{"id":"https://openalex.org/W4223495068","doi":"https://doi.org/10.1038/s41467-022-29514-y","title":"Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery","display_name":"Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery","publication_year":2022,"publication_date":"2022-04-06","ids":{"openalex":"https://openalex.org/W4223495068","doi":"https://doi.org/10.1038/s41467-022-29514-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/35388006","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8987079"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-022-29514-y","doi":"https://doi.org/10.1038/s41467-022-29514-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-29514-y","pdf_url":"https://www.nature.com/articles/s41467-022-29514-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-022-29514-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054848635","display_name":"Tian Zhou","orcid":"https://orcid.org/0000-0002-7871-8798","observed_orcids":["https://orcid.org/0000-0002-7871-8798"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian Zhou","raw_affiliation_strings":["Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China","Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, 518040, China","State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]},{"raw_affiliation_string":"Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, 518040, China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200032, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4210110011","https://openalex.org/I4210138900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101574084","display_name":"Xinyi Zhu","orcid":"https://orcid.org/0009-0006-8106-4277","observed_orcids":["https://orcid.org/0009-0006-8106-4277"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyi Zhu","raw_affiliation_strings":["Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023581100","display_name":"Zhizhong Ye","orcid":"https://orcid.org/0000-0001-8243-7430","observed_orcids":["https://orcid.org/0000-0001-8243-7430","https://orcid.org/0000-0002-2480-6004"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhizhong Ye","raw_affiliation_strings":["Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, 518040, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, 518040, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100769467","display_name":"Yongfei Wang","orcid":"https://orcid.org/0000-0002-1260-6291","observed_orcids":["https://orcid.org/0000-0002-1260-6291"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yong-Fei Wang","raw_affiliation_strings":["Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, 999077, China"],"raw_orcid":"https://orcid.org/0000-0002-1260-6291","affiliations":[{"raw_affiliation_string":"Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, 999077, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chao Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096013","display_name":"Shanghai Institute of Nutrition and Health","ror":"https://ror.org/00rytkh49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Yao","raw_affiliation_strings":["Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences (SIBS), University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences (SIBS), University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, 200031, China","institution_ids":["https://openalex.org/I4210096013","https://openalex.org/I4210106477","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034034468","display_name":"Ning Xu","orcid":"https://orcid.org/0000-0002-2912-6016","observed_orcids":["https://orcid.org/0000-0002-2912-6016"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Xu","raw_affiliation_strings":["Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020759583","display_name":"Mi Zhou","orcid":"https://orcid.org/0000-0001-8696-4940","observed_orcids":["https://orcid.org/0000-0001-8696-4940"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mi Zhou","raw_affiliation_strings":["Sheng Yushou Center of Cell Biology and Immunology, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University (SJTU), Shanghai, 200240, China"],"raw_orcid":"https://orcid.org/0000-0001-8696-4940","affiliations":[{"raw_affiliation_string":"Sheng Yushou Center of Cell Biology and Immunology, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University (SJTU), Shanghai, 200240, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103020719","display_name":"Jianyang Ma","orcid":"https://orcid.org/0000-0002-4203-700X","observed_orcids":["https://orcid.org/0000-0002-4203-700X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianyang Ma","raw_affiliation_strings":["Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050808168","display_name":"Yuting Qin","orcid":"https://orcid.org/0000-0001-7506-2060","observed_orcids":["https://orcid.org/0000-0001-7506-2060"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuting Qin","raw_affiliation_strings":["Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006276479","display_name":"Yiwei Shen","orcid":"https://orcid.org/0000-0003-4594-5035","observed_orcids":["https://orcid.org/0000-0003-4594-5035","https://orcid.org/0000-0003-3286-2118"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiwei Shen","raw_affiliation_strings":["Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110718057","display_name":"Yuanjia Tang","orcid":"https://orcid.org/0000-0002-2044-5424","observed_orcids":["https://orcid.org/0000-0002-2044-5424"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanjia Tang","raw_affiliation_strings":["Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023597320","display_name":"Zhihua Yin","orcid":"https://orcid.org/0000-0003-0850-680X","observed_orcids":["https://orcid.org/0000-0003-0850-680X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhihua Yin","raw_affiliation_strings":["Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, 518040, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, 518040, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037471658","display_name":"Hong Xu","orcid":"https://orcid.org/0000-0003-0314-9145","observed_orcids":["https://orcid.org/0000-0003-0314-9145","https://orcid.org/0000-0003-3255-5177"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4405273332","display_name":"Shanghai Key Laboratory of Gynecologic Oncology","ror":"https://ror.org/05nrnex93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273332"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Xu","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200127, China","Shanghai Key Laboratory of Gynecologic Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200127, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Gynecologic Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4405273332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100766534","display_name":"Yutong Zhang","orcid":"https://orcid.org/0009-0005-6935-7053","observed_orcids":["https://orcid.org/0009-0005-6935-7053","https://orcid.org/0009-0002-1256-798X","https://orcid.org/0009-0009-4432-5003"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yutong Zhang","raw_affiliation_strings":["Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112648321","display_name":"Xiaoli Zang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoli Zang","raw_affiliation_strings":["Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063511824","display_name":"Huihua Ding","orcid":"https://orcid.org/0000-0002-7530-8953","observed_orcids":["https://orcid.org/0000-0002-7530-8953"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huihua Ding","raw_affiliation_strings":["Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039335550","display_name":"Wanling Yang","orcid":"https://orcid.org/0000-0003-0063-6327","observed_orcids":["https://orcid.org/0000-0003-0063-6327"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Wanling Yang","raw_affiliation_strings":["Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, 999077, China"],"raw_orcid":"https://orcid.org/0000-0003-0063-6327","affiliations":[{"raw_affiliation_string":"Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, 999077, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062806590","display_name":"Ya Guo","orcid":"https://orcid.org/0000-0001-5350-266X","observed_orcids":["https://orcid.org/0000-0001-5350-266X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ya Guo","raw_affiliation_strings":["Sheng Yushou Center of Cell Biology and Immunology, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University (SJTU), Shanghai, 200240, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheng Yushou Center of Cell Biology and Immunology, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University (SJTU), Shanghai, 200240, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061226924","display_name":"John B. Harley","orcid":"https://orcid.org/0000-0002-8463-1939","observed_orcids":["https://orcid.org/0000-0002-8463-1939","https://orcid.org/0009-0008-6318-8502"]},"institutions":[{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210143084","display_name":"Cincinnati VA Medical Center","ror":"https://ror.org/045r80n66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210127612","https://openalex.org/I4210143084"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John B. Harley","raw_affiliation_strings":["US Department of Veterans Affairs Medical Center, Cincinnati, OH, 45229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"US Department of Veterans Affairs Medical Center, Cincinnati, OH, 45229, USA","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210143084"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028242793","display_name":"Bahram Namjou","orcid":"https://orcid.org/0000-0002-0949-0101","observed_orcids":["https://orcid.org/0000-0002-0949-0101"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bahram Namjou","raw_affiliation_strings":["Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA"],"raw_orcid":"https://orcid.org/0000-0003-4452-7878","affiliations":[{"raw_affiliation_string":"Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014962817","display_name":"Kenneth M. Kaufman","orcid":"https://orcid.org/0000-0001-8195-1876","observed_orcids":["https://orcid.org/0000-0001-8195-1876"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth M. Kaufman","raw_affiliation_strings":["Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA","Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA","Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024288123","display_name":"Leah Claire Kottyan","orcid":"https://orcid.org/0000-0003-3979-2220","observed_orcids":["https://orcid.org/0000-0003-3979-2220"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leah C. Kottyan","raw_affiliation_strings":["Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA","Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA","Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA"],"raw_orcid":"https://orcid.org/0000-0003-3979-2220","affiliations":[{"raw_affiliation_string":"Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073587598","display_name":"Matthew T. Weirauch","orcid":"https://orcid.org/0000-0001-7977-9122","observed_orcids":["https://orcid.org/0000-0001-7977-9122","https://orcid.org/0000-0002-3782-3962"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew T. Weirauch","raw_affiliation_strings":["Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA","Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA","Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA","Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA"],"raw_orcid":"https://orcid.org/0000-0001-7977-9122","affiliations":[{"raw_affiliation_string":"Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069712423","display_name":"Guojun Hou","orcid":"https://orcid.org/0000-0003-3974-4667","observed_orcids":["https://orcid.org/0000-0003-3974-4667"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guojun Hou","raw_affiliation_strings":["Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China. houguojun225@163.com","Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, 518040, China. houguojun225@163.com","State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200032, China. houguojun225@163.com","Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, 518040, China"],"raw_orcid":"https://orcid.org/0000-0003-3974-4667","affiliations":[{"raw_affiliation_string":"Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China. houguojun225@163.com","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]},{"raw_affiliation_string":"Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, 518040, China. houguojun225@163.com","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200032, China. houguojun225@163.com","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4210110011","https://openalex.org/I4210138900"]},{"raw_affiliation_string":"Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, 518040, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012478380","display_name":"Nan Shen","orcid":"https://orcid.org/0000-0002-5875-4417","observed_orcids":["https://orcid.org/0000-0002-5875-4417","https://orcid.org/0000-0002-0908-2706"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Nan Shen","raw_affiliation_strings":["Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA. nanshensibs@gmail.com","Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA. nanshensibs@gmail.com","Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China. nanshensibs@gmail.com","Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, 518040, China. nanshensibs@gmail.com","State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200032, China. nanshensibs@gmail.com","Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA"],"raw_orcid":"https://orcid.org/0000-0002-5875-4417","affiliations":[{"raw_affiliation_string":"Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA. nanshensibs@gmail.com","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA. nanshensibs@gmail.com","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China. nanshensibs@gmail.com","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]},{"raw_affiliation_string":"Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, 518040, China. nanshensibs@gmail.com","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200032, China. nanshensibs@gmail.com","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4210110011","https://openalex.org/I4210138900"]},{"raw_affiliation_string":"Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5012478380","https://openalex.org/A5069712423"],"corresponding_institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4210110011","https://openalex.org/I4210138900","https://openalex.org/I63135867"],"apc_list":{"value":5890,"currency":"USD","value_usd":5890},"apc_paid":{"value":5890,"currency":"USD","value_usd":5890},"fwci":2.4239,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.91093252,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"1855","last_page":"1855"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.4887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.4887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.43650001287460327,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.02879999950528145,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9629999995231628},{"id":"https://openalex.org/keywords/irf8","display_name":"IRF8","score":0.9419999718666077},{"id":"https://openalex.org/keywords/enhancer-rna","display_name":"enhancer RNA","score":0.8289999961853027},{"id":"https://openalex.org/keywords/tet1","display_name":"TET1","score":0.8339999914169312},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chromatin-state","display_name":"chromatin state","score":0.8220000267028809},{"id":"https://openalex.org/keywords/autoimmune-disease-genetics","display_name":"autoimmune disease genetics","score":0.5350000262260437},{"id":"https://openalex.org/keywords/non-coding-variants","display_name":"non-coding variants","score":0.6449999809265137},{"id":"https://openalex.org/keywords/crispr-activation","display_name":"CRISPR activation","score":0.656000018119812},{"id":"https://openalex.org/keywords/enhancer-promoter-interactions","display_name":"enhancer-promoter interactions","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.781039297580719},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7508411407470703},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5248070955276489},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5091492533683777},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4808555245399475},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.45006030797958374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40908315777778625},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4022914469242096},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37000221014022827},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35017871856689453},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.20144784450531006},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16421714425086975},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.14109361171722412},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11204397678375244}],"mesh":[{"descriptor_ui":"D000099185","descriptor_name":"Interferon Regulatory Factor-8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41467-022-29514-y","doi":"https://doi.org/10.1038/s41467-022-29514-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-29514-y","pdf_url":"https://www.nature.com/articles/s41467-022-29514-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2021.06.11.448156","doi":"https://doi.org/10.1101/2021.06.11.448156","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.06.11.448156","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/06/12/2021.06.11.448156.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:35388006","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35388006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8987079","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8987079/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29514-y","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-022-29514-y","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:b834bed781e544609a560d62e4f3795e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b834bed781e544609a560d62e4f3795e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-022-29514-y","doi":"https://doi.org/10.1038/s41467-022-29514-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-29514-y","pdf_url":"https://www.nature.com/articles/s41467-022-29514-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1205269862","display_name":null,"funder_award_id":"81102266","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2036947440","display_name":null,"funder_award_id":"32141004","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3510887184","display_name":null,"funder_award_id":"SZSM201602087","funder_id":"https://openalex.org/F4320335767","funder_display_name":"Sanming Project of Medicine in Shenzhen"},{"id":"https://openalex.org/G6899371709","display_name":null,"funder_award_id":"2005DKA21300","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G735992408","display_name":"\u72fc\u75ae\u9057\u4f20\u76f8\u5173\u57fa\u56e0\u7ec4\u975e\u7f16\u7801\u533a\u4ecb\u5bfc\u514d\u75ab\u7ec6\u80de\u4e9a\u7fa4\u7279\u5f02\u6027\u8c03\u63a7\u7684\u5206\u5b50\u673a\u5236\u7814\u7a76","funder_award_id":"31930037","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7477358773","display_name":"\u89e3\u6790\u81f4\u75c5\u6027TH17\u7ec6\u80de\u5206\u5316\u53ca\u529f\u80fd\u7684\u8868\u89c2\u9057\u4f20\u8c03\u63a7\u673a\u5236","funder_award_id":"31630021","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7791607688","display_name":"Transcription Factor Genetics in Lupus","funder_award_id":"R01AR073228","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000876880","display_name":"Genetic Linkage in Lupus","funder_award_id":"R01AI024717","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309575","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322832","display_name":"University of Tokyo","ror":"https://ror.org/057zh3y96"},{"id":"https://openalex.org/F4320335767","display_name":"Sanming Project of Medicine in Shenzhen","ror":null},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4223495068.pdf","grobid_xml":"https://content.openalex.org/works/W4223495068.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W50783817","https://openalex.org/W1924370859","https://openalex.org/W1968165696","https://openalex.org/W1971578941","https://openalex.org/W1971833707","https://openalex.org/W1974223852","https://openalex.org/W1989841268","https://openalex.org/W1996003201","https://openalex.org/W1999218213","https://openalex.org/W2005042248","https://openalex.org/W2018439988","https://openalex.org/W2021740276","https://openalex.org/W2025150647","https://openalex.org/W2036619779","https://openalex.org/W2042342193","https://openalex.org/W2043618452","https://openalex.org/W2056198580","https://openalex.org/W2070152235","https://openalex.org/W2079632945","https://openalex.org/W2108856514","https://openalex.org/W2111696544","https://openalex.org/W2118448966","https://openalex.org/W2125362831","https://openalex.org/W2126504590","https://openalex.org/W2127862779","https://openalex.org/W2132576596","https://openalex.org/W2135403800","https://openalex.org/W2137465688","https://openalex.org/W2162105224","https://openalex.org/W2163280759","https://openalex.org/W2163749231","https://openalex.org/W2166026190","https://openalex.org/W2166436539","https://openalex.org/W2174609319","https://openalex.org/W2239511084","https://openalex.org/W2346160085","https://openalex.org/W2524507363","https://openalex.org/W2527523198","https://openalex.org/W2577541440","https://openalex.org/W2590316543","https://openalex.org/W2620769476","https://openalex.org/W2739458618","https://openalex.org/W2753608792","https://openalex.org/W2785443776","https://openalex.org/W2785792383","https://openalex.org/W2788520095","https://openalex.org/W2793341348","https://openalex.org/W2794458614","https://openalex.org/W2795328021","https://openalex.org/W2803062674","https://openalex.org/W2901765988","https://openalex.org/W2903904789","https://openalex.org/W2906884244","https://openalex.org/W2911224643","https://openalex.org/W2912343508","https://openalex.org/W2939381881","https://openalex.org/W2942404826","https://openalex.org/W2947733174","https://openalex.org/W2950859937","https://openalex.org/W2953220337","https://openalex.org/W2954958768","https://openalex.org/W2966999196","https://openalex.org/W2973216672","https://openalex.org/W2981137429","https://openalex.org/W2982511147","https://openalex.org/W2991283206","https://openalex.org/W2994153606","https://openalex.org/W3006148173","https://openalex.org/W3013733909","https://openalex.org/W3083875854","https://openalex.org/W3092457640","https://openalex.org/W3108422731","https://openalex.org/W3110451829","https://openalex.org/W3111335358","https://openalex.org/W3112179900","https://openalex.org/W3115880421","https://openalex.org/W3119610678","https://openalex.org/W3126997388","https://openalex.org/W3129349478","https://openalex.org/W3133859624","https://openalex.org/W3134653139","https://openalex.org/W3135765236","https://openalex.org/W3136167697","https://openalex.org/W3138099387","https://openalex.org/W3151678771","https://openalex.org/W3158914043","https://openalex.org/W3161754181"],"related_works":["https://openalex.org/W3167562048","https://openalex.org/W4306392409","https://openalex.org/W3186920055","https://openalex.org/W4313353661","https://openalex.org/W2075420157","https://openalex.org/W3119610678","https://openalex.org/W4323044560","https://openalex.org/W4229454411","https://openalex.org/W4391930568","https://openalex.org/W4417113407"],"abstract_inverted_index":{"Abstract":[0],"Despite":[1],"strong":[2],"evidence":[3],"that":[4,51,57,68,126],"human":[5],"genetic":[6,124],"variants":[7,26,50,125],"affect":[8],"the":[9,28,58,72,88,128,138,141],"expression":[10,79,93,113,129,145],"of":[11,100,130,143],"many":[12],"key":[13],"transcription":[14],"factors":[15],"involved":[16],"in":[17,133],"autoimmune":[18,134],"diseases,":[19],"establishing":[20],"biological":[21],"links":[22],"between":[23],"non-coding":[24],"risk":[25,149],"and":[27,42,105,111,136],"gene":[29],"targets":[30],"they":[31],"regulate":[32,52,109,127],"remains":[33],"a":[34,63],"considerable":[35],"challenge.":[36],"Here,":[37],"we":[38],"combine":[39],"genetic,":[40],"epigenomic,":[41],"CRISPR":[43],"activation":[44],"approaches":[45],"to":[46,87,108,121],"screen":[47],"for":[48,66],"functional":[49,123],"IRF8":[53,67,73,78,89,92,112,144],"expression.":[54],"We":[55],"demonstrate":[56],"locus":[59],"containing":[60],"rs2280381":[61,76,101],"is":[62],"cell-type-specific":[64],"enhancer":[65,81],"spatially":[69],"interacts":[70],"with":[71],"promoter.":[74],"Further,":[75],"mediates":[77],"through":[80],"RNA":[82],"AC092723.1,":[83],"which":[84],"recruits":[85],"TET1":[86],"promoter":[90],"regulating":[91],"by":[94,147],"affecting":[95],"methylation":[96],"levels.":[97],"The":[98],"alleles":[99],"modulate":[102],"PU.1":[103],"binding":[104],"chromatin":[106],"state":[107],"AC092723.1":[110],"differentially.":[114],"Our":[115],"work":[116],"illustrates":[117],"an":[118],"integrative":[119],"strategy":[120],"define":[122],"critical":[131],"genes":[132],"diseases":[135],"decipher":[137],"mechanisms":[139],"underlying":[140],"dysregulation":[142],"mediated":[146],"lupus":[148],"variants.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-04-15T00:00:00"}