{"id":"https://openalex.org/W4223899028","doi":"https://doi.org/10.3390/biomedicines10040900","title":"Liver-Targeted Nanoparticles Facilitate the Bioavailability and Anti-HBV Efficacy of Baicalin In Vitro and In Vivo","display_name":"Liver-Targeted Nanoparticles Facilitate the Bioavailability and Anti-HBV Efficacy of Baicalin In Vitro and In Vivo","publication_year":2022,"publication_date":"2022-04-14","ids":{"openalex":"https://openalex.org/W4223899028","doi":"https://doi.org/10.3390/biomedicines10040900","pmid":"https://pubmed.ncbi.nlm.nih.gov/35453650","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9025464"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines10040900","doi":"https://doi.org/10.3390/biomedicines10040900","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines10040900","pdf_url":"https://www.mdpi.com/2227-9059/10/4/900/pdf?version=1650009972","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2227-9059/10/4/900/pdf?version=1650009972","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006652463","display_name":"Weiming Xu","orcid":"https://orcid.org/0000-0001-8224-5789","observed_orcids":["https://orcid.org/0000-0001-8224-5789"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiming Xu","raw_affiliation_strings":["Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai 201203, China"],"raw_orcid":"https://orcid.org/0000-0001-8224-5789","affiliations":[{"raw_affiliation_string":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai 201203, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085498631","display_name":"Yijun Niu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yijun Niu","raw_affiliation_strings":["Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai 201203, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039807057","display_name":"Xin Ai","orcid":"https://orcid.org/0000-0002-7870-9867","observed_orcids":["https://orcid.org/0000-0002-7870-9867"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Ai","raw_affiliation_strings":["Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai 201203, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033709274","display_name":"Chengjie Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengjie Xia","raw_affiliation_strings":["Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai 201203, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ping Geng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Geng","raw_affiliation_strings":["Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai 201203, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084269148","display_name":"Haiyan Zhu","orcid":"https://orcid.org/0000-0002-8109-6678","observed_orcids":["https://orcid.org/0000-0002-8109-6678"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyan Zhu","raw_affiliation_strings":["Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai 201203, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004662691","display_name":"Wei Min Zhou","orcid":"https://orcid.org/0000-0001-7467-3628","observed_orcids":["https://orcid.org/0000-0001-7467-3628"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhou","raw_affiliation_strings":["Department of Chemistry, Fudan University, 220 Han Dan Road, Shanghai 200433, China"],"raw_orcid":"https://orcid.org/0000-0001-7467-3628","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Fudan University, 220 Han Dan Road, Shanghai 200433, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027184005","display_name":"Hai Yan Huang","orcid":"https://orcid.org/0000-0002-6928-3198","observed_orcids":["https://orcid.org/0000-0002-6928-3198","https://orcid.org/0000-0001-9841-1147","https://orcid.org/0009-0006-9877-2755"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai Huang","raw_affiliation_strings":["Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai 201203, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078812509","display_name":"Xunlong Shi","orcid":"https://orcid.org/0000-0002-7009-5629","observed_orcids":["https://orcid.org/0000-0002-7009-5629"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xunlong Shi","raw_affiliation_strings":["Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai 201203, China","institution_ids":["https://openalex.org/I24943067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078812509"],"corresponding_institution_ids":["https://openalex.org/I24943067"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2303},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2303},"fwci":1.1883,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.72716178,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"4","first_page":"900","last_page":"900"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.47530001401901245,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.47530001401901245,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.33889999985694885,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.05469999834895134,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/baicalin","display_name":"baicalin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9480000138282776},{"id":"https://openalex.org/keywords/apolipoprotein-a-i","display_name":"apolipoprotein A-I","score":0.9290000200271606},{"id":"https://openalex.org/keywords/hepatocyte-nuclear-factor","display_name":"hepatocyte nuclear factor","score":0.8429999947547913},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.878000020980835},{"id":"https://openalex.org/keywords/drug-bioavailability","display_name":"drug bioavailability","score":0.6869999766349792},{"id":"https://openalex.org/keywords/antiviral-efficacy","display_name":"antiviral efficacy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/nanoparticle-drug-delivery","display_name":"nanoparticle drug delivery","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.7410423755645752},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.6518430709838867},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6325051784515381},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.6112332940101624},{"id":"https://openalex.org/C2775940106","wikidata":"https://www.wikidata.org/wiki/Q10478733","display_name":"HBeAg","level":5,"score":0.5789106488227844},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.5417609214782715},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.5120630860328674},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4936290979385376},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48791834712028503},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43503665924072266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33908987045288086},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3317221999168396},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3176480233669281},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.30542558431625366},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28539296984672546},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biomedicines10040900","doi":"https://doi.org/10.3390/biomedicines10040900","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines10040900","pdf_url":"https://www.mdpi.com/2227-9059/10/4/900/pdf?version=1650009972","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9025464","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9025464","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmid:35453650","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35453650","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1cf604d5b41c4b298932ae91858bd820","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1cf604d5b41c4b298932ae91858bd820","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 10, Iss 4, p 900 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines10040900","doi":"https://doi.org/10.3390/biomedicines10040900","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines10040900","pdf_url":"https://www.mdpi.com/2227-9059/10/4/900/pdf?version=1650009972","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321851","display_name":"Fudan University","ror":"https://ror.org/013q1eq08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4223899028.pdf","grobid_xml":"https://content.openalex.org/works/W4223899028.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1969776963","https://openalex.org/W1988032963","https://openalex.org/W2043372323","https://openalex.org/W2052373015","https://openalex.org/W2067376080","https://openalex.org/W2084810036","https://openalex.org/W2131129763","https://openalex.org/W2155581909","https://openalex.org/W2169854416","https://openalex.org/W2199727581","https://openalex.org/W2305677244","https://openalex.org/W2473631582","https://openalex.org/W2479646223","https://openalex.org/W2548903164","https://openalex.org/W2564271607","https://openalex.org/W2575806121","https://openalex.org/W2597156867","https://openalex.org/W2610554395","https://openalex.org/W2748438517","https://openalex.org/W2794634849","https://openalex.org/W2801666689","https://openalex.org/W2889956192","https://openalex.org/W2899285523","https://openalex.org/W2919608017","https://openalex.org/W2937568308","https://openalex.org/W2941187779","https://openalex.org/W2978002403","https://openalex.org/W2999969925","https://openalex.org/W3043614077","https://openalex.org/W3045668730","https://openalex.org/W3100909427","https://openalex.org/W3108376993","https://openalex.org/W3131215121","https://openalex.org/W3132700945","https://openalex.org/W3204943222"],"related_works":["https://openalex.org/W3043614077","https://openalex.org/W4403889874","https://openalex.org/W2597156867","https://openalex.org/W2581084368","https://openalex.org/W2964080169","https://openalex.org/W3126323932","https://openalex.org/W2886608317","https://openalex.org/W4367671487","https://openalex.org/W2999037327","https://openalex.org/W2354222615"],"abstract_inverted_index":{"The":[0,46],"anti-hepatitis":[1],"B":[2],"virus":[3],"(HBV)":[4],"efficacy":[5,19,100],"of":[6,27,44,71,101],"baicalin":[7],"(BA)":[8],"is":[9,20],"mediated":[10],"by":[11,23,135],"HBV-related":[12],"hepatocyte":[13,109],"nuclear":[14,110],"factors":[15,111],"(HNFs).":[16],"However,":[17],"this":[18],"severely":[21],"limited":[22],"the":[24,39,64,67,97,106,119,124,140],"low":[25],"bioavailability":[26,40,138],"BA.":[28,45],"Therefore,":[29],"a":[30],"novel":[31],"liver-targeted":[32],"BA":[33,128],"liposome":[34],"was":[35,103],"constructed":[36],"to":[37,105],"promote":[38],"and":[41,60,78,86,91,113,133,139],"antiviral":[42],"ability":[43],"results":[47],"showed":[48],"that":[49,96,123],"apolipoprotein":[50],"A1":[51],"(ApoA1)-modified":[52],"liposomes":[53,126],"(BAA1)":[54],"significantly":[55],"enhanced":[56,98],"BA's":[57],"cellular":[58],"uptake":[59],"specific":[61],"distribution":[62],"in":[63,83,129],"liver.":[65],"Furthermore,":[66],"substantial":[68],"inhibitory":[69],"effects":[70],"BAA1":[72,102],"on":[73,118],"HBsAg,":[74],"HBeAg,":[75],"HBV":[76,79,131],"RNA,":[77],"DNA":[80],"were":[81],"assessed":[82],"HB-infected":[84],"cells":[85],"mice.":[87],"Western":[88],"blotting,":[89],"co-immunoprecipitation,":[90],"transcriptomics":[92],"analysis":[93],"further":[94],"revealed":[95],"anti-HBV":[99],"attributed":[104],"interaction":[107],"between":[108],"(HNFs)":[112],"estrogen":[114],"receptors":[115],"(ERs).":[116],"Based":[117],"findings,":[120],"we":[121],"propose":[122],"ApoA1-modified":[125],"aid":[127],"inhibiting":[130],"transcription":[132],"replication":[134],"augmenting":[136],"its":[137],"HNFs-ERs":[141],"axis.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-04-19T00:00:00"}