{"id":"https://openalex.org/W4223531111","doi":"https://doi.org/10.3390/antiox11040767","title":"TLR4 Signaling and Heme Oxygenase-1/Carbon Monoxide Pathway Crosstalk Induces Resiliency of Myeloma Plasma Cells to Bortezomib Treatment","display_name":"TLR4 Signaling and Heme Oxygenase-1/Carbon Monoxide Pathway Crosstalk Induces Resiliency of Myeloma Plasma Cells to Bortezomib Treatment","publication_year":2022,"publication_date":"2022-04-12","ids":{"openalex":"https://openalex.org/W4223531111","doi":"https://doi.org/10.3390/antiox11040767","pmid":"https://pubmed.ncbi.nlm.nih.gov/35453452","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9031632"},"language":"en","primary_location":{"id":"doi:10.3390/antiox11040767","doi":"https://doi.org/10.3390/antiox11040767","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox11040767","pdf_url":"https://www.mdpi.com/2076-3921/11/4/767/pdf?version=1649816702","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-3921/11/4/767/pdf?version=1649816702","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028909368","display_name":"Grazia Scandura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I4210129599","display_name":"Policlinico Universitario di Catania","ror":"https://ror.org/033xwx807","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210129599"]},{"id":"https://openalex.org/I4210160210","display_name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico - San Marco\"","ror":"https://ror.org/051tt6c85","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210160210"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Grazia Scandura","raw_affiliation_strings":["Division of Hematology, Department of General Surgery and Medical-Surgical Specialties, A.O.U. \u201cPoliclinico-Vittorio Emanuele\u201d, University of Catania, 95123 Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of General Surgery and Medical-Surgical Specialties, A.O.U. \u201cPoliclinico-Vittorio Emanuele\u201d, University of Catania, 95123 Catania, Italy","institution_ids":["https://openalex.org/I39063666","https://openalex.org/I4210129599","https://openalex.org/I4210160210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070046619","display_name":"Cesarina Giallongo","orcid":"https://orcid.org/0000-0002-7667-6088","observed_orcids":["https://orcid.org/0000-0002-7667-6088","https://orcid.org/0000-0002-5047-7515"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cesarina Giallongo","raw_affiliation_strings":["Department of Scienze Mediche Chirurgiche e Tecnologie Avanzate \u201cG.F. Ingrassia\u201d, University of Catania, 95123 Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Scienze Mediche Chirurgiche e Tecnologie Avanzate \u201cG.F. Ingrassia\u201d, University of Catania, 95123 Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065763544","display_name":"Fabrizio Puglisi","orcid":"https://orcid.org/0000-0002-6776-9709","observed_orcids":["https://orcid.org/0000-0002-6776-9709"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I4210129599","display_name":"Policlinico Universitario di Catania","ror":"https://ror.org/033xwx807","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210129599"]},{"id":"https://openalex.org/I4210160210","display_name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico - San Marco\"","ror":"https://ror.org/051tt6c85","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210160210"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabrizio Puglisi","raw_affiliation_strings":["Division of Hematology, Department of General Surgery and Medical-Surgical Specialties, A.O.U. \u201cPoliclinico-Vittorio Emanuele\u201d, University of Catania, 95123 Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of General Surgery and Medical-Surgical Specialties, A.O.U. \u201cPoliclinico-Vittorio Emanuele\u201d, University of Catania, 95123 Catania, Italy","institution_ids":["https://openalex.org/I39063666","https://openalex.org/I4210129599","https://openalex.org/I4210160210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018769545","display_name":"Alessandra Romano","orcid":"https://orcid.org/0000-0002-6333-4433","observed_orcids":["https://orcid.org/0000-0002-6333-4433"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I4210129599","display_name":"Policlinico Universitario di Catania","ror":"https://ror.org/033xwx807","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210129599"]},{"id":"https://openalex.org/I4210160210","display_name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico - San Marco\"","ror":"https://ror.org/051tt6c85","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210160210"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Romano","raw_affiliation_strings":["Division of Hematology, Department of General Surgery and Medical-Surgical Specialties, A.O.U. \u201cPoliclinico-Vittorio Emanuele\u201d, University of Catania, 95123 Catania, Italy"],"raw_orcid":"https://orcid.org/0000-0002-6333-4433","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of General Surgery and Medical-Surgical Specialties, A.O.U. \u201cPoliclinico-Vittorio Emanuele\u201d, University of Catania, 95123 Catania, Italy","institution_ids":["https://openalex.org/I39063666","https://openalex.org/I4210129599","https://openalex.org/I4210160210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065852754","display_name":"Nunziatina Laura Parrinello","orcid":"https://orcid.org/0000-0002-9978-2908","observed_orcids":["https://orcid.org/0000-0002-9978-2908"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I4210129599","display_name":"Policlinico Universitario di Catania","ror":"https://ror.org/033xwx807","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210129599"]},{"id":"https://openalex.org/I4210160210","display_name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico - San Marco\"","ror":"https://ror.org/051tt6c85","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210160210"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nunziatina Laura Parrinello","raw_affiliation_strings":["Division of Hematology, Department of General Surgery and Medical-Surgical Specialties, A.O.U. \u201cPoliclinico-Vittorio Emanuele\u201d, University of Catania, 95123 Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of General Surgery and Medical-Surgical Specialties, A.O.U. \u201cPoliclinico-Vittorio Emanuele\u201d, University of Catania, 95123 Catania, Italy","institution_ids":["https://openalex.org/I39063666","https://openalex.org/I4210129599","https://openalex.org/I4210160210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018519363","display_name":"Tatiana Zuppelli","orcid":"https://orcid.org/0009-0006-2148-7606","observed_orcids":["https://orcid.org/0009-0006-2148-7606"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Tatiana Zuppelli","raw_affiliation_strings":["Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076603987","display_name":"Lucia Longhitano","orcid":"https://orcid.org/0000-0002-1296-5884","observed_orcids":["https://orcid.org/0000-0002-1296-5884"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucia Longhitano","raw_affiliation_strings":["Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003311154","display_name":"Sebastiano Giallongo","orcid":"https://orcid.org/0000-0002-5047-7515","observed_orcids":["https://orcid.org/0000-0002-5047-7515"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sebastiano Giallongo","raw_affiliation_strings":["Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy"],"raw_orcid":"https://orcid.org/0000-0002-5047-7515","affiliations":[{"raw_affiliation_string":"Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025100480","display_name":"Michelino Di Rosa","orcid":"https://orcid.org/0000-0002-1837-9325","observed_orcids":["https://orcid.org/0000-0002-1837-9325"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michelino Di Rosa","raw_affiliation_strings":["Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1837-9325","affiliations":[{"raw_affiliation_string":"Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059983020","display_name":"Giuseppe Musumeci","orcid":"https://orcid.org/0000-0002-8260-8890","observed_orcids":["https://orcid.org/0000-0002-8260-8890","https://orcid.org/0000-0002-5917-7279"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Musumeci","raw_affiliation_strings":["Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8260-8890","affiliations":[{"raw_affiliation_string":"Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034436289","display_name":"Roberto Motterlini","orcid":"https://orcid.org/0000-0003-2684-2612","observed_orcids":["https://orcid.org/0000-0003-2684-2612"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I197681013","display_name":"Universit\u00e9 Paris-Est Cr\u00e9teil","ror":"https://ror.org/05ggc9x40","country_code":"FR","type":"education","lineage":["https://openalex.org/I197681013","https://openalex.org/I2800365227"]},{"id":"https://openalex.org/I4210159433","display_name":"Institut Mondor de Recherche Biom\u00e9dicale","ror":"https://ror.org/04qe59j94","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I17606148","https://openalex.org/I197681013","https://openalex.org/I2800365227","https://openalex.org/I4210159433"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Roberto Motterlini","raw_affiliation_strings":["Faculty of Health, University Paris-Est Cr\u00e9teil, INSERM, IMRB, 94010 Cr\u00e9teil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health, University Paris-Est Cr\u00e9teil, INSERM, IMRB, 94010 Cr\u00e9teil, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I197681013","https://openalex.org/I4210159433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041692767","display_name":"Roberta Foresti","orcid":"https://orcid.org/0000-0002-0836-7937","observed_orcids":["https://orcid.org/0000-0002-0836-7937"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I197681013","display_name":"Universit\u00e9 Paris-Est Cr\u00e9teil","ror":"https://ror.org/05ggc9x40","country_code":"FR","type":"education","lineage":["https://openalex.org/I197681013","https://openalex.org/I2800365227"]},{"id":"https://openalex.org/I4210159433","display_name":"Institut Mondor de Recherche Biom\u00e9dicale","ror":"https://ror.org/04qe59j94","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I17606148","https://openalex.org/I197681013","https://openalex.org/I2800365227","https://openalex.org/I4210159433"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Roberta Foresti","raw_affiliation_strings":["Faculty of Health, University Paris-Est Cr\u00e9teil, INSERM, IMRB, 94010 Cr\u00e9teil, France"],"raw_orcid":"https://orcid.org/0000-0002-0836-7937","affiliations":[{"raw_affiliation_string":"Faculty of Health, University Paris-Est Cr\u00e9teil, INSERM, IMRB, 94010 Cr\u00e9teil, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I197681013","https://openalex.org/I4210159433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060107199","display_name":"Giuseppe A. Palumbo","orcid":"https://orcid.org/0000-0003-1859-6319","observed_orcids":["https://orcid.org/0000-0003-1859-6319"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giuseppe Alberto Palumbo","raw_affiliation_strings":["Department of Scienze Mediche Chirurgiche e Tecnologie Avanzate \u201cG.F. Ingrassia\u201d, University of Catania, 95123 Catania, Italy"],"raw_orcid":"https://orcid.org/0000-0003-1859-6319","affiliations":[{"raw_affiliation_string":"Department of Scienze Mediche Chirurgiche e Tecnologie Avanzate \u201cG.F. Ingrassia\u201d, University of Catania, 95123 Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026039152","display_name":"Giovanni Li Volti","orcid":"https://orcid.org/0000-0002-8678-2183","observed_orcids":["https://orcid.org/0000-0002-8678-2183"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giovanni Li Volti","raw_affiliation_strings":["Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8678-2183","affiliations":[{"raw_affiliation_string":"Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034393745","display_name":"Francesco Di Raimondo","orcid":"https://orcid.org/0000-0002-7749-0293","observed_orcids":["https://orcid.org/0000-0002-7749-0293"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I4210129599","display_name":"Policlinico Universitario di Catania","ror":"https://ror.org/033xwx807","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210129599"]},{"id":"https://openalex.org/I4210160210","display_name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico - San Marco\"","ror":"https://ror.org/051tt6c85","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210160210"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Di Raimondo","raw_affiliation_strings":["Division of Hematology, Department of General Surgery and Medical-Surgical Specialties, A.O.U. \u201cPoliclinico-Vittorio Emanuele\u201d, University of Catania, 95123 Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of General Surgery and Medical-Surgical Specialties, A.O.U. \u201cPoliclinico-Vittorio Emanuele\u201d, University of Catania, 95123 Catania, Italy","institution_ids":["https://openalex.org/I39063666","https://openalex.org/I4210129599","https://openalex.org/I4210160210"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072417532","display_name":"Daniele Tibullo","orcid":"https://orcid.org/0000-0002-4416-8556","observed_orcids":["https://orcid.org/0000-0002-4416-8556"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniele Tibullo","raw_affiliation_strings":["Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy"],"raw_orcid":"https://orcid.org/0000-0002-4416-8556","affiliations":[{"raw_affiliation_string":"Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5026039152","https://openalex.org/A5060107199"],"corresponding_institution_ids":["https://openalex.org/I39063666"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2303},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2303},"fwci":1.103,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.74328962,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"11","issue":"4","first_page":"767","last_page":"767"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.6723999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.6723999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.32199999690055847,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.996999979019165},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.8790000081062317},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.796999990940094},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9509999752044678},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":1.0},{"id":"https://openalex.org/keywords/carbon-monoxide","display_name":"carbon monoxide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tak-242","display_name":"TAK-242","score":0.8130000233650208},{"id":"https://openalex.org/keywords/tin-protoporphyrin-ix","display_name":"tin protoporphyrin IX","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.8429999947547913},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mitochondrial-membrane-depolarization","display_name":"mitochondrial depolarization","score":0.9819999933242798},{"id":"https://openalex.org/keywords/plasma-cells","display_name":"plasma cells","score":0.7009999752044678},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.8011798858642578},{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.7683908939361572},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7122239470481873},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5486090183258057},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.5192858576774597},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5092607736587524},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4687281847000122},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.42212167382240295},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37767985463142395},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.29643023014068604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28621935844421387},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27038446068763733},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18221384286880493},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15650016069412231},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/antiox11040767","doi":"https://doi.org/10.3390/antiox11040767","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox11040767","pdf_url":"https://www.mdpi.com/2076-3921/11/4/767/pdf?version=1649816702","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},{"id":"pmid:35453452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35453452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9031632","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9031632/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants (Basel)","raw_type":"Text"},{"id":"pmh:oai:HAL:inserm-04169509v1","doi":null,"is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-04169509","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antioxidants , 2022, 11 (4), pp.767. &#x27E8;10.3390/antiox11040767&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:c8d39cb351654d97b0b17d10102c0ef2","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c8d39cb351654d97b0b17d10102c0ef2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antioxidants, Vol 11, Iss 4, p 767 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/antiox11040767","doi":"https://doi.org/10.3390/antiox11040767","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox11040767","pdf_url":"https://www.mdpi.com/2076-3921/11/4/767/pdf?version=1649816702","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G156594879","display_name":null,"funder_award_id":"IG-2018","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G3541277400","display_name":null,"funder_award_id":"22131","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G6335713934","display_name":null,"funder_award_id":"22131","funder_id":"https://openalex.org/F4320324143","funder_display_name":"Fondazione Italiana per la Ricerca sul Cancro"}],"funders":[{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320324143","display_name":"Fondazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4223531111.pdf","grobid_xml":"https://content.openalex.org/works/W4223531111.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1915870983","https://openalex.org/W1966772446","https://openalex.org/W1983012315","https://openalex.org/W1993688639","https://openalex.org/W1996826558","https://openalex.org/W2000084288","https://openalex.org/W2019637022","https://openalex.org/W2026642838","https://openalex.org/W2045821670","https://openalex.org/W2060574598","https://openalex.org/W2114360920","https://openalex.org/W2116562304","https://openalex.org/W2157014719","https://openalex.org/W2289965873","https://openalex.org/W2343425851","https://openalex.org/W2553381844","https://openalex.org/W2728216690","https://openalex.org/W2770970846","https://openalex.org/W2781897202","https://openalex.org/W2791971573","https://openalex.org/W2793262607","https://openalex.org/W2808327635","https://openalex.org/W2882973658","https://openalex.org/W2889850156","https://openalex.org/W2890210516","https://openalex.org/W2898103885","https://openalex.org/W2905675459","https://openalex.org/W2918442771","https://openalex.org/W2959856664","https://openalex.org/W2966332384","https://openalex.org/W3022621507","https://openalex.org/W3044854098","https://openalex.org/W3114692785","https://openalex.org/W4205353497","https://openalex.org/W4205482119"],"related_works":["https://openalex.org/W3096345132","https://openalex.org/W3044854098","https://openalex.org/W2988822553","https://openalex.org/W2953316078","https://openalex.org/W2026872205","https://openalex.org/W2289965873","https://openalex.org/W2898611829","https://openalex.org/W2265970551","https://openalex.org/W2561304696","https://openalex.org/W2236153578"],"abstract_inverted_index":{"Relapse":[0],"in":[1,94,99,104,116],"multiple":[2],"myeloma":[3],"(MM)":[4],"decreases":[5],"therapy":[6],"efficiency":[7],"through":[8],"unclear":[9],"mechanisms":[10],"of":[11,63,79,119,124,140,153],"chemoresistance.":[12],"Since":[13],"our":[14],"group":[15],"previously":[16],"demonstrated":[17],"that":[18,51,151,167],"heme":[19],"oxygenase-1":[20],"(HO-1)":[21],"and":[22,54,65,73,81,85,178],"Toll-like":[23],"receptor":[24],"4":[25],"(TLR4)":[26],"are":[27],"two":[28],"signaling":[29],"pathways":[30],"protecting":[31,174],"MM":[32,154],"cells":[33,125,155],"from":[34],"the":[35,77,87,111,159],"proteasome":[36],"inhibitor":[37],"bortezomib":[38],"(BTZ),":[39],"we":[40,149],"here":[41],"evaluated":[42],"their":[43],"cross-regulation":[44],"by":[45,57,67],"a":[46,97,117,138,164],"pharmacological":[47],"approach.":[48],"We":[49],"found":[50],"cell":[52,171],"toxicity":[53],"mitochondrial":[55],"depolarization":[56],"BTZ":[58,82,103,157,177],"were":[59],"increased":[60,144,170],"upon":[61],"inhibition":[62],"HO-1":[64,100,130,141],"TLR4":[66,120,145],"using":[68],"tin":[69],"protoporphyrin":[70],"IX":[71],"(SnPP)":[72],"TAK-242,":[74],"respectively.":[75],"Furthermore,":[76],"combination":[78,105],"TAK-242":[80],"activated":[83],"mitophagy":[84],"decreased":[86],"unfolded":[88],"protein":[89],"response":[90],"(UPR)":[91],"survival":[92,172],"pathway":[93],"association":[95],"with":[96,106,113,126,134,156],"downregulation":[98],"expression.":[101,146],"Notably,":[102],"SnPP":[107],"induced":[108],"effects":[109],"mirroring":[110],"treatment":[112,123,152],"TAK-242/BTZ,":[114],"resulting":[115],"blockade":[118],"upregulation.":[121],"Interestingly,":[122],"either":[127],"hemin,":[128],"an":[129],"inducer,":[131],"or":[132],"supplementation":[133],"carbon":[135],"monoxide":[136],"(CO),":[137],"by-product":[139],"enzymatic":[142],"activity,":[143],"In":[147],"conclusion,":[148],"showed":[150],"triggers":[158],"TLR4/HO-1/CO":[160],"axis,":[161],"serving":[162],"as":[163],"stress-responsive":[165],"signal":[166],"leads":[168],"to":[169],"while":[173],"mitochondria":[175],"against":[176],"ultimately":[179],"promoting":[180],"drug":[181],"resistance.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-04-15T00:00:00"}
