746118088","https://openalex.org/W2791091077","https://openalex.org/W2795791614","https://openalex.org/W2810523206","https://openalex.org/W2894737006","https://openalex.org/W2898336519","https://openalex.org/W2900569176","https://openalex.org/W2924715159","https://openalex.org/W2938764052","https://openalex.org/W2944196444","https://openalex.org/W2951099267","https://openalex.org/W2951679282","https://openalex.org/W2955520913","https://openalex.org/W2969894563","https://openalex.org/W2972946432","https://openalex.org/W2979852387","https://openalex.org/W2996076484","https://openalex.org/W3000985212","https://openalex.org/W3005179877","https://openalex.org/W3012612161","https://openalex.org/W3088685410","https://openalex.org/W3107527779","https://openalex.org/W3111792822","https://openalex.org/W3138750974","https://openalex.org/W3158162890","https://openalex.org/W3164931028","https://openalex.org/W3193471647","https://openalex.org/W3214482794","https://openalex.org/W6767923768","https://openalex.org/W7098128289"],"related_works":["https://openalex.org/W4307393657","https://openalex.org/W3193471647","https://openalex.org/W2945532208","https://openalex.org/W3093223940","https://openalex.org/W4313471731","https://openalex.org/W3158162890","https://openalex.org/W4403870590","https://openalex.org/W2976225896","https://openalex.org/W2890858352","https://openalex.org/W4390637245"],"abstract_inverted_index":{"Polycystic":[0],"ovary":[1],"syndrome":[2],"(PCOS)":[3],"is":[4,69],"the":[5,41,44,89,115,120,124,131,142,162,178],"most":[6],"common":[7],"endocrine":[8],"and":[9,15,111,136],"metabolic":[10],"disorder":[11],"in":[12,161],"reproductive-aged":[13],"women,":[14],"it":[16,23],"typically":[17],"involves":[18],"elevated":[19],"androgen":[20,37,150,175],"levels.":[21],"Recently,":[22],"has":[24],"been":[25],"reported":[26],"that":[27,92,165],"human":[28],"bone":[29],"marrow":[30],"mesenchymal":[31],"stem":[32],"cells":[33],"(hBM-MSCs)":[34],"can":[35,166],"regulate":[36],"synthesis":[38],"pathways.":[39],"However,":[40],"details":[42],"of":[43,57,63,66,114,133,141,157],"mechanism":[45],"are":[46,54],"still":[47],"unclear.":[48],"hBM-MSC-derived":[49],"secreted":[50],"factors":[51],"(the":[52],"secretome)":[53],"promising":[55],"sources":[56],"cell-based":[58],"therapy":[59],"as":[60],"they":[61],"consist":[62],"various":[64],"types":[65],"proteins.":[67],"It":[68],"thus":[70],"important":[71],"to":[72,83,122,148,170],"know":[73],"which":[74,85,145],"proteins":[75],"interact":[76],"with":[77],"disease-implicated":[78],"biomolecules.":[79],"This":[80],"work":[81],"aimed":[82],"investigate":[84],"secretome":[86,164],"components":[87,132,159],"contain":[88],"key":[90],"factor":[91],"inhibits":[93],"testosterone":[94],"synthesis.":[95,151],"In":[96],"this":[97,134],"study,":[98],"we":[99],"fractionated":[100],"hBM-MSC-conditioned":[101],"media":[102],"into":[103],"three":[104,116],"fractions":[105],"based":[106],"on":[107],"their":[108],"molecular":[109],"weights":[110],"found":[112],"that,":[113],"fractions,":[117],"one":[118],"had":[119],"ability":[121],"inhibit":[123,149],"androgen-producing":[125],"genes":[126],"efficiently.":[127],"We":[128],"also":[129],"analyzed":[130],"fraction":[135],"established":[137],"a":[138,155],"protein":[139,158],"profile":[140],"hBM-MSC":[143,163],"secretome,":[144],"was":[146],"shown":[147],"Our":[152],"study":[153],"describes":[154],"set":[156],"present":[160],"be":[167],"used":[168],"therapeutically":[169],"treat":[171],"PCOS":[172],"by":[173],"regulating":[174],"production":[176],"for":[177],"first":[179],"time.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-04-26T00:00:00"}
