{"id":"https://openalex.org/W4223563025","doi":"https://doi.org/10.3390/ijms23073925","title":"Recycled Sericin Hydrolysates Modified by Alcalase\u00ae Suppress Melanogenesis in Human Melanin-Producing Cells via Modulating MITF","display_name":"Recycled Sericin Hydrolysates Modified by Alcalase\u00ae Suppress Melanogenesis in Human Melanin-Producing Cells via Modulating MITF","publication_year":2022,"publication_date":"2022-04-01","ids":{"openalex":"https://openalex.org/W4223563025","doi":"https://doi.org/10.3390/ijms23073925","pmid":"https://pubmed.ncbi.nlm.nih.gov/35409284","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8999004"},"language":"en","primary_location":{"id":"doi:10.3390/ijms23073925","doi":"https://doi.org/10.3390/ijms23073925","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23073925","pdf_url":"https://www.mdpi.com/1422-0067/23/7/3925/pdf?version=1648803836","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/7/3925/pdf?version=1648803836","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028300863","display_name":"Keerati Joyjamras","orcid":"https://orcid.org/0000-0003-4867-4760","observed_orcids":["https://orcid.org/0000-0003-4867-4760"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Keerati Joyjamras","raw_affiliation_strings":["Graduate Program of Pharmaceutical Sciences and Technology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10300, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program of Pharmaceutical Sciences and Technology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10300, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076011733","display_name":"Ponsawan Netcharoensirisuk","orcid":"https://orcid.org/0000-0002-2267-4351","observed_orcids":["https://orcid.org/0000-0002-2267-4351"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Ponsawan Netcharoensirisuk","raw_affiliation_strings":["Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084521790","display_name":"Sittiruk Roytrakul","orcid":"https://orcid.org/0000-0003-3696-8390","observed_orcids":["https://orcid.org/0000-0003-3696-8390"]},"institutions":[{"id":"https://openalex.org/I1332092204","display_name":"National Science and Technology Development Agency","ror":"https://ror.org/04vy95b61","country_code":"TH","type":"government","lineage":["https://openalex.org/I1332092204"]},{"id":"https://openalex.org/I902798049","display_name":"National Center for Genetic Engineering and Biotechnology","ror":"https://ror.org/047aswc67","country_code":"TH","type":"facility","lineage":["https://openalex.org/I1332092204","https://openalex.org/I902798049"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Sittiruk Roytrakul","raw_affiliation_strings":["Functional Ingredients and Food Innovation Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani 12120, Thailand"],"raw_orcid":"https://orcid.org/0000-0003-3696-8390","affiliations":[{"raw_affiliation_string":"Functional Ingredients and Food Innovation Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani 12120, Thailand","institution_ids":["https://openalex.org/I1332092204","https://openalex.org/I902798049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019794851","display_name":"Pithi Chanvorachote B","orcid":"https://orcid.org/0000-0002-3103-3249","observed_orcids":["https://orcid.org/0000-0002-3103-3249","https://orcid.org/0000-0003-1700-0640"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Pithi Chanvorachote","raw_affiliation_strings":["Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand","Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]},{"raw_affiliation_string":"Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022507789","display_name":"Chatchai Chaotham","orcid":"https://orcid.org/0000-0002-3206-192X","observed_orcids":["https://orcid.org/0000-0002-3206-192X"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Chatchai Chaotham","raw_affiliation_strings":["Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand","Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]},{"raw_affiliation_string":"Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019794851","https://openalex.org/A5022507789"],"corresponding_institution_ids":["https://openalex.org/I158708052"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":1.1445,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.71299499,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"23","issue":"7","first_page":"3925","last_page":"3925"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanogenesis-inhibition","display_name":"melanogenesis inhibition","score":0.7599999904632568},{"id":"https://openalex.org/keywords/mitf","display_name":"MITF","score":0.906000018119812},{"id":"https://openalex.org/keywords/tyrosinase","display_name":"tyrosinase","score":0.9779999852180481},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.531000018119812},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8999999761581421},{"id":"https://openalex.org/keywords/melanoma-cells","display_name":"melanoma cells","score":0.6389999985694885},{"id":"https://openalex.org/keywords/hyperpigmentation","display_name":"hyperpigmentation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/peptidomics","display_name":"peptidomics","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C206767735","wikidata":"https://www.wikidata.org/wiki/Q2983186","display_name":"Sericin","level":3,"score":0.9796881675720215},{"id":"https://openalex.org/C177504595","wikidata":"https://www.wikidata.org/wiki/Q336500","display_name":"Microphthalmia-associated transcription factor","level":4,"score":0.9533153772354126},{"id":"https://openalex.org/C28800991","wikidata":"https://www.wikidata.org/wiki/Q15634405","display_name":"Hydrolysate","level":3,"score":0.8147002458572388},{"id":"https://openalex.org/C107538193","wikidata":"https://www.wikidata.org/wiki/Q187526","display_name":"Melanin","level":2,"score":0.6840709447860718},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6621447801589966},{"id":"https://openalex.org/C87554066","wikidata":"https://www.wikidata.org/wiki/Q85942926","display_name":"Tyrosinase","level":3,"score":0.5602794289588928},{"id":"https://openalex.org/C122302759","wikidata":"https://www.wikidata.org/wiki/Q2345087","display_name":"Fibroin","level":3,"score":0.4636806845664978},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.42705225944519043},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.375186562538147},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36844098567962646},{"id":"https://openalex.org/C2780431358","wikidata":"https://www.wikidata.org/wiki/Q653622","display_name":"SILK","level":2,"score":0.3442206084728241},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33887577056884766},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3320184648036957},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.24870309233665466},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21481123566627502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17822769284248352},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.13196852803230286},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013381","descriptor_name":"Subtilisins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013381","descriptor_name":"Subtilisins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014442","descriptor_name":"Monophenol Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047030","descriptor_name":"Sericins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047030","descriptor_name":"Sericins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051739","descriptor_name":"Microphthalmia-Associated Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051739","descriptor_name":"Microphthalmia-Associated Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms23073925","doi":"https://doi.org/10.3390/ijms23073925","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23073925","pdf_url":"https://www.mdpi.com/1422-0067/23/7/3925/pdf?version=1648803836","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:35409284","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35409284","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8999004","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8999004/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms23073925","doi":"https://doi.org/10.3390/ijms23073925","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23073925","pdf_url":"https://www.mdpi.com/1422-0067/23/7/3925/pdf?version=1648803836","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2378477385","display_name":null,"funder_award_id":"PHD61I0037","funder_id":"https://openalex.org/F4320322817","funder_display_name":"National Research Council of Thailand"}],"funders":[{"id":"https://openalex.org/F4320322817","display_name":"National Research Council of Thailand","ror":"https://ror.org/018wfhg78"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4223563025.pdf","grobid_xml":"https://content.openalex.org/works/W4223563025.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W157351941","https://openalex.org/W1550461747","https://openalex.org/W1937091029","https://openalex.org/W1968843680","https://openalex.org/W1973632674","https://openalex.org/W1985970349","https://openalex.org/W1990390159","https://openalex.org/W1995729874","https://openalex.org/W2025665097","https://openalex.org/W2033052131","https://openalex.org/W2033652927","https://openalex.org/W2039792487","https://openalex.org/W2043584813","https://openalex.org/W2079028949","https://openalex.org/W2079924190","https://openalex.org/W2087375532","https://openalex.org/W2089173136","https://openalex.org/W2090020569","https://openalex.org/W2098763910","https://openalex.org/W2100838948","https://openalex.org/W2120574479","https://openalex.org/W2135245421","https://openalex.org/W2148488230","https://openalex.org/W2156931352","https://openalex.org/W2157471770","https://openalex.org/W2167973356","https://openalex.org/W2202302911","https://openalex.org/W2254072889","https://openalex.org/W2331343452","https://openalex.org/W2412145118","https://openalex.org/W2463195069","https://openalex.org/W2466687618","https://openalex.org/W2471321097","https://openalex.org/W2518186484","https://openalex.org/W2549467168","https://openalex.org/W2553157303","https://openalex.org/W2559319322","https://openalex.org/W2585096642","https://openalex.org/W2786693416","https://openalex.org/W2884117591","https://openalex.org/W2902234339","https://openalex.org/W2971091456","https://openalex.org/W2973551245","https://openalex.org/W3017925323","https://openalex.org/W3080085469","https://openalex.org/W3080678070","https://openalex.org/W3095031252","https://openalex.org/W3110738372","https://openalex.org/W3112282885","https://openalex.org/W3136342941","https://openalex.org/W3153160673","https://openalex.org/W3186350812","https://openalex.org/W3193545011","https://openalex.org/W3205268042"],"related_works":["https://openalex.org/W4386789962","https://openalex.org/W2902946423","https://openalex.org/W2958899905","https://openalex.org/W2402509114","https://openalex.org/W4210992799","https://openalex.org/W3174305532","https://openalex.org/W4246603726","https://openalex.org/W2120574479","https://openalex.org/W4242400859","https://openalex.org/W4407059073"],"abstract_inverted_index":{"to":[0],"evaluate":[1],"its":[2],"anti-melanogenic":[3],"activity":[4,68],"in":[5,15,59,79,120,149],"human":[6,60,150],"melanin-producing":[7,151],"cells.":[8,63,152],"Sericin":[9],"hydrolysates":[10,52,128,136],"consisted":[11],"of":[12,50,56,75,95,109,158,173],"sericin-related":[13],"peptides":[14],"differing":[16],"amounts":[17],"and":[18,30,170],"smaller":[19],"sizes":[20],"compared":[21,42],"with":[22,43,83,106,124,134],"unhydrolyzed":[23,44],"sericin,":[24],"as":[25,114,167],"respectively":[26],"demonstrated":[27],"by":[28,116],"peptidomic":[29],"SDS-PAGE":[31],"analysis.":[32],"The":[33],"lower":[34],"half-maximum":[35],"inhibitory":[36],"concentration":[37],"(9.05":[38],"\u00b1":[39],"0.66":[40],"mg/mL)":[41],"sericin":[45,51,86,127,135],"indicated":[46],"a":[47,71,100,143,168],"potent":[48],"effect":[49],"on":[53],"the":[54,91,107,156,161],"diminution":[55],"melanin":[57],"content":[58],"melanoma":[61],"MNT1":[62,80,121],"Not":[64],"only":[65],"inhibiting":[66],"enzymatic":[67],"but":[69],"also":[70,140],"downregulated":[72],"expression":[73],"level":[74,94],"tyrosinase":[76,101],"was":[77],"evident":[78],"cells":[81,122],"incubated":[82],"20":[84,125],"mg/mL":[85,126],"hydrolysates.":[87],"Quantitative":[88],"RT-PCR":[89],"revealed":[90],"decreased":[92],"mRNA":[93],"microphthalmia-associated":[96],"transcription":[97,102],"factor":[98],"(MITF),":[99],"factor,":[103],"which":[104],"correlated":[105],"reduction":[108],"pCREB/CREB,":[110],"an":[111],"upstream":[112],"cascade,":[113],"assessed":[115],"Western":[117],"blot":[118],"analysis":[119],"cultured":[123],"for":[129,137,164],"12":[130],"h.":[131],"Interestingly,":[132],"treatment":[133,172],"6-24":[138],"h":[139],"upregulated":[141],"pERK,":[142],"molecule":[144],"that":[145],"triggers":[146],"MITF":[147],"degradation,":[148],"These":[153],"results":[154],"warrant":[155],"recycling":[157],"wastewater":[159],"from":[160],"silk":[162],"industry":[163],"further":[165],"development":[166],"safe":[169],"effective":[171],"hyperpigmentation":[174],"disorders.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-04-15T00:00:00"}
