{"id":"https://openalex.org/W4223554541","doi":"https://doi.org/10.1021/acsomega.1c07335","title":"Interpreting the Pharmacological Mechanisms of Sho-saiko-to on Thyroid Carcinoma through Combining Network Pharmacology and Experimental Evaluation","display_name":"Interpreting the Pharmacological Mechanisms of Sho-saiko-to on Thyroid Carcinoma through Combining Network Pharmacology and Experimental Evaluation","publication_year":2022,"publication_date":"2022-03-25","ids":{"openalex":"https://openalex.org/W4223554541","doi":"https://doi.org/10.1021/acsomega.1c07335","pmid":"https://pubmed.ncbi.nlm.nih.gov/35415320","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8991932"},"language":"en","primary_location":{"id":"doi:10.1021/acsomega.1c07335","doi":"https://doi.org/10.1021/acsomega.1c07335","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.1c07335","pdf_url":null,"source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1021/acsomega.1c07335","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100366745","display_name":"Kun Wang","orcid":"https://orcid.org/0009-0007-3950-3130","observed_orcids":["https://orcid.org/0009-0007-3950-3130"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Wang","raw_affiliation_strings":["Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022909271","display_name":"Ruijie Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruijie Qian","raw_affiliation_strings":["Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100455575","display_name":"Hongyan Li","orcid":"https://orcid.org/0000-0002-0158-3979","observed_orcids":["https://orcid.org/0000-0002-0158-3979"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyan Li","raw_affiliation_strings":["Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100424707","display_name":"Chenyang Wang","orcid":"https://orcid.org/0009-0007-6895-4897","observed_orcids":["https://orcid.org/0009-0007-6895-4897","https://orcid.org/0009-0004-0080-3898"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenyang Wang","raw_affiliation_strings":["Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101894056","display_name":"Ying Ding","orcid":"https://orcid.org/0000-0003-2238-9873","observed_orcids":["https://orcid.org/0000-0003-2238-9873"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Ding","raw_affiliation_strings":["Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080154009","display_name":"Zairong Gao","orcid":"https://orcid.org/0000-0002-8367-2659","observed_orcids":["https://orcid.org/0000-0002-8367-2659"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zairong Gao","raw_affiliation_strings":["Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, China"],"raw_orcid":"https://orcid.org/0000-0002-8367-2659","affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080154009"],"corresponding_institution_ids":["https://openalex.org/I47720641"],"apc_list":{"value":1250,"currency":"USD","value_usd":1250},"apc_paid":{"value":1250,"currency":"USD","value_usd":1250},"fwci":0.9352,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.70381336,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"13","first_page":"11166","last_page":"11176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.885699987411499,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.885699987411499,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.04399999976158142,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sho-saiko-to","display_name":"Sho-saiko-to","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"thyroid cancer","score":0.8309999704360962},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.8669999837875366},{"id":"https://openalex.org/keywords/active-ingredients","display_name":"active ingredients","score":0.5519999861717224},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9049999713897705},{"id":"https://openalex.org/keywords/anaplastic-thyroid-carcinoma","display_name":"anaplastic thyroid carcinoma","score":0.8080000281333923},{"id":"https://openalex.org/keywords/redifferentiation","display_name":"redifferentiation","score":0.722000002861023},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5429999828338623},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.4869999885559082},{"id":"https://openalex.org/keywords/network-pharmacology","display_name":"network pharmacology","score":0.652999997138977},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6423049569129944},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.6083818674087524},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.5964193344116211},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5776544809341431},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.529183566570282},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4984416961669922},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.4821200370788574},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4476090967655182},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.410478413105011},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.230852872133255},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1619071364402771},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1021/acsomega.1c07335","doi":"https://doi.org/10.1021/acsomega.1c07335","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.1c07335","pdf_url":null,"source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8991932","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8991932/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8991932/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"Text"},{"id":"pmid:35415320","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35415320","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS omega","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1021/acsomega.1c07335","doi":"https://doi.org/10.1021/acsomega.1c07335","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.1c07335","pdf_url":null,"source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1358517471","display_name":null,"funder_award_id":"81771866","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320336027","display_name":"Tongji Medical College, Huazhong University of Science and Technology","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4223554541.pdf","grobid_xml":"https://content.openalex.org/works/W4223554541.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1948291609","https://openalex.org/W1967624469","https://openalex.org/W1979566598","https://openalex.org/W1984736455","https://openalex.org/W2003820440","https://openalex.org/W2012041175","https://openalex.org/W2015068460","https://openalex.org/W2018957811","https://openalex.org/W2029563033","https://openalex.org/W2033591223","https://openalex.org/W2040642592","https://openalex.org/W2064301710","https://openalex.org/W2077195956","https://openalex.org/W2094428025","https://openalex.org/W2107890007","https://openalex.org/W2118648566","https://openalex.org/W2124679671","https://openalex.org/W2131360426","https://openalex.org/W2145150141","https://openalex.org/W2150406082","https://openalex.org/W2154139219","https://openalex.org/W2159675211","https://openalex.org/W2163583831","https://openalex.org/W2169589032","https://openalex.org/W2177646965","https://openalex.org/W2345256071","https://openalex.org/W2530953900","https://openalex.org/W2537195015","https://openalex.org/W2537623931","https://openalex.org/W2559588208","https://openalex.org/W2754097617","https://openalex.org/W2885753449","https://openalex.org/W2906595440","https://openalex.org/W2911188335","https://openalex.org/W2913940207","https://openalex.org/W2917340264","https://openalex.org/W2950764390","https://openalex.org/W2980520209","https://openalex.org/W2985785877","https://openalex.org/W2988081723","https://openalex.org/W2991539666","https://openalex.org/W3088464723","https://openalex.org/W3112376646","https://openalex.org/W3119711869","https://openalex.org/W3120436543","https://openalex.org/W3159368935","https://openalex.org/W3167710599","https://openalex.org/W3198379814","https://openalex.org/W3212207872","https://openalex.org/W4200212070","https://openalex.org/W4200416621"],"related_works":["https://openalex.org/W4385612912","https://openalex.org/W4386413586","https://openalex.org/W4388412779","https://openalex.org/W7165483540","https://openalex.org/W3170725226","https://openalex.org/W3197908647","https://openalex.org/W4313458460","https://openalex.org/W7154394261","https://openalex.org/W4396853669","https://openalex.org/W4406627728"],"abstract_inverted_index":{"Sho-saiko-to":[0,29,59,71,96],"is":[1,9],"a":[2,109],"well-known":[3],"traditional":[4],"Chinese":[5],"medicine":[6],"compound":[7],"and":[8,25,41,48,52,76,87],"considered":[10],"to":[11,46],"have":[12],"therapeutic":[13,26],"effects":[14],"against":[15,30,60],"many":[16],"diseases,":[17],"including":[18],"thyroid":[19,104,115,123],"cancer":[20,116,124],"(TC).":[21],"However,":[22],"the":[23,50,55,66,74,84,91,100],"mechanisms":[24,53],"targets":[27,51],"of":[28,54,58,70,78,102],"TC":[31,79],"remain":[32],"unclear.":[33],"In":[34,94],"this":[35],"study,":[36],"network":[37],"pharmacology,":[38],"molecular":[39],"docking,":[40],"cell":[42],"experiments":[43],"were":[44],"combined":[45],"predict":[47],"verify":[49],"active":[56],"ingredients":[57,69],"TC.":[61],"The":[62],"results":[63],"demonstrated":[64],"that":[65],"main":[67],"chemical":[68],"could":[72,97],"suppress":[73],"viability":[75],"proliferation":[77],"cells,":[80],"promote":[81],"apoptosis":[82],"through":[83,90],"caspase3":[85],"pathway,":[86],"induce":[88,99],"autophagy":[89],"PI3K-AKT":[92],"pathway.":[93],"addition,":[95],"also":[98],"redifferentiation":[101],"anaplastic":[103],"cancer.":[105],"Our":[106],"study":[107],"provides":[108],"novel":[110],"approach":[111],"for":[112],"treating":[113],"differentiated":[114,122],"(DTC)":[117],"or":[118],"radioactive":[119],"iodine":[120],"refractory":[121],"(RAIR-DTC).":[125]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-04-15T00:00:00"}
