{"id":"https://openalex.org/W4224123734","doi":"https://doi.org/10.1021/acschemneuro.2c00048","title":"Cobratoxin Alleviates Cancer-Induced Bone Pain in Rats via Inhibiting CaMKII Signaling Pathway after Acting on M4 Muscarinic Cholinergic Receptors","display_name":"Cobratoxin Alleviates Cancer-Induced Bone Pain in Rats via Inhibiting CaMKII Signaling Pathway after Acting on M4 Muscarinic Cholinergic Receptors","publication_year":2022,"publication_date":"2022-04-14","ids":{"openalex":"https://openalex.org/W4224123734","doi":"https://doi.org/10.1021/acschemneuro.2c00048","pmid":"https://pubmed.ncbi.nlm.nih.gov/35420768"},"language":"en","primary_location":{"id":"doi:10.1021/acschemneuro.2c00048","doi":"https://doi.org/10.1021/acschemneuro.2c00048","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschemneuro.2c00048","pdf_url":null,"source":{"id":"https://openalex.org/S180465690","display_name":"ACS Chemical Neuroscience","issn_l":"1948-7193","issn":["1948-7193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063051049","display_name":"Longsheng Xu","orcid":"https://orcid.org/0000-0002-6091-6323","observed_orcids":["https://orcid.org/0000-0002-6091-6323"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longsheng Xu","raw_affiliation_strings":["Department of Anesthesia and Pain Medicine, Affiliated Hospital of Jiaxing University, Jiaxing 314000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia and Pain Medicine, Affiliated Hospital of Jiaxing University, Jiaxing 314000, China","institution_ids":["https://openalex.org/I4210092870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101887366","display_name":"Shizhen Wang","orcid":"https://orcid.org/0000-0003-1065-4756","observed_orcids":["https://orcid.org/0000-0003-1065-4756"]},"institutions":[{"id":"https://openalex.org/I4405279425","display_name":"Jiangsu College of Nursing","ror":"https://ror.org/01etr5g41","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405279425"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shizhen Wang","raw_affiliation_strings":["Department of Basic Medicine, Jiangsu Vocational College of Nursing, Huaian 223001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Medicine, Jiangsu Vocational College of Nursing, Huaian 223001, China","institution_ids":["https://openalex.org/I4405279425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100450749","display_name":"Ling Zhang","orcid":"https://orcid.org/0000-0002-8308-6553","observed_orcids":["https://orcid.org/0000-0002-8308-6553","https://orcid.org/0000-0001-6913-9068"]},"institutions":[{"id":"https://openalex.org/I4405254887","display_name":"Suzhou University","ror":"https://ror.org/02bz8aa76","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405254887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Zhang","raw_affiliation_strings":["Department of central laboratory, Affiliated Zhangjiagang Hospital of Suzhou University, Zhangjiagang 215600, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of central laboratory, Affiliated Zhangjiagang Hospital of Suzhou University, Zhangjiagang 215600, China","institution_ids":["https://openalex.org/I4405254887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100623316","display_name":"Beibei Liu","orcid":"https://orcid.org/0000-0002-8729-6590","observed_orcids":["https://orcid.org/0000-0002-8729-6590"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Beibei Liu","raw_affiliation_strings":["Department of Anesthesia and Pain Medicine, Affiliated Hospital of Jiaxing University, Jiaxing 314000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia and Pain Medicine, Affiliated Hospital of Jiaxing University, Jiaxing 314000, China","institution_ids":["https://openalex.org/I4210092870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101004280","display_name":"Zheng Shang","orcid":"https://orcid.org/0009-0007-3929-2353","observed_orcids":["https://orcid.org/0009-0007-3929-2353"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shang Zheng","raw_affiliation_strings":["Department of Anesthesia and Pain Medicine, Affiliated Hospital of Jiaxing University, Jiaxing 314000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia and Pain Medicine, Affiliated Hospital of Jiaxing University, Jiaxing 314000, China","institution_ids":["https://openalex.org/I4210092870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107991294","display_name":"Ming Yao","orcid":"https://orcid.org/0000-0002-4226-8473","observed_orcids":["https://orcid.org/0000-0002-4226-8473"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ming Yao","raw_affiliation_strings":["Department of Anesthesia and Pain Medicine, Affiliated Hospital of Jiaxing University, Jiaxing 314000, China"],"raw_orcid":"https://orcid.org/0000-0002-4226-8473","affiliations":[{"raw_affiliation_string":"Department of Anesthesia and Pain Medicine, Affiliated Hospital of Jiaxing University, Jiaxing 314000, China","institution_ids":["https://openalex.org/I4210092870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5107991294"],"corresponding_institution_ids":["https://openalex.org/I4210092870"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.902,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.71202405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":"9","first_page":"1422","last_page":"1432"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-induced-bone-pain","display_name":"cancer-induced bone pain","score":0.8880000114440918},{"id":"https://openalex.org/keywords/alpha-cobratoxin","display_name":"alpha-cobratoxin","score":0.875},{"id":"https://openalex.org/keywords/m4-muscarinic-acetylcholine-receptor","display_name":"M4 muscarinic acetylcholine receptor","score":0.9829999804496765},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.8989999890327454},{"id":"https://openalex.org/keywords/neuronal-excitability","display_name":"neuronal excitability","score":0.7289999723434448},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.921999990940094},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.8209999799728394},{"id":"https://openalex.org/keywords/mechanical-allodynia","display_name":"mechanical allodynia","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.5727174282073975},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.5138314366340637},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.48827219009399414},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4858565032482147},{"id":"https://openalex.org/C47488739","wikidata":"https://www.wikidata.org/wiki/Q17861931","display_name":"Muscarinic acetylcholine receptor M2","level":4,"score":0.4546433687210083},{"id":"https://openalex.org/C116289061","wikidata":"https://www.wikidata.org/wiki/Q17861955","display_name":"Muscarinic acetylcholine receptor M3","level":4,"score":0.45152395963668823},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44031697511672974},{"id":"https://openalex.org/C207723603","wikidata":"https://www.wikidata.org/wiki/Q17861926","display_name":"Muscarinic acetylcholine receptor M1","level":4,"score":0.43592262268066406},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4346415102481842},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3762136995792389},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32959991693496704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28808122873306274},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24752849340438843}],"mesh":[{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018678","descriptor_name":"Cholinergic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018678","descriptor_name":"Cholinergic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018678","descriptor_name":"Cholinergic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D043588","descriptor_name":"Receptor, Muscarinic M4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043588","descriptor_name":"Receptor, Muscarinic M4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043588","descriptor_name":"Receptor, Muscarinic M4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acschemneuro.2c00048","doi":"https://doi.org/10.1021/acschemneuro.2c00048","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschemneuro.2c00048","pdf_url":null,"source":{"id":"https://openalex.org/S180465690","display_name":"ACS Chemical Neuroscience","issn_l":"1948-7193","issn":["1948-7193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Neuroscience","raw_type":"journal-article"},{"id":"pmid:35420768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35420768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS chemical neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8100000023841858}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3163952365","display_name":null,"funder_award_id":"82001176","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G363112877","display_name":null,"funder_award_id":"LY20H090020","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1976961119","https://openalex.org/W1977434574","https://openalex.org/W1982853371","https://openalex.org/W2005426891","https://openalex.org/W2008634539","https://openalex.org/W2032249286","https://openalex.org/W2035010157","https://openalex.org/W2037721775","https://openalex.org/W2060532125","https://openalex.org/W2067856993","https://openalex.org/W2070847243","https://openalex.org/W2093960797","https://openalex.org/W2103238221","https://openalex.org/W2115049725","https://openalex.org/W2123206529","https://openalex.org/W2140525483","https://openalex.org/W2190719547","https://openalex.org/W2466150714","https://openalex.org/W2493995421","https://openalex.org/W2605438746","https://openalex.org/W2760671143","https://openalex.org/W2802241020","https://openalex.org/W2883411848","https://openalex.org/W2883631299","https://openalex.org/W2889360353","https://openalex.org/W2892848287","https://openalex.org/W2990444652","https://openalex.org/W3010775569","https://openalex.org/W3010967667","https://openalex.org/W3011499824","https://openalex.org/W3019164864","https://openalex.org/W3084298769","https://openalex.org/W3190287796","https://openalex.org/W3208506851"],"related_works":["https://openalex.org/W2014913952","https://openalex.org/W2045552364","https://openalex.org/W2041005648","https://openalex.org/W2023374499","https://openalex.org/W1991634597","https://openalex.org/W2081309033","https://openalex.org/W2066315102","https://openalex.org/W4236619235","https://openalex.org/W2043159065","https://openalex.org/W1999663284"],"abstract_inverted_index":{"Cancer-induced":[0],"bone":[1],"pain":[2,7],"(CIBP)":[3],"is":[4,28],"a":[5,62,73],"common":[6],"in":[8,61,72,122,205,231,234],"clinics,":[9],"which":[10],"can":[11,109],"reduce":[12],"the":[13,19,24,36,47,57,77,111,153,164,175,195,219,235],"quality":[14],"of":[15,21,26,39,67,88,94,98,119,166,177,197,221],"life":[16],"and":[17,43,50,76,114,140,148,156,168,174],"increase":[18],"mortality":[20],"patients,":[22],"but":[23],"treatment":[25],"CIBP":[27,42,63,123,154,236],"limited.":[29],"This":[30],"study":[31],"was":[32,179],"designed":[33],"to":[34,45],"investigate":[35],"analgesic":[37,78],"effect":[38,176],"\u03b1-cobratoxin":[40,68,108,135,173,178,193,211],"on":[41],"further":[44],"explore":[46],"molecular":[48],"target":[49],"potential":[51],"signal":[52],"pathway.":[53],"As":[54],"shown":[55],"by":[56,82,172,181],"mechanical":[58],"allodynia":[59],"test":[60],"rat":[64,237],"model,":[65],"administration":[66],"produced":[69],"significant":[70],"analgesia":[71],"dose-dependent":[74],"manner,":[75],"effects":[79,233],"were":[80,150,170],"blocked":[81],"pretreatment":[83],"with":[84],"an":[85,96],"intrathecal":[86],"injection":[87,93],"M4":[89,99,144,182,201,214],"mAChR-siRNA":[90],"or":[91],"intraperitoneal":[92],"tropicamide,":[95],"antagonist":[97],"muscarinic":[100,145,202,215],"cholinergic":[101,146,203,216],"receptor.":[102],"Whole-cell":[103],"patch-clamp":[104],"recording":[105],"showed":[106,162,191],"that":[107,134,143,163,192,210],"decrease":[110],"spontaneous":[112,115],"firing":[113],"excitatory":[116],"postsynaptic":[117],"currents":[118],"SDH":[120,128,158,222],"neurons":[121],"rats.":[124],"In":[125,152],"primary":[126,157],"lumber":[127],"neurons,":[129,159],"intracellular":[130,137],"calcium":[131,138],"measurement":[132],"revealed":[133],"decreased":[136],"concentration,":[139],"immunofluorescence":[141],"demonstrated":[142],"receptor":[147,204],"CaMKII/CREB":[149],"co-expressed.":[151],"model":[155],"Western":[160],"blot":[161],"levels":[165],"p-CaMKII":[167],"p-CREB":[169],"increased":[171],"antagonized":[180],"mAChR-siRNA.":[183],"The":[184],"quantitative":[185],"polymerase":[186],"chain":[187],"reaction":[188],"(qPCR)":[189],"results":[190,208],"downregulated":[194],"expression":[196],"proinflammatory":[198],"cytokines":[199],"through":[200],"SDH.":[206],"These":[207],"suggest":[209],"may":[212],"activate":[213],"receptor,":[217],"triggering":[218],"inhibition":[220],"neuronal":[223],"excitability":[224],"via":[225],"CaMKII":[226],"signaling":[227],"pathway,":[228],"thereby":[229],"resulting":[230],"antagonistic":[232],"model.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2025-10-10T00:00:00"}