{"id":"https://openalex.org/W4223536554","doi":"https://doi.org/10.55524/ijirem.2022.9.1.19","title":"Homocysteine Role in Neural Tube Defect: A Review Paper","display_name":"Homocysteine Role in Neural Tube Defect: A Review Paper","publication_year":2022,"publication_date":"2022-02-01","ids":{"openalex":"https://openalex.org/W4223536554","doi":"https://doi.org/10.55524/ijirem.2022.9.1.19"},"language":"en","primary_location":{"id":"doi:10.55524/ijirem.2022.9.1.19","doi":"https://doi.org/10.55524/ijirem.2022.9.1.19","is_oa":true,"landing_page_url":"https://doi.org/10.55524/ijirem.2022.9.1.19","pdf_url":"https://doi.org/10.55524/ijirem.2022.9.1.19","source":{"id":"https://openalex.org/S4210225444","display_name":"International Journal of Innovative Research in Engineering & Management","issn_l":"2350-0557","issn":["2350-0557"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Innovative Research in Engineering &amp; Management","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.55524/ijirem.2022.9.1.19","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061532460","display_name":"Krishan Raj Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405258449","display_name":"Sanskriti University, Mathura","ror":"https://ror.org/00nvd7q77","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405258449"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Krishan Raj Singh","raw_affiliation_strings":["Assistant Professor, School of Applied Sciences, Sanskriti University, Mathura, Uttar Pradesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, School of Applied Sciences, Sanskriti University, Mathura, Uttar Pradesh","institution_ids":["https://openalex.org/I4405258449"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002092534","display_name":"Arminder Kaur","orcid":"https://orcid.org/0000-0002-5314-0096","observed_orcids":["https://orcid.org/0000-0002-5314-0096"]},"institutions":[{"id":"https://openalex.org/I4405258449","display_name":"Sanskriti University, Mathura","ror":"https://ror.org/00nvd7q77","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405258449"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dr. Arminder Kaur","raw_affiliation_strings":["Assistant Professor, School of Applied Sciences, Sanskriti University, Mathura, Uttar Pradesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, School of Applied Sciences, Sanskriti University, Mathura, Uttar Pradesh","institution_ids":["https://openalex.org/I4405258449"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405258449"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.05425943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"110","last_page":"115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11833","display_name":"Spinal Dysraphism and Malformations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.9739999771118164},{"id":"https://openalex.org/keywords/neural-tube-defects","display_name":"neural tube defects","score":0.9980000257492065},{"id":"https://openalex.org/keywords/folic-acid-supplementation","display_name":"folic acid supplementation","score":0.824999988079071},{"id":"https://openalex.org/keywords/periconceptional-folic-acid","display_name":"periconceptional folic acid","score":0.8130000233650208},{"id":"https://openalex.org/keywords/homocysteine-metabolism","display_name":"homocysteine metabolism","score":0.8999999761581421},{"id":"https://openalex.org/keywords/methionine-synthase","display_name":"methionine synthase","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cystathionine-beta-synthase","display_name":"cystathionine beta-synthase","score":0.9629999995231628},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":0.7850000262260437},{"id":"https://openalex.org/keywords/methionine","display_name":"methionine","score":0.7739999890327454},{"id":"https://openalex.org/keywords/neural-tube-closure","display_name":"neural tube closure","score":0.9670000076293945},{"id":"https://openalex.org/keywords/folate-deficiency","display_name":"folate deficiency","score":0.4269999861717224},{"id":"https://openalex.org/keywords/fortified-foods","display_name":"fortified foods","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C2780594696","wikidata":"https://www.wikidata.org/wiki/Q1127402","display_name":"Neural tube","level":3,"score":0.8802369236946106},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.8675541877746582},{"id":"https://openalex.org/C16525657","wikidata":"https://www.wikidata.org/wiki/Q5201183","display_name":"Cystathionine beta synthase","level":4,"score":0.7939848303794861},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.7227288484573364},{"id":"https://openalex.org/C80315684","wikidata":"https://www.wikidata.org/wiki/Q2737583","display_name":"Methionine synthase","level":4,"score":0.6785719990730286},{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.6637051105499268},{"id":"https://openalex.org/C2779375456","wikidata":"https://www.wikidata.org/wiki/Q994859","display_name":"Homocystinuria","level":4,"score":0.5537329316139221},{"id":"https://openalex.org/C2992130864","wikidata":"https://www.wikidata.org/wiki/Q127060","display_name":"Folic acid","level":2,"score":0.5469442009925842},{"id":"https://openalex.org/C2777003008","wikidata":"https://www.wikidata.org/wiki/Q548213","display_name":"Neural tube defect","level":4,"score":0.5080692768096924},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4977555572986603},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4860246777534485},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.44574180245399475},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38177424669265747},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.357557475566864},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33710551261901855},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32694515585899353},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.19410467147827148},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.14713364839553833},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07928332686424255},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.55524/ijirem.2022.9.1.19","doi":"https://doi.org/10.55524/ijirem.2022.9.1.19","is_oa":true,"landing_page_url":"https://doi.org/10.55524/ijirem.2022.9.1.19","pdf_url":"https://doi.org/10.55524/ijirem.2022.9.1.19","source":{"id":"https://openalex.org/S4210225444","display_name":"International Journal of Innovative Research in Engineering & Management","issn_l":"2350-0557","issn":["2350-0557"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Innovative Research in Engineering &amp; Management","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.55524/ijirem.2022.9.1.19","doi":"https://doi.org/10.55524/ijirem.2022.9.1.19","is_oa":true,"landing_page_url":"https://doi.org/10.55524/ijirem.2022.9.1.19","pdf_url":"https://doi.org/10.55524/ijirem.2022.9.1.19","source":{"id":"https://openalex.org/S4210225444","display_name":"International Journal of Innovative Research in Engineering & Management","issn_l":"2350-0557","issn":["2350-0557"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Innovative Research in Engineering &amp; Management","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4223536554.pdf","grobid_xml":"https://content.openalex.org/works/W4223536554.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1898544180","https://openalex.org/W1963860577","https://openalex.org/W2041225825","https://openalex.org/W2059188255","https://openalex.org/W2072630514","https://openalex.org/W2073097537","https://openalex.org/W2087212278","https://openalex.org/W2106675348","https://openalex.org/W2110684459","https://openalex.org/W2325417132","https://openalex.org/W4252773899"],"related_works":["https://openalex.org/W1827231142","https://openalex.org/W2051136548","https://openalex.org/W2394224740","https://openalex.org/W2089786626","https://openalex.org/W2019146309","https://openalex.org/W2118559751","https://openalex.org/W2069258339","https://openalex.org/W2097478746","https://openalex.org/W1566423811","https://openalex.org/W2006833102"],"abstract_inverted_index":{"Folic":[0,21,62],"acid,":[1,170],"when":[2],"administered":[3],"periconceptionally,":[4],"is":[5,109,137,161],"now":[6],"well":[7],"recognized":[8],"as":[9,168],"having":[10],"the":[11,67,103,125,146,162,177,193,202],"potential":[12],"to":[13,25,34,65,74,111,121,129,191],"prevent":[14],"a":[15,27,35,49,75,172,181],"variety":[16],"of":[17,102,119,175,195,204],"neural":[18,43,140],"tube":[19,44,141],"disorders.":[20],"acid":[22,63,197,206],"seems":[23,40,64],"not":[24],"treat":[26],"nutritional":[28],"deficiency":[29],"in":[30,106,114,198],"pregnant":[31],"women,":[32],"according":[33,73,128],"recent":[36],"research.":[37,77,131],"Rather,":[38],"it":[39],"that":[41,80,100],"these":[42],"anomalies":[45],"are":[46],"caused":[47],"by":[48],"metabolic":[50],"flaw":[51],"or":[52],"errors,":[53],"which":[54],"may":[55,123,187],"be":[56,112,124],"corrected":[57],"with":[58],"enough":[59],"folic":[60,169,196,205],"acid.":[61],"have":[66],"most":[68],"influence":[69],"on":[70],"homocysteine":[71,90,107,120],"metabolism,":[72],"new":[76],"We":[78],"observed":[79],"moms":[81],"who":[82,94],"were":[83,95],"carrying":[84],"diseased":[85],"fetuses":[86],"had":[87],"much":[88],"greater":[89],"levels":[91],"than":[92],"those":[93],"not.":[96],"These":[97],"data":[98],"suggest":[99],"one":[101],"enzymes":[104,147],"involved":[105],"metabolism":[108,144],"likely":[110],"aberrant":[113,178],"afflicted":[115],"pregnancies.":[116],"The":[117],"conversion":[118],"methionine":[122,136,148,159],"essential":[126],"stage,":[127],"animal":[130],"In":[132],"cultured":[133],"rat":[134],"embryos,":[135],"necessary":[138],"for":[139],"closure.":[142],"Homocysteine":[143],"necessitates":[145],"synthase,":[149,151],"cystathionine":[150],"and":[152],"5,":[153],"10":[154],"methylene":[155],"tetrahydrofolate":[156],"reductase.":[157],"If":[158],"synthase":[160],"dominant":[163],"enzyme,":[164,179],"vitamin":[165],"B-12,":[166],"such":[167],"has":[171],"higher":[173],"chance":[174],"activating":[176],"posing":[180],"public":[182],"health":[183],"risk.":[184],"Vitamin":[185],"B-12":[186],"find":[188],"things":[189],"simpler":[190],"limit":[192],"amount":[194],"fortified":[199],"foods,":[200],"reducing":[201],"risk":[203],"overdose.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-04-15T00:00:00"}
