{"id":"https://openalex.org/W4223494864","doi":"https://doi.org/10.3390/pharmaceutics14040839","title":"Preclinical Therapeutic Assessment of a New Chemotherapeutics [Dichloro(4,4\u2019-Bis(2,2,3,3-Tetrafluoropropoxy) Methyl)-2,2\u2019-Bipryridine) Platinum] in an Orthotopic Patient-Derived Xenograft Model of Triple-Negative Breast Cancers","display_name":"Preclinical Therapeutic Assessment of a New Chemotherapeutics [Dichloro(4,4\u2019-Bis(2,2,3,3-Tetrafluoropropoxy) Methyl)-2,2\u2019-Bipryridine) Platinum] in an Orthotopic Patient-Derived Xenograft Model of Triple-Negative Breast Cancers","publication_year":2022,"publication_date":"2022-04-11","ids":{"openalex":"https://openalex.org/W4223494864","doi":"https://doi.org/10.3390/pharmaceutics14040839","pmid":"https://pubmed.ncbi.nlm.nih.gov/35456673","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9031226"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics14040839","doi":"https://doi.org/10.3390/pharmaceutics14040839","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics14040839","pdf_url":"https://www.mdpi.com/1999-4923/14/4/839/pdf?version=1649736577","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/14/4/839/pdf?version=1649736577","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041866979","display_name":"Tzu-Chun Kan","orcid":"https://orcid.org/0000-0002-5880-7347","observed_orcids":["https://orcid.org/0000-0002-5880-7347"]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tzu-Chun Kan","raw_affiliation_strings":["Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-5880-7347","affiliations":[{"raw_affiliation_string":"Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025361218","display_name":"Mei\u2010Hsiang Lin","orcid":"https://orcid.org/0000-0002-4188-6413","observed_orcids":["https://orcid.org/0000-0002-4188-6413"]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Mei-Hsiang Lin","raw_affiliation_strings":["School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059004237","display_name":"Chun\u2010Chia Cheng","orcid":"https://orcid.org/0000-0002-6455-1798","observed_orcids":["https://orcid.org/0000-0002-6455-1798"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chun-Chia Cheng","raw_affiliation_strings":["Radiation Biology Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Taoyuan 33302, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-6455-1798","affiliations":[{"raw_affiliation_string":"Radiation Biology Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Taoyuan 33302, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053985678","display_name":"Jeng\u2010Wei Lu","orcid":"https://orcid.org/0000-0003-2128-2046","observed_orcids":["https://orcid.org/0000-0003-2128-2046"]},"institutions":[{"id":"https://openalex.org/I4210167254","display_name":"Singapore-MIT Alliance for Research and Technology","ror":"https://ror.org/05yb3w112","country_code":"SG","type":"education","lineage":["https://openalex.org/I4210167254"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jeng-Wei Lu","raw_affiliation_strings":["Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT-Alliance for Research and Technology, Singapore 138602, Singapore"],"raw_orcid":"https://orcid.org/0000-0003-2128-2046","affiliations":[{"raw_affiliation_string":"Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT-Alliance for Research and Technology, Singapore 138602, Singapore","institution_ids":["https://openalex.org/I4210167254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068926704","display_name":"Ming\u2010Thau Sheu","orcid":"https://orcid.org/0000-0003-1995-8369","observed_orcids":["https://orcid.org/0000-0003-1995-8369"]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Thau Sheu","raw_affiliation_strings":["School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan"],"raw_orcid":"https://orcid.org/0000-0003-1995-8369","affiliations":[{"raw_affiliation_string":"School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047215644","display_name":"Yuan\u2010Soon Ho","orcid":"https://orcid.org/0000-0002-3649-6680","observed_orcids":["https://orcid.org/0000-0002-3649-6680"]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yuan-Soon Ho","raw_affiliation_strings":["College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-3649-6680","affiliations":[{"raw_affiliation_string":"College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103198236","display_name":"Sri Rahayu","orcid":"https://orcid.org/0000-0002-7050-0583","observed_orcids":["https://orcid.org/0000-0002-7050-0583"]},"institutions":[{"id":"https://openalex.org/I3133421993","display_name":"State University of Jakarta","ror":"https://ror.org/01hgg7b81","country_code":"ID","type":"education","lineage":["https://openalex.org/I3133421993"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Sri Rahayu","raw_affiliation_strings":["Department of Biology, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Jakarta 13220, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Jakarta 13220, Indonesia","institution_ids":["https://openalex.org/I3133421993"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072122231","display_name":"Jungshan Chang","orcid":"https://orcid.org/0000-0002-9537-064X","observed_orcids":["https://orcid.org/0000-0002-9537-064X"]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Jungshan Chang","raw_affiliation_strings":["Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan","International Master/Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan","International Ph.D. Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"International Master/Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"International Ph.D. Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5072122231"],"corresponding_institution_ids":["https://openalex.org/I47519274"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2513},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2513},"fwci":0.3365,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.5175307,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"14","issue":"4","first_page":"839","last_page":"839"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin-analogues","display_name":"cisplatin analogues","score":0.7080000042915344},{"id":"https://openalex.org/keywords/platinum-based-chemotherapy","display_name":"platinum-based chemotherapy","score":0.5199999809265137},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.968999981880188},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cell-line-derived-xenografts","display_name":"cell line-derived xenografts","score":0.8870000243186951},{"id":"https://openalex.org/keywords/dna-cross-linking","display_name":"DNA cross-linking","score":0.765999972820282},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9670000076293945},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6949999928474426},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.8339999914169312},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.5759999752044678},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.8159999847412109},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.9099839925765991},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.70355224609375},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.6093547940254211},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5753904581069946},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4574098587036133},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.43872907757759094},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4312346875667572},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.41118454933166504},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40607374906539917},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34587839245796204},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3338034749031067},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3075879216194153},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.1402541995048523},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07590183615684509}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/pharmaceutics14040839","doi":"https://doi.org/10.3390/pharmaceutics14040839","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics14040839","pdf_url":"https://www.mdpi.com/1999-4923/14/4/839/pdf?version=1649736577","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:35456673","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35456673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9031226","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9031226/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:544131621a934047b7c9de05ddc9bc17","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/544131621a934047b7c9de05ddc9bc17","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 14, Iss 4, p 839 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics14040839","doi":"https://doi.org/10.3390/pharmaceutics14040839","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics14040839","pdf_url":"https://www.mdpi.com/1999-4923/14/4/839/pdf?version=1649736577","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G153804037","display_name":null,"funder_award_id":"MOST110-2320-B-038-031","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G2576912404","display_name":null,"funder_award_id":"110-2320-B-038-082 awarded","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G2667661164","display_name":"Studies on the Anti-Tumor Effects of Receptor-Specific-Rna Aptamer-Derived Nanoparticles Induced Type-3 Hyaluronan Synthase Activation in Breast Carcinogenesis","funder_award_id":"MOST109-2314-B038-033-MY3","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G5218271880","display_name":"Studies on the Mechanisms of Histamine N-Methyl-Transferase (Hnmt) as a Novel Molecular Marker to Help Clinician for Identifying of Herceptin Responder in Breast Cancer Patients","funder_award_id":"MOST108-2320-B038-033-MY3","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G8666156772","display_name":"Studies on the Carcinogenic Mechanisms of Serine/Threonine-Protein Kinase (Sik3) Involved in the Process of Breast Tumor Formation","funder_award_id":"MOST109-2320-B038-017","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4223494864.pdf","grobid_xml":"https://content.openalex.org/works/W4223494864.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W20074971","https://openalex.org/W626649172","https://openalex.org/W1585512529","https://openalex.org/W1963521777","https://openalex.org/W1970837937","https://openalex.org/W1981199426","https://openalex.org/W1985509570","https://openalex.org/W1986499818","https://openalex.org/W1987604182","https://openalex.org/W1988338487","https://openalex.org/W1998238577","https://openalex.org/W2000157315","https://openalex.org/W2001857585","https://openalex.org/W2023897374","https://openalex.org/W2027310997","https://openalex.org/W2028738450","https://openalex.org/W2031594579","https://openalex.org/W2040464160","https://openalex.org/W2044702943","https://openalex.org/W2048999501","https://openalex.org/W2049775342","https://openalex.org/W2055040221","https://openalex.org/W2060433089","https://openalex.org/W2071389910","https://openalex.org/W2074550396","https://openalex.org/W2074579348","https://openalex.org/W2075209314","https://openalex.org/W2075591668","https://openalex.org/W2076994510","https://openalex.org/W2079351077","https://openalex.org/W2084848682","https://openalex.org/W2100770564","https://openalex.org/W2114305819","https://openalex.org/W2120352508","https://openalex.org/W2150134401","https://openalex.org/W2158305374","https://openalex.org/W2163436015","https://openalex.org/W2213319157","https://openalex.org/W2250135126","https://openalex.org/W2346606536","https://openalex.org/W2466494474","https://openalex.org/W2489242686","https://openalex.org/W2518944870","https://openalex.org/W2591446714","https://openalex.org/W2594064133","https://openalex.org/W2594345796","https://openalex.org/W2754511548","https://openalex.org/W2774937715","https://openalex.org/W2789954858","https://openalex.org/W2790169105","https://openalex.org/W2790979656","https://openalex.org/W2792471731","https://openalex.org/W2801248003","https://openalex.org/W2807706797","https://openalex.org/W2907182858","https://openalex.org/W2937766145","https://openalex.org/W2949765486","https://openalex.org/W2969314362","https://openalex.org/W2995778686","https://openalex.org/W2997001789","https://openalex.org/W3010954881","https://openalex.org/W3015442469","https://openalex.org/W3019266968","https://openalex.org/W3034380669","https://openalex.org/W3044093631","https://openalex.org/W3092181870","https://openalex.org/W3095431398","https://openalex.org/W3108822966","https://openalex.org/W3124165020","https://openalex.org/W3137126526","https://openalex.org/W3139166337","https://openalex.org/W3211839918","https://openalex.org/W4200084067","https://openalex.org/W4210409925","https://openalex.org/W6748970405"],"related_works":["https://openalex.org/W4412019789","https://openalex.org/W2888835451","https://openalex.org/W4317103707","https://openalex.org/W3193050721","https://openalex.org/W4228999840","https://openalex.org/W4363651607","https://openalex.org/W4320806757","https://openalex.org/W2894770440","https://openalex.org/W3130393297","https://openalex.org/W7112772113"],"abstract_inverted_index":{"Cisplatin":[0],"is":[1,183],"one":[2],"of":[3,11,14,49,111,120,135,144,178,189],"the":[4,47,81,86,126,176],"most":[5],"common":[6],"therapeutics":[7],"used":[8],"in":[9,45,77,99,155,165,170],"treatments":[10,188],"several":[12,50],"types":[13],"cancers.":[15,66,199],"To":[16],"enhance":[17],"cisplatin":[18,29],"lipophilicity":[19],"and":[20,23,36,63,71,89,114,138,153,167,172],"reduce":[21],"resistance":[22],"side":[24],"effects,":[25],"a":[26,105,115,184],"polyfluorinated":[27],"bipyridine-modified":[28],"analogue,":[30],"dichloro[4,4'-bis(2,2,3,3-tetrafluoropropoxy)methyl)-2,2'-bipryridine]":[31],"platinum":[32],"(TFBPC),":[33],"was":[34,151],"synthesized":[35],"therapeutic":[37],"assessments":[38],"were":[39,163],"performed.":[40],"TFBPC":[41,67,94,149,182],"displayed":[42],"superior":[43],"effects":[44],"inhibiting":[46],"proliferation":[48],"cisplatin-resistant":[51,112,198],"human":[52],"cancer":[53],"cell":[54,82,106],"lines,":[55],"including":[56],"MDA-MB-231":[57],"breast":[58,122],"cancers,":[59],"COLO205":[60],"colon":[61],"cancers":[62,123],"SK-OV-3":[64],"ovarian":[65],"bound":[68],"to":[69],"DNA":[70,73,78],"formed":[72],"crosslinks":[74],"that":[75],"resulted":[76,154],"degradation,":[79],"triggering":[80],"death":[83],"program":[84],"through":[85],"PARP/Bax/Bcl-2":[87],"apoptosis":[88],"LC3-related":[90],"autophagy":[91],"pathway.":[92],"Moreover,":[93],"significantly":[95],"inhibited":[96],"tumor":[97],"growth":[98],"both":[100],"animal":[101],"models":[102],"which":[103],"include":[104],"line-derived":[107],"xenograft":[108,117],"model":[109,119],"(CDX)":[110],"MDA-MB-231,":[113],"patient-derived":[116],"(PDX)":[118],"triple-negative":[121],"(TNBCs).":[124],"Furthermore,":[125],"biopsy":[127],"specimen":[128,177],"from":[129,175,192],"TFBPC-treated":[130],"xenografts":[131],"revealed":[132],"decreased":[133],"expressions":[134],"P53,":[136],"Ki-67":[137],"PD-L1":[139],"coupled":[140],"with":[141],"higher":[142],"expression":[143],"cleaved":[145],"caspase":[146],"3,":[147],"suggesting":[148],"treatment":[150],"effective":[152],"good":[156],"prognostic":[157],"indications.":[158],"No":[159],"significant":[160],"pathological":[161],"changes":[162],"observed":[164],"hematological":[166],"biochemistry":[168],"tests":[169],"blood":[171],"histological":[173],"examinations":[174],"major":[179],"organs.":[180],"Therefore,":[181],"potential":[185],"candidate":[186],"for":[187],"patients":[190],"suffering":[191],"TNBCs":[193],"as":[194,196],"well":[195],"other":[197]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-04-15T00:00:00"}