{"id":"https://openalex.org/W4220985197","doi":"https://doi.org/10.3390/metabo12040305","title":"A Review on Differential Abundance Analysis Methods for Mass Spectrometry-Based Metabolomic Data","display_name":"A Review on Differential Abundance Analysis Methods for Mass Spectrometry-Based Metabolomic Data","publication_year":2022,"publication_date":"2022-03-30","ids":{"openalex":"https://openalex.org/W4220985197","doi":"https://doi.org/10.3390/metabo12040305","pmid":"https://pubmed.ncbi.nlm.nih.gov/35448492","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9032534"},"language":"en","primary_location":{"id":"doi:10.3390/metabo12040305","doi":"https://doi.org/10.3390/metabo12040305","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo12040305","pdf_url":"https://www.mdpi.com/2218-1989/12/4/305/pdf?version=1648623323","source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2218-1989/12/4/305/pdf?version=1648623323","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069648795","display_name":"Zhengyan Huang","orcid":"https://orcid.org/0000-0003-2901-7853","observed_orcids":["https://orcid.org/0000-0003-2901-7853"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zhengyan Huang","raw_affiliation_strings":["Everest Clinical Research Corporation, Little Falls, NJ 07424, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Everest Clinical Research Corporation, Little Falls, NJ 07424, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100342205","display_name":"Chi Wang","orcid":"https://orcid.org/0000-0001-8984-4995","observed_orcids":["https://orcid.org/0000-0001-8984-4995"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chi Wang","raw_affiliation_strings":["Markey Cancer Center, Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Markey Cancer Center, Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069648795","https://openalex.org/A5100342205"],"corresponding_institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2094},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2094},"fwci":0.2602,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.22207901,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"12","issue":"4","first_page":"305","last_page":"305"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/differential-abundance-analysis","display_name":"differential abundance","score":0.984000027179718},{"id":"https://openalex.org/keywords/mass-spectrometry-based-metabolomics","display_name":"mass spectrometry-based metabolomics","score":0.8519999980926514},{"id":"https://openalex.org/keywords/zero-inflated-data","display_name":"zero-inflated data","score":0.9620000123977661},{"id":"https://openalex.org/keywords/statistical-modeling","display_name":"statistical modeling","score":0.4729999899864197},{"id":"https://openalex.org/keywords/parametric-models","display_name":"parametric models","score":0.6370000243186951},{"id":"https://openalex.org/keywords/non-parametric-methods","display_name":"non-parametric methods","score":0.7770000100135803},{"id":"https://openalex.org/keywords/semiparametric-models","display_name":"semiparametric models","score":0.7319999933242798},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.8646273612976074},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.523441731929779},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.509968638420105},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.43929415941238403},{"id":"https://openalex.org/C77077793","wikidata":"https://www.wikidata.org/wiki/Q336019","display_name":"Abundance (ecology)","level":2,"score":0.41697168350219727},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.4108917713165283},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.36819759011268616},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35673660039901733},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28274303674697876},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.22981444001197815},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18127751350402832},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1640005111694336},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.16357767581939697},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/metabo12040305","doi":"https://doi.org/10.3390/metabo12040305","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo12040305","pdf_url":"https://www.mdpi.com/2218-1989/12/4/305/pdf?version=1648623323","source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9032534","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9032534","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"Text"},{"id":"pmid:35448492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35448492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ca8f5405c58f4c99b37c072dc64e4450","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ca8f5405c58f4c99b37c072dc64e4450","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Metabolites, Vol 12, Iss 4, p 305 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/metabo12040305","doi":"https://doi.org/10.3390/metabo12040305","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo12040305","pdf_url":"https://www.mdpi.com/2218-1989/12/4/305/pdf?version=1648623323","source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5843850540","display_name":"Differential Abundance Methods for Large Heterogeneous-Featured Metabolomics Datasets","funder_award_id":"1r03ca211835-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6720377861","display_name":null,"funder_award_id":"R03 CA211835","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6888208216","display_name":null,"funder_award_id":"P30 CA177558","funder_id":"https://openalex.org/F4320309825","funder_display_name":"University of Kentucky"},{"id":"https://openalex.org/G9000134899","display_name":"University of Kentucky Markey Cancer Center \u2013 Cancer Center Support Grant","funder_award_id":"P30CA177558","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309825","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4220985197.pdf","grobid_xml":"https://content.openalex.org/works/W4220985197.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1976913681","https://openalex.org/W1981434053","https://openalex.org/W1985121360","https://openalex.org/W1996644428","https://openalex.org/W2000403772","https://openalex.org/W2001265990","https://openalex.org/W2023535481","https://openalex.org/W2031619997","https://openalex.org/W2034873249","https://openalex.org/W2039764641","https://openalex.org/W2047767947","https://openalex.org/W2052792986","https://openalex.org/W2076572088","https://openalex.org/W2081098333","https://openalex.org/W2091520496","https://openalex.org/W2096088529","https://openalex.org/W2098223125","https://openalex.org/W2099598705","https://openalex.org/W2100463095","https://openalex.org/W2103088299","https://openalex.org/W2105938721","https://openalex.org/W2113223906","https://openalex.org/W2125419939","https://openalex.org/W2126253371","https://openalex.org/W2137471181","https://openalex.org/W2139846209","https://openalex.org/W2140351394","https://openalex.org/W2154425398","https://openalex.org/W2155275310","https://openalex.org/W2167540852","https://openalex.org/W2170416157","https://openalex.org/W2278988761","https://openalex.org/W2343047725","https://openalex.org/W2412054932","https://openalex.org/W2509933440","https://openalex.org/W2556428520","https://openalex.org/W2587034866","https://openalex.org/W2592359670","https://openalex.org/W2622731880","https://openalex.org/W2781939187","https://openalex.org/W2788797421","https://openalex.org/W2795425364","https://openalex.org/W2802473898","https://openalex.org/W2899207596","https://openalex.org/W2950871538","https://openalex.org/W2963831345","https://openalex.org/W2981004117","https://openalex.org/W2987640385","https://openalex.org/W3000266016","https://openalex.org/W3001983899","https://openalex.org/W3005260507","https://openalex.org/W3023008864","https://openalex.org/W3091839106","https://openalex.org/W3109638769","https://openalex.org/W3113104240","https://openalex.org/W3125488374","https://openalex.org/W3181660183","https://openalex.org/W3185610568","https://openalex.org/W3196948502","https://openalex.org/W4205797027","https://openalex.org/W4221047126","https://openalex.org/W4252684946"],"related_works":["https://openalex.org/W2981004117","https://openalex.org/W3001983899","https://openalex.org/W2948590773","https://openalex.org/W7120562095","https://openalex.org/W4408291656","https://openalex.org/W2465060029","https://openalex.org/W4376607484","https://openalex.org/W6902064452","https://openalex.org/W2104787245","https://openalex.org/W3178157798"],"abstract_inverted_index":{"This":[0],"review":[1],"presents":[2],"an":[3],"overview":[4],"of":[5,43,50,58],"the":[6,48,54,68],"statistical":[7,61,104],"methods":[8,62,99],"on":[9],"differential":[10],"abundance":[11,27],"(DA)":[12],"analysis":[13,98],"for":[14,25],"mass":[15],"spectrometry":[16],"(MS)-based":[17],"metabolomic":[18,26,70],"data.":[19],"MS":[20,37],"has":[21],"been":[22,64],"widely":[23],"used":[24],"profiling":[28],"in":[29],"biological":[30],"samples.":[31],"The":[32],"high-throughput":[33],"data":[34,71],"produced":[35],"by":[36,47],"often":[38],"contain":[39],"a":[40],"large":[41],"fraction":[42],"zero":[44],"values":[45],"caused":[46],"absence":[49],"certain":[51],"metabolites":[52],"and":[53,72,87,95,103],"technical":[55],"detection":[56],"limits":[57],"MS.":[59],"Various":[60],"have":[63],"developed":[65],"to":[66,80],"characterize":[67],"zero-inflated":[69],"perform":[73],"DA":[74,97],"analysis,":[75],"ranging":[76],"from":[77],"simple":[78],"tests":[79],"more":[81],"complex":[82],"models":[83],"including":[84],"parametric,":[85],"semi-parametric,":[86],"non-parametric":[88],"approaches.":[89],"In":[90],"this":[91],"article,":[92],"we":[93],"discuss":[94],"compare":[96],"regarding":[100],"their":[101],"assumptions":[102],"modeling":[105],"techniques.":[106]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-04-03T00:00:00"}
