{"id":"https://openalex.org/W4223554688","doi":"https://doi.org/10.1161/circulationaha.121.058595","title":"Prioritizing Quad Therapy and the Path Forward in Guideline-Directed Medical Therapy for Patients With Heart Failure With Reduced Ejection Fraction","display_name":"Prioritizing Quad Therapy and the Path Forward in Guideline-Directed Medical Therapy for Patients With Heart Failure With Reduced Ejection Fraction","publication_year":2022,"publication_date":"2022-04-11","ids":{"openalex":"https://openalex.org/W4223554688","doi":"https://doi.org/10.1161/circulationaha.121.058595","pmid":"https://pubmed.ncbi.nlm.nih.gov/35404676"},"language":"en","primary_location":{"id":"doi:10.1161/circulationaha.121.058595","doi":"https://doi.org/10.1161/circulationaha.121.058595","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circulationaha.121.058595","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009193721","display_name":"Josephine Harrington","orcid":"https://orcid.org/0000-0001-5169-117X","observed_orcids":["https://orcid.org/0000-0001-5169-117X"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4405286153","display_name":"Duke Clinical Research Institute","ror":"https://ror.org/019mv4g96","country_code":"US","type":"facility","lineage":["https://openalex.org/I170897317","https://openalex.org/I4405286153"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josephine Harrington","raw_affiliation_strings":["Duke Clinical Research Institute (J.H., R.J.M.), Durham, NC","Duke University School of Medicine (J.H., R.J.M.), Durham, NC","Josephine Harrington https://orcid.org/0000-0001-5169-117X Duke University School of Medicine (J.H., R.J.M.), Durham, NC. Duke Clinical Research Institute (J.H., R.J.M.), Durham, NC"],"raw_orcid":"https://orcid.org/0000-0001-5169-117X","affiliations":[{"raw_affiliation_string":"Duke Clinical Research Institute (J.H., R.J.M.), Durham, NC","institution_ids":["https://openalex.org/I4405286153"]},{"raw_affiliation_string":"Duke University School of Medicine (J.H., R.J.M.), Durham, NC","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Josephine Harrington https://orcid.org/0000-0001-5169-117X Duke University School of Medicine (J.H., R.J.M.), Durham, NC. Duke Clinical Research Institute (J.H., R.J.M.), Durham, NC","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4405286153"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068642565","display_name":"Robert John Mentz","orcid":"https://orcid.org/0000-0002-3222-1719","observed_orcids":["https://orcid.org/0000-0002-3222-1719"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4405286153","display_name":"Duke Clinical Research Institute","ror":"https://ror.org/019mv4g96","country_code":"US","type":"facility","lineage":["https://openalex.org/I170897317","https://openalex.org/I4405286153"]}],"countries":["CH","US"],"is_corresponding":true,"raw_author_name":"Robert J. Mentz","raw_affiliation_strings":["Duke Clinical Research Institute (J.H., R.J.M.), Durham, NC","Duke University School of Medicine (J.H., R.J.M.), Durham, NC","Duke University School of Medicine, 200 Trent Dr, 4th Floor, Orange Zone, Room 4221, Durham, NC 27710","Fast BioMedical, Gilead, Innolife, Medtronic, Merck, Novartis, Re-lypsa, Respicardia, Roche,"],"raw_orcid":"https://orcid.org/0000-0002-3222-1719","affiliations":[{"raw_affiliation_string":"Duke Clinical Research Institute (J.H., R.J.M.), Durham, NC","institution_ids":["https://openalex.org/I4405286153"]},{"raw_affiliation_string":"Duke University School of Medicine (J.H., R.J.M.), Durham, NC","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Duke University School of Medicine, 200 Trent Dr, 4th Floor, Orange Zone, Room 4221, Durham, NC 27710","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Fast BioMedical, Gilead, Innolife, Medtronic, Merck, Novartis, Re-lypsa, Respicardia, Roche,","institution_ids":["https://openalex.org/I1283582996"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5068642565"],"corresponding_institution_ids":["https://openalex.org/I1283582996","https://openalex.org/I170897317","https://openalex.org/I4210126298","https://openalex.org/I4405286153"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"145","issue":"15","first_page":"1105","last_page":"1107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure-with-reduced-ejection-fraction","display_name":"heart failure with reduced ejection fraction","score":0.9679999947547913},{"id":"https://openalex.org/keywords/guideline-directed-medical-therapy","display_name":"guideline-directed medical therapy","score":0.8180000185966492},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.7080000042915344},{"id":"https://openalex.org/keywords/mineralocorticoid-receptor-antagonists","display_name":"mineralocorticoid receptor antagonists","score":0.8579999804496765},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.7379999756813049},{"id":"https://openalex.org/keywords/renin-angiotensin-system-inhibitors","display_name":"renin-angiotensin system inhibitors","score":0.7609999775886536},{"id":"https://openalex.org/keywords/treatment-prioritization","display_name":"treatment prioritization","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.8278146982192993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7610352039337158},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7051689624786377},{"id":"https://openalex.org/C2780182762","wikidata":"https://www.wikidata.org/wiki/Q1630279","display_name":"Guideline","level":2,"score":0.7030720710754395},{"id":"https://openalex.org/C2994510025","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Medical therapy","level":2,"score":0.5221986174583435},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43927818536758423},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.39626187086105347},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07560145854949951}],"mesh":[{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1161/circulationaha.121.058595","doi":"https://doi.org/10.1161/circulationaha.121.058595","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circulationaha.121.058595","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:35404676","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35404676","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W14989627","https://openalex.org/W2744242890","https://openalex.org/W2745438221","https://openalex.org/W4238907867"],"related_works":["https://openalex.org/W4389039038","https://openalex.org/W4405272470","https://openalex.org/W7087775144","https://openalex.org/W4378700872","https://openalex.org/W4393995938","https://openalex.org/W4400003698","https://openalex.org/W7220391665","https://openalex.org/W4401325920","https://openalex.org/W6960031638","https://openalex.org/W4396743103"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-04-15T00:00:00"}