{"id":"https://openalex.org/W4224236830","doi":"https://doi.org/10.1016/j.neo.2022.100796","title":"Mathematical modeling of radiotherapy and its impact on tumor interactions with the immune system","display_name":"Mathematical modeling of radiotherapy and its impact on tumor interactions with the immune system","publication_year":2022,"publication_date":"2022-04-18","ids":{"openalex":"https://openalex.org/W4224236830","doi":"https://doi.org/10.1016/j.neo.2022.100796","pmid":"https://pubmed.ncbi.nlm.nih.gov/35447601","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9043662"},"language":"en","primary_location":{"id":"doi:10.1016/j.neo.2022.100796","doi":"https://doi.org/10.1016/j.neo.2022.100796","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neo.2022.100796","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1476558622000239/pdf","source":{"id":"https://openalex.org/S20008548","display_name":"Neoplasia","issn_l":"1476-5586","issn":["1476-5586","1522-8002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1476558622000239/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079520836","display_name":"Rebecca Anne Bekker","orcid":"https://orcid.org/0000-0002-3002-2724","observed_orcids":["https://orcid.org/0000-0002-3002-2724"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rebecca Anne Bekker","raw_affiliation_strings":["Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. Electronic address: Rebecca.Bekker@moffitt.org","Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA"],"raw_orcid":"https://orcid.org/0000-0002-3002-2724","affiliations":[{"raw_affiliation_string":"Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. Electronic address: Rebecca.Bekker@moffitt.org","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":"Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103362234","display_name":"Sungjune Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sungjune Kim","raw_affiliation_strings":["Department of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006278901","display_name":"Shari Pilon\u2010Thomas","orcid":"https://orcid.org/0000-0001-7785-3034","observed_orcids":["https://orcid.org/0000-0001-7785-3034"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shari Pilon-Thomas","raw_affiliation_strings":["Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014796235","display_name":"Heiko Enderling","orcid":"https://orcid.org/0000-0002-9696-6410","observed_orcids":["https://orcid.org/0000-0002-9696-6410"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Heiko Enderling","raw_affiliation_strings":["Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA; Department of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. Electronic address: Heiko.Enderling@moffitt.org","Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA","Department of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA; Department of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. Electronic address: Heiko.Enderling@moffitt.org","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":"Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":"Department of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014796235","https://openalex.org/A5079520836"],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":{"value":3170,"currency":"USD","value_usd":3170},"apc_paid":{"value":3170,"currency":"USD","value_usd":3170},"fwci":1.3103,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.84577114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"28","issue":null,"first_page":"100796","last_page":"100796"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.8241999745368958,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.8241999745368958,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.14470000565052032,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.9769999980926514},{"id":"https://openalex.org/keywords/tumor-immune-interactions","display_name":"tumor-immune interactions","score":0.7910000085830688},{"id":"https://openalex.org/keywords/radiotherapy-immunotherapy-combination","display_name":"radiotherapy-immunotherapy combination","score":0.7459999918937683},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8299999833106995},{"id":"https://openalex.org/keywords/dose-fractionation","display_name":"dose fractionation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/metastatic-disease","display_name":"metastatic disease","score":0.9610000252723694},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.8349999785423279},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.8538335561752319},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6757871508598328},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6609783172607422},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6474865674972534},{"id":"https://openalex.org/C2781274730","wikidata":"https://www.wikidata.org/wiki/Q4669679","display_name":"Abscopal effect","level":4,"score":0.6167674660682678},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5328044891357422},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4878854751586914},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43936488032341003},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42873480916023254},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4224497377872467},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4178916811943054},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4091099202632904},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32324323058128357},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2844690680503845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2483828067779541}],"mesh":[{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.neo.2022.100796","doi":"https://doi.org/10.1016/j.neo.2022.100796","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neo.2022.100796","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1476558622000239/pdf","source":{"id":"https://openalex.org/S20008548","display_name":"Neoplasia","issn_l":"1476-5586","issn":["1476-5586","1522-8002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9043662","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9043662","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"Text"},{"id":"pmid:35447601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35447601","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9ad5f9d529d540fbb898a3395eab99a0","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9ad5f9d529d540fbb898a3395eab99a0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neoplasia: An International Journal for Oncology Research, Vol 28, Iss , Pp 100796- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.neo.2022.100796","doi":"https://doi.org/10.1016/j.neo.2022.100796","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neo.2022.100796","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1476558622000239/pdf","source":{"id":"https://openalex.org/S20008548","display_name":"Neoplasia","issn_l":"1476-5586","issn":["1476-5586","1522-8002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000899198","display_name":"Predict radiation-induced shifts in patient-specific tumor immune ecosystem composition to harness immunological consequences of radiotherapy","funder_award_id":"U01CA244100","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320314894","display_name":"Florida Breast Cancer Foundation","ror":"https://ror.org/05em00y90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4224236830.pdf","grobid_xml":"https://content.openalex.org/works/W4224236830.grobid-xml"},"referenced_works_count":149,"referenced_works":["https://openalex.org/W21553284","https://openalex.org/W115452890","https://openalex.org/W1512206713","https://openalex.org/W1651834713","https://openalex.org/W1780348968","https://openalex.org/W1846159518","https://openalex.org/W1852730814","https://openalex.org/W1896760514","https://openalex.org/W1926432155","https://openalex.org/W1931474344","https://openalex.org/W1943338723","https://openalex.org/W1964083798","https://openalex.org/W1968371014","https://openalex.org/W1977943543","https://openalex.org/W1979575182","https://openalex.org/W1984266465","https://openalex.org/W1986723404","https://openalex.org/W1989169469","https://openalex.org/W1994993231","https://openalex.org/W1995087795","https://openalex.org/W1995801872","https://openalex.org/W1998209775","https://openalex.org/W1999020268","https://openalex.org/W2006664445","https://openalex.org/W2009913017","https://openalex.org/W2019214729","https://openalex.org/W2025421597","https://openalex.org/W2027326319","https://openalex.org/W2029159090","https://openalex.org/W2029517266","https://openalex.org/W2033649139","https://openalex.org/W2038132127","https://openalex.org/W2039550372","https://openalex.org/W2039575792","https://openalex.org/W2045434770","https://openalex.org/W2046008851","https://openalex.org/W2050034556","https://openalex.org/W2051202148","https://openalex.org/W2052727153","https://openalex.org/W2058089640","https://openalex.org/W2058257534","https://openalex.org/W2064641323","https://openalex.org/W2073769648","https://openalex.org/W2080833363","https://openalex.org/W2083337908","https://openalex.org/W2090883361","https://openalex.org/W2104043654","https://openalex.org/W2109294354","https://openalex.org/W2111663010","https://openalex.org/W2117157957","https://openalex.org/W2117878645","https://openalex.org/W2118863472","https://openalex.org/W2124356165","https://openalex.org/W2126877253","https://openalex.org/W2132564070","https://openalex.org/W2139183953","https://openalex.org/W2140762690","https://openalex.org/W2145485696","https://openalex.org/W2148638342","https://openalex.org/W2154745425","https://openalex.org/W2158667119","https://openalex.org/W2159094759","https://openalex.org/W2160400298","https://openalex.org/W2166406736","https://openalex.org/W2173690212","https://openalex.org/W2177804662","https://openalex.org/W2179429273","https://openalex.org/W2188061941","https://openalex.org/W2197131168","https://openalex.org/W2267989363","https://openalex.org/W2280306471","https://openalex.org/W2411685931","https://openalex.org/W2429444364","https://openalex.org/W2466485619","https://openalex.org/W2527129822","https://openalex.org/W2527772066","https://openalex.org/W2536322725","https://openalex.org/W2566074209","https://openalex.org/W2609535107","https://openalex.org/W2618641368","https://openalex.org/W2624275086","https://openalex.org/W2626019299","https://openalex.org/W2728173650","https://openalex.org/W2734008477","https://openalex.org/W2784563802","https://openalex.org/W2790297007","https://openalex.org/W2794762714","https://openalex.org/W2799838464","https://openalex.org/W2806116757","https://openalex.org/W2807825151","https://openalex.org/W2885183295","https://openalex.org/W2892224885","https://openalex.org/W2895822422","https://openalex.org/W2897329047","https://openalex.org/W2900887235","https://openalex.org/W2901051058","https://openalex.org/W2911948847","https://openalex.org/W2915998799","https://openalex.org/W2918238426","https://openalex.org/W2938305903","https://openalex.org/W2940075519","https://openalex.org/W2949797623","https://openalex.org/W2950835872","https://openalex.org/W2950918617","https://openalex.org/W2952816528","https://openalex.org/W2955197368","https://openalex.org/W2955678947","https://openalex.org/W2962150852","https://openalex.org/W2963655326","https://openalex.org/W2964993184","https://openalex.org/W2971006194","https://openalex.org/W2974641100","https://openalex.org/W2980057232","https://openalex.org/W2980537150","https://openalex.org/W2981764820","https://openalex.org/W2990211116","https://openalex.org/W2991179912","https://openalex.org/W2998059585","https://openalex.org/W3005824507","https://openalex.org/W3005837382","https://openalex.org/W3005897484","https://openalex.org/W3007791756","https://openalex.org/W3008274705","https://openalex.org/W3009157211","https://openalex.org/W3009698679","https://openalex.org/W3011642937","https://openalex.org/W3016215086","https://openalex.org/W3022215592","https://openalex.org/W3022765906","https://openalex.org/W3032886052","https://openalex.org/W3037264776","https://openalex.org/W3042819313","https://openalex.org/W3081663584","https://openalex.org/W3108774824","https://openalex.org/W3113081570","https://openalex.org/W3118654906","https://openalex.org/W3126899606","https://openalex.org/W3163959720","https://openalex.org/W3165170726","https://openalex.org/W3171645542","https://openalex.org/W3182628359","https://openalex.org/W3183191781","https://openalex.org/W3192108828","https://openalex.org/W3204908221","https://openalex.org/W4236697815","https://openalex.org/W4237997615","https://openalex.org/W6639164789","https://openalex.org/W6687098967","https://openalex.org/W6750925105"],"related_works":["https://openalex.org/W2133114089","https://openalex.org/W2990211116","https://openalex.org/W2478486416","https://openalex.org/W2954708288","https://openalex.org/W4386221275","https://openalex.org/W2905453470","https://openalex.org/W1980307742","https://openalex.org/W7118521213","https://openalex.org/W4400732129","https://openalex.org/W2115964409"],"abstract_inverted_index":{"Radiotherapy":[0],"is":[1,36,50],"a":[2],"primary":[3],"therapeutic":[4],"modality":[5],"widely":[6,38],"utilized":[7],"with":[8,122],"curative":[9],"intent.":[10],"Traditionally":[11],"tumor":[12,61,96,149],"response":[13,104],"was":[14],"hypothesized":[15],"to":[16,19,59,105,157],"be":[17],"due":[18],"high":[20],"levels":[21],"of":[22,34,46,54,115,132,135,145,147,154,160,162,168],"cell":[23],"death":[24],"induced":[25],"by":[26],"irreparable":[27],"DNA":[28],"damage.":[29],"However,":[30,70],"the":[31,44,52,57,73,102,133,143,148,152,158,166,180],"immunomodulatory":[32,109],"aspect":[33],"radiation":[35,163],"now":[37],"accepted.":[39],"As":[40],"such,":[41],"interest":[42],"into":[43],"combination":[45],"radiotherapy":[47,106,136],"and":[48,78,92,107,118],"immunotherapy":[49],"increasing,":[51],"synergy":[53],"which":[55],"has":[56],"potential":[58],"improve":[60],"regression":[62],"beyond":[63],"that":[64,85],"observed":[65],"after":[66],"either":[67],"treatment":[68],"alone.":[69],"questions":[71],"regarding":[72],"timing":[74],"(sequential":[75],"vs":[76],"concurrent)":[77],"dose":[79],"fractionation":[80],"(hyper-,":[81],"standard-,":[82],"or":[83],"hypo-fractionation)":[84],"result":[86],"in":[87,165,178],"improved":[88],"anti-tumor":[89,155],"immune":[90],"responses,":[91,156],"thus":[93],"potentially":[94],"enhanced":[95],"inhibition,":[97],"remain.":[98],"Here":[99],"we":[100,127],"discuss":[101],"biological":[103],"its":[108],"properties":[110,146],"before":[111],"giving":[112],"an":[113,175],"overview":[114],"pre-clinical":[116],"data":[117],"clinical":[119],"trials":[120],"concerned":[121],"answering":[123],"these":[124,171],"questions.":[125],"Finally,":[126],"review":[128],"published":[129],"mathematical":[130],"models":[131,172],"impact":[134,144,159],"on":[137,151],"tumor-immune":[138],"interactions.":[139],"Ranging":[140],"from":[141],"considering":[142],"microenvironment":[150],"induction":[153],"choice":[161],"site":[164],"setting":[167],"metastatic":[169],"disease,":[170],"all":[173],"have":[174],"underlying":[176],"feature":[177],"common:":[179],"push":[181],"towards":[182],"personalized":[183],"therapy.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-04-26T00:00:00"}
