{"id":"https://openalex.org/W4223459555","doi":"https://doi.org/10.1016/j.jbc.2022.101917","title":"Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences","display_name":"Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences","publication_year":2022,"publication_date":"2022-04-08","ids":{"openalex":"https://openalex.org/W4223459555","doi":"https://doi.org/10.1016/j.jbc.2022.101917","pmid":"https://pubmed.ncbi.nlm.nih.gov/35405095","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9118916"},"language":"en","primary_location":{"id":"doi:10.1016/j.jbc.2022.101917","doi":"https://doi.org/10.1016/j.jbc.2022.101917","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2022.101917","pdf_url":"http://www.jbc.org/article/S002192582200357X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.jbc.org/article/S002192582200357X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089399618","display_name":"D. Judy Shon","orcid":"https://orcid.org/0000-0001-8379-6195","observed_orcids":["https://orcid.org/0000-0001-8379-6195"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Judy Shon","raw_affiliation_strings":["Department of Chemistry and Stanford ChEM-H, Stanford University, Stanford, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Stanford ChEM-H, Stanford University, Stanford, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040731166","display_name":"Daniel Fern\u00e1ndez","orcid":"https://orcid.org/0000-0002-6221-152X","observed_orcids":["https://orcid.org/0000-0002-6221-152X"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Fernandez","raw_affiliation_strings":["Stanford ChEM-H Macromolecular Structure Knowledge Center, Stanford University, Stanford, California, USA"],"raw_orcid":"https://orcid.org/0000-0002-6221-152X","affiliations":[{"raw_affiliation_string":"Stanford ChEM-H Macromolecular Structure Knowledge Center, Stanford University, Stanford, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004888617","display_name":"Nicholas McIlvain Riley","orcid":"https://orcid.org/0000-0002-1536-2966","observed_orcids":["https://orcid.org/0000-0002-1536-2966"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas M. Riley","raw_affiliation_strings":["Department of Chemistry and Stanford ChEM-H, Stanford University, Stanford, California, USA"],"raw_orcid":"https://orcid.org/0000-0002-1536-2966","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Stanford ChEM-H, Stanford University, Stanford, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085960613","display_name":"Michael J. Ferracane","orcid":"https://orcid.org/0000-0002-3007-3126","observed_orcids":["https://orcid.org/0000-0002-3007-3126"]},"institutions":[{"id":"https://openalex.org/I193054373","display_name":"University of Redlands","ror":"https://ror.org/02hfyct53","country_code":"US","type":"education","lineage":["https://openalex.org/I193054373"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Ferracane","raw_affiliation_strings":["Department of Chemistry, University of Redlands, Redlands, California, USA"],"raw_orcid":"https://orcid.org/0000-0002-3007-3126","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Redlands, Redlands, California, USA","institution_ids":["https://openalex.org/I193054373"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088409133","display_name":"Carolyn Ruth Bertozzi","orcid":"https://orcid.org/0000-0003-4482-2754","observed_orcids":["https://orcid.org/0000-0003-4482-2754"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carolyn R. Bertozzi","raw_affiliation_strings":["Department of Chemistry and Stanford ChEM-H, Stanford University, Stanford, California, USA; Howard Hughes Medical Institute, Stanford University, Stanford, California, USA. Electronic address: bertozzi@stanford.edu","Department of Chemistry and Stanford ChEM-H, Stanford University, Stanford, California, USA","Howard Hughes Medical Institute, Stanford University, Stanford, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Stanford ChEM-H, Stanford University, Stanford, California, USA; Howard Hughes Medical Institute, Stanford University, Stanford, California, USA. Electronic address: bertozzi@stanford.edu","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Chemistry and Stanford ChEM-H, Stanford University, Stanford, California, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Stanford University, Stanford, California, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088409133"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I97018004"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":1.4258,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.81054978,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"298","issue":"5","first_page":"101917","last_page":"101917"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.5859000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.5859000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.2888000011444092,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/akkermansia-muciniphila","display_name":"Akkermansia muciniphila","score":1.0},{"id":"https://openalex.org/keywords/mucin-degradation","display_name":"mucin degradation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/muc2","display_name":"MUC2","score":0.9190000295639038},{"id":"https://openalex.org/keywords/core-1-o-glycans","display_name":"core 1 O-glycans","score":0.8090000152587891},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.7459999918937683},{"id":"https://openalex.org/keywords/structure-based-mutagenesis","display_name":"structure-guided mutagenesis","score":0.7789999842643738},{"id":"https://openalex.org/keywords/x-ray-crystal-structure","display_name":"X-ray crystal structure","score":0.8370000123977661},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7400000095367432},{"id":"https://openalex.org/keywords/mucus","display_name":"mucus","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.9112671613693237},{"id":"https://openalex.org/C2775941767","wikidata":"https://www.wikidata.org/wiki/Q15020908","display_name":"Akkermansia muciniphila","level":3,"score":0.8688488602638245},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.7202332019805908},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6214619278907776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5475035309791565},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5130354166030884},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.42295169830322266},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4135097861289978},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.4110827147960663},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3705423176288605},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.13755205273628235},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.12948408722877502},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11158475279808044}],"mesh":[{"descriptor_ui":"D000086102","descriptor_name":"Akkermansia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000086102","descriptor_name":"Akkermansia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009077","descriptor_name":"Mucins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045726","descriptor_name":"Metalloproteases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061327","descriptor_name":"Verrucomicrobia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jbc.2022.101917","doi":"https://doi.org/10.1016/j.jbc.2022.101917","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2022.101917","pdf_url":"http://www.jbc.org/article/S002192582200357X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9118916","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9118916","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:35405095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35405095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:osti.gov:1863124","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/1863124","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.jbc.2022.101917","doi":"https://doi.org/10.1016/j.jbc.2022.101917","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2022.101917","pdf_url":"http://www.jbc.org/article/S002192582200357X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1229526393","display_name":null,"funder_award_id":"AC02-76SF00515","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G1286251239","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G1804828992","display_name":null,"funder_award_id":"P41GM103393","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G1831385526","display_name":null,"funder_award_id":"P41 GM103393","funder_id":"https://openalex.org/F4320337509","funder_display_name":"Biological and Environmental Research"},{"id":"https://openalex.org/G2371548206","display_name":null,"funder_award_id":"76SF00515","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G262532246","display_name":null,"funder_award_id":"DEAC02\u221276SF00515","funder_id":"https://openalex.org/F4320338381","funder_display_name":"SLAC National Accelerator Laboratory"},{"id":"https://openalex.org/G303061748","display_name":null,"funder_award_id":"DE\u2013AC02\u201376SF00515","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G315621713","display_name":null,"funder_award_id":"DE- AC0276SF00515","funder_id":"https://openalex.org/F4320337509","funder_display_name":"Biological and Environmental Research"},{"id":"https://openalex.org/G3488436650","display_name":null,"funder_award_id":"P41GM103393","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G3629260272","display_name":null,"funder_award_id":"P41GM103393","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G4235786860","display_name":null,"funder_award_id":"AC02\u201076SF00515","funder_id":"https://openalex.org/F4320338381","funder_display_name":"SLAC National Accelerator Laboratory"},{"id":"https://openalex.org/G4280418065","display_name":null,"funder_award_id":"P41GM103393","funder_id":"https://openalex.org/F4320338381","funder_display_name":"SLAC National Accelerator Laboratory"},{"id":"https://openalex.org/G4581610328","display_name":null,"funder_award_id":"DE-AC02-76SF00515","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4908923434","display_name":null,"funder_award_id":"Contract No. DE-AC02-76SF00515","funder_id":"https://openalex.org/F4320338381","funder_display_name":"SLAC National Accelerator Laboratory"},{"id":"https://openalex.org/G495301720","display_name":null,"funder_award_id":"DE-AC02-76SF0051 5","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G498139845","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G5570207115","display_name":null,"funder_award_id":"AC02\u201076SF00515","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G628751139","display_name":null,"funder_award_id":"No. DE-AC02\u201376SF00515","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G6550344761","display_name":null,"funder_award_id":"76SF00515","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G6857735821","display_name":"Uniting Mass Spectrometry and Glycoscience to Investigate Cancer Biology","funder_award_id":"K00CA212454","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7083997402","display_name":null,"funder_award_id":"Contract No. DE-AC02-76SF00515","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G7283024673","display_name":null,"funder_award_id":"AC02-76SF00515","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G7313278570","display_name":null,"funder_award_id":"Contract No. DE-AC02-76SF00515","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G8382000481","display_name":null,"funder_award_id":"76SF00515","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G876745251","display_name":"A Synchrotron Radiation Structural Biology Resource","funder_award_id":"P41GM103393","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8925327636","display_name":null,"funder_award_id":"DE-AC02-76SF00515","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000858706","display_name":"Chemical Glycoproteomics","funder_award_id":"R01CA200423","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G911061179","display_name":null,"funder_award_id":"DE-AC-02-76SF00515","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G969889393","display_name":null,"funder_award_id":"DE-AC02-","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337480","display_name":"Basic Energy Sciences","ror":"https://ror.org/05mg91w61"},{"id":"https://openalex.org/F4320337509","display_name":"Biological and Environmental Research","ror":"https://ror.org/0114b2m14"},{"id":"https://openalex.org/F4320338381","display_name":"SLAC National Accelerator Laboratory","ror":"https://ror.org/05gzmn429"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4223459555.pdf","grobid_xml":"https://content.openalex.org/works/W4223459555.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W913777339","https://openalex.org/W1598859659","https://openalex.org/W1948266836","https://openalex.org/W1969547178","https://openalex.org/W1979046104","https://openalex.org/W1996933969","https://openalex.org/W2004228538","https://openalex.org/W2007216182","https://openalex.org/W2009393104","https://openalex.org/W2015392436","https://openalex.org/W2016853666","https://openalex.org/W2017306282","https://openalex.org/W2021251015","https://openalex.org/W2030517878","https://openalex.org/W2032112360","https://openalex.org/W2038840577","https://openalex.org/W2039388179","https://openalex.org/W2060838494","https://openalex.org/W2071430019","https://openalex.org/W2083102356","https://openalex.org/W2088192427","https://openalex.org/W2094102556","https://openalex.org/W2094296002","https://openalex.org/W2094646744","https://openalex.org/W2097493124","https://openalex.org/W2108921801","https://openalex.org/W2117672117","https://openalex.org/W2120717049","https://openalex.org/W2122994276","https://openalex.org/W2124026197","https://openalex.org/W2143815085","https://openalex.org/W2147790901","https://openalex.org/W2164536401","https://openalex.org/W2276038575","https://openalex.org/W2319705746","https://openalex.org/W2345070902","https://openalex.org/W2532769502","https://openalex.org/W2552041992","https://openalex.org/W2559267012","https://openalex.org/W2579867384","https://openalex.org/W2593928562","https://openalex.org/W2729285740","https://openalex.org/W2765314233","https://openalex.org/W2765633603","https://openalex.org/W2793748821","https://openalex.org/W2924483954","https://openalex.org/W2954124338","https://openalex.org/W2972555397","https://openalex.org/W2977901918","https://openalex.org/W2982535496","https://openalex.org/W3003593158","https://openalex.org/W3015066429","https://openalex.org/W3034064336","https://openalex.org/W3049699113","https://openalex.org/W3083241614","https://openalex.org/W3088398787","https://openalex.org/W3092199848","https://openalex.org/W3092277989","https://openalex.org/W3093525434","https://openalex.org/W3094309494","https://openalex.org/W3134348576","https://openalex.org/W3142827258","https://openalex.org/W3158046103","https://openalex.org/W3208691473","https://openalex.org/W4214834963","https://openalex.org/W4230386739","https://openalex.org/W4248872320"],"related_works":["https://openalex.org/W4293718623","https://openalex.org/W4288009878","https://openalex.org/W3088398787","https://openalex.org/W3002445927","https://openalex.org/W3045987672","https://openalex.org/W4409180106","https://openalex.org/W4392103889","https://openalex.org/W4393275251","https://openalex.org/W7123348332","https://openalex.org/W4200113337"],"abstract_inverted_index":{"Akkermansia":[0],"muciniphila,":[1],"a":[2,48,57,78],"mucin-degrading":[3],"microbe":[4,89],"found":[5],"in":[6,60,93,142,191],"the":[7,25,42,61,83,94,105,136,143,165,171,197,203],"human":[8],"gut,":[9],"is":[10,22,71,96,111,128],"often":[11],"associated":[12],"with":[13],"positive":[14],"health":[15],"outcomes.":[16],"The":[17],"abundance":[18],"of":[19,29,50,64,130,140,149,187,206],"A.":[20,69],"muciniphila":[21,70],"modulated":[23],"by":[24,87],"presence":[26],"and":[27,80],"accessibility":[28],"nutrients,":[30],"which":[31,110],"can":[32],"be":[33],"derived":[34],"from":[35,164],"diet":[36],"or":[37],"host":[38,46],"glycoproteins.":[39],"In":[40],"particular,":[41],"ability":[43],"to":[44,73,90,113,178,196],"degrade":[45],"mucins,":[47],"class":[49],"proteins":[51],"carrying":[52,118],"densely":[53],"O-glycosylated":[54],"domains,":[55],"provides":[56],"competitive":[58],"advantage":[59],"sustained":[62],"colonization":[63],"niche":[65],"mucosal":[66],"environments.":[67],"Although":[68],"known":[72,112],"rely":[74],"on":[75,104],"mucins":[76,92],"as":[77],"carbon":[79],"nitrogen":[81],"source,":[82],"enzymatic":[84],"machinery":[85],"used":[86],"this":[88,126],"process":[91],"gut":[95],"not":[97],"yet":[98],"fully":[99],"characterized.":[100],"Here,":[101],"we":[102],"focus":[103],"mucin-selective":[106],"metalloprotease,":[107],"Amuc_0627":[108],"(AM0627),":[109],"cleave":[114],"between":[115,160],"adjacent":[116],"residues":[117,156,189],"truncated":[119],"core":[120],"1":[121],"O-glycans.":[122],"We":[123,168,183],"showed":[124],"that":[125,157,185],"enzyme":[127],"capable":[129],"degrading":[131],"purified":[132],"mucin":[133],"2":[134],"(MUC2),":[135],"major":[137],"protein":[138],"component":[139],"mucus":[141],"gut.":[144],"An":[145],"X-ray":[146],"crystal":[147],"structure":[148],"AM0627":[150],"(1.9":[151],"\u00c5":[152],"resolution)":[153],"revealed":[154],"O-glycan-binding":[155],"are":[158],"conserved":[159],"structurally":[161],"characterized":[162],"enzymes":[163],"same":[166],"family.":[167],"further":[169],"rationalized":[170],"substrate":[172,193],"cleavage":[173],"motif":[174],"using":[175],"molecular":[176],"modeling":[177],"identify":[179],"nonconserved":[180],"glycan-interacting":[181],"residues.":[182],"conclude":[184],"mutagenesis":[186],"these":[188],"resulted":[190],"altered":[192],"preferences":[194],"down":[195],"glycan":[198],"level,":[199],"providing":[200],"insight":[201],"into":[202],"structural":[204],"determinants":[205],"O-glycan":[207],"recognition.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-04-15T00:00:00"}
