{"id":"https://openalex.org/W4224251189","doi":"https://doi.org/10.14302/issn.2689-5773.jcdp-22-4123","title":"Distinguish Thyroid Malignant from Benign Alterations using Trace Element Contents in Nodular Tissue determined by Neutron Activation and Inductively Coupled Plasma Mass Spectrometry","display_name":"Distinguish Thyroid Malignant from Benign Alterations using Trace Element Contents in Nodular Tissue determined by Neutron Activation and Inductively Coupled Plasma Mass Spectrometry","publication_year":2022,"publication_date":"2022-04-08","ids":{"openalex":"https://openalex.org/W4224251189","doi":"https://doi.org/10.14302/issn.2689-5773.jcdp-22-4123"},"language":"en","primary_location":{"id":"doi:10.14302/issn.2689-5773.jcdp-22-4123","doi":"https://doi.org/10.14302/issn.2689-5773.jcdp-22-4123","is_oa":true,"landing_page_url":"https://doi.org/10.14302/issn.2689-5773.jcdp-22-4123","pdf_url":"http://openaccesspub.org/article/1809/pdf","source":{"id":"https://openalex.org/S4210236936","display_name":"Journal of Clinical and Diagnostic Pathology","issn_l":"2689-5773","issn":["2689-5773"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4404660901","host_organization_name":"Open Access Pub","host_organization_lineage":["https://openalex.org/P4404660901"],"host_organization_lineage_names":["Open Access Pub"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Diagnostic Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://openaccesspub.org/article/1809/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067362841","display_name":"Vladimir Zaichick","orcid":"https://orcid.org/0000-0002-4286-4267","observed_orcids":["https://orcid.org/0000-0002-4286-4267"]},"institutions":[{"id":"https://openalex.org/I4210117327","display_name":"Medical Radiological Research Center","ror":"https://ror.org/02dr19631","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210117327"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Vladimir Zaichick","raw_affiliation_strings":["Radionuclide Diagnostics Department, Medical Radiological Research Centre , Obninsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radionuclide Diagnostics Department, Medical Radiological Research Centre , Obninsk, Russia","institution_ids":["https://openalex.org/I4210117327"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067362841"],"corresponding_institution_ids":["https://openalex.org/I4210117327"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04376909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"4","first_page":"18","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.030500000342726707,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-nodules","display_name":"thyroid nodules","score":0.8790000081062317},{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"thyroid cancer","score":0.7289999723434448},{"id":"https://openalex.org/keywords/benign-thyroid-nodules","display_name":"benign thyroid nodules","score":0.8349999785423279},{"id":"https://openalex.org/keywords/trace-elements","display_name":"trace elements","score":0.8769999742507935},{"id":"https://openalex.org/keywords/elemental-composition","display_name":"elemental composition","score":0.5720000267028809},{"id":"https://openalex.org/keywords/iodine","display_name":"iodine","score":0.6990000009536743},{"id":"https://openalex.org/keywords/selenium","display_name":"selenium","score":0.578000009059906},{"id":"https://openalex.org/keywords/scandium","display_name":"scandium","score":0.7509999871253967},{"id":"https://openalex.org/keywords/rubidium","display_name":"rubidium","score":0.7300000190734863},{"id":"https://openalex.org/keywords/molybdenum","display_name":"molybdenum","score":0.8579999804496765},{"id":"https://openalex.org/keywords/gallium","display_name":"gallium","score":0.6700000166893005},{"id":"https://openalex.org/keywords/radionuclide-determination","display_name":"radionuclide analysis","score":0.5550000071525574},{"id":"https://openalex.org/keywords/neutron-activation-analysis","display_name":"neutron activation analysis","score":0.753000020980835},{"id":"https://openalex.org/keywords/inductively-coupled-plasma-mass-spectrometry","display_name":"inductively coupled plasma mass spectrometry","score":0.8220000267028809},{"id":"https://openalex.org/keywords/thyroid-nodule-diagnosis","display_name":"thyroid nodule diagnosis","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7522153854370117},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.7123199105262756},{"id":"https://openalex.org/C4666530","wikidata":"https://www.wikidata.org/wiki/Q2408111","display_name":"Neutron activation analysis","level":2,"score":0.6222481727600098},{"id":"https://openalex.org/C551831248","wikidata":"https://www.wikidata.org/wiki/Q713","display_name":"Scandium","level":2,"score":0.5768609046936035},{"id":"https://openalex.org/C165697059","wikidata":"https://www.wikidata.org/wiki/Q900680","display_name":"Inductively coupled plasma mass spectrometry","level":3,"score":0.5178530812263489},{"id":"https://openalex.org/C542576722","wikidata":"https://www.wikidata.org/wiki/Q1112","display_name":"Barium","level":2,"score":0.46300840377807617},{"id":"https://openalex.org/C523597863","wikidata":"https://www.wikidata.org/wiki/Q1385","display_name":"Cerium","level":2,"score":0.4464332163333893},{"id":"https://openalex.org/C555894677","wikidata":"https://www.wikidata.org/wiki/Q1801","display_name":"Lanthanum","level":2,"score":0.42972731590270996},{"id":"https://openalex.org/C559099789","wikidata":"https://www.wikidata.org/wiki/Q932","display_name":"Thallium","level":2,"score":0.4274525046348572},{"id":"https://openalex.org/C528890316","wikidata":"https://www.wikidata.org/wiki/Q731","display_name":"Manganese","level":2,"score":0.41536611318588257},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.38704532384872437},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.34953558444976807},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.1959158182144165},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0829058587551117},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14302/issn.2689-5773.jcdp-22-4123","doi":"https://doi.org/10.14302/issn.2689-5773.jcdp-22-4123","is_oa":true,"landing_page_url":"https://doi.org/10.14302/issn.2689-5773.jcdp-22-4123","pdf_url":"http://openaccesspub.org/article/1809/pdf","source":{"id":"https://openalex.org/S4210236936","display_name":"Journal of Clinical and Diagnostic Pathology","issn_l":"2689-5773","issn":["2689-5773"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4404660901","host_organization_name":"Open Access Pub","host_organization_lineage":["https://openalex.org/P4404660901"],"host_organization_lineage_names":["Open Access Pub"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Diagnostic Pathology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.14302/issn.2689-5773.jcdp-22-4123","doi":"https://doi.org/10.14302/issn.2689-5773.jcdp-22-4123","is_oa":true,"landing_page_url":"https://doi.org/10.14302/issn.2689-5773.jcdp-22-4123","pdf_url":"http://openaccesspub.org/article/1809/pdf","source":{"id":"https://openalex.org/S4210236936","display_name":"Journal of Clinical and Diagnostic Pathology","issn_l":"2689-5773","issn":["2689-5773"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4404660901","host_organization_name":"Open Access Pub","host_organization_lineage":["https://openalex.org/P4404660901"],"host_organization_lineage_names":["Open Access Pub"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Diagnostic Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4224251189.pdf","grobid_xml":"https://content.openalex.org/works/W4224251189.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1968188089","https://openalex.org/W1970525917","https://openalex.org/W1971197661","https://openalex.org/W1975638148","https://openalex.org/W1977121159","https://openalex.org/W1977131646","https://openalex.org/W1990506531","https://openalex.org/W1999128901","https://openalex.org/W2005582565","https://openalex.org/W2007101086","https://openalex.org/W2010019495","https://openalex.org/W2021257565","https://openalex.org/W2029038413","https://openalex.org/W2046303367","https://openalex.org/W2050213310","https://openalex.org/W2051538584","https://openalex.org/W2057694816","https://openalex.org/W2059136911","https://openalex.org/W2061431457","https://openalex.org/W2063324236","https://openalex.org/W2083706539","https://openalex.org/W2084505148","https://openalex.org/W2095356872","https://openalex.org/W2095532080","https://openalex.org/W2112165467","https://openalex.org/W2132487121","https://openalex.org/W2140243011","https://openalex.org/W2158825460","https://openalex.org/W2161329240","https://openalex.org/W2321012043","https://openalex.org/W2584046468","https://openalex.org/W2596114599","https://openalex.org/W2753491954","https://openalex.org/W2769001448","https://openalex.org/W2787642236","https://openalex.org/W2788384775","https://openalex.org/W2891256793","https://openalex.org/W2895924978","https://openalex.org/W2899098890","https://openalex.org/W2905488679","https://openalex.org/W2940449679","https://openalex.org/W2964497655","https://openalex.org/W2987485148","https://openalex.org/W2997374692","https://openalex.org/W2998866379","https://openalex.org/W3073841933","https://openalex.org/W3087233996","https://openalex.org/W3105420046","https://openalex.org/W3162980103","https://openalex.org/W3185758058","https://openalex.org/W3190655687","https://openalex.org/W3191294573","https://openalex.org/W3203554440","https://openalex.org/W3209775842","https://openalex.org/W3215456601","https://openalex.org/W4206488352","https://openalex.org/W4221083911","https://openalex.org/W4251535555","https://openalex.org/W4256487898"],"related_works":["https://openalex.org/W4388080693","https://openalex.org/W4280580636","https://openalex.org/W4286457678","https://openalex.org/W6893934154","https://openalex.org/W4283834934","https://openalex.org/W4285197329","https://openalex.org/W4320074746","https://openalex.org/W4220815868","https://openalex.org/W4280529055","https://openalex.org/W4225287070"],"abstract_inverted_index":{"Background":[0],"Thyroid":[1],"benign":[2],"(TBN)":[3],"and":[4,22,124,139,162,166,169,197,205,217,221,255,261,285,317],"malignant":[5],"(TMN)":[6],"nodules":[7,295],"are":[8,29,199,311],"a":[9,19,148,291,297],"common":[10],"thyroid":[11,54,294,302],"lesion.":[12],"The":[13,31],"differentiation":[14],"of":[15,25,33,40,53,58,133,150,160,192,214,231,264,293,309],"TMN":[16,26,141,186,262],"often":[17],"remains":[18],"clinical":[20],"challenge":[21],"further":[23],"improvements":[24],"diagnostic":[27],"accuracy":[28],"warranted.":[30],"aim":[32],"present":[34],"study":[35],"was":[36,182,272],"to":[37,140,274,300,313],"evaluate":[38],"possibilities":[39],"using":[41,147],"differences":[42],"in":[43,48,130,185,227,258,290],"trace":[44],"elements":[45],"(TEs)":[46],"contents":[47],"nodular":[49,131,265],"tissue":[50,132,187,266],"for":[51],"diagnosis":[52],"malignancy.":[55,303],"Methods":[56],"Contents":[57,230],"TEs":[59],"such":[60,172],"as":[61,173,280,282,296],"silver":[62],"(Ag),":[63],"aluminum":[64],"(Al),":[65],"boron":[66],"(B),,":[67],"beryllium":[68],"(Be),":[69],"bismuth":[70],"(Bi),":[71],"cadmium":[72],"(Cd),":[73],"cerium":[74],"(Ce),":[75],"cobalt":[76],"(Co),":[77],"chromium":[78],"(Cr),":[79],"cesium":[80],"(Cs),":[81],"iron":[82],"(Fe),":[83],"gallium":[84],"(Ga),":[85],"mercury":[86],"(Hg),":[87],"iodine":[88],"(I),":[89],"lanthanum":[90],"(La),":[91],"lithium":[92],"(Li),":[93],"manganese":[94],"(Mn),":[95],"molybdenum":[96],"(Mo),":[97],"neodymium":[98],"(Nd),":[99],"nickel":[100],"(Ni),":[101],"lead":[102],"(Pb),":[103],"praseodymium":[104],"(Pr),":[105],"rubidium":[106],"(Rb),":[107],"antimony":[108],"(Sb),":[109],"scandium":[110],"(Sc),":[111],"selenium":[112],"(Se),":[113],"samarium":[114],"(Sm),":[115],"tin":[116],"(Sn),":[117],"thallium":[118],"(Tl),":[119],"uranium":[120],"(U),":[121],"yttrium":[122],"(Y),":[123],"zinc":[125],"(Zn)":[126],"were":[127,145,268],"prospectively":[128],"evaluated":[129],"thyroids":[134],"with":[135,156],"TBN":[136,228,260],"(79":[137],"patients)":[138],"(41":[142],"patients).":[143],"Measurements":[144],"performed":[146],"combination":[149],"non-destructive":[151],"instrumental":[152],"neutron":[153],"activation":[154],"analysis":[155],"high":[157],"resolution":[158],"spectrometry":[159,178],"short-":[161],"long-lived":[163],"radionuclides":[164],"(INAA-SLR":[165],"INAA-LLR,":[167],"respectively)":[168],"destructive":[170],"method":[171],"inductively":[174],"coupled":[175],"plasma":[176],"mass":[177,190,212,278,287],"(ICP-MS).":[179],"Results":[180],"It":[181,271],"observed":[183],"that":[184],"the":[188,211,259,276],"mean":[189],"fractions":[191],"Be,":[193],"Fe,":[194],"I,":[195],"Sc,":[196],"Se":[198],"approximately":[200],"1.9,":[201],"1.7,":[202],"14,":[203],"3.1,":[204],"1.6":[206],"times,":[207],"respectively,":[208,223],"lower":[209],"while":[210],"fraction":[213,288],"Ga,":[215],"Mo,":[216],"Rb":[218],"62%,":[219],"51%,":[220],"33%,":[222],"higher":[224],"than":[225],"those":[226],"tissue.":[229],"Ag,":[232],"Al,":[233],"B,":[234],"Bi,":[235],"Cd,":[236],"Ce,":[237],"Co,":[238],"Cr,":[239],"Cs,":[240],"Hg,":[241],"La,":[242],"Li,":[243],"Mn,":[244],"Nd,":[245],"Ni,":[246],"Pb,":[247],"Pr,":[248],"Sb,":[249],"Sm,":[250],"Sn,":[251],"Tl,":[252],"U,":[253],"Y,":[254],"Zn":[256],"found":[257],"groups":[263],"samples":[267,310],"similar.":[269],"Conclusions":[270],"proposed":[273],"use":[275],"I":[277],"fraction,":[279],"well":[281],"I/Ga,":[283],"I/Mo,":[284],"I/Rb":[286],"ratios":[289],"needle-biopsy":[292],"potential":[298],"tool":[299],"diagnose":[301],"Further":[304],"studies":[305],"on":[306],"larger":[307],"number":[308],"required":[312],"confirm":[314],"our":[315],"findings":[316],"proposals.":[318]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-04-26T00:00:00"}