{"id":"https://openalex.org/W4220878686","doi":"https://doi.org/10.1002/elps.202100379","title":"Microfluidic device integrating single\u2010cell extraction and electrical lysis for mass spectrometry detection of intracellular compounds","display_name":"Microfluidic device integrating single\u2010cell extraction and electrical lysis for mass spectrometry detection of intracellular compounds","publication_year":2022,"publication_date":"2022-03-22","ids":{"openalex":"https://openalex.org/W4220878686","doi":"https://doi.org/10.1002/elps.202100379","pmid":"https://pubmed.ncbi.nlm.nih.gov/35315940"},"language":"en","primary_location":{"id":"doi:10.1002/elps.202100379","doi":"https://doi.org/10.1002/elps.202100379","is_oa":false,"landing_page_url":"https://doi.org/10.1002/elps.202100379","pdf_url":null,"source":{"id":"https://openalex.org/S2849398","display_name":"Electrophoresis","issn_l":"0173-0835","issn":["0173-0835","1522-2683"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ELECTROPHORESIS","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082092640","display_name":"Tom\u00e1\u0161 V\u00e1clavek","orcid":"https://orcid.org/0000-0001-8555-400X","observed_orcids":["https://orcid.org/0000-0001-8555-400X"]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]},{"id":"https://openalex.org/I4210152186","display_name":"Czech Academy of Sciences, Institute of Analytical Chemistry","ror":"https://ror.org/05g7knd32","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210152186"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Tom\u00e1\u0161 V\u00e1clavek","raw_affiliation_strings":["Department of Bioanalytical Instrumentation, Institute of Analytical Chemistry of the CAS, Brno, Czech Republic","Department of Biochemistry, Masaryk University, Brno, Czech Republic"],"raw_orcid":"https://orcid.org/0000-0001-8555-400X","affiliations":[{"raw_affiliation_string":"Department of Bioanalytical Instrumentation, Institute of Analytical Chemistry of the CAS, Brno, Czech Republic","institution_ids":["https://openalex.org/I4210152186"]},{"raw_affiliation_string":"Department of Biochemistry, Masaryk University, Brno, Czech Republic","institution_ids":["https://openalex.org/I21449261"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037353844","display_name":"Franti\u0161ek Foret","orcid":"https://orcid.org/0000-0002-0060-7350","observed_orcids":["https://orcid.org/0000-0002-0060-7350"]},"institutions":[{"id":"https://openalex.org/I4210152186","display_name":"Czech Academy of Sciences, Institute of Analytical Chemistry","ror":"https://ror.org/05g7knd32","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210152186"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Franti\u0161ek Foret","raw_affiliation_strings":["Department of Bioanalytical Instrumentation, Institute of Analytical Chemistry of the CAS, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioanalytical Instrumentation, Institute of Analytical Chemistry of the CAS, Brno, Czech Republic","institution_ids":["https://openalex.org/I4210152186"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082092640"],"corresponding_institution_ids":["https://openalex.org/I21449261","https://openalex.org/I4210152186"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":1.7149,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.83818464,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"44","issue":"1-2","first_page":"313","last_page":"322"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.1234000027179718,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-erythrocytes","display_name":"human erythrocytes","score":0.8759999871253967},{"id":"https://openalex.org/keywords/hemoglobin-alpha-chain","display_name":"hemoglobin alpha chain","score":0.9169999957084656},{"id":"https://openalex.org/keywords/hemoglobin-beta-chain","display_name":"hemoglobin beta chain","score":1.0},{"id":"https://openalex.org/keywords/cell-heterogeneity","display_name":"cellular heterogeneity","score":0.7649999856948853},{"id":"https://openalex.org/keywords/single-cell-mass-spectrometry","display_name":"single-cell mass spectrometry","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.8479403257369995},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.7709722518920898},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7344388365745544},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6024917364120483},{"id":"https://openalex.org/C2778576202","wikidata":"https://www.wikidata.org/wiki/Q2540164","display_name":"Sample preparation","level":2,"score":0.5626667737960815},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.5447635650634766},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5420542359352112},{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.5062162280082703},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.5015184879302979},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.48754996061325073},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.47684967517852783},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.4576432406902313},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.44814062118530273},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3628748655319214},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35117286443710327},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2572222650051117},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.224469393491745},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2188108265399933},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.177837073802948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17726486921310425},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/elps.202100379","doi":"https://doi.org/10.1002/elps.202100379","is_oa":false,"landing_page_url":"https://doi.org/10.1002/elps.202100379","pdf_url":null,"source":{"id":"https://openalex.org/S2849398","display_name":"Electrophoresis","issn_l":"0173-0835","issn":["0173-0835","1522-2683"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ELECTROPHORESIS","raw_type":"journal-article"},{"id":"pmid:35315940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35315940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Electrophoresis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G770842330","display_name":null,"funder_award_id":"CZ.02.1.01/0.0/0.0/16 026/0008446","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"}],"funders":[{"id":"https://openalex.org/F4320322482","display_name":"Akademie V\u011bd \u010cesk\u00e9 Republiky","ror":"https://ror.org/053avzc18"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W196727512","https://openalex.org/W378324101","https://openalex.org/W1602974015","https://openalex.org/W1965437384","https://openalex.org/W1966177314","https://openalex.org/W1972511164","https://openalex.org/W1974830441","https://openalex.org/W1981111847","https://openalex.org/W1998698032","https://openalex.org/W2014552343","https://openalex.org/W2017661443","https://openalex.org/W2030618194","https://openalex.org/W2032405584","https://openalex.org/W2044450978","https://openalex.org/W2060156302","https://openalex.org/W2064776542","https://openalex.org/W2070706554","https://openalex.org/W2082781273","https://openalex.org/W2103073077","https://openalex.org/W2120029008","https://openalex.org/W2220577367","https://openalex.org/W2334323124","https://openalex.org/W2512843343","https://openalex.org/W2581122375","https://openalex.org/W2592168063","https://openalex.org/W2731991504","https://openalex.org/W2790561925","https://openalex.org/W2895935342","https://openalex.org/W2900516275","https://openalex.org/W2904740297","https://openalex.org/W2910317946","https://openalex.org/W2949769764","https://openalex.org/W3115159478","https://openalex.org/W3134832934","https://openalex.org/W3156537923"],"related_works":["https://openalex.org/W1965437384","https://openalex.org/W2970241996","https://openalex.org/W3156537923","https://openalex.org/W2344574562","https://openalex.org/W4297934189","https://openalex.org/W2910317946","https://openalex.org/W4389500114","https://openalex.org/W2974984078","https://openalex.org/W2044450978","https://openalex.org/W2989306592"],"abstract_inverted_index":{"Analysis":[0],"of":[1,17,46,56,63,97,113],"cellular":[2,32],"composition":[3],"and":[4,48,65,94,102],"metabolism":[5],"at":[6],"a":[7,38,79],"single-cell":[8,85],"resolution":[9],"allows":[10],"gaining":[11],"more":[12],"information":[13],"about":[14],"complex":[15],"relationships":[16],"cells":[18],"within":[19],"tissues":[20],"or":[21],"whole":[22],"living":[23],"organisms":[24],"by":[25],"resolving":[26],"the":[27,31,43,61],"variance":[28],"stemming":[29],"from":[30,87],"heterogeneity.":[33],"Mass":[34],"spectrometry":[35],"(MS)":[36],"is":[37,68],"perfect":[39],"analytical":[40],"tool":[41],"satisfying":[42],"demanding":[44],"requirements":[45],"detecting":[47],"identifying":[49],"compounds":[50],"present":[51,78],"in":[52,70,110],"such":[53],"ultralow-volume":[54],"samples":[55],"high":[57],"chemical":[58],"complexity.":[59],"However,":[60],"method":[62],"sampling":[64,81],"sample":[66],"ionization":[67],"crucial":[69],"obtaining":[71],"relevant":[72],"information.":[73],"In":[74],"this":[75],"work,":[76],"we":[77],"microfluidic":[80],"platform":[82],"that":[83],"integrates":[84],"extraction":[86],"MS-incompatible":[88],"media":[89],"with":[90],"electrical":[91],"cell":[92],"lysis":[93],"nanoESI-MS":[95],"analysis":[96],"human":[98],"erythrocytes.":[99],"Hemoglobin":[100],"alpha":[101],"beta":[103],"chains":[104],"(300":[105],"amol/cell)":[106],"were":[107],"successfully":[108],"identified":[109],"mass":[111],"spectra":[112],"single-erythrocyte":[114],"lysates.":[115]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-04-03T00:00:00"}
