{"id":"https://openalex.org/W42214381","doi":null,"title":"Targeting \u03b14 Integrin Containing Complexes in Multiple Myeloma Using Peptidomimetics","display_name":"Targeting \u03b14 Integrin Containing Complexes in Multiple Myeloma Using Peptidomimetics","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W42214381","mag":"42214381"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.usf.edu:etd-5510","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.usf.edu/etd/4314","pdf_url":"https://digitalcommons.usf.edu/cgi/viewcontent.cgi?article=5510&context=etd","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"USF Tampa Graduate Theses and Dissertations","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.usf.edu/cgi/viewcontent.cgi?article=5510&context=etd","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013287959","display_name":"Michael F. Emmons","orcid":"https://orcid.org/0000-0002-0008-8335","observed_orcids":["https://orcid.org/0000-0002-0008-8335"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael F. Emmons","raw_affiliation_strings":["H. Lee Moffitt Cancer Center and Research Institute"],"raw_orcid":"https://orcid.org/0000-0002-0008-8335","affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center and Research Institute","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013287959"],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.6708999872207642,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.6708999872207642,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.32519999146461487,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/integrin-alpha4","display_name":"CD49d","score":0.7879999876022339},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.9340000152587891},{"id":"https://openalex.org/keywords/integrin-antagonists","display_name":"integrin antagonists","score":0.7590000033378601},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8960000276565552},{"id":"https://openalex.org/keywords/peptidomimetics","display_name":"peptidomimetics","score":0.871999979019165},{"id":"https://openalex.org/keywords/vla-4","display_name":"VLA-4","score":0.8140000104904175},{"id":"https://openalex.org/keywords/extracellular-matrix-binding","display_name":"extracellular matrix binding","score":0.7020000219345093},{"id":"https://openalex.org/keywords/bone-marrow-stroma","display_name":"bone marrow stroma","score":0.6620000004768372},{"id":"https://openalex.org/keywords/melphalan","display_name":"melphalan","score":0.703000009059906},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/syndecan-1","display_name":"syndecan-1","score":0.8970000147819519},{"id":"https://openalex.org/keywords/calcium-oscillations","display_name":"calcium oscillations","score":0.8109999895095825},{"id":"https://openalex.org/keywords/er-calcium-release","display_name":"endoplasmic reticulum calcium release","score":0.8529999852180481},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9760000109672546}],"concepts":[{"id":"https://openalex.org/C124790011","wikidata":"https://www.wikidata.org/wiki/Q2069797","display_name":"Peptidomimetic","level":3,"score":0.913075864315033},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6384677290916443},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.41079992055892944},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36642855405807495},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.348507821559906},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3344588875770569},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32431626319885254},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23598161339759827},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21184024214744568},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19468173384666443},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1214894950389862},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.06410530209541321}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:digitalcommons.usf.edu:etd-5510","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.usf.edu/etd/4314","pdf_url":"https://digitalcommons.usf.edu/cgi/viewcontent.cgi?article=5510&context=etd","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"USF Tampa Graduate Theses and Dissertations","raw_type":"dissertation"},{"id":"pmh:oai:scholarcommons.usf.edu:etd-5510","doi":null,"is_oa":true,"landing_page_url":"https://scholarcommons.usf.edu/etd/4314","pdf_url":"https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=5510&context=etd","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"text"},{"id":"mag:42214381","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usf.edu/cgi/viewcontent.cgi?article=5510&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.usf.edu:etd-5510","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.usf.edu/etd/4314","pdf_url":"https://digitalcommons.usf.edu/cgi/viewcontent.cgi?article=5510&context=etd","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"USF Tampa Graduate Theses and Dissertations","raw_type":"dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W42214381.pdf","grobid_xml":"https://content.openalex.org/works/W42214381.grobid-xml"},"referenced_works_count":191,"referenced_works":["https://openalex.org/W75558007","https://openalex.org/W85975769","https://openalex.org/W189370476","https://openalex.org/W195783192","https://openalex.org/W1480527484","https://openalex.org/W1482479272","https://openalex.org/W1484090866","https://openalex.org/W1490418776","https://openalex.org/W1498837690","https://openalex.org/W1504413484","https://openalex.org/W1507988772","https://openalex.org/W1509556944","https://openalex.org/W1524710534","https://openalex.org/W1528751727","https://openalex.org/W1544549727","https://openalex.org/W1549235322","https://openalex.org/W1551392207","https://openalex.org/W1568956696","https://openalex.org/W1598875012","https://openalex.org/W1606990197","https://openalex.org/W1611185316","https://openalex.org/W1650068461","https://openalex.org/W1667478348","https://openalex.org/W1723444490","https://openalex.org/W1828227463","https://openalex.org/W1845459216","https://openalex.org/W1944291718","https://openalex.org/W1963521777","https://openalex.org/W1963909872","https://openalex.org/W1965410156","https://openalex.org/W1968252950","https://openalex.org/W1970101770","https://openalex.org/W1970649283","https://openalex.org/W1971908211","https://openalex.org/W1974983065","https://openalex.org/W1976058007","https://openalex.org/W1977707370","https://openalex.org/W1978927384","https://openalex.org/W1982687089","https://openalex.org/W1983519301","https://openalex.org/W1984295575","https://openalex.org/W1986491356","https://openalex.org/W1990518937","https://openalex.org/W1992538067","https://openalex.org/W1995246165","https://openalex.org/W1996257032","https://openalex.org/W1999620129","https://openalex.org/W2001258425","https://openalex.org/W2005727437","https://openalex.org/W2006446936","https://openalex.org/W2009032298","https://openalex.org/W2010069724","https://openalex.org/W2010163650","https://openalex.org/W2011387568","https://openalex.org/W2011849469","https://openalex.org/W2012183972","https://openalex.org/W2012422873","https://openalex.org/W2013907250","https://openalex.org/W2013977404","https://openalex.org/W2015880063","https://openalex.org/W2016794759","https://openalex.org/W2017302947","https://openalex.org/W2017583069","https://openalex.org/W2020708758","https://openalex.org/W2021015401","https://openalex.org/W2024267837","https://openalex.org/W2024712102","https://openalex.org/W2025639113","https://openalex.org/W2025969634","https://openalex.org/W2027389500","https://openalex.org/W2028413876","https://openalex.org/W2030885435","https://openalex.org/W2031157863","https://openalex.org/W2033024649","https://openalex.org/W2033319174","https://openalex.org/W2035033750","https://openalex.org/W2035967549","https://openalex.org/W2036528355","https://openalex.org/W2038160847","https://openalex.org/W2039215669","https://openalex.org/W2039847348","https://openalex.org/W2040081814","https://openalex.org/W2040722278","https://openalex.org/W2041997066","https://openalex.org/W2044436186","https://openalex.org/W2044895919","https://openalex.org/W2044970136","https://openalex.org/W2045149893","https://openalex.org/W2049150145","https://openalex.org/W2051517030","https://openalex.org/W2055757796","https://openalex.org/W2056206654","https://openalex.org/W2057067749","https://openalex.org/W2061298493","https://openalex.org/W2065638011","https://openalex.org/W2066295909","https://openalex.org/W2066363570","https://openalex.org/W2066371830","https://openalex.org/W2066881746","https://openalex.org/W2070739194","https://openalex.org/W2070920868","https://openalex.org/W2074690413","https://openalex.org/W2075262248","https://openalex.org/W2077476993","https://openalex.org/W2078520986","https://openalex.org/W2079286948","https://openalex.org/W2080678485","https://openalex.org/W2080875457","https://openalex.org/W2081617727","https://openalex.org/W2083719521","https://openalex.org/W2083863704","https://openalex.org/W2084498285","https://openalex.org/W2086218235","https://openalex.org/W2086337788","https://openalex.org/W2086990334","https://openalex.org/W2090565997","https://openalex.org/W2091587585","https://openalex.org/W2093241572","https://openalex.org/W2094469836","https://openalex.org/W2095688897","https://openalex.org/W2096207943","https://openalex.org/W2096399528","https://openalex.org/W2097638181","https://openalex.org/W2099370186","https://openalex.org/W2100282039","https://openalex.org/W2102401722","https://openalex.org/W2106258762","https://openalex.org/W2110486997","https://openalex.org/W2112099873","https://openalex.org/W2114727688","https://openalex.org/W2115516828","https://openalex.org/W2118294470","https://openalex.org/W2120474651","https://openalex.org/W2120531949","https://openalex.org/W2122212799","https://openalex.org/W2122690963","https://openalex.org/W2122874647","https://openalex.org/W2124560610","https://openalex.org/W2125262390","https://openalex.org/W2125457182","https://openalex.org/W2125655694","https://openalex.org/W2129515878","https://openalex.org/W2131180956","https://openalex.org/W2133389067","https://openalex.org/W2133795104","https://openalex.org/W2135201591","https://openalex.org/W2136204313","https://openalex.org/W2136401881","https://openalex.org/W2137878070","https://openalex.org/W2138935969","https://openalex.org/W2141027894","https://openalex.org/W2141089307","https://openalex.org/W2147934034","https://openalex.org/W2149687359","https://openalex.org/W2150160340","https://openalex.org/W2152065071","https://openalex.org/W2154378559","https://openalex.org/W2154699417","https://openalex.org/W2156293127","https://openalex.org/W2157330541","https://openalex.org/W2157766835","https://openalex.org/W2159190959","https://openalex.org/W2159250071","https://openalex.org/W2161017587","https://openalex.org/W2161735235","https://openalex.org/W2161830466","https://openalex.org/W2163239556","https://openalex.org/W2167656141","https://openalex.org/W2168275907","https://openalex.org/W2168392730","https://openalex.org/W2168828935","https://openalex.org/W2168929741","https://openalex.org/W2168941586","https://openalex.org/W2169774815","https://openalex.org/W2170515647","https://openalex.org/W2171581347","https://openalex.org/W2173742377","https://openalex.org/W2282757418","https://openalex.org/W2303045765","https://openalex.org/W2318252390","https://openalex.org/W2326945137","https://openalex.org/W2327145068","https://openalex.org/W2330355806","https://openalex.org/W2398878900","https://openalex.org/W2401974398","https://openalex.org/W2412555968","https://openalex.org/W2438869247","https://openalex.org/W2467215608","https://openalex.org/W2471102940","https://openalex.org/W2599485869","https://openalex.org/W4295332264"],"related_works":["https://openalex.org/W2129741180","https://openalex.org/W2042730601","https://openalex.org/W2334344757","https://openalex.org/W2327997691","https://openalex.org/W180027602","https://openalex.org/W2561168083","https://openalex.org/W2142585396","https://openalex.org/W2558990819","https://openalex.org/W2530955200","https://openalex.org/W3014588757"],"abstract_inverted_index":{"In":[0,28,192],"our":[1,381],"previous":[2],"work":[3],"we":[4,38,71,194],"demonstrated":[5],"that":[6,49,73,174,384,401],"the":[7,50,61,87,98,113,127,151,196,207,308,312,324,331,341,349],"integrin":[8,64,78,166,179],"antagonist,":[9],"HYD1,":[10],"induced":[11,123,146,159,268,274,395,423],"necrotic":[12],"cell":[13,17,102,124,147,160,190,275,396,424],"death":[14,125,148,161,425],"in":[15,19,22,79,107,126,188,222,279,316,353,365,367,403,415,426,438],"myeloma":[16,80,139,189],"lines":[18],"vitro":[20,354,427],"and":[21,66,97,121,155,230,296,355,375,428,434],"vivo":[23,368,430],"as":[24,240,452],"a":[25,388,412,453],"single":[26],"agent.":[27,208,456],"order":[29],"to":[30,36,94,109,117,119,144,150,172,185,203,216,227,234,245,248,253,289,329,347,362,393,443],"further":[31,257,447],"delineate":[32],"biomarkers":[33],"of":[34,52,60,112,133,157,198,201,206,238,261,314,333,351,391,450],"response":[35,392],"HYD1":[37,55,74,145,158,202,231,394,451],"developed":[39],"an":[40,366],"isogenic":[41],"drug":[42,134],"resistant":[43,88,114,247],"variant":[44,89,115],"named":[45,212],"H929-60.":[46],"We":[47,168,256,398],"show":[48,173],"acquisition":[51],"resistance":[53,187],"towards":[54],"correlates":[56],"with":[57,76,83,164,285,340,370,409],"reduced":[58,84],"expression":[59,386],"cleaved":[62],"\u03b14":[63,77,165,176],"subunit":[65],"beta":[67],"1":[68],"integrin.":[69],"Moreover,":[70,136,418],"demonstrate":[72],"interacts":[75],"cells.":[81,255,318,417],"Consistent":[82],"VLA-4":[85,385],"expression,":[86],"showed":[90,400],"ablated":[91],"functional":[92],"binding":[93,108],"fibronectin,":[95],"VCAM-1":[96],"bone":[99,128],"marrow":[100,129],"stroma":[101,130],"line,":[103],"HS-5.":[104],"The":[105,277],"reduction":[106],"extracellular":[110],"matrices":[111],"translated":[116],"sensitivity":[118],"melphalan":[120],"bortezomib":[122,374,433],"co-culture":[131],"model":[132,369],"resistance.":[135],"CD138":[137,152],"positive":[138],"cells":[140,224,242,339],"were":[141,169,232,243,287],"more":[142,220],"sensitive":[143],"compared":[149,226,252],"negative":[153],"fraction,":[154],"potency":[156,205],"significantly":[162],"correlated":[163],"expression.":[167],"also":[170,310,327,360,399],"able":[171],"reducing":[175],"or":[177],"\u03b21":[178],"using":[180],"shRNA":[181],"strategies":[182],"was":[183,214,326,345,359],"sufficient":[184],"cause":[186],"lines.":[191],"addition":[193],"investigated":[195],"effects":[197,266,313],"cyclized":[199],"variants":[200],"improve":[204],"One":[209],"such":[210],"compound,":[211],"HM-27,":[213],"determined":[215,233,288],"be":[217,246],"30":[218],"fold":[219],"active":[221],"H929":[223,254],"when":[225,251],"HYD1.":[228],"HM-27":[229,267,273,286,315,352,358,376,410,422,435],"have":[235,363],"similar":[236],"mechanisms":[237],"action":[239,262],"H929-60":[241],"shown":[244,328,346,361],"both":[249],"compounds":[250],"characterized":[258],"HM-27's":[259],"mechanism":[260],"by":[263],"investigating":[264],"what":[265],"Ca2+":[269,281,305,321,405],"oscillations":[270],"had":[271,411],"on":[272],"death.":[276,397],"increases":[278,402],"intracellular":[280,404],"seen":[282,406],"after":[283,335,407],"treatment":[284,372,408],"occur":[290],"via":[291],"release":[292,306,322],"from":[293,307,323],"ER":[294,309,325,336],"stores":[295],"not":[297],"through":[298,300],"influx":[299],"plasma":[301],"membrane":[302],"channels.":[303],"Inhibiting":[304],"potentiated":[311],"MM":[317,416],"Furthermore,":[319],"inhibiting":[320],"block":[330],"onset":[332],"autophagy":[334,420],"treatment.":[337],"Treating":[338],"lysosomotropic":[342],"agent,":[343],"chloroquine,":[344],"potentiate":[348],"activity":[350,364],"ex":[356,429],"vivo.":[357,439],"combination":[371],"containing":[373],"increasing":[377],"mouse":[378],"survival.":[379],"Collectively":[380],"data":[382,441],"indicate":[383],"is":[387],"critical":[389],"determinant":[390],"cytoprotective":[413],"effect":[414],"neutralizing":[419],"potentiates":[421],"while":[431],"combining":[432],"increased":[436],"survival":[437],"These":[440],"continue":[442],"provide":[444],"rationale":[445],"for":[446],"pre-clinical":[448],"development":[449],"novel":[454],"anticancer":[455]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}