{"id":"https://openalex.org/W4220994635","doi":"https://doi.org/10.1002/adma.202200839","title":"Coupling Lipid Nanoparticle Structure and Automated Single\u2010Particle Composition Analysis to Design Phospholipase\u2010Responsive Nanocarriers","display_name":"Coupling Lipid Nanoparticle Structure and Automated Single\u2010Particle Composition Analysis to Design Phospholipase\u2010Responsive Nanocarriers","publication_year":2022,"publication_date":"2022-03-31","ids":{"openalex":"https://openalex.org/W4220994635","doi":"https://doi.org/10.1002/adma.202200839","pmid":"https://pubmed.ncbi.nlm.nih.gov/35358374"},"language":"en","primary_location":{"id":"doi:10.1002/adma.202200839","doi":"https://doi.org/10.1002/adma.202200839","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adma.202200839","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adma.202200839","source":{"id":"https://openalex.org/S99352657","display_name":"Advanced Materials","issn_l":"0935-9648","issn":["0935-9648","1521-4095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Materials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adma.202200839","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004292213","display_name":"Hanna M. G. Barriga","orcid":"https://orcid.org/0000-0002-2530-5332","observed_orcids":["https://orcid.org/0000-0002-2530-5332"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Hanna M. G. Barriga","raw_affiliation_strings":["Department of Medical Biochemistry and Biophysics Karolinska Institutet  Stockholm SE\u2010171 77 Sweden","Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, SE-171 77 Sweden"],"raw_orcid":"https://orcid.org/0000-0002-2530-5332","affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics Karolinska Institutet  Stockholm SE\u2010171 77 Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, SE-171 77 Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054435650","display_name":"Isaac J. Pence","orcid":"https://orcid.org/0000-0002-5635-1374","observed_orcids":["https://orcid.org/0000-0002-5635-1374"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Isaac J. Pence","raw_affiliation_strings":["Department of Materials Department of Bioengineering and Institute of Biomedical Engineering Imperial College London  London SW7 2AZ UK","Department of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ UK"],"raw_orcid":"https://orcid.org/0000-0002-5635-1374","affiliations":[{"raw_affiliation_string":"Department of Materials Department of Bioengineering and Institute of Biomedical Engineering Imperial College London  London SW7 2AZ UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038866966","display_name":"Margaret N. Holme","orcid":"https://orcid.org/0000-0002-7314-9493","observed_orcids":["https://orcid.org/0000-0002-7314-9493"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SE"],"is_corresponding":false,"raw_author_name":"Margaret N. Holme","raw_affiliation_strings":["Department of Materials Department of Bioengineering and Institute of Biomedical Engineering Imperial College London  London SW7 2AZ UK","Department of Medical Biochemistry and Biophysics Karolinska Institutet  Stockholm SE\u2010171 77 Sweden","Department of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ UK","Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, SE-171 77 Sweden"],"raw_orcid":"https://orcid.org/0000-0002-7314-9493","affiliations":[{"raw_affiliation_string":"Department of Materials Department of Bioengineering and Institute of Biomedical Engineering Imperial College London  London SW7 2AZ UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics Karolinska Institutet  Stockholm SE\u2010171 77 Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, SE-171 77 Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057424651","display_name":"James Doutch","orcid":"https://orcid.org/0000-0003-0747-8368","observed_orcids":["https://orcid.org/0000-0003-0747-8368"]},"institutions":[{"id":"https://openalex.org/I1286704778","display_name":"Rutherford Appleton Laboratory","ror":"https://ror.org/03gq8fr08","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1286704778","https://openalex.org/I162524378","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I4387152483","display_name":"ISIS Neutron and Muon Source","ror":"https://ror.org/01t8fg661","country_code":null,"type":"facility","lineage":["https://openalex.org/I162524378","https://openalex.org/I4210087105","https://openalex.org/I4387152483"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James J. Doutch","raw_affiliation_strings":["ISIS Neutron and Muon Source STFC Rutherford Appleton Laboratory  Didcot OX11 ODE UK","ISIS Neutron and Muon Source, STFC, Rutherford Appleton Laboratory, Didcot, OX11 ODE UK"],"raw_orcid":"https://orcid.org/0000-0003-0747-8368","affiliations":[{"raw_affiliation_string":"ISIS Neutron and Muon Source STFC Rutherford Appleton Laboratory  Didcot OX11 ODE UK","institution_ids":["https://openalex.org/I1286704778","https://openalex.org/I4387152483"]},{"raw_affiliation_string":"ISIS Neutron and Muon Source, STFC, Rutherford Appleton Laboratory, Didcot, OX11 ODE UK","institution_ids":["https://openalex.org/I1286704778","https://openalex.org/I4387152483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055432666","display_name":"Jelle Penders","orcid":"https://orcid.org/0000-0002-5232-917X","observed_orcids":["https://orcid.org/0000-0002-5232-917X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jelle Penders","raw_affiliation_strings":["Department of Materials Department of Bioengineering and Institute of Biomedical Engineering Imperial College London  London SW7 2AZ UK","Department of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ UK"],"raw_orcid":"https://orcid.org/0000-0002-5232-917X","affiliations":[{"raw_affiliation_string":"Department of Materials Department of Bioengineering and Institute of Biomedical Engineering Imperial College London  London SW7 2AZ UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085035474","display_name":"Valeria Nele","orcid":"https://orcid.org/0000-0002-7263-7209","observed_orcids":["https://orcid.org/0000-0002-7263-7209"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Valeria Nele","raw_affiliation_strings":["Department of Materials Department of Bioengineering and Institute of Biomedical Engineering Imperial College London  London SW7 2AZ UK","Department of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ UK"],"raw_orcid":"https://orcid.org/0000-0002-7263-7209","affiliations":[{"raw_affiliation_string":"Department of Materials Department of Bioengineering and Institute of Biomedical Engineering Imperial College London  London SW7 2AZ UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012037445","display_name":"Michael R. Thomas","orcid":"https://orcid.org/0000-0001-7795-9648","observed_orcids":["https://orcid.org/0000-0001-7795-9648","https://orcid.org/0000-0001-6451-4439"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael R. Thomas","raw_affiliation_strings":["Department of Materials Department of Bioengineering and Institute of Biomedical Engineering Imperial College London  London SW7 2AZ UK","Department of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ UK"],"raw_orcid":"https://orcid.org/0000-0001-7795-9648","affiliations":[{"raw_affiliation_string":"Department of Materials Department of Bioengineering and Institute of Biomedical Engineering Imperial College London  London SW7 2AZ UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089155180","display_name":"Marta Carroni","orcid":"https://orcid.org/0000-0002-7697-6427","observed_orcids":["https://orcid.org/0000-0002-7697-6427"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Marta Carroni","raw_affiliation_strings":["Department of Biochemistry and Biophysics Science for Life Laboratory Stockholm University  Stockholm 171 65 Sweden","Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Stockholm, 171 65 Sweden"],"raw_orcid":"https://orcid.org/0000-0002-7697-6427","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics Science for Life Laboratory Stockholm University  Stockholm 171 65 Sweden","institution_ids":["https://openalex.org/I161593684","https://openalex.org/I2800139495"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Stockholm, 171 65 Sweden","institution_ids":["https://openalex.org/I161593684","https://openalex.org/I2800139495"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044430674","display_name":"Molly M. Stevens","orcid":"https://orcid.org/0000-0002-7335-266X","observed_orcids":["https://orcid.org/0000-0002-7335-266X"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SE"],"is_corresponding":true,"raw_author_name":"Molly M. Stevens","raw_affiliation_strings":["Department of Materials Department of Bioengineering and Institute of Biomedical Engineering Imperial College London  London SW7 2AZ UK","Department of Medical Biochemistry and Biophysics Karolinska Institutet  Stockholm SE\u2010171 77 Sweden","Department of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ UK","Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, SE-171 77 Sweden"],"raw_orcid":"https://orcid.org/0000-0002-1146-7090","affiliations":[{"raw_affiliation_string":"Department of Materials Department of Bioengineering and Institute of Biomedical Engineering Imperial College London  London SW7 2AZ UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics Karolinska Institutet  Stockholm SE\u2010171 77 Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, SE-171 77 Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5044430674"],"corresponding_institution_ids":["https://openalex.org/I28166907","https://openalex.org/I47508984"],"apc_list":{"value":5100,"currency":"USD","value_usd":5100},"apc_paid":{"value":5100,"currency":"USD","value_usd":5100},"fwci":1.9076,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.85936587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"34","issue":"26","first_page":"e2200839","last_page":"e2200839"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5810999870300293,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5810999870300293,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.2345999926328659,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.155799999833107,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-nanoparticles","display_name":"lipid nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/phospholipase-d","display_name":"phospholipase D","score":0.9810000061988831},{"id":"https://openalex.org/keywords/intracellular-trafficking","display_name":"intracellular trafficking","score":0.6919999718666077},{"id":"https://openalex.org/keywords/stimuli-responsive-drug-delivery","display_name":"stimuli-responsive drug delivery","score":0.7059999704360962},{"id":"https://openalex.org/keywords/vaccine-delivery","display_name":"vaccine delivery","score":0.640999972820282},{"id":"https://openalex.org/keywords/rna-therapeutics","display_name":"RNA therapeutics","score":0.9399999976158142},{"id":"https://openalex.org/keywords/sparta","display_name":"Sparta","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.6581873297691345},{"id":"https://openalex.org/C6182249","wikidata":"https://www.wikidata.org/wiki/Q700007","display_name":"Phospholipase D","level":3,"score":0.6399940252304077},{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.634758710861206},{"id":"https://openalex.org/C131888329","wikidata":"https://www.wikidata.org/wiki/Q3027679","display_name":"Small-angle X-ray scattering","level":3,"score":0.5844629406929016},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5641052722930908},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.559964120388031},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.4881194531917572},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.47180595993995667},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4313696622848511},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.41666150093078613},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.384480744600296},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.31558477878570557},{"id":"https://openalex.org/C191486275","wikidata":"https://www.wikidata.org/wiki/Q210028","display_name":"Scattering","level":2,"score":0.24352946877479553},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2432967722415924},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22060716152191162},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1495596170425415},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010740","descriptor_name":"Phospholipases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010740","descriptor_name":"Phospholipases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010740","descriptor_name":"Phospholipases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010740","descriptor_name":"Phospholipases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010740","descriptor_name":"Phospholipases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010740","descriptor_name":"Phospholipases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053838","descriptor_name":"Scattering, Small Angle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053838","descriptor_name":"Scattering, Small Angle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053838","descriptor_name":"Scattering, Small Angle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053838","descriptor_name":"Scattering, Small Angle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053838","descriptor_name":"Scattering, Small Angle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053838","descriptor_name":"Scattering, Small Angle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1002/adma.202200839","doi":"https://doi.org/10.1002/adma.202200839","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adma.202200839","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adma.202200839","source":{"id":"https://openalex.org/S99352657","display_name":"Advanced Materials","issn_l":"0935-9648","issn":["0935-9648","1521-4095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Materials","raw_type":"journal-article"},{"id":"pmid:35358374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35358374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced materials (Deerfield Beach, Fla.)","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10146434","doi":null,"is_oa":true,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10146434/","pdf_url":"https://discovery.ucl.ac.uk/id/eprint/10146434/1/Coupling%20Lipid%20Nanoparticle%20Structure%20VoR.pdf","source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Advanced Materials , Article e2200839. (2022) (In press).","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7615489","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7615489","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Adv Mater","raw_type":"Text"},{"id":"pmh:oai:purl.org/net/epubs:work/52463033","doi":null,"is_oa":true,"landing_page_url":"http://purl.org/net/epubs/work/52463033","pdf_url":null,"source":{"id":"https://openalex.org/S4306400334","display_name":"Science and Technology Facilities Council","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I162524378","host_organization_name":"Science and Technology Facilities Council","host_organization_lineage":["https://openalex.org/I162524378"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/98592","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/98592","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"11","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/adma.202200839","doi":"https://doi.org/10.1002/adma.202200839","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adma.202200839","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adma.202200839","source":{"id":"https://openalex.org/S99352657","display_name":"Advanced Materials","issn_l":"0935-9648","issn":["0935-9648","1521-4095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Materials","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5099999904632568,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1212808833","display_name":"Hybrid Vesicles for Cardiovascular Therapeutics","funder_award_id":"171540","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G1331437543","display_name":null,"funder_award_id":"626766","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G1430250911","display_name":null,"funder_award_id":"SINE2020","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G1689194922","display_name":null,"funder_award_id":"0520547","funder_id":"https://openalex.org/F4320337367","funder_display_name":"Division of Materials Research"},{"id":"https://openalex.org/G263695037","display_name":null,"funder_award_id":"EP/R00529X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2650702889","display_name":null,"funder_award_id":"CiET2021\u221694","funder_id":"https://openalex.org/F4320320005","funder_display_name":"Royal Academy of Engineering"},{"id":"https://openalex.org/G3108985476","display_name":null,"funder_award_id":"SINE2020","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3537589354","display_name":null,"funder_award_id":"DMR-0520547","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4221288801","display_name":null,"funder_award_id":"616417","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4310665315","display_name":null,"funder_award_id":"DMR-0520547","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4937468798","display_name":null,"funder_award_id":"H2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5045220161","display_name":null,"funder_award_id":"H2020","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G509393837","display_name":"An innovative class of nanoparticles (\u201cSmartCubes\u201d) for the targeted delivery of protein therapeutics","funder_award_id":"703666","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5170841131","display_name":null,"funder_award_id":"EP/K031953/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G5190930545","display_name":null,"funder_award_id":"DMR-0520547","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G5214689270","display_name":null,"funder_award_id":"654000","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5586684623","display_name":null,"funder_award_id":"654000","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G578660387","display_name":"Bio-functionalised Nanomaterials for Ultrasensitive Biosensing","funder_award_id":"EP/K020641/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G5870772928","display_name":"Nanomedicine: an integrative approach","funder_award_id":"676137","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5996562161","display_name":null,"funder_award_id":"676137","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G6259803259","display_name":"World class Science and Innovation with Neutrons in Europe 2020 \u2013 SINE2020","funder_award_id":"654000","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6271517897","display_name":null,"funder_award_id":"DMR\u20100520547","funder_id":"https://openalex.org/F4320337367","funder_display_name":"Division of Materials Research"},{"id":"https://openalex.org/G7085717010","display_name":"IMR-MIP DANSE -  Distributed Data Analysis for Neutron Scattering Experiments - CNST","funder_award_id":"0520547","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7619790591","display_name":null,"funder_award_id":"EP/K020641/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G777516347","display_name":"Targeting atherosclerosis: Raman-spectroscopy validated, triggered release of drugs from de novo phospholipid-incorporating liposomes by sphingomyelinase enzymatic degradation of the membrane bilayer","funder_award_id":"626766","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7892797065","display_name":null,"funder_award_id":"616417","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G789883748","display_name":null,"funder_award_id":"SM23642","funder_id":"https://openalex.org/F4320313096","funder_display_name":"Diamond Light Source"},{"id":"https://openalex.org/G8287237980","display_name":"EPSRC IRC in Early-Warning Sensing Systems for Infectious Diseases","funder_award_id":"EP/K031953/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8380713174","display_name":null,"funder_award_id":"SINE2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G925626064","display_name":"i-sense: EPSRC IRC in Agile Early Warning Sensing Systems for Infectious Diseases and Antimicrobial Resistance","funder_award_id":"EP/R00529X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310126","display_name":"Whitaker International Program","ror":"https://ror.org/05s5kq870"},{"id":"https://openalex.org/F4320313096","display_name":"Diamond Light Source","ror":"https://ror.org/05etxs293"},{"id":"https://openalex.org/F4320316838","display_name":"Kempe Foundation","ror":"https://ror.org/05vbwqf43"},{"id":"https://openalex.org/F4320320005","display_name":"Royal Academy of Engineering","ror":"https://ror.org/0526snb40"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320320","display_name":"Rosetrees Trust","ror":"https://ror.org/04e3zg361"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320322971","display_name":"Ume\u00e5 Universitet","ror":"https://ror.org/05kb8h459"},{"id":"https://openalex.org/F4320324135","display_name":"Kempestiftelserna","ror":"https://ror.org/05cszw148"},{"id":"https://openalex.org/F4320325669","display_name":"Stockholms Universitet","ror":"https://ror.org/05f0yaq80"},{"id":"https://openalex.org/F4320325677","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334632","display_name":"Science and Technology Facilities Council","ror":"https://ror.org/057g20z61"},{"id":"https://openalex.org/F4320337367","display_name":"Division of Materials Research","ror":"https://ror.org/01pc7k308"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4220994635.pdf","grobid_xml":"https://content.openalex.org/works/W4220994635.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1964956421","https://openalex.org/W1973744740","https://openalex.org/W2019078959","https://openalex.org/W2027134108","https://openalex.org/W2035868905","https://openalex.org/W2036295204","https://openalex.org/W2045532688","https://openalex.org/W2061946229","https://openalex.org/W2073253325","https://openalex.org/W2076847674","https://openalex.org/W2085732026","https://openalex.org/W2106885643","https://openalex.org/W2128399137","https://openalex.org/W2155239981","https://openalex.org/W2157990526","https://openalex.org/W2249755146","https://openalex.org/W2267902799","https://openalex.org/W2326859466","https://openalex.org/W2412195345","https://openalex.org/W2541908770","https://openalex.org/W2564419925","https://openalex.org/W2564652835","https://openalex.org/W2588185867","https://openalex.org/W2788311872","https://openalex.org/W2808722599","https://openalex.org/W2885645856","https://openalex.org/W2887337631","https://openalex.org/W2897952682","https://openalex.org/W2912438062","https://openalex.org/W2943987854","https://openalex.org/W2946492735","https://openalex.org/W2968060972","https://openalex.org/W2981917056","https://openalex.org/W2985704140","https://openalex.org/W2992823069","https://openalex.org/W2993671286","https://openalex.org/W3003461910","https://openalex.org/W3011420310","https://openalex.org/W3015140168","https://openalex.org/W3016359030","https://openalex.org/W3047744822","https://openalex.org/W3083301834","https://openalex.org/W3137532348","https://openalex.org/W3164967630","https://openalex.org/W3165381670","https://openalex.org/W3198374844"],"related_works":["https://openalex.org/W4366721369","https://openalex.org/W2895282589","https://openalex.org/W3126369458","https://openalex.org/W4386456777","https://openalex.org/W4311202961","https://openalex.org/W2902445771","https://openalex.org/W4387534949","https://openalex.org/W3032807122","https://openalex.org/W4205459909","https://openalex.org/W2592240858"],"abstract_inverted_index":{"Lipid":[0],"nanoparticles":[1],"(LNPs)":[2],"are":[3,11],"versatile":[4],"structures":[5],"with":[6,53,65,104],"tunable":[7],"physicochemical":[8],"properties":[9],"that":[10,81,117],"ideally":[12],"suited":[13],"as":[14],"a":[15,83],"platform":[16],"for":[17,139],"vaccine":[18],"delivery":[19,141],"and":[20,36,41,56,68,70,142],"RNA":[21],"therapeutics.":[22],"A":[23],"key":[24,84],"barrier":[25],"to":[26,33,38,61,71,95,126,134],"LNP":[27,63,92,119,137],"rational":[28],"design":[29,135],"is":[30,51,110,146],"the":[31,90,118],"inability":[32],"relate":[34],"composition":[35,64],"structure":[37,67,122],"intracellular":[39,85],"processing":[40],"function.":[42],"Here":[43],"Single":[44],"Particle":[45],"Automated":[46],"Raman":[47],"Trapping":[48],"Analysis":[49],"(SPARTA)":[50],"combined":[52],"small-angle":[54],"X-ray":[55],"neutron":[57],"scattering":[58],"(SAXS/SANS)":[59],"techniques":[60],"link":[62],"internal":[66],"morphology":[69],"monitor":[72],"dynamic":[73],"LNP-phospholipase":[74],"D":[75],"(PLD)":[76],"interactions.":[77,129],"This":[78,130],"analysis":[79],"demonstrates":[80],"PLD,":[82],"trafficking":[86],"mediator,":[87],"can":[88,123],"access":[89],"entire":[91],"lipid":[93,120],"membrane":[94,121],"generate":[96],"stable,":[97],"anionic":[98],"LNPs.":[99],"PLD":[100,145],"activity":[101],"on":[102],"vesicles":[103],"matched":[105],"amounts":[106],"of":[107,113],"enzyme":[108,128],"substrate":[109],"an":[111,132],"order":[112],"magnitude":[114],"lower,":[115],"indicating":[116],"be":[124],"used":[125],"control":[127],"represents":[131],"opportunity":[133],"enzyme-responsive":[136],"solutions":[138],"stimuli-responsive":[140],"diseases":[143],"where":[144],"dysregulated.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
