{"id":"https://openalex.org/W4221007135","doi":"https://doi.org/10.1186/s12885-022-09265-1","title":"The prognostic and predictive value of ESR1 fusion gene transcripts in primary breast cancer","display_name":"The prognostic and predictive value of ESR1 fusion gene transcripts in primary breast cancer","publication_year":2022,"publication_date":"2022-02-12","ids":{"openalex":"https://openalex.org/W4221007135","doi":"https://doi.org/10.1186/s12885-022-09265-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/35151276","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8840267"},"language":"en","primary_location":{"id":"doi:10.1186/s12885-022-09265-1","doi":"https://doi.org/10.1186/s12885-022-09265-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-022-09265-1","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12885-022-09265-1.pdf","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12885-022-09265-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068350069","display_name":"Silvia Rita Vitale","orcid":"https://orcid.org/0000-0002-7948-3580","observed_orcids":["https://orcid.org/0000-0002-7948-3580"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I4210149908","display_name":"Erasmus MC Cancer Institute","ror":"https://ror.org/03r4m3349","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]},{"id":"https://openalex.org/I4210160210","display_name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico - San Marco\"","ror":"https://ror.org/051tt6c85","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210160210"]}],"countries":["IT","NL"],"is_corresponding":false,"raw_author_name":"Silvia R. Vitale","raw_affiliation_strings":["Center of Experimental Oncology and Hematology, A.O.U. Policlinico \"G. Rodolico- San Marco\", 95123, Catania, Italy","Department of Clinical and Experimental Medicine, University of Catania, 95123, Catania, Italy","Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Experimental Oncology and Hematology, A.O.U. Policlinico \"G. Rodolico- San Marco\", 95123, Catania, Italy","institution_ids":["https://openalex.org/I39063666","https://openalex.org/I4210160210"]},{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Catania, 95123, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030195934","display_name":"Kirsten Ruigrok-Ritstier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I4210149908","display_name":"Erasmus MC Cancer Institute","ror":"https://ror.org/03r4m3349","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Kirsten Ruigrok-Ritstier","raw_affiliation_strings":["Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Mieke Timmermans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I4210149908","display_name":"Erasmus MC Cancer Institute","ror":"https://ror.org/03r4m3349","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. Mieke Timmermans","raw_affiliation_strings":["Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109336816","display_name":"Ren\u00e9e Foekens","orcid":"https://orcid.org/0009-0000-6645-7079","observed_orcids":["https://orcid.org/0009-0000-6645-7079"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I4210149908","display_name":"Erasmus MC Cancer Institute","ror":"https://ror.org/03r4m3349","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ren\u00e9e Foekens","raw_affiliation_strings":["Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045028002","display_name":"Anita Trapman-Jansen","orcid":"https://orcid.org/0009-0000-5959-8607","observed_orcids":["https://orcid.org/0009-0000-5959-8607"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I4210149908","display_name":"Erasmus MC Cancer Institute","ror":"https://ror.org/03r4m3349","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anita M. A. C. Trapman-Jansen","raw_affiliation_strings":["Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006584364","display_name":"Corine M. Beaufort","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I4210149908","display_name":"Erasmus MC Cancer Institute","ror":"https://ror.org/03r4m3349","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Corine M. Beaufort","raw_affiliation_strings":["Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043599930","display_name":"Paolo Giovanni Vigneri","orcid":"https://orcid.org/0000-0002-5943-6066","observed_orcids":["https://orcid.org/0000-0002-5943-6066"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I4210160210","display_name":"Azienda Ospedaliero Universitaria Policlinico \"G.Rodolico - San Marco\"","ror":"https://ror.org/051tt6c85","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210160210"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Vigneri","raw_affiliation_strings":["Center of Experimental Oncology and Hematology, A.O.U. Policlinico \"G. Rodolico- San Marco\", 95123, Catania, Italy","Department of Clinical and Experimental Medicine, University of Catania, 95123, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Experimental Oncology and Hematology, A.O.U. Policlinico \"G. Rodolico- San Marco\", 95123, Catania, Italy","institution_ids":["https://openalex.org/I39063666","https://openalex.org/I4210160210"]},{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Catania, 95123, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047837719","display_name":"Stefan Sleijfer","orcid":"https://orcid.org/0000-0002-0446-9039","observed_orcids":["https://orcid.org/0000-0002-0446-9039"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I4210149908","display_name":"Erasmus MC Cancer Institute","ror":"https://ror.org/03r4m3349","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Stefan Sleijfer","raw_affiliation_strings":["Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066926133","display_name":"John W.M. Martens","orcid":"https://orcid.org/0000-0002-3428-3366","observed_orcids":["https://orcid.org/0000-0002-3428-3366"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I4210149908","display_name":"Erasmus MC Cancer Institute","ror":"https://ror.org/03r4m3349","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"John W. M. Martens","raw_affiliation_strings":["Cancer Genomics Netherlands, Rotterdam, The Netherlands","Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genomics Netherlands, Rotterdam, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041093711","display_name":"Anieta M. Sieuwerts","orcid":"https://orcid.org/0000-0003-1341-5400","observed_orcids":["https://orcid.org/0000-0003-1341-5400"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I4210149908","display_name":"Erasmus MC Cancer Institute","ror":"https://ror.org/03r4m3349","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anieta M. Sieuwerts","raw_affiliation_strings":["Cancer Genomics Netherlands, Rotterdam, The Netherlands","Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genomics Netherlands, Rotterdam, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085490585","display_name":"Maurice P.H.M. Jansen","orcid":"https://orcid.org/0000-0003-1258-9804","observed_orcids":["https://orcid.org/0000-0003-1258-9804"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I4210149908","display_name":"Erasmus MC Cancer Institute","ror":"https://ror.org/03r4m3349","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Maurice P. H. M. Jansen","raw_affiliation_strings":["Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands. m.p.h.m.jansen@erasmusmc.nl","Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands. m.p.h.m.jansen@erasmusmc.nl","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]},{"raw_affiliation_string":"Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5085490585"],"corresponding_institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.7853,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.85260852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"22","issue":"1","first_page":"165","last_page":"165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.04820000007748604,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.8519999980926514},{"id":"https://openalex.org/keywords/akap12","display_name":"AKAP12","score":0.8999999761581421},{"id":"https://openalex.org/keywords/primary-breast-cancer","display_name":"primary breast cancer","score":0.6830000281333923},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8659999966621399},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9629999995231628},{"id":"https://openalex.org/keywords/endocrine-therapy-response","display_name":"endocrine therapy response","score":0.8870000243186951},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.800000011920929},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9739999771118164},{"id":"https://openalex.org/keywords/node-negative-breast-cancer","display_name":"node-negative breast cancer","score":0.7680000066757202},{"id":"https://openalex.org/keywords/advanced-breast-cancer","display_name":"advanced breast cancer","score":0.878000020980835}],"concepts":[{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6696133613586426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6632519960403442},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6411678791046143},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5750476717948914},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5588374733924866},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.5128331780433655},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.5052347779273987},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5013103485107422},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.4871372878551483},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.448219895362854},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38450899720191956},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33640599250793457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22047537565231323},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14989802241325378},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0959821343421936}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050939","descriptor_name":"Gene Fusion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12885-022-09265-1","doi":"https://doi.org/10.1186/s12885-022-09265-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-022-09265-1","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12885-022-09265-1.pdf","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-1110533/v1","doi":"https://doi.org/10.21203/rs.3.rs-1110533/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1110533/v1","pdf_url":"https://www.researchsquare.com/article/rs-1110533/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:8840267","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8840267","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmid:35151276","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35151276","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pure.eur.nl:openaire/b0867091-071e-4562-8263-cf3e095635da","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/b0867091-071e-4562-8263-cf3e095635da","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vitale, S R, Ruigrok-Ritstier, K, Timmermans, A M, Foekens, R, Trapman-Jansen, A M A C, Beaufort, C M, Vigneri, P, Sleijfer, S, Martens, J W M, Sieuwerts, A M & Jansen, M P H M 2022, 'The prognostic and predictive value of ESR1 fusion gene transcripts in primary breast cancer', BMC Cancer, vol. 22, no. 1, 165. https://doi.org/10.1186/s12885-022-09265-1","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/b0867091-071e-4562-8263-cf3e095635da","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/b0867091-071e-4562-8263-cf3e095635da","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, 22(1):165. BioMed Central Ltd.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:5619f8611366419781ebf77950eb8c5c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5619f8611366419781ebf77950eb8c5c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, Vol 22, Iss 1, Pp 1-16 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12885-022-09265-1","doi":"https://doi.org/10.1186/s12885-022-09265-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-022-09265-1","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12885-022-09265-1.pdf","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G522392972","display_name":"Identification and functional validation of drugable targets/pathways for triple negative breast cancer","funder_award_id":"322737","funder_id":"https://openalex.org/F4320338352","funder_display_name":"FP7 Ideas: European Research Council"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320338352","display_name":"FP7 Ideas: European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4221007135.pdf","grobid_xml":"https://content.openalex.org/works/W4221007135.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W913623683","https://openalex.org/W1542163462","https://openalex.org/W1599349966","https://openalex.org/W1968700783","https://openalex.org/W2012297324","https://openalex.org/W2018336040","https://openalex.org/W2025784247","https://openalex.org/W2027963144","https://openalex.org/W2040393574","https://openalex.org/W2042337609","https://openalex.org/W2044348501","https://openalex.org/W2046243732","https://openalex.org/W2058681718","https://openalex.org/W2088578081","https://openalex.org/W2089595068","https://openalex.org/W2096374664","https://openalex.org/W2106425267","https://openalex.org/W2117357260","https://openalex.org/W2124358769","https://openalex.org/W2131964282","https://openalex.org/W2139133938","https://openalex.org/W2154467144","https://openalex.org/W2154905832","https://openalex.org/W2155399095","https://openalex.org/W2159431488","https://openalex.org/W2169438753","https://openalex.org/W2177855755","https://openalex.org/W2201598970","https://openalex.org/W2254017615","https://openalex.org/W2272111630","https://openalex.org/W2467112370","https://openalex.org/W2743649404","https://openalex.org/W2766133222","https://openalex.org/W2778700697","https://openalex.org/W2793487091","https://openalex.org/W2799561351","https://openalex.org/W2806130668","https://openalex.org/W2895672952","https://openalex.org/W2897779677","https://openalex.org/W2917288175","https://openalex.org/W2944068509","https://openalex.org/W3048242943","https://openalex.org/W3169471863","https://openalex.org/W4238436703"],"related_works":["https://openalex.org/W2944219555","https://openalex.org/W3131369145","https://openalex.org/W2887208641","https://openalex.org/W1925661138","https://openalex.org/W7130681161","https://openalex.org/W2897779677","https://openalex.org/W3211255002","https://openalex.org/W1513714274","https://openalex.org/W4210777760","https://openalex.org/W2887861528"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,21,229,245,282],"breast":[2],"cancer":[3],"(BC),":[4],"recurrent":[5],"fusion":[6,40,88,166,211,236,268,280,288,330,339],"genes":[7],"of":[8,29,38,68,83,115,133,163,217,225,234,336],"estrogen":[9],"receptor":[10],"alpha":[11],"(ESR1)":[12],"and":[13,16,80,103,129,172,195,200,222,252,257,270,273,307],"AKAP12,":[14],"ARMT1":[15],"CCDC170":[17],"have":[18,71,345],"been":[19,32,59,73],"reported.":[20,74],"these":[22,49,69],"gene":[23,50,151,267,329],"fusions":[24,51,70],"the":[25,35,39,44,65,78,164,192,205,218,226,230,235,246,249,337],"ligand":[26],"binding":[27],"domain":[28,37],"ESR1":[30,87,338],"has":[31],"replaced":[33],"by":[34,156],"transactivation":[36],"partner":[41],"constitutively":[42],"activating":[43],"receptor.":[45],"As":[46],"a":[47,130,283],"result,":[48],"can":[52],"drive":[53],"tumor":[54],"growth":[55],"hormone":[56],"independently":[57],"as":[58],"shown":[60],"in":[61,90,170,191,204,215,223,322,353],"preclinical":[62],"models,":[63],"but":[64],"clinical":[66],"value":[67,82],"not":[72],"Here,":[75],"we":[76],"studied":[77],"prognostic":[79,206,247,293,333],"predictive":[81,193,231,350],"different":[84,165],"frequently":[85],"reported":[86],"transcripts":[89,167,237],"primary":[91,99,323],"BC.":[92],"METHODS:":[93],"We":[94],"evaluated":[95],"732":[96],"patients":[97,117,135,261,277],"with":[98,118,136,240,262,355,359],"BC":[100,110,220,324,354],"(131":[101],"ESR1-negative":[102,227],"601":[104],"ESR1-positive":[105,219],"cases),":[106],"including":[107],"two":[108],"ER-positive":[109],"patient":[111],"cohorts:":[112],"one":[113],"cohort":[114,132],"322":[116],"advanced":[119,356],"disease":[120,140,357],"who":[121,142],"received":[122,143],"first-line":[123,188,243],"endocrine":[124,189,360],"therapy":[125,190],"(ET)":[126],"(predictive":[127],"cohort),":[128],"second":[131],"279":[134],"lymph":[137],"node":[138],"negative":[139],"(LNN)":[141],"no":[144],"adjuvant":[145],"systemic":[146],"treatment":[147],"(prognostic":[148],"cohort).":[149],"Fusion":[150],"transcript":[152,212,269,289,331],"levels":[153],"were":[154,238,254],"measured":[155],"reverse":[157],"transcriptase":[158],"quantitative":[159],"PCR.":[160],"The":[161,209],"presence":[162],"was":[168,213,290,349],"associated,":[169],"uni-":[171],"multivariable":[173,284],"Cox":[174],"regression":[175],"analysis":[176],"taking":[177],"along":[178],"current":[179],"clinico-pathological":[180],"characteristics,":[181],"to":[182,242,344],"progression":[183],"free":[184,197],"survival":[185,198,202],"(PFS)":[186],"during":[187],"cohort,":[194,232,248],"disease-":[196],"(DFS)":[199],"overall":[201],"(OS)":[203],"cohort.":[207],"RESULTS:":[208],"ESR1-CCDC170":[210,264,287,326],"present":[214],"27.6%":[216],"subjects":[221],"2.3%":[224],"cases.":[228],"none":[233],"associated":[239],"response":[241],"ET.":[244],"median":[250],"DFS":[251,296],"OS":[253,308],"respectively":[255,271],"37":[256],"93":[258],"months":[259,275],"for":[260,276,295,351],"an":[263,291],"exon":[265,327],"8":[266,328],"91":[272],"212":[274],"without":[278],"this":[279,286],"transcript.":[281],"analysis,":[285],"independent":[292],"factor":[294],"(HR)":[297],"(95%":[298,310],"confidence":[299],"interval":[300],"(CI):":[301],"1.8":[302],"(1.2-2.8),":[303],"P":[304,314],"=":[305,315],"0.005)":[306],"(HR":[309],"CI:":[311],"1.7":[312],"(1.1-2.7),":[313],"0.023).":[316],"CONCLUSIONS:":[317],"Our":[318],"study":[319],"shows":[320],"that":[321],"only":[325],"carries":[332],"value.":[334],"None":[335],"transcripts,":[340],"which":[341],"are":[342],"considered":[343],"constitutive":[346],"ER":[347],"activity,":[348],"outcome":[352],"treated":[358],"treatment.":[361]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2022-04-03T00:00:00"}
