{"id":"https://openalex.org/W4223540107","doi":"https://doi.org/10.3389/fvets.2022.862308","title":"Dose Escalation Trial of Desulfated Heparin (ODSH) in Septic Peritonitis","display_name":"Dose Escalation Trial of Desulfated Heparin (ODSH) in Septic Peritonitis","publication_year":2022,"publication_date":"2022-04-13","ids":{"openalex":"https://openalex.org/W4223540107","doi":"https://doi.org/10.3389/fvets.2022.862308","pmid":"https://pubmed.ncbi.nlm.nih.gov/35498738","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9043859"},"language":"en","primary_location":{"id":"doi:10.3389/fvets.2022.862308","doi":"https://doi.org/10.3389/fvets.2022.862308","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2022.862308","pdf_url":"https://www.frontiersin.org/articles/10.3389/fvets.2022.862308/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fvets.2022.862308/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042494005","display_name":"Katie Davis Mauro","orcid":"https://orcid.org/0000-0002-0297-3020","observed_orcids":["https://orcid.org/0000-0002-0297-3020"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie D. Mauro","raw_affiliation_strings":["Matthew J. Ryan Hospital, Department of Clinical Science and Advanced Medicine, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Matthew J. Ryan Hospital, Department of Clinical Science and Advanced Medicine, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034517358","display_name":"Michele P. Lambert","orcid":"https://orcid.org/0000-0003-0439-402X","observed_orcids":["https://orcid.org/0000-0003-0439-402X"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michele P. Lambert","raw_affiliation_strings":["Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031898067","display_name":"Maria Anna Kowalska","orcid":"https://orcid.org/0000-0003-3849-8812","observed_orcids":["https://orcid.org/0000-0003-3849-8812"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Anna Kowalska","raw_affiliation_strings":["Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021481835","display_name":"Vincent J. Thawley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent J. Thawley","raw_affiliation_strings":["Matthew J. Ryan Hospital, Department of Clinical Science and Advanced Medicine, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Matthew J. Ryan Hospital, Department of Clinical Science and Advanced Medicine, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030315782","display_name":"Mortimer Poncz","orcid":"https://orcid.org/0000-0001-7237-3613","observed_orcids":["https://orcid.org/0000-0001-7237-3613"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mortimer Poncz","raw_affiliation_strings":["Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013294186","display_name":"Cynthia M. Otto","orcid":"https://orcid.org/0000-0003-0846-2114","observed_orcids":["https://orcid.org/0000-0003-0846-2114"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cynthia M. Otto","raw_affiliation_strings":["Matthew J. Ryan Hospital, Department of Clinical Science and Advanced Medicine, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Matthew J. Ryan Hospital, Department of Clinical Science and Advanced Medicine, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013294186"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.1803,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.43248236,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":null,"first_page":"862308","last_page":"862308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/septic-peritonitis","display_name":"septic peritonitis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.9480000138282776},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/platelet-factor-4","display_name":"platelet factor 4","score":0.9649999737739563},{"id":"https://openalex.org/keywords/histones","display_name":"histones","score":0.765999972820282},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.8799999952316284},{"id":"https://openalex.org/keywords/apple-score","display_name":"APPLE score","score":0.6039999723434448},{"id":"https://openalex.org/keywords/source-control","display_name":"source control","score":0.597000002861023},{"id":"https://openalex.org/keywords/hemorrhage","display_name":"hemorrhage","score":0.33500000834465027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8901159763336182},{"id":"https://openalex.org/C2780199535","wikidata":"https://www.wikidata.org/wiki/Q223102","display_name":"Peritonitis","level":2,"score":0.7032384872436523},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6822386980056763},{"id":"https://openalex.org/C162156334","wikidata":"https://www.wikidata.org/wiki/Q473420","display_name":"Dose","level":2,"score":0.6803874969482422},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5082749724388123},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.498870849609375},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.45903539657592773},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.41610950231552124},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29081881046295166}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fvets.2022.862308","doi":"https://doi.org/10.3389/fvets.2022.862308","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2022.862308","pdf_url":"https://www.frontiersin.org/articles/10.3389/fvets.2022.862308/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9043859","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9043859","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Vet Sci","raw_type":"Text"},{"id":"pmid:35498738","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35498738","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in veterinary science","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f01c027bfb714645a4eebc6646d84295","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f01c027bfb714645a4eebc6646d84295","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Veterinary Science, Vol 9 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fvets.2022.862308","doi":"https://doi.org/10.3389/fvets.2022.862308","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2022.862308","pdf_url":"https://www.frontiersin.org/articles/10.3389/fvets.2022.862308/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4192053967","display_name":"Studies of Physiologic and Pathologic Platelet Plug Formation","funder_award_id":"P01HL146373","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4223540107.pdf","grobid_xml":"https://content.openalex.org/works/W4223540107.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1511657256","https://openalex.org/W1912969395","https://openalex.org/W1999871169","https://openalex.org/W2119437744","https://openalex.org/W2160950389","https://openalex.org/W2280404143","https://openalex.org/W2333540045","https://openalex.org/W2524520603","https://openalex.org/W2594200670","https://openalex.org/W2741450112","https://openalex.org/W2789561812","https://openalex.org/W2983391355"],"related_works":["https://openalex.org/W2745565145","https://openalex.org/W2070144094","https://openalex.org/W2741450112","https://openalex.org/W2587878856","https://openalex.org/W2320311025","https://openalex.org/W7120509278","https://openalex.org/W2073678282","https://openalex.org/W3028953649","https://openalex.org/W4413274288","https://openalex.org/W2274753275"],"abstract_inverted_index":{"Objective":[0],"Septic":[1],"peritonitis":[2],"is":[3,257],"associated":[4],"with":[5,50,65,250],"significant":[6],"morbidity":[7],"and":[8,27,43,83,87,104,117,176,185,197],"mortality.":[9],"As":[10],"a":[11,142,154,263],"potential":[12],"therapeutic":[13,265],"agent":[14],"in":[15,32,47,62,161,248,266],"the":[16,41,99,126,162,215,267],"treatment":[17,268],"of":[18,45,93,101,128,134,144,168,195,204,211,232,243,269],"sepsis,":[19],"2-O,":[20],"3-O":[21],"desulfated":[22],"heparin":[23],"(ODSH)":[24],"reduces":[25],"histones":[26],"platelet":[28,118],"factor":[29,119],"4":[30,120,145,192],"(PF4)":[31,121],"mouse":[33],"sepsis":[34],"models.":[35],"This":[36],"pilot":[37],"clinical":[38,60,169],"trial":[39,61,256],"evaluated":[40],"safety":[42],"effect":[44],"ODSH":[46,69,130,135,196,205,212,244,261],"client-owned":[48],"dogs":[49,64,190,199,235,249],"septic":[51,67,94,251,270],"peritonitis.":[52,252,271],"Interventions":[53],"In":[54],"an":[55],"IACUC-approved,":[56],"open-label,":[57],"prospective,":[58],"dose-escalation":[59],"6":[63,184],"spontaneous":[66],"peritonitis,":[68,95],"administration":[70,100,165,245],"was":[71,136,218],"initiated":[72],"following":[73,164],"surgical":[74],"explore":[75],"to":[76,106,237,259],"achieve":[77],"source":[78,92],"control.":[79],"Acute":[80],"patient":[81],"physiology":[82],"laboratory":[84],"evaluation":[85],"(APPLEfast":[86],"APPLEfull)":[88],"scores":[89,178],"on":[90,153,179],"admission,":[91],"requirement":[96],"for":[97,141,166],"vasopressors,":[98],"blood":[102],"products,":[103],"survival":[105],"discharge":[107],"were":[108,123,159,181,246],"recorded.":[109],"Platelet":[110],"count,":[111],"cell":[112],"free":[113],"DNA":[114],"(cfDNA)":[115],"concentration,":[116],"concentrations":[122],"measured":[124],"at":[125],"time":[127],"each":[129],"dosage.":[131],"A":[132,253],"dose":[133,226],"administered":[137,213],"every":[138],"8":[139],"hs":[140],"total":[143,148,193,202,209],"doses":[146],"(maximum":[147],"dosage":[149,210],"75":[150],"mg/kg)":[151],"based":[152],"pre-determined":[155],"escalation":[156],"protocol.":[157],"Patients":[158],"monitored":[160],"ICU":[163],"evidence":[167,231],"hemorrhage.":[170],"Main":[171],"Results":[172],"The":[173,207],"mean":[174,208],"APPLEfast":[175],"APPLEfull":[177],"admission":[180],"22":[182],"+/-":[183,220],"32":[186],"+/-10,":[187],"respectively.":[188],"Four":[189,234],"received":[191,200],"dosages":[194,203],"2":[198],"3":[201],"intravenously.":[206],"during":[214],"study":[216],"period":[217],"48.3":[219],"21.6":[221],"mg/kg.":[222],"No":[223,240],"dog":[224],"required":[225],"de-escalation":[227],"or":[228],"had":[229],"any":[230],"bleeding.":[233],"survived":[236],"discharge.":[238],"Conclusions":[239],"adverse":[241],"effects":[242],"documented":[247],"randomized":[254],"controlled":[255],"necessary":[258],"evaluate":[260],"as":[262],"novel":[264]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-04-15T00:00:00"}
