{"id":"https://openalex.org/W4224251072","doi":"https://doi.org/10.17843/rpmesp.2022.391.10136","title":"Evaluaci\u00f3n de la susceptibilidad in vitro a esparte\u00edna, en cuatro cepas de Mycobacterium tuberculosis","display_name":"Evaluaci\u00f3n de la susceptibilidad in vitro a esparte\u00edna, en cuatro cepas de Mycobacterium tuberculosis","publication_year":2022,"publication_date":"2022-03-31","ids":{"openalex":"https://openalex.org/W4224251072","doi":"https://doi.org/10.17843/rpmesp.2022.391.10136","pmid":"https://pubmed.ncbi.nlm.nih.gov/35766744","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11397676"},"language":"es","primary_location":{"id":"doi:10.17843/rpmesp.2022.391.10136","doi":"https://doi.org/10.17843/rpmesp.2022.391.10136","is_oa":true,"landing_page_url":"https://doi.org/10.17843/rpmesp.2022.391.10136","pdf_url":"https://rpmesp.ins.gob.pe/index.php/rpmesp/article/download/10136/4773","source":{"id":"https://openalex.org/S2738398777","display_name":"Revista Peruana de Medicina Experimental y Salud P\u00fablica","issn_l":"1726-4634","issn":["1726-4634","1726-4642"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","medline","norway-1","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310318243","host_organization_name":"National Institute of Health of Peru","host_organization_lineage":["https://openalex.org/P4310318243"],"host_organization_lineage_names":["National Institute of Health of Peru"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Peruana de Medicina Experimental y Salud P\u00fablica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://rpmesp.ins.gob.pe/index.php/rpmesp/article/download/10136/4773","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015934952","display_name":"Manuel Hidalgo","orcid":"https://orcid.org/0000-0002-6595-0037","observed_orcids":["https://orcid.org/0000-0002-6595-0037"]},"institutions":[{"id":"https://openalex.org/I3130994585","display_name":"Antenor Orrego Private University","ror":"https://ror.org/03eek8g24","country_code":"PE","type":"education","lineage":["https://openalex.org/I3130994585"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Manuel Hidalgo","raw_affiliation_strings":["Universidad Privada Antenor Orrego, La Libertad, Trujillo, Per\u00fa","Universidad Privada Antenor Orrego, La Libertad, Trujillo, Per\u00fa.\nBi\u00f3logo, mag\u00edster scientiae en Mejoramiento Gen\u00e9tico de Plantas"],"raw_orcid":"https://orcid.org/0000-0002-6595-0037","affiliations":[{"raw_affiliation_string":"Universidad Privada Antenor Orrego, La Libertad, Trujillo, Per\u00fa","institution_ids":["https://openalex.org/I3130994585"]},{"raw_affiliation_string":"Universidad Privada Antenor Orrego, La Libertad, Trujillo, Per\u00fa.\nBi\u00f3logo, mag\u00edster scientiae en Mejoramiento Gen\u00e9tico de Plantas","institution_ids":["https://openalex.org/I3130994585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039649141","display_name":"Percy Asmat","orcid":"https://orcid.org/0000-0003-1899-4499","observed_orcids":["https://orcid.org/0000-0003-1899-4499","https://orcid.org/0000-0003-3377-6713"]},"institutions":[{"id":"https://openalex.org/I3130994585","display_name":"Antenor Orrego Private University","ror":"https://ror.org/03eek8g24","country_code":"PE","type":"education","lineage":["https://openalex.org/I3130994585"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Percy Asmat Marrufo","raw_affiliation_strings":["Laboratorio de Referencia Regional La Libertad, Per\u00fa","Universidad Privada Antenor Orrego, La Libertad, Trujillo, Per\u00fa","Universidad Privada Antenor Orrego, La Libertad, Trujillo, Per\u00fa.\nLaboratorio de Referencia Regional La Libertad, Per\u00fa.\nbi\u00f3logo microbi\u00f3logo, maestro en Farmacia y\nBioqu\u00edmica"],"raw_orcid":"https://orcid.org/0000-0003-1899-4499","affiliations":[{"raw_affiliation_string":"Laboratorio de Referencia Regional La Libertad, Per\u00fa","institution_ids":[]},{"raw_affiliation_string":"Universidad Privada Antenor Orrego, La Libertad, Trujillo, Per\u00fa","institution_ids":["https://openalex.org/I3130994585"]},{"raw_affiliation_string":"Universidad Privada Antenor Orrego, La Libertad, Trujillo, Per\u00fa.\nLaboratorio de Referencia Regional La Libertad, Per\u00fa.\nbi\u00f3logo microbi\u00f3logo, maestro en Farmacia y\nBioqu\u00edmica","institution_ids":["https://openalex.org/I3130994585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018416297","display_name":"Pedro Lezama Asencio","orcid":"https://orcid.org/0000-0002-8594-0346","observed_orcids":["https://orcid.org/0000-0002-8594-0346"]},"institutions":[{"id":"https://openalex.org/I3130994585","display_name":"Antenor Orrego Private University","ror":"https://ror.org/03eek8g24","country_code":"PE","type":"education","lineage":["https://openalex.org/I3130994585"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Pedro Lezama Asencio","raw_affiliation_strings":["Universidad Privada Antenor Orrego, La Libertad, Trujillo, Per\u00fa","Universidad Privada Antenor Orrego, La Libertad, Trujillo, Per\u00fa.\nbi\u00f3logo, doctor en Ciencias Biol\u00f3gicas"],"raw_orcid":"https://orcid.org/0000-0002-8594-0346","affiliations":[{"raw_affiliation_string":"Universidad Privada Antenor Orrego, La Libertad, Trujillo, Per\u00fa","institution_ids":["https://openalex.org/I3130994585"]},{"raw_affiliation_string":"Universidad Privada Antenor Orrego, La Libertad, Trujillo, Per\u00fa.\nbi\u00f3logo, doctor en Ciencias Biol\u00f3gicas","institution_ids":["https://openalex.org/I3130994585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033661807","display_name":"Cynthia Ramos","orcid":"https://orcid.org/0000-0003-1739-634X","observed_orcids":["https://orcid.org/0000-0003-1739-634X"]},"institutions":[{"id":"https://openalex.org/I3130994585","display_name":"Antenor Orrego Private University","ror":"https://ror.org/03eek8g24","country_code":"PE","type":"education","lineage":["https://openalex.org/I3130994585"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Cynthia Ramos","raw_affiliation_strings":["Universidad Privada Antenor Orrego, La Libertad, Trujillo, Per\u00fa","Universidad Privada Antenor Orrego, La Libertad, Trujillo, Per\u00fa.\nBi\u00f3logo, mag\u00edster scientiae en Mejoramiento Gen\u00e9tico de Plantas"],"raw_orcid":"https://orcid.org/0000-0003-1739-634X","affiliations":[{"raw_affiliation_string":"Universidad Privada Antenor Orrego, La Libertad, Trujillo, Per\u00fa","institution_ids":["https://openalex.org/I3130994585"]},{"raw_affiliation_string":"Universidad Privada Antenor Orrego, La Libertad, Trujillo, Per\u00fa.\nBi\u00f3logo, mag\u00edster scientiae en Mejoramiento Gen\u00e9tico de Plantas","institution_ids":["https://openalex.org/I3130994585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005069588","display_name":"Carlos Alfonso Chimoy Tu\u00f1oque","orcid":"https://orcid.org/0000-0003-1333-8919","observed_orcids":["https://orcid.org/0000-0003-1333-8919"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos Alfonso Chimoy Tu\u00f1oque","raw_affiliation_strings":["Laboratorio de Referencia Regional La Libertad, Per\u00fa","Laboratorio de Referencia Regional La Libertad, Per\u00fa.\nbi\u00f3logo microbi\u00f3logo, maestro en Farmacia y\nBioqu\u00edmica"],"raw_orcid":"https://orcid.org/0000-0003-1333-8919","affiliations":[{"raw_affiliation_string":"Laboratorio de Referencia Regional La Libertad, Per\u00fa","institution_ids":[]},{"raw_affiliation_string":"Laboratorio de Referencia Regional La Libertad, Per\u00fa.\nbi\u00f3logo microbi\u00f3logo, maestro en Farmacia y\nBioqu\u00edmica","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088642741","display_name":"Gast\u00f3n Zolla","orcid":"https://orcid.org/0000-0002-0432-1050","observed_orcids":["https://orcid.org/0000-0002-0432-1050"]},"institutions":[{"id":"https://openalex.org/I79080234","display_name":"Universidad Nacional Agraria La Molina","ror":"https://ror.org/00vr49948","country_code":"PE","type":"education","lineage":["https://openalex.org/I79080234"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Gast\u00f3n Zolla","raw_affiliation_strings":["Laboratorio de Fisiolog\u00eda Vegetal de la Universidad Nacional Agraria La Molina, Lima, Per\u00fa","Laboratorio de Fisiolog\u00eda Vegetal de la Universidad Nacional Agraria La Molina, Lima, Per\u00fa.\ningeniero agr\u00f3nomo, doctor en Filosof\u00eda"],"raw_orcid":"https://orcid.org/0000-0002-0432-1050","affiliations":[{"raw_affiliation_string":"Laboratorio de Fisiolog\u00eda Vegetal de la Universidad Nacional Agraria La Molina, Lima, Per\u00fa","institution_ids":["https://openalex.org/I79080234"]},{"raw_affiliation_string":"Laboratorio de Fisiolog\u00eda Vegetal de la Universidad Nacional Agraria La Molina, Lima, Per\u00fa.\ningeniero agr\u00f3nomo, doctor en Filosof\u00eda","institution_ids":["https://openalex.org/I79080234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8772,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.71397255,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"39","issue":"1","first_page":"77","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/multidrug-resistant-tuberculosis","display_name":"multidrug-resistant tuberculosis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/antimicrobial-susceptibility","display_name":"antimicrobial susceptibility","score":0.6499999761581421},{"id":"https://openalex.org/keywords/isoniazid-resistance","display_name":"isoniazid resistance","score":0.8379999995231628},{"id":"https://openalex.org/keywords/rifampicin-resistance","display_name":"rifampicin resistance","score":0.996999979019165},{"id":"https://openalex.org/keywords/bactericidal-activity","display_name":"bactericidal activity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/alkaloids","display_name":"alkaloids","score":0.5360000133514404},{"id":"https://openalex.org/keywords/in-vitro-antibacterial-activity","display_name":"in vitro antibacterial activity","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6771796941757202},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.6708972454071045},{"id":"https://openalex.org/C2776967927","wikidata":"https://www.wikidata.org/wiki/Q423169","display_name":"Isoniazid","level":3,"score":0.6481056213378906},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6322796940803528},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5734185576438904},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.43984276056289673},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35153257846832275},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33086252212524414},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.28014320135116577},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.24213245511054993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1823423206806183},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007538","descriptor_name":"Isoniazid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013034","descriptor_name":"Sparteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.17843/rpmesp.2022.391.10136","doi":"https://doi.org/10.17843/rpmesp.2022.391.10136","is_oa":true,"landing_page_url":"https://doi.org/10.17843/rpmesp.2022.391.10136","pdf_url":"https://rpmesp.ins.gob.pe/index.php/rpmesp/article/download/10136/4773","source":{"id":"https://openalex.org/S2738398777","display_name":"Revista Peruana de Medicina Experimental y Salud P\u00fablica","issn_l":"1726-4634","issn":["1726-4634","1726-4642"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","medline","norway-1","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310318243","host_organization_name":"National Institute of Health of Peru","host_organization_lineage":["https://openalex.org/P4310318243"],"host_organization_lineage_names":["National Institute of Health of Peru"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Peruana de Medicina Experimental y Salud P\u00fablica","raw_type":"journal-article"},{"id":"pmid:35766744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35766744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista peruana de medicina experimental y salud publica","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11397676","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11397676/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rev Peru Med Exp Salud Publica","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ead75c8b36e74631809289f39329a426","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ead75c8b36e74631809289f39329a426","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista Peruana de Medicina Experimental y Salud P\u00fablica, Vol 39, Iss 1, Pp 77-82 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.17843/rpmesp.2022.391.10136","doi":"https://doi.org/10.17843/rpmesp.2022.391.10136","is_oa":true,"landing_page_url":"https://doi.org/10.17843/rpmesp.2022.391.10136","pdf_url":"https://rpmesp.ins.gob.pe/index.php/rpmesp/article/download/10136/4773","source":{"id":"https://openalex.org/S2738398777","display_name":"Revista Peruana de Medicina Experimental y Salud P\u00fablica","issn_l":"1726-4634","issn":["1726-4634","1726-4642"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","medline","norway-1","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310318243","host_organization_name":"National Institute of Health of Peru","host_organization_lineage":["https://openalex.org/P4310318243"],"host_organization_lineage_names":["National Institute of Health of Peru"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Peruana de Medicina Experimental y Salud P\u00fablica","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4224251072.pdf","grobid_xml":"https://content.openalex.org/works/W4224251072.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W2055043387","https://openalex.org/W2057825463","https://openalex.org/W2062143165","https://openalex.org/W2078927877","https://openalex.org/W2108815635","https://openalex.org/W2110310370","https://openalex.org/W2139619362","https://openalex.org/W2621405323","https://openalex.org/W2724949514","https://openalex.org/W2770023778","https://openalex.org/W2797704881","https://openalex.org/W2904190809","https://openalex.org/W2951642830","https://openalex.org/W3107825098","https://openalex.org/W3179954378"],"related_works":["https://openalex.org/W7027808838","https://openalex.org/W2361195925","https://openalex.org/W7015889464","https://openalex.org/W7000021487","https://openalex.org/W2137716053","https://openalex.org/W2600771793","https://openalex.org/W2426945358","https://openalex.org/W2114611961","https://openalex.org/W2919868989","https://openalex.org/W7133418933"],"abstract_inverted_index":{"La":[0,46],"esparte\u00edna":[1,24,55,140],"es":[2],"un":[3],"alcaloide":[4],"con":[5],"actividad":[6,50],"bacteriost\u00e1tica":[7],"sobre":[8],"el":[9,26,84,88,93,132],"g\u00e9nero":[10],"Mycobacterium.":[11],"El":[12],"objetivo":[13],"de":[14,22,28,32,48,54,60,65,67,96,104,110,112,119,126,138],"este":[15],"trabajo":[16],"fue":[17],"evaluar":[18],"la":[19,23,49,139,142],"acci\u00f3n":[20],"antimicrobiana":[21],"en":[25,81,87,121,141],"crecimiento":[27],"cuatro":[29,123],"cepas":[30,124],"ATCC":[31],"Mycobacterium":[33,127],"tuberculosis":[34,143],"(susceptible,":[35],"resistente":[36,39],"a":[37,40,58,71,102],"isoniazida,":[38],"rifampicina":[41],"y":[42,69,107],"multidrogorresistente)":[43],"in":[44,136],"vitro.":[45],"evaluaci\u00f3n":[47],"bactericida":[51],"del":[52,63],"sulfato":[53,111],"se":[56,115],"realiz\u00f3":[57],"trav\u00e9s":[59],"una":[61],"adaptaci\u00f3n":[62],"m\u00e9todo":[64],"ensayo":[66],"cultivo":[68],"susceptibilidad":[70],"medicamentos":[72],"antituberculosos":[73],"mediante":[74],"observaci\u00f3n":[75],"microsc\u00f3pica":[76],"(MODS,":[77],"por":[78,92],"sus":[79],"siglas":[80],"ingl\u00e9s),":[82],"seg\u00fan":[83],"protocolo":[85],"descrito":[86],"manual":[89],"t\u00e9cnico":[90],"elaborado":[91],"Instituto":[94],"Nacional":[95],"Salud.":[97],"Los":[98,129],"resultados":[99,130],"demuestran":[100,131],"que":[101],"concentraciones":[103],"25;":[105],"50":[106],"100":[108],"mM":[109],"esparte\u00edna,":[113],"no":[114],"desarrollan":[116],"unidades":[117],"formadoras":[118],"colonia":[120],"las":[122],"evaluadas":[125],"tuberculosis.":[128],"potencial":[133],"efecto":[134],"antimicrobiano":[135],"vitro":[137],"multidrogorresistente.":[144]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-04-26T00:00:00"}