{"id":"https://openalex.org/W4223640902","doi":"https://doi.org/10.3389/fneur.2022.841310","title":"Molecular Hydrogen as a Medical Gas for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Possible Efficacy Based on a Literature Review","display_name":"Molecular Hydrogen as a Medical Gas for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Possible Efficacy Based on a Literature Review","publication_year":2022,"publication_date":"2022-04-11","ids":{"openalex":"https://openalex.org/W4223640902","doi":"https://doi.org/10.3389/fneur.2022.841310","pmid":"https://pubmed.ncbi.nlm.nih.gov/35493814","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9042428"},"language":"en","primary_location":{"id":"doi:10.3389/fneur.2022.841310","doi":"https://doi.org/10.3389/fneur.2022.841310","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2022.841310","pdf_url":"https://www.frontiersin.org/articles/10.3389/fneur.2022.841310/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fneur.2022.841310/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055040028","display_name":"Shin\u2010ichi Hirano","orcid":"https://orcid.org/0000-0002-8610-8922","observed_orcids":["https://orcid.org/0000-0002-8610-8922"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shin-ichi Hirano","raw_affiliation_strings":["Department of Research and Development, MiZ Company Limited, Kamakura, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research and Development, MiZ Company Limited, Kamakura, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054125372","display_name":"Yusuke Ichikawa","orcid":"https://orcid.org/0000-0002-2526-4681","observed_orcids":["https://orcid.org/0000-0002-2526-4681","https://orcid.org/0009-0009-8450-8947"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yusuke Ichikawa","raw_affiliation_strings":["Department of Research and Development, MiZ Company Limited, Kamakura, Japan","MiZ Inc., Newark, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research and Development, MiZ Company Limited, Kamakura, Japan","institution_ids":[]},{"raw_affiliation_string":"MiZ Inc., Newark, CA, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069932959","display_name":"Bunpei Sato","orcid":"https://orcid.org/0000-0003-1972-9646","observed_orcids":["https://orcid.org/0000-0003-1972-9646"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bunpei Sato","raw_affiliation_strings":["Department of Research and Development, MiZ Company Limited, Kamakura, Japan","MiZ Inc., Newark, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research and Development, MiZ Company Limited, Kamakura, Japan","institution_ids":[]},{"raw_affiliation_string":"MiZ Inc., Newark, CA, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050160318","display_name":"Yoshiyasu Takefuji","orcid":"https://orcid.org/0000-0002-1826-742X","observed_orcids":["https://orcid.org/0000-0002-1826-742X"]},"institutions":[{"id":"https://openalex.org/I200641316","display_name":"Musashino University","ror":"https://ror.org/04bcbax71","country_code":"JP","type":"education","lineage":["https://openalex.org/I200641316"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiyasu Takefuji","raw_affiliation_strings":["Faculty of Data Science, Musashino University, Tokyo, Japan","Professor Emeritus, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Data Science, Musashino University, Tokyo, Japan","institution_ids":["https://openalex.org/I200641316"]},{"raw_affiliation_string":"Professor Emeritus, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087345430","display_name":"Fumitake Satoh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fumitake Satoh","raw_affiliation_strings":["Department of Research and Development, MiZ Company Limited, Kamakura, Japan","MiZ Inc., Newark, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research and Development, MiZ Company Limited, Kamakura, Japan","institution_ids":[]},{"raw_affiliation_string":"MiZ Inc., Newark, CA, United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055040028"],"corresponding_institution_ids":[],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.5939,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.49463933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"13","issue":null,"first_page":"841310","last_page":"841310"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12930","display_name":"Biomedical and Chemical Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-hydrogen","display_name":"molecular hydrogen","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chronic-fatigue-syndrome","display_name":"chronic fatigue syndrome","score":0.9559999704360962},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9539999961853027},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7310000061988831},{"id":"https://openalex.org/keywords/hydroxyl-radical-scavenging","display_name":"hydroxyl radical scavenging","score":0.9909999966621399},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.5070000290870667},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C2779566273","wikidata":"https://www.wikidata.org/wiki/Q209733","display_name":"Chronic fatigue syndrome","level":2,"score":0.9434304237365723},{"id":"https://openalex.org/C2777899865","wikidata":"https://www.wikidata.org/wiki/Q1634879","display_name":"Encephalomyelitis","level":3,"score":0.6873148679733276},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5880431532859802},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.5485768914222717},{"id":"https://openalex.org/C3020395016","wikidata":"https://www.wikidata.org/wiki/Q5113974","display_name":"Chronic fatigue","level":3,"score":0.5342330932617188},{"id":"https://openalex.org/C2780247198","wikidata":"https://www.wikidata.org/wiki/Q633403","display_name":"Weakness","level":2,"score":0.5177432894706726},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4807834029197693},{"id":"https://openalex.org/C2910239545","wikidata":"https://www.wikidata.org/wiki/Q3843811","display_name":"Immune Dysfunction","level":3,"score":0.46306389570236206},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.41594403982162476},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3472089171409607},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21157634258270264},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.14949962496757507},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1442040205001831},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.13550028204917908},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fneur.2022.841310","doi":"https://doi.org/10.3389/fneur.2022.841310","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2022.841310","pdf_url":"https://www.frontiersin.org/articles/10.3389/fneur.2022.841310/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9042428","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9042428","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurol","raw_type":"Text"},{"id":"pmid:35493814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35493814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neurology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e5e5348d315e420198a8818ee938a4af","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e5e5348d315e420198a8818ee938a4af","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neurology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fneur.2022.841310","doi":"https://doi.org/10.3389/fneur.2022.841310","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2022.841310","pdf_url":"https://www.frontiersin.org/articles/10.3389/fneur.2022.841310/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325772","display_name":"National Center of Neurology and Psychiatry","ror":"https://ror.org/0254bmq54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4223640902.pdf","grobid_xml":"https://content.openalex.org/works/W4223640902.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W22984044","https://openalex.org/W789633868","https://openalex.org/W888585091","https://openalex.org/W1234938742","https://openalex.org/W1574052502","https://openalex.org/W1964751354","https://openalex.org/W2002033816","https://openalex.org/W2008087869","https://openalex.org/W2008751223","https://openalex.org/W2018563185","https://openalex.org/W2020560218","https://openalex.org/W2022027387","https://openalex.org/W2035043415","https://openalex.org/W2035999441","https://openalex.org/W2050943437","https://openalex.org/W2058179498","https://openalex.org/W2062212261","https://openalex.org/W2064648786","https://openalex.org/W2074891216","https://openalex.org/W2090450186","https://openalex.org/W2098287790","https://openalex.org/W2099420745","https://openalex.org/W2101144366","https://openalex.org/W2110408075","https://openalex.org/W2123850354","https://openalex.org/W2131700094","https://openalex.org/W2135082935","https://openalex.org/W2138937898","https://openalex.org/W2155596333","https://openalex.org/W2159054927","https://openalex.org/W2162299609","https://openalex.org/W2169657429","https://openalex.org/W2171593851","https://openalex.org/W2179518026","https://openalex.org/W2230204591","https://openalex.org/W2285758361","https://openalex.org/W2417114627","https://openalex.org/W2466448612","https://openalex.org/W2509132807","https://openalex.org/W2513623425","https://openalex.org/W2528122092","https://openalex.org/W2530974160","https://openalex.org/W2560871666","https://openalex.org/W2563536139","https://openalex.org/W2595623234","https://openalex.org/W2619324823","https://openalex.org/W2750885285","https://openalex.org/W2766330091","https://openalex.org/W2782950904","https://openalex.org/W2796050959","https://openalex.org/W2799847483","https://openalex.org/W2884912010","https://openalex.org/W2889716489","https://openalex.org/W2898785855","https://openalex.org/W2910382915","https://openalex.org/W2915870237","https://openalex.org/W2927595596","https://openalex.org/W2953544727","https://openalex.org/W2959063900","https://openalex.org/W2963115826","https://openalex.org/W2972236099","https://openalex.org/W2973058655","https://openalex.org/W2973509862","https://openalex.org/W2978153486","https://openalex.org/W2980422429","https://openalex.org/W2981623279","https://openalex.org/W2987502704","https://openalex.org/W2995337439","https://openalex.org/W3005344716","https://openalex.org/W3009306586","https://openalex.org/W3009595715","https://openalex.org/W3016815940","https://openalex.org/W3033825698","https://openalex.org/W3037277607","https://openalex.org/W3045680995","https://openalex.org/W3048514840","https://openalex.org/W3048712936","https://openalex.org/W3097767461","https://openalex.org/W3111677977","https://openalex.org/W3115342510","https://openalex.org/W3115777139","https://openalex.org/W3116326249","https://openalex.org/W3133692365","https://openalex.org/W3154413300","https://openalex.org/W3159251768","https://openalex.org/W3182633410","https://openalex.org/W3193852797","https://openalex.org/W3201882851","https://openalex.org/W3202160767","https://openalex.org/W4211184994","https://openalex.org/W4285741580","https://openalex.org/W6628204841"],"related_works":["https://openalex.org/W4386545140","https://openalex.org/W7138946967","https://openalex.org/W4225090621","https://openalex.org/W3115342510","https://openalex.org/W2973058655","https://openalex.org/W4410496185","https://openalex.org/W6940328787","https://openalex.org/W2343824947","https://openalex.org/W7172545926","https://openalex.org/W4200053155"],"abstract_inverted_index":{"Myalgic":[0],"encephalomyelitis/chronic":[1],"fatigue":[2,12,128],"syndrome":[3],"(ME/CFS)":[4],"is":[5,9,76],"a":[6,38,115],"disorder":[7],"that":[8,13,102,136,172],"characterized":[10],"by":[11,84,121,142],"persists":[14],"for":[15,31,50,71,181],"more":[16],"than":[17],"6":[18],"months,":[19],"weakness,":[20],"sleep":[21],"disturbances,":[22],"and":[23,98,109,126,131,134,161],"cognitive":[24],"dysfunction.":[25],"There":[26],"are":[27,155],"multiple":[28],"possible":[29],"etiologies":[30],"ME/CFS,":[32,167],"among":[33,92],"which":[34,122],"mitochondrial":[35,82,140],"dysfunction":[36,83,141],"plays":[37],"major":[39],"role":[40],"in":[41,129,147,166],"abnormal":[42],"energy":[43],"metabolism.":[44],"The":[45,66],"potential":[46],"of":[47,53,68,139,163,184],"many":[48],"substances":[49,70],"the":[51,88,119,137,148,159,182],"treatment":[52,183],"ME/CFS":[54],"has":[55],"been":[56,64],"examined;":[57],"however,":[58],"satisfactory":[59],"outcomes":[60],"have":[61],"not":[62,73],"yet":[63],"achieved.":[65],"development":[67],"new":[69],"curative,":[72],"symptomatic,":[74],"treatments":[75],"desired.":[77],"Molecular":[78],"hydrogen":[79],"(H2)":[80],"ameliorates":[81],"scavenging":[85],"hydroxyl":[86],"radicals,":[87],"most":[89],"potent":[90],"oxidant":[91],"reactive":[93],"oxygen":[94],"species.":[95],"Animal":[96],"experiments":[97],"clinical":[99,153],"trials":[100,154],"reported":[101],"H2":[103,123,143,164,173],"exerted":[104],"ameliorative":[105,149],"effects":[106],"on":[107,118],"acute":[108,125],"chronic":[110,127],"fatigue.":[111],"Therefore,":[112],"we":[113],"conducted":[114],"literature":[116,169],"review":[117,170],"mechanism":[120,162],"improves":[124],"animals":[130],"healthy":[132],"people":[133],"showed":[135],"attenuation":[138],"may":[144,175],"be":[145,176],"involved":[146],"effects.":[150],"Although":[151],"further":[152],"needed":[156],"to":[157],"determine":[158],"efficacy":[160],"gas":[165,174,180],"our":[168],"suggested":[171],"an":[177],"effective":[178],"medical":[179],"ME/CFS.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-04-15T00:00:00"}
