{"id":"https://openalex.org/W4223439745","doi":"https://doi.org/10.1080/15376516.2022.2064258","title":"N-acetylcysteine ameliorates monocrotophos exposure-induced mitochondrial dysfunctions in rat liver","display_name":"N-acetylcysteine ameliorates monocrotophos exposure-induced mitochondrial dysfunctions in rat liver","publication_year":2022,"publication_date":"2022-04-11","ids":{"openalex":"https://openalex.org/W4223439745","doi":"https://doi.org/10.1080/15376516.2022.2064258","pmid":"https://pubmed.ncbi.nlm.nih.gov/35403558"},"language":"en","primary_location":{"id":"doi:10.1080/15376516.2022.2064258","doi":"https://doi.org/10.1080/15376516.2022.2064258","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15376516.2022.2064258","pdf_url":null,"source":{"id":"https://openalex.org/S93207707","display_name":"Toxicology Mechanisms and Methods","issn_l":"1537-6516","issn":["1537-6516","1537-6524"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Mechanisms and Methods","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082093044","display_name":"Jagjeet Singh","orcid":"https://orcid.org/0000-0002-6936-9223","observed_orcids":["https://orcid.org/0000-0002-6936-9223"]},"institutions":[{"id":"https://openalex.org/I905734797","display_name":"Maharshi Dayanand University","ror":"https://ror.org/03kaab451","country_code":"IN","type":"education","lineage":["https://openalex.org/I905734797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jagjeet Singh","raw_affiliation_strings":["Department of Zoology, Maharshi Dayanand University, Rohtak, India"],"raw_orcid":"https://orcid.org/0000-0002-6936-9223","affiliations":[{"raw_affiliation_string":"Department of Zoology, Maharshi Dayanand University, Rohtak, India","institution_ids":["https://openalex.org/I905734797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006936400","display_name":"Annu Phogat","orcid":"https://orcid.org/0000-0002-7456-5405","observed_orcids":["https://orcid.org/0000-0002-7456-5405"]},"institutions":[{"id":"https://openalex.org/I905734797","display_name":"Maharshi Dayanand University","ror":"https://ror.org/03kaab451","country_code":"IN","type":"education","lineage":["https://openalex.org/I905734797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Annu Phogat","raw_affiliation_strings":["Department of Zoology, Maharshi Dayanand University, Rohtak, India"],"raw_orcid":"https://orcid.org/0000-0002-7456-5405","affiliations":[{"raw_affiliation_string":"Department of Zoology, Maharshi Dayanand University, Rohtak, India","institution_ids":["https://openalex.org/I905734797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100621514","display_name":"Vijay Jyoti Kumar","orcid":"https://orcid.org/0000-0001-5559-0624","observed_orcids":["https://orcid.org/0000-0001-5559-0624"]},"institutions":[{"id":"https://openalex.org/I905734797","display_name":"Maharshi Dayanand University","ror":"https://ror.org/03kaab451","country_code":"IN","type":"education","lineage":["https://openalex.org/I905734797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vijay Kumar","raw_affiliation_strings":["Department of Biochemistry, Maharshi Dayanand University, Rohtak, India"],"raw_orcid":"https://orcid.org/0000-0001-5559-0624","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Maharshi Dayanand University, Rohtak, India","institution_ids":["https://openalex.org/I905734797"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065507001","display_name":"Vinay Malik","orcid":"https://orcid.org/0000-0001-8909-9542","observed_orcids":["https://orcid.org/0000-0001-8909-9542"]},"institutions":[{"id":"https://openalex.org/I905734797","display_name":"Maharshi Dayanand University","ror":"https://ror.org/03kaab451","country_code":"IN","type":"education","lineage":["https://openalex.org/I905734797"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Vinay Malik","raw_affiliation_strings":["Department of Zoology, Maharshi Dayanand University, Rohtak, India"],"raw_orcid":"https://orcid.org/0000-0001-8909-9542","affiliations":[{"raw_affiliation_string":"Department of Zoology, Maharshi Dayanand University, Rohtak, India","institution_ids":["https://openalex.org/I905734797"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065507001"],"corresponding_institution_ids":["https://openalex.org/I905734797"],"apc_list":null,"apc_paid":null,"fwci":2.1064,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.84787124,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"32","issue":"9","first_page":"686","last_page":"694"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.11240000277757645,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9610000252723694},{"id":"https://openalex.org/keywords/monocrotophos","display_name":"monocrotophos","score":0.9990000128746033},{"id":"https://openalex.org/keywords/organophosphate-pesticide-toxicity","display_name":"organophosphate pesticide toxicity","score":0.9309999942779541},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8700000047683716},{"id":"https://openalex.org/keywords/liver-mitochondria","display_name":"liver mitochondria","score":0.8169999718666077},{"id":"https://openalex.org/keywords/nrf1","display_name":"NRF1","score":0.9200000166893005},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":1.0},{"id":"https://openalex.org/keywords/tfam","display_name":"TFAM","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.7490000128746033},{"id":"https://openalex.org/keywords/antioxidant-therapy","display_name":"antioxidant therapy","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C2778403829","wikidata":"https://www.wikidata.org/wiki/Q412441","display_name":"Monocrotophos","level":3,"score":0.8538089990615845},{"id":"https://openalex.org/C169415338","wikidata":"https://www.wikidata.org/wiki/Q18031951","display_name":"TFAM","level":4,"score":0.7811785936355591},{"id":"https://openalex.org/C2777847592","wikidata":"https://www.wikidata.org/wiki/Q375613","display_name":"Acetylcysteine","level":3,"score":0.6947144269943237},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6478684544563293},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.555401086807251},{"id":"https://openalex.org/C2776588719","wikidata":"https://www.wikidata.org/wiki/Q411097","display_name":"Organophosphate","level":3,"score":0.5456623435020447},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4947897791862488},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44184374809265137},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4402100443840027},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4367116689682007},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4323250353336334},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.4125116765499115},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.41131266951560974},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4056299030780792},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34240013360977173},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26784875988960266},{"id":"https://openalex.org/C2777229759","wikidata":"https://www.wikidata.org/wiki/Q6881848","display_name":"Mitochondrial biogenesis","level":3,"score":0.23921462893486023},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.12266305088996887},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008999","descriptor_name":"Monocrotophos","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008999","descriptor_name":"Monocrotophos","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D010575","descriptor_name":"Pesticides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/15376516.2022.2064258","doi":"https://doi.org/10.1080/15376516.2022.2064258","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15376516.2022.2064258","pdf_url":null,"source":{"id":"https://openalex.org/S93207707","display_name":"Toxicology Mechanisms and Methods","issn_l":"1537-6516","issn":["1537-6516","1537-6524"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Mechanisms and Methods","raw_type":"journal-article"},{"id":"pmid:35403558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35403558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology mechanisms and methods","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8837993728","display_name":null,"funder_award_id":"09/382(0221)/2019-EMR-I","funder_id":"https://openalex.org/F4320320721","funder_display_name":"Council of Scientific and Industrial Research, India"}],"funders":[{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1775749144","https://openalex.org/W1965269645","https://openalex.org/W1972728679","https://openalex.org/W1984381718","https://openalex.org/W1998356037","https://openalex.org/W2001113682","https://openalex.org/W2002662437","https://openalex.org/W2003761115","https://openalex.org/W2028101737","https://openalex.org/W2041963475","https://openalex.org/W2049114235","https://openalex.org/W2058468405","https://openalex.org/W2069217287","https://openalex.org/W2069484147","https://openalex.org/W2079167667","https://openalex.org/W2082928755","https://openalex.org/W2085534442","https://openalex.org/W2087884735","https://openalex.org/W2092888258","https://openalex.org/W2098436069","https://openalex.org/W2104311857","https://openalex.org/W2105404724","https://openalex.org/W2111401978","https://openalex.org/W2117800935","https://openalex.org/W2125262244","https://openalex.org/W2128557475","https://openalex.org/W2147041971","https://openalex.org/W2152165298","https://openalex.org/W2236805708","https://openalex.org/W2289081559","https://openalex.org/W2333398145","https://openalex.org/W2482486185","https://openalex.org/W2590809958","https://openalex.org/W2765667521","https://openalex.org/W2892783277","https://openalex.org/W2896524469","https://openalex.org/W2901759195","https://openalex.org/W2910945106","https://openalex.org/W2913039709","https://openalex.org/W2915918918","https://openalex.org/W2949692705","https://openalex.org/W2977991037","https://openalex.org/W2980378339","https://openalex.org/W2985445212","https://openalex.org/W3005152119","https://openalex.org/W3014759727","https://openalex.org/W3015756344","https://openalex.org/W3022689963","https://openalex.org/W3025286369","https://openalex.org/W3098787407","https://openalex.org/W3109288740","https://openalex.org/W3111360360","https://openalex.org/W3136041166","https://openalex.org/W3139285687","https://openalex.org/W3144721170","https://openalex.org/W3158836534","https://openalex.org/W3184781050","https://openalex.org/W4205270459"],"related_works":["https://openalex.org/W4323852985","https://openalex.org/W3169949310","https://openalex.org/W4205270459","https://openalex.org/W4280613460","https://openalex.org/W4310811367","https://openalex.org/W1993263247","https://openalex.org/W3194894723","https://openalex.org/W2381994253","https://openalex.org/W2030389000","https://openalex.org/W2954355210"],"abstract_inverted_index":{"Background:":[0],"Monocrotophos":[1],"(MCP)":[2],"is":[3,15],"an":[4],"organophosphate":[5],"pesticide":[6],"with":[7,17,59],"well-known":[8],"toxicity":[9],"in":[10,38],"mammals.":[11],"Exposure":[12,91],"of":[13,29,41,76,92,107,112,124,140,154,162],"MCP":[14,33,52,93],"associated":[16],"altered":[18],"molecular":[19],"physiology":[20],"at":[21],"sub-cellular":[22],"levels.":[23],"This":[24],"study":[25,164],"investigated":[26],"the":[27,151],"efficacy":[28],"N-acetylcysteine":[30],"(NAC)":[31],"against":[32],"exposure":[34],"mediated":[35],"mitochondrial":[36,77,101,134,147,170,187],"dysfunctions":[37,171,188],"hepatic":[39,169],"tissue":[40],"rats.Methods:":[42],"Male":[43],"Wistar":[44],"rats":[45],"were":[46,69,85],"given":[47],"NAC":[48,57,125,144,167,178],"(200":[49,126],"mg/kg":[50,54,95,127],"b.wt),":[51],"(0.9":[53,94],"b.wt)":[55],"and":[56,81,104,116,137,149,156,172],"together":[58],"MCP,":[60],"intragastrically":[61],"for":[62,186],"28":[63,98,130],"consecutive":[64],"days.":[65],"Mitochondrial":[66],"complexes":[67,78,102,108,135,141],"activities":[68,103,136],"evaluated":[70],"using":[71,87],"biochemical":[72],"analysis.":[73],"mRNA":[74],"expression":[75,106,111,139,153],"subunits,":[79],"PGC-1\u03b1":[80,155,174],"its":[82,157],"downstream":[83,158],"regulators":[84],"analyzed":[86],"polymerase":[88],"chain":[89],"reaction.Results:":[90],"b.wt,":[96,128],"intragastrically,":[97,129],"d)":[99,131],"decreased":[100],"gene":[105,138,152],"subunits.":[109,142],"The":[110,122,160],"PGC-1\u03b1,":[113],"NRF-1,":[114],"NRF-2,":[115],"Tfam":[117],"was":[118],"also":[119,145],"reduced":[120],"significantly.":[121],"administration":[123],"significantly":[132],"increased":[133],"Additionally,":[143],"maintained":[146],"functions,":[148],"enhanced":[150],"regulators.Conclusion:":[159],"results":[161],"this":[163],"indicate":[165],"that":[166],"prevents":[168],"maintains":[173],"signaling.":[175],"In":[176],"conclusion,":[177],"might":[179],"be":[180],"speculated":[181],"as":[182],"a":[183],"therapeutic":[184],"agent":[185],"following":[189],"toxic":[190],"exposures.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-04-14T00:00:00"}
