{"id":"https://openalex.org/W4221047540","doi":"https://doi.org/10.1002/rth2.12677","title":"Evaluation of a new bead\u2010based assay to measure levels of human tissue factor antigen in extracellular vesicles in plasma","display_name":"Evaluation of a new bead\u2010based assay to measure levels of human tissue factor antigen in extracellular vesicles in plasma","publication_year":2022,"publication_date":"2022-02-01","ids":{"openalex":"https://openalex.org/W4221047540","doi":"https://doi.org/10.1002/rth2.12677","pmid":"https://pubmed.ncbi.nlm.nih.gov/35284777","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8897283"},"language":"en","primary_location":{"id":"doi:10.1002/rth2.12677","doi":"https://doi.org/10.1002/rth2.12677","is_oa":true,"landing_page_url":"https://doi.org/10.1002/rth2.12677","pdf_url":null,"source":{"id":"https://openalex.org/S4210185368","display_name":"Research and Practice in Thrombosis and Haemostasis","issn_l":"2475-0379","issn":["2475-0379"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/rth2.12677","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055823433","display_name":"Sierra J. Archibald","orcid":"https://orcid.org/0000-0002-6052-5680","observed_orcids":["https://orcid.org/0000-0002-6052-5680"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sierra J. Archibald","raw_affiliation_strings":["Division of Hematology, UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"],"raw_orcid":"https://orcid.org/0000-0002-6052-5680","affiliations":[{"raw_affiliation_string":"Division of Hematology, UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017127306","display_name":"Yohei Hisada","orcid":"https://orcid.org/0000-0001-9157-0524","observed_orcids":["https://orcid.org/0000-0001-9157-0524"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yohei Hisada","raw_affiliation_strings":["Division of Hematology, UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"],"raw_orcid":"https://orcid.org/0000-0001-9157-0524","affiliations":[{"raw_affiliation_string":"Division of Hematology, UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007925500","display_name":"Victoria Lin Bae-Jump","orcid":"https://orcid.org/0000-0001-6778-0951","observed_orcids":["https://orcid.org/0000-0001-6778-0951"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria L. Bae\u2010Jump","raw_affiliation_strings":["Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA","Lineberger Comprehensive Cancer Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075629445","display_name":"Nigel Mackman","orcid":"https://orcid.org/0000-0002-9170-7700","observed_orcids":["https://orcid.org/0000-0002-9170-7700"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nigel Mackman","raw_affiliation_strings":["Division of Hematology, UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"],"raw_orcid":"https://orcid.org/0000-0002-9170-7700","affiliations":[{"raw_affiliation_string":"Division of Hematology, UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075629445"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":0.8935,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.68706975,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"6","issue":"2","first_page":"e12677","last_page":"e12677"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9890000224113464},{"id":"https://openalex.org/keywords/bead-based-assays","display_name":"bead-based assays","score":0.8119999766349792},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.6480000019073486},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.8190000057220459},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.7730000019073486},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/plasma","display_name":"plasma","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.8184998035430908},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.7894038558006287},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.6018824577331543},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.5511427521705627},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5431267023086548},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.539291501045227},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47954341769218445},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4467388987541199},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.41267094016075134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27204757928848267},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24173542857170105},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23283439874649048},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19978144764900208},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16763168573379517},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.10336515307426453},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07895699143409729},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07031163573265076},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1002/rth2.12677","doi":"https://doi.org/10.1002/rth2.12677","is_oa":true,"landing_page_url":"https://doi.org/10.1002/rth2.12677","pdf_url":null,"source":{"id":"https://openalex.org/S4210185368","display_name":"Research and Practice in Thrombosis and Haemostasis","issn_l":"2475-0379","issn":["2475-0379"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8897283","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8897283","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Res Pract Thromb Haemost","raw_type":"Text"},{"id":"pmid:35284777","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35284777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and practice in thrombosis and haemostasis","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:5138jt48j","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/y1gy-qd31","pdf_url":"https://cdr.lib.unc.edu/downloads/1544c499q","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis, 6(2)","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:e6fdd26cbe0a49c3a95c0e26bed3f682","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e6fdd26cbe0a49c3a95c0e26bed3f682","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 2, Pp n/a-n/a (2022)","raw_type":"article"},{"id":"doi:10.17615/y1gy-qd31","doi":"https://doi.org/10.17615/y1gy-qd31","is_oa":true,"landing_page_url":"https://doi.org/10.17615/y1gy-qd31","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1002/rth2.12677","doi":"https://doi.org/10.1002/rth2.12677","is_oa":true,"landing_page_url":"https://doi.org/10.1002/rth2.12677","pdf_url":null,"source":{"id":"https://openalex.org/S4210185368","display_name":"Research and Practice in Thrombosis and Haemostasis","issn_l":"2475-0379","issn":["2475-0379"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000878702","display_name":"Tissue factor-dependent coagulation in thrombosis and immune responses","funder_award_id":"R35HL155657","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1677330418","https://openalex.org/W1967618170","https://openalex.org/W1989515923","https://openalex.org/W1994300073","https://openalex.org/W2012535096","https://openalex.org/W2060044255","https://openalex.org/W2083600156","https://openalex.org/W2257098687","https://openalex.org/W2274860869","https://openalex.org/W2567430982","https://openalex.org/W2786262376","https://openalex.org/W2901892038","https://openalex.org/W2963153523","https://openalex.org/W3110426240","https://openalex.org/W3127339583","https://openalex.org/W3159774591","https://openalex.org/W3161705187","https://openalex.org/W3193381896"],"related_works":["https://openalex.org/W4286241747","https://openalex.org/W4400012230","https://openalex.org/W4413149238","https://openalex.org/W4377041321","https://openalex.org/W2901892038","https://openalex.org/W4390431433","https://openalex.org/W4324363265","https://openalex.org/W4392893246","https://openalex.org/W4361213437","https://openalex.org/W2884734211"],"abstract_inverted_index":{"Background":[0],"Circulating":[1],"tissue":[2],"factor":[3],"(TF)-expressing":[4],"extracellular":[5],"vesicles":[6],"(EVs)":[7],"are":[8,65],"associated":[9],"with":[10,88,117],"thrombosis":[11],"in":[12,36,54,84,105,171,190,212,252],"several":[13],"diseases,":[14],"such":[15],"as":[16,156],"coronavirus":[17],"disease":[18],"2019":[19],"(COVID-19).":[20],"Activity":[21],"assays":[22,31],"have":[23,245],"higher":[24],"sensitivity":[25,247],"and":[26,128,208,242],"specificity":[27],"compared":[28,148],"to":[29,44,78,100,149,248],"antigen":[30,143],"for":[32,240],"measuring":[33],"TF+":[34,82,112,250],"EVs":[35,53,83,104,113,191,213,251],"plasma.":[37,106,253],"The":[38,61,134],"MACSPlex":[39,75,97,130,135,233],"Exosome":[40,76,98,131,136,234],"Kit":[41,77,99,137,235],"is":[42],"designed":[43],"detect":[45,101,249],"37":[46],"exosomal":[47],"surface":[48],"epitopes,":[49],"including":[50],"TF,":[51],"on":[52,103],"plasma":[55,116,194,216],"using":[56,122],"various":[57],"fluorescently":[58],"labeled":[59],"beads.":[60],"different":[62],"EV-bead":[63],"complexes":[64],"detected":[66,121],"by":[67],"flow":[68],"cytometry.":[69],"A":[70],"recent":[71],"study":[72],"used":[73,155],"the":[74,93,96,129,186,232,246],"measure":[79],"levels":[80,110,162,178,204],"of":[81,95,111,163,175,179,205],"serum":[85],"from":[86,115,193,195,215,217],"patients":[87,220],"COVID-19.":[89],"Objectives":[90],"To":[91],"evaluate":[92],"ability":[94],"TF":[102,120,142,168,176,187,209,241],"Methods":[107],"We":[108],"measured":[109],"isolated":[114,192,214],"or":[118],"without":[119],"our":[123],"in-house":[124],"EVTF":[125,164,180,206],"activity":[126,165,181,207],"assay":[127],"Kit.":[132],"Results":[133],"gave":[138],"a":[139,157,237],"very":[140],"low":[141],"signal":[144,170,189,211,239],"(TF":[145],"bead":[146,169,188,210],"signal)":[147],"platelet-derived":[150],"CD41b+":[151],"EVs,":[152],"which":[153],"was":[154],"control.":[158],"Lipopolysaccharide":[159],"(LPS)":[160],"increased":[161],"but":[166,182],"not":[167,184,244],"four":[172],"donors.":[173],"Inhibition":[174],"reduced":[177],"did":[183],"affect":[185],"LPS-treated":[196],"blood.":[197],"Finally,":[198],"we":[199],"found":[200],"no":[201],"correlation":[202],"between":[203],"ovarian":[218],"cancer":[219],"(r":[221],"=":[222,225],".16,":[223],"P":[224],".62).":[226],"Conclusion":[227],"Our":[228],"data":[229],"suggest":[230],"that":[231],"gives":[236],"nonspecific":[238],"does":[243]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2022-04-03T00:00:00"}