{"id":"https://openalex.org/W42210556","doi":null,"title":"Hepatocyte growth factor receptor in human RPE cells: implications in proliferative vitreoretinopathy.","display_name":"Hepatocyte growth factor receptor in human RPE cells: implications in proliferative vitreoretinopathy.","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W42210556","mag":"42210556","pmid":"https://pubmed.ncbi.nlm.nih.gov/9888438"},"language":"en","primary_location":{"id":"pmid:9888438","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9888438","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076992416","display_name":"Kameran Lashkari","orcid":"https://orcid.org/0000-0003-3855-0246","observed_orcids":["https://orcid.org/0000-0003-3855-0246"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Lashkari","raw_affiliation_strings":["The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050700218","display_name":"Nader Rahimi","orcid":"https://orcid.org/0000-0002-6745-1725","observed_orcids":["https://orcid.org/0000-0002-6745-1725"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Rahimi","raw_affiliation_strings":["The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084984241","display_name":"Andrius Kazlauskas","orcid":"https://orcid.org/0000-0003-1919-3327","observed_orcids":["https://orcid.org/0000-0003-1919-3327"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Kazlauskas","raw_affiliation_strings":["The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":6.303,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.96769013,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"40","issue":"1","first_page":"149","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.12600000202655792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.026399999856948853,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-met","display_name":"c-Met","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9480000138282776},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.949999988079071},{"id":"https://openalex.org/keywords/proliferative-vitreoretinopathy","display_name":"proliferative vitreoretinopathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/idiopathic-epiretinal-membrane","display_name":"idiopathic epiretinal membrane","score":0.9279999732971191},{"id":"https://openalex.org/keywords/epiretinal-membrane","display_name":"epiretinal membrane","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9860000014305115}],"concepts":[{"id":"https://openalex.org/C2779059073","wikidata":"https://www.wikidata.org/wiki/Q7249608","display_name":"Proliferative vitreoretinopathy","level":4,"score":0.9161989092826843},{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.6285951137542725},{"id":"https://openalex.org/C2910739307","wikidata":"https://www.wikidata.org/wiki/Q5005897","display_name":"Hepatocyte Growth Factor Receptor","level":5,"score":0.47703975439071655},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.4394860863685608},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4315549433231354},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4226819574832916},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.41354307532310486},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3837617337703705},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3818591237068176},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3266984224319458},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.29532837867736816},{"id":"https://openalex.org/C2780428090","wikidata":"https://www.wikidata.org/wiki/Q625164","display_name":"Retinal detachment","level":3,"score":0.19241291284561157},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11763355135917664},{"id":"https://openalex.org/C2780467284","wikidata":"https://www.wikidata.org/wiki/Q5005897","display_name":"C-Met","level":4,"score":0.11585506796836853}],"mesh":[{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008566","descriptor_name":"Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008566","descriptor_name":"Membranes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013539","descriptor_name":"Simian virus 40","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018630","descriptor_name":"Vitreoretinopathy, Proliferative","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018630","descriptor_name":"Vitreoretinopathy, Proliferative","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9888438","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9888438","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:42210556","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9888438","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W117902596","https://openalex.org/W200392529","https://openalex.org/W1507872558","https://openalex.org/W1979275441","https://openalex.org/W1982487075","https://openalex.org/W1992449776","https://openalex.org/W1993781672","https://openalex.org/W1994629221","https://openalex.org/W2001046604","https://openalex.org/W2003463361","https://openalex.org/W2005782838","https://openalex.org/W2034242793","https://openalex.org/W2035174231","https://openalex.org/W2078753736","https://openalex.org/W2088253804","https://openalex.org/W2099673935","https://openalex.org/W2151005088","https://openalex.org/W2156498737","https://openalex.org/W2165568197"],"related_works":["https://openalex.org/W2353002948","https://openalex.org/W2369454574","https://openalex.org/W2002934996","https://openalex.org/W2042470405","https://openalex.org/W2047179487","https://openalex.org/W3030047009","https://openalex.org/W1996851421","https://openalex.org/W2992619579","https://openalex.org/W2138437225","https://openalex.org/W237810136"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1,28],"determine":[2],"whether":[3,21],"hepatocyte":[4],"growth":[5],"factor":[6],"(HGF)":[7],"receptor":[8],"(HGFR)":[9],"is":[10,201,226],"expressed":[11,122,202],"in":[12,33,38,55,85,97,102,123,129,178,195,203,207,211,216,244,251],"retinal":[13],"pigment":[14],"epithelial":[15],"(RPE)":[16],"cells":[17,23,64,87,125,249],"and":[18,37,46,53,57,71,77,90,101,111,126,175,215,242,250],"to":[19,26,131],"test":[20],"RPE":[22,63,86,124,140,159,205,209,233,248],"are":[24],"responsive":[25],"HGF.":[27,132],"evaluate":[29],"expression":[30,76],"of":[31,80,95,149,152,182,247],"HGFR":[32,81,96,120,172,192,200,243],"human":[34,62,98,153,212,232],"donor":[35,99,154,213],"eyes":[36,100,155],"several":[39,103],"epiretinal":[40,48,104,113,183,197,217],"membranes":[41,105,114,184,218],"associated":[42,106,185],"with":[43,107,186,222],"proliferative":[44,108],"vitreoretinopathy":[45,109],"idiopathic":[47,112,196],"membranes.":[49,198],"METHODS:":[50],"HGF-dependent":[51],"migration":[52],"proliferation":[54],"primary":[56],"simian":[58],"virus":[59],"(SV)":[60],"40-transformed":[61],"was":[65,83,115,121,127,135,161,167,173,193],"studied":[66],"using":[67],"a":[68,136,145,227,238],"Boyden":[69],"chamber":[70],"[3H]thymidine":[72],"uptake,":[73],"respectively.":[74],"The":[75],"tyrosine":[78],"phosphorylation":[79],"protein":[82],"evaluated":[84],"by":[88,117],"immunoprecipitation":[89],"western":[91],"blot":[92],"analysis.":[93],"Expression":[94],"(PVR)":[110],"analyzed":[116],"immunohistochemistry.":[118],"RESULTS:":[119],"tyrosine-phosphorylated":[128],"response":[130],"Whereas":[133],"HGF":[134,225,241],"potent":[137,228],"motogen":[138],"for":[139,170,230,240],"cells,":[141,206],"it":[142],"induced":[143],"only":[144],"modest,":[146],"dose-dependent":[147],"uptake":[148],"[3H]thymidine.":[150],"Evaluation":[151],"showed":[156],"that":[157,166],"the":[158,162,179,208],"monolayer":[160,210],"major":[163],"cell":[164],"type":[165],"strongly":[168],"positive":[169],"HGFR.":[171],"uniformly":[174],"readily":[176],"detected":[177],"cellular":[180],"component":[181],"PVR,":[187],"whereas":[188],"little":[189],"or":[190],"no":[191],"found":[194],"CONCLUSIONS:":[199],"cultured":[204,231],"eyes,":[214],"obtained":[219],"from":[220],"patients":[221],"PVR.":[223,256],"Furthermore,":[224],"chemoattractant":[229],"cells.":[234],"These":[235],"observations":[236],"suggest":[237],"role":[239],"normal":[245],"function":[246],"RPE-related":[252],"disease":[253],"such":[254],"as":[255]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}