{"id":"https://openalex.org/W4220988560","doi":"https://doi.org/10.1016/j.nut.2022.111658","title":"Effects of acute arginine supplementation on neuroendocrine, metabolic, cardiovascular, and mood outcomes in younger men: A double-blind, placebo-controlled trial","display_name":"Effects of acute arginine supplementation on neuroendocrine, metabolic, cardiovascular, and mood outcomes in younger men: A double-blind, placebo-controlled trial","publication_year":2022,"publication_date":"2022-03-20","ids":{"openalex":"https://openalex.org/W4220988560","doi":"https://doi.org/10.1016/j.nut.2022.111658","pmid":"https://pubmed.ncbi.nlm.nih.gov/35691183","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9310054"},"language":"en","primary_location":{"id":"doi:10.1016/j.nut.2022.111658","doi":"https://doi.org/10.1016/j.nut.2022.111658","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nut.2022.111658","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0899900722000715/pdf","source":{"id":"https://openalex.org/S59739785","display_name":"Nutrition","issn_l":"0899-9007","issn":["0899-9007","1873-1244"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0899900722000715/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075815262","display_name":"John William Apolzan","orcid":"https://orcid.org/0000-0001-8492-7820","observed_orcids":["https://orcid.org/0000-0001-8492-7820"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"id":"https://openalex.org/I107341208","display_name":"Louisiana State University System","ror":"https://ror.org/022gnbj15","country_code":"US","type":"education","lineage":["https://openalex.org/I107341208"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John W. Apolzan","raw_affiliation_strings":["Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana. Electronic address: John.Apolzan@pbrc.edu","Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana"],"raw_orcid":"https://orcid.org/0000-0001-8492-7820","affiliations":[{"raw_affiliation_string":"Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana. Electronic address: John.Apolzan@pbrc.edu","institution_ids":["https://openalex.org/I103990859","https://openalex.org/I107341208"]},{"raw_affiliation_string":"Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana","institution_ids":["https://openalex.org/I103990859","https://openalex.org/I107341208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085453324","display_name":"Jesse A. Stein","orcid":"https://orcid.org/0000-0002-8830-8207","observed_orcids":["https://orcid.org/0000-0002-8830-8207"]},"institutions":[{"id":"https://openalex.org/I121067369","display_name":"U.S. Army Research Institute of Environmental Medicine","ror":"https://ror.org/00rg6zq05","country_code":"US","type":"funder","lineage":["https://openalex.org/I106965489","https://openalex.org/I121067369","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893"]},{"id":"https://openalex.org/I4210088792","display_name":"United States Army","ror":"https://ror.org/00afsp483","country_code":"US","type":"government","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I4210088792"]},{"id":"https://openalex.org/I4389425366","display_name":"Oak Ridge Institute for Science and Education","ror":"https://ror.org/040vxhp34","country_code":"US","type":"education","lineage":["https://openalex.org/I1281378812","https://openalex.org/I1330989302","https://openalex.org/I4389425366"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesse A. Stein","raw_affiliation_strings":["Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts; Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee","Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts","Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts; Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee","institution_ids":["https://openalex.org/I121067369","https://openalex.org/I4389425366"]},{"raw_affiliation_string":"Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts","institution_ids":["https://openalex.org/I121067369","https://openalex.org/I4210088792"]},{"raw_affiliation_string":"Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee","institution_ids":["https://openalex.org/I4389425366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067412959","display_name":"Jennifer Carlton Rood","orcid":"https://orcid.org/0000-0001-5848-2987","observed_orcids":["https://orcid.org/0000-0001-5848-2987"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"id":"https://openalex.org/I107341208","display_name":"Louisiana State University System","ror":"https://ror.org/022gnbj15","country_code":"US","type":"education","lineage":["https://openalex.org/I107341208"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer C. Rood","raw_affiliation_strings":["Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana"],"raw_orcid":"https://orcid.org/0000-0001-5848-2987","affiliations":[{"raw_affiliation_string":"Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana","institution_ids":["https://openalex.org/I103990859","https://openalex.org/I107341208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008176801","display_name":"Robbie A. Beyl","orcid":"https://orcid.org/0000-0002-8582-744X","observed_orcids":["https://orcid.org/0000-0002-8582-744X"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"id":"https://openalex.org/I107341208","display_name":"Louisiana State University System","ror":"https://ror.org/022gnbj15","country_code":"US","type":"education","lineage":["https://openalex.org/I107341208"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robbie A. Beyl","raw_affiliation_strings":["Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana"],"raw_orcid":"https://orcid.org/0000-0002-8582-744X","affiliations":[{"raw_affiliation_string":"Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana","institution_ids":["https://openalex.org/I103990859","https://openalex.org/I107341208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057836828","display_name":"Shengping Yang","orcid":"https://orcid.org/0000-0001-6298-6301","observed_orcids":["https://orcid.org/0000-0001-6298-6301"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"id":"https://openalex.org/I107341208","display_name":"Louisiana State University System","ror":"https://ror.org/022gnbj15","country_code":"US","type":"education","lineage":["https://openalex.org/I107341208"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shengping Yang","raw_affiliation_strings":["Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana"],"raw_orcid":"https://orcid.org/0000-0001-6298-6301","affiliations":[{"raw_affiliation_string":"Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana","institution_ids":["https://openalex.org/I103990859","https://openalex.org/I107341208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080400693","display_name":"Frank L. Greenway","orcid":"https://orcid.org/0000-0002-1766-6111","observed_orcids":["https://orcid.org/0000-0002-1766-6111"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"id":"https://openalex.org/I107341208","display_name":"Louisiana State University System","ror":"https://ror.org/022gnbj15","country_code":"US","type":"education","lineage":["https://openalex.org/I107341208"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank L. Greenway","raw_affiliation_strings":["Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana"],"raw_orcid":"https://orcid.org/0000-0002-1766-6111","affiliations":[{"raw_affiliation_string":"Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana","institution_ids":["https://openalex.org/I103990859","https://openalex.org/I107341208"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014750352","display_name":"Harris R. Lieberman","orcid":"https://orcid.org/0000-0002-1519-0156","observed_orcids":["https://orcid.org/0000-0002-1519-0156"]},"institutions":[{"id":"https://openalex.org/I121067369","display_name":"U.S. Army Research Institute of Environmental Medicine","ror":"https://ror.org/00rg6zq05","country_code":"US","type":"funder","lineage":["https://openalex.org/I106965489","https://openalex.org/I121067369","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893"]},{"id":"https://openalex.org/I4210088792","display_name":"United States Army","ror":"https://ror.org/00afsp483","country_code":"US","type":"government","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I4210088792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harris R. Lieberman","raw_affiliation_strings":["Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts","institution_ids":["https://openalex.org/I121067369","https://openalex.org/I4210088792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5075815262"],"corresponding_institution_ids":["https://openalex.org/I103990859","https://openalex.org/I107341208"],"apc_list":{"value":3440,"currency":"USD","value_usd":3440},"apc_paid":{"value":3440,"currency":"USD","value_usd":3440},"fwci":2.0367,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.86555137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"101","issue":null,"first_page":"111658","last_page":"111658"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.48829999566078186,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.48829999566078186,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.39010000228881836,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13551","display_name":"Biochemical effects in animals","score":0.02410000003874302,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-arginine-supplementation","display_name":"arginine supplementation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.8960000276565552},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.9100000262260437},{"id":"https://openalex.org/keywords/nitric-oxide-precursor","display_name":"nitric oxide precursor","score":0.7149999737739563},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.7139999866485596},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.4050000011920929},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.5720000267028809},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.5180000066757202},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.984000027179718},{"id":"https://openalex.org/keywords/dehydroepiandrosterone","display_name":"dehydroepiandrosterone","score":0.9359999895095825},{"id":"https://openalex.org/keywords/mood-states","display_name":"mood states","score":0.6899999976158142},{"id":"https://openalex.org/keywords/gut-microbiota-metabolites","display_name":"gut microbiota metabolites","score":0.6449999809265137},{"id":"https://openalex.org/keywords/urea-cycle","display_name":"urea cycle","score":0.6809999942779541},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.7749999761581421},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.8259999752044678},{"id":"https://openalex.org/keywords/young-men","display_name":"young men","score":0.6779999732971191},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.5299999713897705},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.531000018119812},{"id":"https://openalex.org/keywords/thyroid-function","display_name":"thyroid function","score":0.3659999966621399},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7849639654159546},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7583545446395874},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7543838024139404},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.7264043688774109},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.5767470598220825},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5483000874519348},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.4345262050628662},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4112364947795868},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2012644112110138},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17597106099128723},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09081724286079407},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.nut.2022.111658","doi":"https://doi.org/10.1016/j.nut.2022.111658","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nut.2022.111658","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0899900722000715/pdf","source":{"id":"https://openalex.org/S59739785","display_name":"Nutrition","issn_l":"0899-9007","issn":["0899-9007","1873-1244"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition","raw_type":"journal-article"},{"id":"pmid:35691183","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35691183","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition (Burbank, Los Angeles County, Calif.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9310054","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9310054","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nutrition","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.nut.2022.111658","doi":"https://doi.org/10.1016/j.nut.2022.111658","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nut.2022.111658","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0899900722000715/pdf","source":{"id":"https://openalex.org/S59739785","display_name":"Nutrition","issn_l":"0899-9007","issn":["0899-9007","1873-1244"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5600000023841858,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G2222671754","display_name":null,"funder_award_id":"DK072476","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3667826151","display_name":null,"funder_award_id":"U54GM104940","funder_id":"https://openalex.org/F4320317903","funder_display_name":"Louisiana Clinical and Translational Science Center"},{"id":"https://openalex.org/G4370236196","display_name":null,"funder_award_id":"GM104940","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5850863802","display_name":null,"funder_award_id":"GM104940","funder_id":"https://openalex.org/F4320317903","funder_display_name":"Louisiana Clinical and Translational Science Center"},{"id":"https://openalex.org/G9000133560","display_name":null,"funder_award_id":"DK072476","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000311072","display_name":null,"funder_award_id":"GM104940","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000898112","display_name":"Louisiana Clinical and Translational Science Center","funder_award_id":"U54GM104940","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000905746","display_name":"Pennington/Louisiana NORC","funder_award_id":"P30DK072476","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306250","display_name":"Battelle","ror":"https://ror.org/01h5tnr73"},{"id":"https://openalex.org/F4320315784","display_name":"U.S. Army Combat Capabilities Development Command Soldier Center","ror":"https://ror.org/02rdkx920"},{"id":"https://openalex.org/F4320317903","display_name":"Louisiana Clinical and Translational Science Center","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320338415","display_name":"U.S. Army Medical Research and Development Command","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4220988560.pdf","grobid_xml":"https://content.openalex.org/works/W4220988560.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W20340481","https://openalex.org/W167840274","https://openalex.org/W253642632","https://openalex.org/W1511030966","https://openalex.org/W1584001019","https://openalex.org/W1586074051","https://openalex.org/W1980270094","https://openalex.org/W1982533403","https://openalex.org/W1988600687","https://openalex.org/W1998710776","https://openalex.org/W2000796869","https://openalex.org/W2006171178","https://openalex.org/W2007681355","https://openalex.org/W2010799584","https://openalex.org/W2013977886","https://openalex.org/W2014985603","https://openalex.org/W2024458952","https://openalex.org/W2030016656","https://openalex.org/W2045138089","https://openalex.org/W2053575156","https://openalex.org/W2057765693","https://openalex.org/W2063034416","https://openalex.org/W2067737646","https://openalex.org/W2072976356","https://openalex.org/W2074914712","https://openalex.org/W2075436080","https://openalex.org/W2077586452","https://openalex.org/W2082233445","https://openalex.org/W2086909498","https://openalex.org/W2095330684","https://openalex.org/W2102839002","https://openalex.org/W2104168812","https://openalex.org/W2106549634","https://openalex.org/W2121524058","https://openalex.org/W2129252526","https://openalex.org/W2133740866","https://openalex.org/W2157839166","https://openalex.org/W2160283180","https://openalex.org/W2161363220","https://openalex.org/W2162066244","https://openalex.org/W2167851640","https://openalex.org/W2192290221","https://openalex.org/W2328745476","https://openalex.org/W2334426418","https://openalex.org/W2400950941","https://openalex.org/W2461475931","https://openalex.org/W2549272161","https://openalex.org/W2554620027","https://openalex.org/W2756287690","https://openalex.org/W2885586552","https://openalex.org/W2913282397","https://openalex.org/W2945887817","https://openalex.org/W2981533364","https://openalex.org/W2990706223","https://openalex.org/W3022924256","https://openalex.org/W3043314556","https://openalex.org/W3087636143","https://openalex.org/W3104088357","https://openalex.org/W3135627827","https://openalex.org/W3211777890","https://openalex.org/W4200449705","https://openalex.org/W4206545847"],"related_works":["https://openalex.org/W7112899821","https://openalex.org/W3030540511","https://openalex.org/W2085675670","https://openalex.org/W2584661985","https://openalex.org/W1998710776","https://openalex.org/W4309902447","https://openalex.org/W7096804216","https://openalex.org/W2077997300","https://openalex.org/W1978791759","https://openalex.org/W2103017847"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Arginine":[1,46,129,163,180,271],"is":[2],"an":[3,57,248,289],"amino-acid":[4],"supplement":[5],"and":[6,33,49,66,69,80,93,136,143,146,173,201,222,226,244,247,256,277,288],"precursor":[7],"for":[8],"nitric-oxide":[9],"synthesis,":[10],"which":[11],"affects":[12],"various":[13],"biologic":[14],"processes.":[15],"The":[16,74],"objective":[17],"of":[18,26,119,239,264,305],"this":[19],"study":[20],"was":[21],"to":[22,261,293],"determine":[23],"the":[24,122,198,294,302],"effects":[25,124],"arginine":[27,159,208,314],"supplementation":[28,272],"on":[29],"growth":[30],"hormone":[31,148],"(GH)":[32],"metabolic":[34],"parameters.":[35],"METHODS:":[36],")":[37],"were":[38,54,62,77,96,104,204],"randomized":[39],"in":[40,102,197,280],"a":[41,262],"double-blind,":[42],"placebo-controlled,":[43],"crossover":[44],"trial.":[45],"(10":[47],"g)":[48,52],"placebo":[50,161,165,182,210],"(0":[51],"beverages":[53],"consumed":[55],"after":[56,72,158,313],"overnight":[58],"fast.":[59],"Blood":[60],"samples":[61],"collected":[63],"at":[64,114,125,132,152,169,213,218,228,242,252],"baseline":[65,243],"1.5,":[67],"3.0,":[68],"24":[70,153,229,257],"h":[71,134,138,154,171,175,215,220,224,230,258],"supplementation.":[73,315],"primary":[75],"outcomes":[76],"serum":[78],"GH":[79,103,144,212,311],"metabolomics.":[81],"Also,":[82],"amino":[83],"acids,":[84],"glucose,":[85,276],"insulin,":[86],"triacylglycerols,":[87],"thyroid":[88],"hormones,":[89],"testosterone,":[90],"cortisol,":[91],"dehydroepiandrosterone,":[92],"mood":[94,190],"state":[95,191],"assessed.":[97],"Individuals":[98],"with":[99,310],"detectable":[100],"increases":[101],"analyzed":[105],"separately":[106],"(responders:":[107],"n":[108],"=":[109],"16;":[110],"<":[111,156,233,268],"0.05":[112],"ng/mL":[113],"1.5":[115,133,170,214,219,245,254],"h).":[116],"Repeated-measure":[117],"analyses":[118],"variance":[120],"estimated":[121],"treatment":[123],"each":[126],"timepoint.":[127],"RESULTS:":[128],"levels":[130,151,168,238,279],"increased":[131,166,211,274,303],"(146%)":[135],"3.0":[137,174,223],"(95%;":[139],"P":[140,177,232],"\u2264":[141,178],"0.001)":[142],"(193%)":[145],"thyroid-stimulating":[147],"(TSH;":[149],"10%)":[150],"(P":[155,192,267],"0.05)":[157],"versus":[160,164,181,209],"consumption.":[162],"glucose":[167,217],"(5%)":[172],"(3%;":[176],"0.001).":[179],"did":[183],"not":[184],"affect":[185],"other":[186],"dependent":[187],"measures,":[188],"including":[189],">":[193],"0.05),":[194],"but":[195],"changes":[196],"urea,":[199],"glutamate,":[200],"citric-acid":[202],"pathways":[203],"observed.":[205],"Among":[206],"responders,":[207],"(37%),":[216],"(4%)":[221],"(4%),":[225],"TSH":[227,278],"(9%;":[231],"0.05).":[234,269],"Responders":[235,283],"had":[236,284],"higher":[237,285],"benzoate":[240,286],"metabolites":[241,287],"h,":[246,255],"unknown":[249,290],"compound":[250],"(X-16124)":[251],"baseline,":[253],"that":[259],"corresponds":[260,309],"class":[263],"gut":[265,295,307],"microbes":[266],"CONCLUSIONS:":[270],"modestly":[273],"GH,":[275],"younger":[281],"men.":[282],"analyte":[291],"attributed":[292],"microbiome.":[296],"Future":[297],"studies":[298],"should":[299],"examine":[300],"whether":[301],"prevalence":[304],"these":[306],"microorganisms":[308],"response":[312]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-04-03T00:00:00"}