{"id":"https://openalex.org/W4224079201","doi":"https://doi.org/10.1016/j.mne.2022.100134","title":"AFM macro-probes to investigate whole 3D cardiac spheroids","display_name":"AFM macro-probes to investigate whole 3D cardiac spheroids","publication_year":2022,"publication_date":"2022-04-01","ids":{"openalex":"https://openalex.org/W4224079201","doi":"https://doi.org/10.1016/j.mne.2022.100134"},"language":"en","primary_location":{"id":"doi:10.1016/j.mne.2022.100134","doi":"https://doi.org/10.1016/j.mne.2022.100134","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mne.2022.100134","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2590007222000314/pdf","source":{"id":"https://openalex.org/S4210214524","display_name":"Micro and Nano Engineering","issn_l":"2590-0072","issn":["2590-0072"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Micro and Nano Engineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2590007222000314/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016525819","display_name":"Michele Zanetti","orcid":"https://orcid.org/0000-0002-5581-1754","observed_orcids":["https://orcid.org/0000-0002-5581-1754"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Michele Zanetti","raw_affiliation_strings":["CNR-IOM, SS 14, km 163.5, Basovizza, Trieste, 34149, Italy","University of Trieste, Department of Physics, Via Valerio 10, 34127 Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNR-IOM, SS 14, km 163.5, Basovizza, Trieste, 34149, Italy","institution_ids":[]},{"raw_affiliation_string":"University of Trieste, Department of Physics, Via Valerio 10, 34127 Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087771861","display_name":"Laura Andolfi","orcid":"https://orcid.org/0000-0001-6380-6747","observed_orcids":["https://orcid.org/0000-0001-6380-6747"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Andolfi","raw_affiliation_strings":["CNR-IOM, SS 14, km 163.5, Basovizza, Trieste, 34149, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNR-IOM, SS 14, km 163.5, Basovizza, Trieste, 34149, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066041440","display_name":"Matthew R.G. Taylor","orcid":"https://orcid.org/0000-0001-9043-0810","observed_orcids":["https://orcid.org/0000-0001-9043-0810"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew R.G. Taylor","raw_affiliation_strings":["Molecular Genetics, Cardiovascular Institute, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045-2507, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics, Cardiovascular Institute, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045-2507, USA","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067654253","display_name":"Luisa Mestroni","orcid":"https://orcid.org/0000-0003-1116-2286","observed_orcids":["https://orcid.org/0000-0003-1116-2286"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luisa Mestroni","raw_affiliation_strings":["Molecular Genetics, Cardiovascular Institute, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045-2507, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics, Cardiovascular Institute, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045-2507, USA","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085355219","display_name":"Marco Lazzarino","orcid":"https://orcid.org/0000-0003-1077-6569","observed_orcids":["https://orcid.org/0000-0003-1077-6569"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marco Lazzarino","raw_affiliation_strings":["CNR-IOM, SS 14, km 163.5, Basovizza, Trieste, 34149, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNR-IOM, SS 14, km 163.5, Basovizza, Trieste, 34149, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016525819"],"corresponding_institution_ids":["https://openalex.org/I142444530"],"apc_list":{"value":1380,"currency":"USD","value_usd":1380},"apc_paid":{"value":1380,"currency":"USD","value_usd":1380},"fwci":0.5125,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.52834741,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"15","issue":null,"first_page":"100134","last_page":"100134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.8672000169754028,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.8672000169754028,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.13109999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stress-relaxation","display_name":"stress relaxation","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.846634566783905},{"id":"https://openalex.org/C166955791","wikidata":"https://www.wikidata.org/wiki/Q629579","display_name":"Macro","level":2,"score":0.6888391375541687},{"id":"https://openalex.org/C102951782","wikidata":"https://www.wikidata.org/wiki/Q49295","display_name":"Atomic force microscopy","level":2,"score":0.5770373344421387},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.42517656087875366},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4211198091506958},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.310085654258728},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2503317594528198},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.055197328329086304},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.mne.2022.100134","doi":"https://doi.org/10.1016/j.mne.2022.100134","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mne.2022.100134","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2590007222000314/pdf","source":{"id":"https://openalex.org/S4210214524","display_name":"Micro and Nano Engineering","issn_l":"2590-0072","issn":["2590-0072"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Micro and Nano Engineering","raw_type":"journal-article"},{"id":"pmh:oai:arts.units.it:11368/3040678","doi":null,"is_oa":true,"landing_page_url":"https://www.sciencedirect.com/science/article/pii/S2590007222000314","pdf_url":"https://arts.units.it/bitstream/11368/3040678/2/1-s2.0-S2590007222000314-main.pdf","source":{"id":"https://openalex.org/S4306400480","display_name":"ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142444530","host_organization_name":"University of Trieste","host_organization_lineage":["https://openalex.org/I142444530"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:9c568ea42a7f4167832efefc0e5e0135","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9c568ea42a7f4167832efefc0e5e0135","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Micro and Nano Engineering, Vol 15, Iss , Pp 100134- (2022)","raw_type":"article"},{"id":"pmh:oai:it.cnr:prodotti:486520","doi":null,"is_oa":false,"landing_page_url":"https://publications.cnr.it/doc/486520","pdf_url":null,"source":{"id":"https://openalex.org/S7407055101","display_name":"CNR ExploRA","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"info:cnr-pdr/source/autori:Zanetti, Michele; Andolfi, Laura; Taylor, Matthew R. G.; Mestroni, Luisa; Lazzarino, Marco/titolo:AFM macro-probes to investigate whole 3D cardiac spheroids/doi:10.1016%2Fj.mne.2022.100134/rivista:Micro and nano engineering Online/anno:2022/pagina_da:/pagina_a:/intervallo_pagine:/volume:15","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.mne.2022.100134","doi":"https://doi.org/10.1016/j.mne.2022.100134","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mne.2022.100134","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2590007222000314/pdf","source":{"id":"https://openalex.org/S4210214524","display_name":"Micro and Nano Engineering","issn_l":"2590-0072","issn":["2590-0072"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Micro and Nano Engineering","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319609","display_name":"Fondazione Italiana Fegato Onlus","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4224079201.pdf","grobid_xml":"https://content.openalex.org/works/W4224079201.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W164268069","https://openalex.org/W606516014","https://openalex.org/W1012521920","https://openalex.org/W1266734045","https://openalex.org/W1965689674","https://openalex.org/W1988055796","https://openalex.org/W2000806692","https://openalex.org/W2010227280","https://openalex.org/W2024631759","https://openalex.org/W2042010963","https://openalex.org/W2057499308","https://openalex.org/W2086557128","https://openalex.org/W2118465348","https://openalex.org/W2118722808","https://openalex.org/W2125454893","https://openalex.org/W2399731495","https://openalex.org/W2732673781","https://openalex.org/W2737012672","https://openalex.org/W2768648218","https://openalex.org/W2791455773","https://openalex.org/W2795872572","https://openalex.org/W2898894785","https://openalex.org/W2946977172","https://openalex.org/W2947495825","https://openalex.org/W3006530715","https://openalex.org/W3045557762","https://openalex.org/W3126743042","https://openalex.org/W3130522032","https://openalex.org/W3177651069","https://openalex.org/W3183867006","https://openalex.org/W3186849777","https://openalex.org/W3199036317","https://openalex.org/W3204555669","https://openalex.org/W6755803642","https://openalex.org/W6778261130"],"related_works":["https://openalex.org/W2946977172","https://openalex.org/W2732673781","https://openalex.org/W2752335977","https://openalex.org/W2899465761","https://openalex.org/W619158931","https://openalex.org/W4200244651","https://openalex.org/W4321366853","https://openalex.org/W4409350565","https://openalex.org/W1999008705","https://openalex.org/W4312407652"],"abstract_inverted_index":{"In":[0,105],"its":[1],"many":[2],"applications,":[3],"the":[4,20,29,46,63,85,90,118,145,158],"Atomic":[5],"Force":[6],"Microscope":[7],"(AFM)":[8],"is":[9,37,92],"a":[10,79,95,155],"promising":[11],"tool":[12],"in":[13],"cardiac":[14],"mechanobiology":[15],"because":[16],"it":[17],"can":[18,57,113,136],"unravel":[19],"viscoelastic":[21],"and":[22,77,103,149,152],"mechano-dynamic":[23],"properties":[24],"of":[25,32,121,143],"individual":[26],"cardiomyocytes.":[27],"However,":[28],"biophysical":[30],"investigation":[31],"more":[33],"accurate":[34],"3D":[35],"models":[36],"hampered":[38],"by":[39,61,74,125],"commercial":[40],"probes,":[41],"which":[42],"typically":[43],"operate":[44],"at":[45],"cell":[47],"sub-compartmental":[48],"resolution.":[49],"We":[50],"have":[51],"previously":[52],"shown":[53],"how":[54,110],"flat":[55,80],"macro-probes":[56,71,112,135],"overcome":[58],"these":[59,111,134],"limitations":[60],"extending":[62],"AFM":[64,86,91],"mechanical":[65],"measurements":[66],"to":[67,83,94,116,153],"multicellular":[68],"aggregates.":[69],"Such":[70],"are":[72],"fabricated":[73],"standard":[75],"micromachining":[76],"carry":[78],"polymeric":[81],"wedge":[82],"offset":[84],"mounting":[87],"tilt.":[88],"Therefore,":[89],"upgraded":[93],"micro-parallel":[96],"plate":[97],"rheometer":[98],"with":[99],"unmatched":[100],"force":[101,148],"range":[102],"sensitivity.":[104],"this":[106],"article,":[107],"we":[108,131],"show":[109],"be":[114,137],"applied":[115],"reveal":[117],"global":[119],"rheology":[120],"primary":[122],"cardiomyocytes":[123],"spheroids,":[124],"performing":[126],"stress-relaxation":[127],"tests.":[128],"More":[129],"importantly,":[130],"demonstrate":[132],"that":[133],"used":[138],"as":[139],"passive":[140],"sensors":[141],"capable":[142],"monitoring":[144],"spheroid":[146,159],"beating":[147,150],"pattern,":[151],"perform":[154],"\u201cmicro-CPR\u201d":[156],"on":[157],"itself.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2022-04-19T00:00:00"}
