{"id":"https://openalex.org/W4223595569","doi":"https://doi.org/10.1186/s13063-022-06213-z","title":"Trial of Early Antiviral Therapies during Non-hospitalized Outpatient Window (TREAT NOW) for COVID-19: a summary of the protocol and analysis plan for a decentralized randomized controlled trial","display_name":"Trial of Early Antiviral Therapies during Non-hospitalized Outpatient Window (TREAT NOW) for COVID-19: a summary of the protocol and analysis plan for a decentralized randomized controlled trial","publication_year":2022,"publication_date":"2022-04-08","ids":{"openalex":"https://openalex.org/W4223595569","doi":"https://doi.org/10.1186/s13063-022-06213-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/35395957","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8990452"},"language":"en","primary_location":{"id":"doi:10.1186/s13063-022-06213-z","doi":"https://doi.org/10.1186/s13063-022-06213-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13063-022-06213-z","pdf_url":"https://trialsjournal.biomedcentral.com/track/pdf/10.1186/s13063-022-06213-z","source":{"id":"https://openalex.org/S109512841","display_name":"Trials","issn_l":"1745-6215","issn":["1745-6215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://trialsjournal.biomedcentral.com/track/pdf/10.1186/s13063-022-06213-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043681011","display_name":"Alexander M. Kaizer","orcid":"https://orcid.org/0000-0003-2334-5514","observed_orcids":["https://orcid.org/0000-0003-2334-5514"]},"institutions":[{"id":"https://openalex.org/I151808059","display_name":"Colorado School of Public Health","ror":"https://ror.org/005x9g035","country_code":"US","type":"education","lineage":["https://openalex.org/I151808059"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander M. Kaizer","raw_affiliation_strings":["Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado, Aurora, USA. ALEX.KAIZER@CUANSCHUTZ.EDU","Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado, Aurora, USA"],"raw_orcid":"https://orcid.org/0000-0003-2334-5514","affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado, Aurora, USA. ALEX.KAIZER@CUANSCHUTZ.EDU","institution_ids":["https://openalex.org/I151808059"]},{"raw_affiliation_string":"Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado, Aurora, USA","institution_ids":["https://openalex.org/I151808059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005191806","display_name":"Jessica L. Wild","orcid":"https://orcid.org/0000-0002-2927-8239","observed_orcids":["https://orcid.org/0000-0002-2927-8239"]},"institutions":[{"id":"https://openalex.org/I151808059","display_name":"Colorado School of Public Health","ror":"https://ror.org/005x9g035","country_code":"US","type":"education","lineage":["https://openalex.org/I151808059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Wild","raw_affiliation_strings":["Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado, Aurora, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado, Aurora, USA","institution_ids":["https://openalex.org/I151808059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006953289","display_name":"Christopher John Lindsell","orcid":"https://orcid.org/0000-0002-3297-2811","observed_orcids":["https://orcid.org/0000-0002-3297-2811"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Lindsell","raw_affiliation_strings":["Department of Biostatistics, Vanderbilt University, Nashville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Vanderbilt University, Nashville, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049402910","display_name":"Todd W. Rice","orcid":"https://orcid.org/0000-0002-7136-5408","observed_orcids":["https://orcid.org/0000-0002-7136-5408"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd W. Rice","raw_affiliation_strings":["Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038114338","display_name":"Wesley H. Self","orcid":"https://orcid.org/0000-0002-9300-3045","observed_orcids":["https://orcid.org/0000-0002-9300-3045"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wesley H. Self","raw_affiliation_strings":["Department of Emergency Medicine and Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine and Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073422869","display_name":"Samuel Morris Brown","orcid":"https://orcid.org/0000-0003-1206-6261","observed_orcids":["https://orcid.org/0000-0003-1206-6261"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2803061204","display_name":"Intermountain Medical Center","ror":"https://ror.org/009c06z12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I108785884","https://openalex.org/I2803061204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Brown","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, USA","Division of Pulmonary and Critical Care Medicine, Department of Medicine, Intermountain Medical Center, Salt Lake City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Intermountain Medical Center, Salt Lake City, USA","institution_ids":["https://openalex.org/I2803061204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006201777","display_name":"Bruce Thompson","orcid":"https://orcid.org/0000-0001-6391-0448","observed_orcids":["https://orcid.org/0000-0001-6391-0448","https://orcid.org/0000-0002-5885-0652"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Taylor Thompson","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109923640","display_name":"Kimberly Ward Hart","orcid":"https://orcid.org/0009-0000-4432-9455","observed_orcids":["https://orcid.org/0009-0000-4432-9455"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly W. Hart","raw_affiliation_strings":["Department of Biostatistics, Vanderbilt University, Nashville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Vanderbilt University, Nashville, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018949363","display_name":"Clay B. Smith","orcid":"https://orcid.org/0000-0003-0429-4635","observed_orcids":["https://orcid.org/0000-0003-0429-4635"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clay Smith","raw_affiliation_strings":["Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063290842","display_name":"Michael S. Pulia","orcid":"https://orcid.org/0000-0001-5809-4060","observed_orcids":["https://orcid.org/0000-0001-5809-4060"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S. Pulia","raw_affiliation_strings":["Departments of Emergency Medicine and Industrial and Systems Engineering, University of Wisconsin-Madison, Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Emergency Medicine and Industrial and Systems Engineering, University of Wisconsin-Madison, Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039748898","display_name":"Nathan Ivan Shapiro","orcid":"https://orcid.org/0000-0003-3508-4390","observed_orcids":["https://orcid.org/0000-0003-3508-4390"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan I. Shapiro","raw_affiliation_strings":["Department of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029459847","display_name":"Adit A. Ginde","orcid":"https://orcid.org/0000-0003-2325-206X","observed_orcids":["https://orcid.org/0000-0003-2325-206X"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adit A. Ginde","raw_affiliation_strings":["Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, USA","institution_ids":["https://openalex.org/I51713134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5043681011"],"corresponding_institution_ids":["https://openalex.org/I151808059"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.7296,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.68794193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"23","issue":"1","first_page":"273","last_page":"273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11296","display_name":"COVID-19 and healthcare impacts","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.7929999828338623},{"id":"https://openalex.org/keywords/outpatient-care","display_name":"outpatient care","score":0.75},{"id":"https://openalex.org/keywords/mild-covid-19","display_name":"mild COVID-19","score":0.75},{"id":"https://openalex.org/keywords/hydroxychloroquine","display_name":"hydroxychloroquine","score":0.8960000276565552},{"id":"https://openalex.org/keywords/lopinavir-ritonavir","display_name":"lopinavir/ritonavir","score":1.0},{"id":"https://openalex.org/keywords/decentralized-clinical-trials","display_name":"decentralized clinical trials","score":0.8009999990463257},{"id":"https://openalex.org/keywords/adaptive-trial-design","display_name":"adaptive trial design","score":0.6430000066757202},{"id":"https://openalex.org/keywords/symptom-duration","display_name":"symptom duration","score":0.6100000143051147},{"id":"https://openalex.org/keywords/disease-progression-prevention","display_name":"disease progression prevention","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9116166234016418},{"id":"https://openalex.org/C2779123688","wikidata":"https://www.wikidata.org/wiki/Q421094","display_name":"Hydroxychloroquine","level":5,"score":0.7319488525390625},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6243221163749695},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6138054728507996},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5230870246887207},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.48962146043777466},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.46270325779914856},{"id":"https://openalex.org/C2777182164","wikidata":"https://www.wikidata.org/wiki/Q422585","display_name":"Lopinavir","level":5,"score":0.4535263180732727},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.41858017444610596},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.3422676920890808},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3367358446121216},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3304828107357025},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.3297632336616516},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.32358214259147644},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.18807876110076904},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08440771698951721},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000074099","descriptor_name":"Equivalence Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075522","descriptor_name":"Adaptive Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006886","descriptor_name":"Hydroxychloroquine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006886","descriptor_name":"Hydroxychloroquine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010045","descriptor_name":"Outpatients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015337","descriptor_name":"Multicenter Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064792","descriptor_name":"Pragmatic Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13063-022-06213-z","doi":"https://doi.org/10.1186/s13063-022-06213-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13063-022-06213-z","pdf_url":"https://trialsjournal.biomedcentral.com/track/pdf/10.1186/s13063-022-06213-z","source":{"id":"https://openalex.org/S109512841","display_name":"Trials","issn_l":"1745-6215","issn":["1745-6215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8990452","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8990452","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"Text"},{"id":"pmid:35395957","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35395957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"Clinical Trial Protocol"},{"id":"pmh:oai:doaj.org/article:1bf004d8143d460882da4454efee07ce","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1bf004d8143d460882da4454efee07ce","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Trials, Vol 23, Iss 1, Pp 1-12 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13063-022-06213-z","doi":"https://doi.org/10.1186/s13063-022-06213-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13063-022-06213-z","pdf_url":"https://trialsjournal.biomedcentral.com/track/pdf/10.1186/s13063-022-06213-z","source":{"id":"https://openalex.org/S109512841","display_name":"Trials","issn_l":"1745-6215","issn":["1745-6215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Study Protocol","id":"https://openalex.org/study-designs/study-protocol"}],"awards":[{"id":"https://openalex.org/G5819989809","display_name":null,"funder_award_id":"ID07200010-301-2","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G9000880388","display_name":"Statistical Methods and Adaptive Trial Designs for Cardiovascular Outcomes with Information Sharing","funder_award_id":"K01HL151754","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320333023","display_name":"AbbVie Biotherapeutics","ror":"https://ror.org/03a0g6939"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4223595569.pdf","grobid_xml":"https://content.openalex.org/works/W4223595569.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W2042819373","https://openalex.org/W3003668884","https://openalex.org/W3005212621","https://openalex.org/W3008125026","https://openalex.org/W3008928028","https://openalex.org/W3012379316","https://openalex.org/W3023346879","https://openalex.org/W3043308024","https://openalex.org/W3044118599","https://openalex.org/W3046496943","https://openalex.org/W3087151262","https://openalex.org/W3091868035","https://openalex.org/W3102453076","https://openalex.org/W3210957001","https://openalex.org/W4250454938"],"related_works":["https://openalex.org/W6920688490","https://openalex.org/W6939860402","https://openalex.org/W4388052115","https://openalex.org/W4388456426","https://openalex.org/W3182188484","https://openalex.org/W6906620555","https://openalex.org/W3185293010","https://openalex.org/W3167819168","https://openalex.org/W4404788051","https://openalex.org/W4412957766"],"abstract_inverted_index":{"BACKGROUND:":[0],"Coronavirus":[1],"disease":[2],"2019":[3],"(COVID-19)":[4],"has":[5,123,256],"a":[6,17,44,124,170,185,272],"heterogeneous":[7],"outcome":[8,174],"in":[9,35,55,82,135,215,271],"individuals":[10,214],"from":[11],"remaining":[12],"asymptomatic":[13],"to":[14,70,78,118,139,166,193,222,229,263],"death.":[15],"In":[16],"majority":[18],"of":[19,127,242],"cases,":[20],"mild":[21],"symptoms":[22,40,168],"are":[23,177],"present":[24],"that":[25,49],"do":[26],"not":[27],"require":[28],"hospitalization":[29],"and":[30,104,106,162,169,182,196,238,267],"can":[31,210],"be":[32,132,211],"successfully":[33],"treated":[34],"the":[36,76,83,109,216,234,240,252],"outpatient":[37,217],"setting,":[38],"though":[39],"may":[41],"persist":[42],"for":[43,52,149,208,213,236],"long":[45],"duration.":[46],"We":[47],"hypothesize":[48],"drugs":[50],"suitable":[51],"decentralized":[53],"study":[54,188,194,269],"outpatients":[56,62],"will":[57,131,226],"have":[58],"efficacy":[59],"among":[60],"infected":[61],"METHODS:":[63],"The":[64,244],"TREAT":[65,85,253],"NOW":[66,86,254],"platform":[67,255],"is":[68,87,190],"designed":[69],"accommodate":[71],"testing":[72],"multiple":[73],"agents":[74,81],"with":[75,99,108,152,184],"ability":[77],"incorporate":[79],"new":[80],"future.":[84],"an":[88,136,142],"adaptive,":[89],"blinded,":[90],"multi-center,":[91],"placebo-controlled":[92],"superiority":[93],"randomized":[94],"clinical":[95],"trial":[96],"which":[97],"started":[98],"two":[100],"active":[101,143],"therapies":[102],"(hydroxychloroquine":[103],"lopinavir/ritonavir)":[105],"placebo,":[107],"hydroxychloroquine":[110],"arm":[111,122],"dropped":[112],"shortly":[113],"after":[114],"enrollment":[115,126],"began":[116],"due":[117],"external":[119],"evidence.":[120],"Each":[121],"target":[125],"300":[128],"participants":[129],"who":[130],"randomly":[133],"assigned":[134],"equal":[137],"allocation":[138],"receive":[140],"either":[141],"therapy":[144],"or":[145],"placebo":[146],"twice":[147],"daily":[148,153],"14":[150],"days":[151,158],"electronic":[154],"surveys":[155],"collected":[156],"over":[157,259],"1":[159],"through":[160],"16":[161],"on":[163,282,288],"day":[164],"29":[165],"evaluate":[167],"modified":[171],"COVID-19":[172,209],"ordinal":[173],"scale.":[175],"Participants":[176],"enrolled":[178],"remotely":[179],"by":[180,251],"telephone":[181],"consented":[183],"digital":[186],"interface,":[187],"drug":[189],"overnight":[191],"mailed":[192],"participants,":[195],"data":[197],"collection":[198],"occurs":[199],"electronically":[200],"without":[201],"in-person":[202,261],"interactions.":[203],"DISCUSSION:":[204],"If":[205],"effective":[206],"treatments":[207],"identified":[212],"setting":[218],"before":[219],"they":[220],"advance":[221],"severe":[223,231],"disease,":[224,232],"it":[225],"prevent":[227],"progression":[228],"more":[230],"reduce":[233],"need":[235],"hospitalization,":[237],"shorten":[239],"duration":[241],"symptoms.":[243],"novel":[245],"decentralized,":[246],"\"no":[247],"touch\"":[248],"approach":[249],"used":[250],"distinction":[257],"advantages":[258],"traditional":[260],"trials":[262],"reach":[264],"broader":[265],"populations":[266],"perform":[268],"procedures":[270],"pragmatic":[273],"yet":[274],"rigorous":[275],"manner.":[276],"TRIAL":[277],"REGISTRATION:":[278],"ClinicalTrials.gov":[279],"NCT04372628.":[280],"Registered":[281],"April":[283],"30,":[284],"2020.":[285,291],"First":[286],"posted":[287],"May":[289],"4,":[290]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-04-15T00:00:00"}
