{"id":"https://openalex.org/W4223593367","doi":"https://doi.org/10.1016/j.envint.2022.107242","title":"Ozone exposure and blood transcriptome: A randomized, controlled, crossover trial among healthy adults","display_name":"Ozone exposure and blood transcriptome: A randomized, controlled, crossover trial among healthy adults","publication_year":2022,"publication_date":"2022-04-11","ids":{"openalex":"https://openalex.org/W4223593367","doi":"https://doi.org/10.1016/j.envint.2022.107242","pmid":"https://pubmed.ncbi.nlm.nih.gov/35430440"},"language":"en","primary_location":{"id":"doi:10.1016/j.envint.2022.107242","doi":"https://doi.org/10.1016/j.envint.2022.107242","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.envint.2022.107242","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0160412022001684/pdf","source":{"id":"https://openalex.org/S143381477","display_name":"Environment International","issn_l":"0160-4120","issn":["0160-4120","1873-6750"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environment International","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S0160412022001684/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066843127","display_name":"Xihao Du","orcid":"https://orcid.org/0000-0001-6060-3071","observed_orcids":["https://orcid.org/0000-0001-6060-3071"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xihao Du","raw_affiliation_strings":["School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079485108","display_name":"Yue Niu","orcid":"https://orcid.org/0000-0001-5735-4959","observed_orcids":["https://orcid.org/0000-0001-5735-4959","https://orcid.org/0000-0001-9819-8614"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Niu","raw_affiliation_strings":["School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100695152","display_name":"Cuiping Wang","orcid":"https://orcid.org/0000-0002-4249-709X","observed_orcids":["https://orcid.org/0000-0002-4249-709X"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cuiping Wang","raw_affiliation_strings":["School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100432921","display_name":"Weidong Wang","orcid":"https://orcid.org/0000-0001-8206-0282","observed_orcids":["https://orcid.org/0000-0001-8206-0282"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weidong Wang","raw_affiliation_strings":["School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100331635","display_name":"Cong Liu","orcid":"https://orcid.org/0000-0003-2192-6489","observed_orcids":["https://orcid.org/0000-0003-2192-6489"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cong Liu","raw_affiliation_strings":["School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013523273","display_name":"Xia Meng","orcid":"https://orcid.org/0000-0002-0751-1722","observed_orcids":["https://orcid.org/0000-0002-0751-1722"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Meng","raw_affiliation_strings":["School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100741518","display_name":"Chu Chen","orcid":"https://orcid.org/0000-0003-2267-8050","observed_orcids":["https://orcid.org/0000-0003-2267-8050","https://orcid.org/0000-0002-8952-573X"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159329","display_name":"Children's Hospital of Fudan University","ror":"https://ror.org/05n13be63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159329"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chen Chu","raw_affiliation_strings":["Heart Center, Children's Hospital of Fudan University, National Center for Children's Health, Shanghai 201102, China. Electronic address: chickenchu@163.com","Heart Center, Children's Hospital of Fudan University, National Center for Children's Health, Shanghai 201102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center, Children's Hospital of Fudan University, National Center for Children's Health, Shanghai 201102, China. Electronic address: chickenchu@163.com","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159329"]},{"raw_affiliation_string":"Heart Center, Children's Hospital of Fudan University, National Center for Children's Health, Shanghai 201102, China","institution_ids":["https://openalex.org/I4210159329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100694762","display_name":"Renjie Chen","orcid":"https://orcid.org/0000-0002-9448-0820","observed_orcids":["https://orcid.org/0000-0002-9448-0820"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Renjie Chen","raw_affiliation_strings":["School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China. Electronic address: chenrenjie@fudan.edu.cn","School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China. Electronic address: chenrenjie@fudan.edu.cn","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013092108","display_name":"Haidong Kan","orcid":"https://orcid.org/0000-0002-1871-8999","observed_orcids":["https://orcid.org/0000-0002-1871-8999"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haidong Kan","raw_affiliation_strings":["School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Shanghai Institute of Infectious Disease and Biosecurity, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100694762","https://openalex.org/A5100741518"],"corresponding_institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159329"],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":{"value":3610,"currency":"USD","value_usd":3610},"fwci":1.3412,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.7507313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"163","issue":null,"first_page":"107242","last_page":"107242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11002","display_name":"Indoor Air Quality and Microbial Exposure","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ozone-exposure","display_name":"ozone exposure","score":0.9589999914169312},{"id":"https://openalex.org/keywords/blood-transcriptome","display_name":"blood transcriptome","score":0.8159999847412109},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.7409999966621399},{"id":"https://openalex.org/keywords/neutrophil-degranulation","display_name":"neutrophil degranulation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9169999957084656},{"id":"https://openalex.org/keywords/glucocorticoid-receptor-signaling","display_name":"glucocorticoid receptor signaling","score":1.0},{"id":"https://openalex.org/keywords/healthy-young-adults","display_name":"healthy young adults","score":0.5709999799728394},{"id":"https://openalex.org/keywords/rna-sequencing","display_name":"RNA sequencing","score":0.3479999899864197}],"concepts":[{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.6907109022140503},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6378659009933472},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5926748514175415},{"id":"https://openalex.org/C122507166","wikidata":"https://www.wikidata.org/wiki/Q628906","display_name":"Crossover","level":2,"score":0.4905690550804138},{"id":"https://openalex.org/C508106653","wikidata":"https://www.wikidata.org/wiki/Q36933","display_name":"Ozone","level":2,"score":0.41354721784591675},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39091286063194275},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3810965418815613},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.37139129638671875},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.35132694244384766},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27033236622810364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1762750744819641},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1357744336128235},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12837505340576172},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.12253865599632263},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.1142224371433258},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11285403370857239},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08193519711494446},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000393","descriptor_name":"Air Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010126","descriptor_name":"Ozone","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.envint.2022.107242","doi":"https://doi.org/10.1016/j.envint.2022.107242","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.envint.2022.107242","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0160412022001684/pdf","source":{"id":"https://openalex.org/S143381477","display_name":"Environment International","issn_l":"0160-4120","issn":["0160-4120","1873-6750"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environment International","raw_type":"journal-article"},{"id":"pmid:35430440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35430440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environment international","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b4b8f269d2dc44df9ce1fcedebabc048","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b4b8f269d2dc44df9ce1fcedebabc048","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Environment International, Vol 163, Iss , Pp 107242- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.envint.2022.107242","doi":"https://doi.org/10.1016/j.envint.2022.107242","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.envint.2022.107242","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0160412022001684/pdf","source":{"id":"https://openalex.org/S143381477","display_name":"Environment International","issn_l":"0160-4120","issn":["0160-4120","1873-6750"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environment International","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G1115659565","display_name":null,"funder_award_id":"92043301","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6690785075","display_name":null,"funder_award_id":"82030103","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G6801590115","display_name":null,"funder_award_id":"GWV-10.1-XK11","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7007758946","display_name":null,"funder_award_id":"92043301","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G8113790401","display_name":null,"funder_award_id":"82030103","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4223593367.pdf","grobid_xml":"https://content.openalex.org/works/W4223593367.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W624676297","https://openalex.org/W1964047410","https://openalex.org/W2006185943","https://openalex.org/W2097082612","https://openalex.org/W2120026123","https://openalex.org/W2146512944","https://openalex.org/W2148856081","https://openalex.org/W2159533784","https://openalex.org/W2172238206","https://openalex.org/W2224963001","https://openalex.org/W2321108629","https://openalex.org/W2429031812","https://openalex.org/W2550190683","https://openalex.org/W2588976094","https://openalex.org/W2617831508","https://openalex.org/W2768033464","https://openalex.org/W2793204952","https://openalex.org/W2801534526","https://openalex.org/W2809535657","https://openalex.org/W2809751535","https://openalex.org/W2822386675","https://openalex.org/W2889664408","https://openalex.org/W2901222235","https://openalex.org/W2937102232","https://openalex.org/W2951832587","https://openalex.org/W2976532919","https://openalex.org/W2981938452","https://openalex.org/W2998444755","https://openalex.org/W3022781531","https://openalex.org/W3026646312","https://openalex.org/W3036913367","https://openalex.org/W3082691563","https://openalex.org/W3085189456","https://openalex.org/W3092861045","https://openalex.org/W3110464087","https://openalex.org/W3154578622","https://openalex.org/W3185549550","https://openalex.org/W6761062821"],"related_works":["https://openalex.org/W3092592394","https://openalex.org/W4410273743","https://openalex.org/W2981191564","https://openalex.org/W7154488897","https://openalex.org/W4386583874","https://openalex.org/W3202359646","https://openalex.org/W2277006662","https://openalex.org/W2170173300","https://openalex.org/W2023057447","https://openalex.org/W6920876741"],"abstract_inverted_index":{"RATIONALE:":[0],"Transcriptome-wide":[1],"analysis":[2,215],"is":[3],"powerful":[4],"in":[5,49,103,170,245,261],"studying":[6],"systemic":[7,274],"RNA":[8,39],"changes":[9,242],"following":[10],"environmental":[11],"exposures.":[12],"However,":[13],"impacts":[14],"of":[15,31,63,78,111,128,149,178,188,194,218,243,254,263,277],"ozone":[16,33,64,92,129,144,161,223,248],"inhalation":[17],"on":[18,35],"circulating":[19,36],"transcriptome":[20,37,123],"have":[21],"not":[22],"yet":[23],"been":[24],"examined.":[25],"OBJECTIVES:":[26],"To":[27],"explore":[28],"the":[29,76,104,195,234,240,273],"impact":[30],"acute":[32],"exposure":[34,54,61,93,145,162],"using":[38,96],"sequencing":[40],"(RNA-seq).":[41],"METHODS:":[42],"We":[43,250],"recruited":[44],"32":[45],"healthy":[46],"young":[47],"adults":[48],"a":[50,164,175,252],"randomized,":[51],"crossover,":[52],"controlled":[53],"trial.":[55],"Each":[56],"participant":[57],"completed":[58],"two":[59],"2-h":[60],"sessions":[62],"(200":[65],"ppb)":[66],"and":[67,81,117,138,157,210,228,266],"clean":[68,136],"air,":[69],"respectively.":[70],"Blood":[71],"samples":[72,121],"were":[73,82,94,152,199,220,259],"collected":[74],"at":[75,163],"end":[77],"each":[79],"session":[80],"used":[83],"for":[84,122],"RNA-seq.":[85],"The":[86,125,184],"differentially":[87,196,255],"expressed":[88,197,256],"genes":[89,151,173,198,257],"associated":[90],"with":[91],"assessed":[95],"Bayesian":[97],"adjusted":[98],"statistics":[99],"from":[100],"linear":[101],"models":[102],"limma":[105],"R":[106],"package.":[107],"RESULTS:":[108],"A":[109,147],"total":[110,148],"29":[112],"participants":[113],"finished":[114],"this":[115,237],"trial":[116,238],"donated":[118],"their":[119],"blood":[120],"analysis.":[124],"average":[126],"concentration":[127],"was":[130],"7.8":[131],"\u00b1":[132,140],"2.6":[133],"ppb":[134,142],"under":[135,143],"air":[137],"201.1":[139],"1.7":[141],"session.":[146],"1899":[150],"significantly":[153],"changed":[154],"(1067":[155],"up-regulated":[156],"832":[158],"down-regulated)":[159],"by":[160],"false":[165],"discovery":[166],"rate":[167],"<":[168,182],"0.05,":[169],"which":[171],"403":[172],"had":[174],"fold":[176],"change":[177],">":[179],"1.2":[180],"or":[181],"0.8.":[183],"top":[185],"10":[186],"terms":[187],"biological":[189,264,270],"processes":[190,265],"showed":[191,216],"that":[192,258],"most":[193],"related":[200],"to":[201,247],"various":[202],"functions,":[203],"such":[204],"as":[205],"neutrophil":[206,211],"degranulation,":[207],"immune":[208],"response,":[209],"activation.":[212],"Pathway":[213],"enrichment":[214],"dozens":[217,262],"pathways":[219],"dysregulated":[221],"after":[222],"exposure,":[224],"including":[225],"mitochondrial":[226],"dysfunction,":[227],"glucocorticoid":[229],"receptor":[230],"signaling.":[231],"CONCLUSION:":[232],"For":[233],"first":[235],"time":[236],"characterized":[239],"genome-wide":[241],"mRNA":[244],"response":[246],"exposure.":[249],"identified":[251],"range":[253],"involved":[260],"pathways,":[267],"providing":[268],"novel":[269],"insights":[271],"into":[272],"health":[275],"effects":[276],"ozone.":[278]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-04-15T00:00:00"}
