{"id":"https://openalex.org/W4221031238","doi":"https://doi.org/10.1080/21645515.2022.2043103","title":"A multicenter, single-blind, randomized, phase-2/3 study to evaluate immunogenicity and safety of a single intramuscular dose of biological E\u2019s Vi-capsular polysaccharide-CRM 197 conjugate typhoid vaccine (TyphiBEV TM ) in healthy infants, children, and adults in comparison with a licensed comparator","display_name":"A multicenter, single-blind, randomized, phase-2/3 study to evaluate immunogenicity and safety of a single intramuscular dose of biological E\u2019s Vi-capsular polysaccharide-CRM 197 conjugate typhoid vaccine (TyphiBEV TM ) in healthy infants, children, and adults in comparison with a licensed comparator","publication_year":2022,"publication_date":"2022-03-25","ids":{"openalex":"https://openalex.org/W4221031238","doi":"https://doi.org/10.1080/21645515.2022.2043103","pmid":"https://pubmed.ncbi.nlm.nih.gov/35333702","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9196756"},"language":"en","primary_location":{"id":"doi:10.1080/21645515.2022.2043103","doi":"https://doi.org/10.1080/21645515.2022.2043103","is_oa":true,"landing_page_url":"https://doi.org/10.1080/21645515.2022.2043103","pdf_url":null,"source":{"id":"https://openalex.org/S2483136528","display_name":"Human Vaccines & Immunotherapeutics","issn_l":"2164-5515","issn":["2164-5515","2164-554X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Vaccines & Immunotherapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1080/21645515.2022.2043103","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043558119","display_name":"Subhash Thuluva","orcid":"https://orcid.org/0000-0002-9099-420X","observed_orcids":["https://orcid.org/0000-0002-9099-420X"]},"institutions":[{"id":"https://openalex.org/I4210096236","display_name":"Biological E (India)","ror":"https://ror.org/00qxm3x60","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210096236"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Subhash Thuluva","raw_affiliation_strings":["Clinical Development Department, Biological E Limited, Hyderabad, India"],"raw_orcid":"https://orcid.org/0000-0002-9099-420X","affiliations":[{"raw_affiliation_string":"Clinical Development Department, Biological E Limited, Hyderabad, India","institution_ids":["https://openalex.org/I4210096236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056089019","display_name":"Vikram M. Paradkar","orcid":"https://orcid.org/0000-0001-9500-7237","observed_orcids":["https://orcid.org/0000-0001-9500-7237"]},"institutions":[{"id":"https://openalex.org/I4210096236","display_name":"Biological E (India)","ror":"https://ror.org/00qxm3x60","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210096236"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vikram Paradkar","raw_affiliation_strings":["Clinical Development Department, Biological E Limited, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Development Department, Biological E Limited, Hyderabad, India","institution_ids":["https://openalex.org/I4210096236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033391594","display_name":"Ramesh V. Matur","orcid":"https://orcid.org/0000-0001-5891-2684","observed_orcids":["https://orcid.org/0000-0001-5891-2684"]},"institutions":[{"id":"https://openalex.org/I4210096236","display_name":"Biological E (India)","ror":"https://ror.org/00qxm3x60","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210096236"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ramesh Matur","raw_affiliation_strings":["Clinical Development Department, Biological E Limited, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Development Department, Biological E Limited, Hyderabad, India","institution_ids":["https://openalex.org/I4210096236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044337627","display_name":"Kishore Turaga","orcid":"https://orcid.org/0000-0003-4197-9457","observed_orcids":["https://orcid.org/0000-0003-4197-9457"]},"institutions":[{"id":"https://openalex.org/I4210096236","display_name":"Biological E (India)","ror":"https://ror.org/00qxm3x60","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210096236"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kishore Turaga","raw_affiliation_strings":["Clinical Development Department, Biological E Limited, Hyderabad, India"],"raw_orcid":"https://orcid.org/0000-0003-4197-9457","affiliations":[{"raw_affiliation_string":"Clinical Development Department, Biological E Limited, Hyderabad, India","institution_ids":["https://openalex.org/I4210096236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061365267","display_name":"Subba Reddy GV","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096236","display_name":"Biological E (India)","ror":"https://ror.org/00qxm3x60","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210096236"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Subba Reddy GV","raw_affiliation_strings":["Clinical Development Department, Biological E Limited, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Development Department, Biological E Limited, Hyderabad, India","institution_ids":["https://openalex.org/I4210096236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043558119"],"corresponding_institution_ids":["https://openalex.org/I4210096236"],"apc_list":{"value":2895,"currency":"EUR","value_usd":3175},"apc_paid":{"value":2895,"currency":"EUR","value_usd":3175},"fwci":3.9386,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.95492992,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"18","issue":"5","first_page":"2043103","last_page":"2043103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.7324000000953674,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.7324000000953674,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.2517000138759613,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/typhoid-conjugate-vaccine","display_name":"typhoid conjugate vaccine","score":0.9279999732971191},{"id":"https://openalex.org/keywords/vi-polysaccharide","display_name":"Vi polysaccharide","score":0.734000027179718},{"id":"https://openalex.org/keywords/crm197","display_name":"CRM197","score":0.902999997138977},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.8140000104904175},{"id":"https://openalex.org/keywords/seroconversion","display_name":"seroconversion","score":0.9539999961853027},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.9120000004768372},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.9470000267028809},{"id":"https://openalex.org/keywords/reactogenicity","display_name":"reactogenicity","score":0.9129999876022339},{"id":"https://openalex.org/keywords/typhoid-fever-prevention","display_name":"typhoid fever prevention","score":0.8579999804496765},{"id":"https://openalex.org/keywords/infants-and-children","display_name":"infants and children","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.810165286064148},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7805805206298828},{"id":"https://openalex.org/C2779583294","wikidata":"https://www.wikidata.org/wiki/Q5161160","display_name":"Conjugate vaccine","level":4,"score":0.7016202211380005},{"id":"https://openalex.org/C520601542","wikidata":"https://www.wikidata.org/wiki/Q83319","display_name":"Typhoid fever","level":2,"score":0.700543999671936},{"id":"https://openalex.org/C2777451964","wikidata":"https://www.wikidata.org/wiki/Q2141450","display_name":"Seroconversion","level":3,"score":0.6518986821174622},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5801699161529541},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5758265256881714},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5619630813598633},{"id":"https://openalex.org/C2776714567","wikidata":"https://www.wikidata.org/wiki/Q7861081","display_name":"Typhoid vaccine","level":3,"score":0.5418620109558105},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.524486243724823},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47704237699508667},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4008139371871948},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3437688946723938},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2975548505783081},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.19166460633277893}],"mesh":[{"descriptor_ui":"D000071497","descriptor_name":"Immunogenicity, Vaccine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014435","descriptor_name":"Typhoid Fever","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D014436","descriptor_name":"Typhoid-Paratyphoid Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016037","descriptor_name":"Single-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018074","descriptor_name":"Vaccines, Conjugate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/21645515.2022.2043103","doi":"https://doi.org/10.1080/21645515.2022.2043103","is_oa":true,"landing_page_url":"https://doi.org/10.1080/21645515.2022.2043103","pdf_url":null,"source":{"id":"https://openalex.org/S2483136528","display_name":"Human Vaccines & Immunotherapeutics","issn_l":"2164-5515","issn":["2164-5515","2164-554X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Vaccines & Immunotherapeutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9196756","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9196756","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Vaccin Immunother","raw_type":"Text"},{"id":"pmid:35333702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35333702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human vaccines & immunotherapeutics","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:doaj.org/article:f5a8490266444c4dac436680a97d8ef8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f5a8490266444c4dac436680a97d8ef8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Vaccines & Immunotherapeutics, Vol 18, Iss 5 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/21645515.2022.2043103","doi":"https://doi.org/10.1080/21645515.2022.2043103","is_oa":true,"landing_page_url":"https://doi.org/10.1080/21645515.2022.2043103","pdf_url":null,"source":{"id":"https://openalex.org/S2483136528","display_name":"Human Vaccines & Immunotherapeutics","issn_l":"2164-5515","issn":["2164-5515","2164-554X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Vaccines & Immunotherapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1546864109","https://openalex.org/W1579195201","https://openalex.org/W1968151569","https://openalex.org/W1969104565","https://openalex.org/W1996188732","https://openalex.org/W2010136790","https://openalex.org/W2015767342","https://openalex.org/W2054481171","https://openalex.org/W2065122103","https://openalex.org/W2082236560","https://openalex.org/W2090362268","https://openalex.org/W2130832976","https://openalex.org/W2140447452","https://openalex.org/W2147278081","https://openalex.org/W2419529528","https://openalex.org/W2492761795","https://openalex.org/W2587454028","https://openalex.org/W2807081252","https://openalex.org/W2884064856","https://openalex.org/W2889076370","https://openalex.org/W2902587412","https://openalex.org/W2909150434","https://openalex.org/W2917067204","https://openalex.org/W2942290778","https://openalex.org/W2999588408","https://openalex.org/W3008414529","https://openalex.org/W3046465593","https://openalex.org/W3107226521","https://openalex.org/W3156817388","https://openalex.org/W4210348703","https://openalex.org/W4210463927"],"related_works":["https://openalex.org/W4410708239","https://openalex.org/W3156817388","https://openalex.org/W3046210988","https://openalex.org/W4416276073","https://openalex.org/W2075531693","https://openalex.org/W4410530023","https://openalex.org/W2054481171","https://openalex.org/W2049532298","https://openalex.org/W4390670464","https://openalex.org/W3003282012"],"abstract_inverted_index":{"The":[0,65,120,133,153],"current":[1],"scenario":[2],"of":[3,35,74,78,84,92,99,116,140,151,164,228],"typhoid":[4,10],"fever":[5],"warrants":[6],"early":[7],"prevention":[8],"with":[9,87],"conjugate":[11,40,46],"vaccines":[12],"in":[13,57,76,81,105,170,195,211,213,226,236],"susceptible":[14],"populations":[15],"to":[16,29,44,70,126,224],"provide":[17],"lifelong":[18],"protection.":[19],"We":[20],"conducted":[21],"a":[22,88],"multicenter,":[23],"single-blind,":[24],"randomized,":[25],"Phase":[26],"2/3":[27],"study":[28,118],"assess":[30,71],"the":[31,72,79,82,113,117,127,141,148,184,196,231],"immunogenicity":[32],"and":[33,61,111,162,186,230,234,240],"safety":[34,197,233],"Biological":[36],"E\u2019s":[37],"Typhoid":[38],"Vi-CRM197":[39],"vaccine":[41,47,107,188,201],"(TyphiBEVTM)":[42],"compared":[43,125],"Vi-TT":[45],"manufactured":[48],"by":[49],"Bharat":[50],"Biotech":[51],"International":[52],"Limited":[53],"(Typbar-TCV;":[54],"licensed":[55],"comparator)":[56],"healthy":[58,101,237],"infants,":[59,238],"children,":[60,239],"adults":[62,241],"from":[63,243],"India.":[64],"study\u2019s":[66],"primary":[67],"objective":[68],"was":[69,144,193,245],"non-inferiority":[73,149],"TyphiBEVTM":[75,121,185,221],"terms":[77,227],"difference":[80,143,192],"proportion":[83,163],"subjects":[85,102,165],"seroconverted":[86],"seroconversion":[89],"threshold":[90],"value":[91],"\u22652.0":[93],"\u00b5g/mL":[94,158],"against":[95],"Typbar-TCV.":[96],"A":[97],"total":[98],"622":[100],"(311":[103],"each":[104],"both":[106,200],"groups)":[108],"were":[109,181,207],"randomized":[110],"received":[112],"single":[114],"dose":[115],"vaccine.":[119],"group":[122,129,142],"demonstrated":[123],"noninferiority":[124],"Typbar-TCV":[128,187],"at":[130,178],"Day":[131,179],"42.":[132],"lower":[134],"2-sided":[135],"95%":[136],"confidence":[137],"interval":[138],"limit":[139],"\u2212.34%,":[145],"which":[146],"met":[147],"criteria":[150],"\u226510.0%.":[152],"geometric":[154],"mean":[155],"concentration":[156],"(24.79":[157],"vs.":[159,176],"26.58":[160],"\u00b5g/mL)":[161],"who":[166],"achieved":[167],"\u22654-fold":[168],"increase":[169],"antiVi":[171],"IgG":[172],"antibody":[173],"concentrations":[174],"(96.95%":[175],"97.64%)":[177],"42":[180],"comparable":[182],"between":[183,199],"groups.":[189,202],"No":[190],"apparent":[191],"observed":[194],"profile":[198],"All":[203],"adverse":[204],"events":[205],"reported":[206],"mild":[208],"or":[209],"moderate":[210],"intensity":[212],"all":[214],"age":[215],"subsets.":[216],"This":[217],"data":[218],"demonstrates":[219],"that":[220],"is":[222],"non-inferior":[223],"TypbarTCV":[225],"immunogenicity,":[229],"overall":[232],"reactogenicity":[235],"studied":[242],"India":[244],"comparable.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-04-03T00:00:00"}