{"id":"https://openalex.org/W4223607823","doi":"https://doi.org/10.1039/d2tb00126h","title":"Responsive hydrogel-based microneedle dressing for diabetic wound healing","display_name":"Responsive hydrogel-based microneedle dressing for diabetic wound healing","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4223607823","doi":"https://doi.org/10.1039/d2tb00126h","pmid":"https://pubmed.ncbi.nlm.nih.gov/35416225"},"language":"en","primary_location":{"id":"doi:10.1039/d2tb00126h","doi":"https://doi.org/10.1039/d2tb00126h","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d2tb00126h","pdf_url":null,"source":{"id":"https://openalex.org/S2479884170","display_name":"Journal of Materials Chemistry B","issn_l":"2050-750X","issn":["2050-750X","2050-7518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Materials Chemistry B","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059282595","display_name":"Zhaoyang Guo","orcid":"https://orcid.org/0000-0002-5057-4227","observed_orcids":["https://orcid.org/0000-0002-5057-4227"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaoyang Guo","raw_affiliation_strings":["School of Power and Mechanical Engineering & The Institute of Technological Science, Wuhan University, Wuhan 430072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Power and Mechanical Engineering & The Institute of Technological Science, Wuhan University, Wuhan 430072, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100422473","display_name":"Haiyang Liu","orcid":"https://orcid.org/0000-0002-4024-2827","observed_orcids":["https://orcid.org/0000-0002-4024-2827"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyang Liu","raw_affiliation_strings":["School of Power and Mechanical Engineering & The Institute of Technological Science, Wuhan University, Wuhan 430072, China"],"raw_orcid":"https://orcid.org/0000-0002-4024-2827","affiliations":[{"raw_affiliation_string":"School of Power and Mechanical Engineering & The Institute of Technological Science, Wuhan University, Wuhan 430072, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041146140","display_name":"Zhekun Shi","orcid":"https://orcid.org/0000-0003-0334-6923","observed_orcids":["https://orcid.org/0000-0003-0334-6923"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhekun Shi","raw_affiliation_strings":["School of Power and Mechanical Engineering & The Institute of Technological Science, Wuhan University, Wuhan 430072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Power and Mechanical Engineering & The Institute of Technological Science, Wuhan University, Wuhan 430072, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007362000","display_name":"Lulu Lin","orcid":"https://orcid.org/0000-0002-3513-8195","observed_orcids":["https://orcid.org/0000-0002-3513-8195"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lulu Lin","raw_affiliation_strings":["School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058005286","display_name":"Yinping Li","orcid":"https://orcid.org/0000-0003-1674-6694","observed_orcids":["https://orcid.org/0000-0003-1674-6694"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinping Li","raw_affiliation_strings":["School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Miao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Miao Wang","raw_affiliation_strings":["Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013, China","institution_ids":["https://openalex.org/I115592961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087231101","display_name":"Guoqing Pan","orcid":"https://orcid.org/0000-0001-5187-796X","observed_orcids":["https://orcid.org/0000-0001-5187-796X"]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoqing Pan","raw_affiliation_strings":["Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013, China"],"raw_orcid":"https://orcid.org/0000-0001-5187-796X","affiliations":[{"raw_affiliation_string":"Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013, China","institution_ids":["https://openalex.org/I115592961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008110151","display_name":"Yifeng Lei","orcid":"https://orcid.org/0000-0002-3523-6887","observed_orcids":["https://orcid.org/0000-0002-3523-6887"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yifeng Lei","raw_affiliation_strings":["School of Power and Mechanical Engineering & The Institute of Technological Science, Wuhan University, Wuhan 430072, China","Wuhan University Shenzhen Research Institute, Shenzhen 518057, China"],"raw_orcid":"https://orcid.org/0000-0002-3523-6887","affiliations":[{"raw_affiliation_string":"School of Power and Mechanical Engineering & The Institute of Technological Science, Wuhan University, Wuhan 430072, China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"Wuhan University Shenzhen Research Institute, Shenzhen 518057, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084211676","display_name":"Longjian Xue","orcid":"https://orcid.org/0000-0001-5512-747X","observed_orcids":["https://orcid.org/0000-0001-5512-747X"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longjian Xue","raw_affiliation_strings":["School of Power and Mechanical Engineering & The Institute of Technological Science, Wuhan University, Wuhan 430072, China"],"raw_orcid":"https://orcid.org/0000-0001-5512-747X","affiliations":[{"raw_affiliation_string":"School of Power and Mechanical Engineering & The Institute of Technological Science, Wuhan University, Wuhan 430072, China","institution_ids":["https://openalex.org/I37461747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008110151"],"corresponding_institution_ids":["https://openalex.org/I115592961","https://openalex.org/I37461747"],"apc_list":null,"apc_paid":null,"fwci":25.7655,"has_fulltext":false,"cited_by_count":144,"citation_normalized_percentile":{"value":0.99848269,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"10","issue":"18","first_page":"3501","last_page":"3511"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.02879999950528145,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-wound-healing","display_name":"diabetic wound healing","score":0.8130000233650208},{"id":"https://openalex.org/keywords/glucose-responsive-hydrogels","display_name":"glucose-responsive hydrogels","score":0.7940000295639038},{"id":"https://openalex.org/keywords/gelatin-methacryloyl","display_name":"gelatin methacryloyl","score":0.9520000219345093},{"id":"https://openalex.org/keywords/phenylboronic-acid","display_name":"phenylboronic acid","score":0.8059999942779541},{"id":"https://openalex.org/keywords/subcutaneous-insulin-delivery","display_name":"subcutaneous insulin administration","score":0.746999979019165},{"id":"https://openalex.org/keywords/wound-adhesion","display_name":"wound adhesion","score":0.6029999852180481},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.8489999771118164},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7208624482154846},{"id":"https://openalex.org/C2993269979","wikidata":"https://www.wikidata.org/wiki/Q523536","display_name":"Wound dressing","level":2,"score":0.5401638150215149},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5088822841644287},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5039297938346863},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.44270122051239014},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2824029326438904},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.12406575679779053}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001458","descriptor_name":"Bandages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1039/d2tb00126h","doi":"https://doi.org/10.1039/d2tb00126h","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d2tb00126h","pdf_url":null,"source":{"id":"https://openalex.org/S2479884170","display_name":"Journal of Materials Chemistry B","issn_l":"2050-750X","issn":["2050-750X","2050-7518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Materials Chemistry B","raw_type":"journal-article"},{"id":"pmid:35416225","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35416225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of materials chemistry. B","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1601987227","display_name":null,"funder_award_id":"82172096","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2218975790","display_name":null,"funder_award_id":"81871484","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6609003955","display_name":null,"funder_award_id":"21875092","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W208525513","https://openalex.org/W1120477740","https://openalex.org/W1913879859","https://openalex.org/W1969806743","https://openalex.org/W1985274666","https://openalex.org/W1991552237","https://openalex.org/W2002257633","https://openalex.org/W2014887370","https://openalex.org/W2079364989","https://openalex.org/W2081316578","https://openalex.org/W2085293124","https://openalex.org/W2109431901","https://openalex.org/W2120472250","https://openalex.org/W2127903487","https://openalex.org/W2130166533","https://openalex.org/W2132748744","https://openalex.org/W2141871922","https://openalex.org/W2142162781","https://openalex.org/W2588988001","https://openalex.org/W2608522719","https://openalex.org/W2730972618","https://openalex.org/W2760699020","https://openalex.org/W2782477370","https://openalex.org/W2789732774","https://openalex.org/W2794162149","https://openalex.org/W2795652485","https://openalex.org/W2800642284","https://openalex.org/W2909883725","https://openalex.org/W2911903264","https://openalex.org/W2917580846","https://openalex.org/W2922512922","https://openalex.org/W2948990438","https://openalex.org/W2950151274","https://openalex.org/W2965199122","https://openalex.org/W2969439804","https://openalex.org/W3004514673","https://openalex.org/W3016630914","https://openalex.org/W3082579544","https://openalex.org/W3087649273","https://openalex.org/W3094518103","https://openalex.org/W3103274862","https://openalex.org/W3110057408","https://openalex.org/W3116629552","https://openalex.org/W3128954820","https://openalex.org/W3141759544","https://openalex.org/W3149191282","https://openalex.org/W3159855635","https://openalex.org/W3160012011","https://openalex.org/W3164949448","https://openalex.org/W3194060209","https://openalex.org/W3200847019","https://openalex.org/W3209734681","https://openalex.org/W3216192297","https://openalex.org/W3216650910","https://openalex.org/W4206321479"],"related_works":["https://openalex.org/W4413452696","https://openalex.org/W3199567169","https://openalex.org/W7118601653","https://openalex.org/W4415746361","https://openalex.org/W4408915737","https://openalex.org/W7164411742","https://openalex.org/W4401734419","https://openalex.org/W7202169579","https://openalex.org/W4403930880","https://openalex.org/W4412044308"],"abstract_inverted_index":{"Wound":[0],"healing":[1,138],"is":[2,166],"a":[3,23,37,50],"critical":[4],"challenge":[5],"in":[6,157,168],"diabetic":[7,64,136,169],"patients,":[8],"mainly":[9],"due":[10],"to":[11,36,115,122,126],"long-term":[12],"dysglycemia":[13],"and":[14,58,82,86,119,152,172],"its":[15,61],"related":[16],"pathological":[17],"complications.":[18],"Subcutaneous":[19],"insulin":[20,32,84,110],"injection":[21],"represents":[22],"typical":[24],"clinical":[25],"solution,":[26],"while":[27],"the":[28,41,87,123,135,148,160],"low":[29],"controllability":[30],"of":[31,72,177],"administration":[33],"commonly":[34],"leads":[35],"result":[38],"far":[39],"from":[40],"optimal":[42],"therapeutic":[43],"effect.":[44],"In":[45],"this":[46],"work,":[47],"we":[48],"developed":[49,93],"glucose-responsive":[51,77,109,161],"insulin-releasing":[52,162],"hydrogel":[53,68,100,163],"for":[54,175],"microneedle":[55,90,101,131,164],"dressing":[56,91,102,132,165],"fabrication":[57],"then":[59],"investigated":[60],"effects":[62],"on":[63,147],"wound":[65,137,170],"healing.":[66],"The":[67,98,130],"system":[69],"was":[70,92],"composed":[71],"biocompatible":[73],"gelatin":[74],"methacrylate":[75],"(GelMa),":[76],"monomer":[78],"4-(2-acrylamidoethylcarbamoyl)-3-fluorophenylboronic":[79],"acid":[80],"(AFPBA)":[81],"gluconic":[83],"(G-insulin),":[85],"Gel-AFPBA-ins":[88],"hydrogel-based":[89],"by":[94],"replicating":[95],"PDMS":[96],"molds.":[97],"resultant":[99],"exhibited":[103],"adequate":[104],"mechanical":[105],"properties,":[106],"high":[107],"biocompatibility,":[108],"release":[111],"behavior":[112],"upon":[113],"exposure":[114],"different":[116],"glucose":[117,155],"solutions,":[118],"potent":[120],"adhesion":[121],"skin":[124,180],"compared":[125],"hydrogels":[127],"without":[128],"microstructures.":[129],"could":[133],"accelerate":[134],"process":[139],"with":[140],"decreased":[141],"inflammatory":[142],"reaction,":[143],"enhanced":[144],"collagen":[145],"deposition":[146],"regenerated":[149],"tissue":[150],"sites,":[151],"improved":[153],"blood":[154],"control":[156],"animals.":[158],"Therefore,":[159],"effective":[167],"management":[171],"has":[173],"potential":[174],"treatment":[176],"other":[178],"chronic":[179],"injuries.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":23},{"year":2025,"cited_by_count":35},{"year":2024,"cited_by_count":40},{"year":2023,"cited_by_count":40},{"year":2022,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-04-15T00:00:00"}
