{"id":"https://openalex.org/W4220841007","doi":"https://doi.org/10.36347/sajp.2022.v11i02.001","title":"Development of a Validated HPLC Method for Candesartan Cilexetil to Evaluate the Process of Grinding Tablets on Dispensing in Japan","display_name":"Development of a Validated HPLC Method for Candesartan Cilexetil to Evaluate the Process of Grinding Tablets on Dispensing in Japan","publication_year":2022,"publication_date":"2022-02-11","ids":{"openalex":"https://openalex.org/W4220841007","doi":"https://doi.org/10.36347/sajp.2022.v11i02.001"},"language":"en","primary_location":{"id":"doi:10.36347/sajp.2022.v11i02.001","doi":"https://doi.org/10.36347/sajp.2022.v11i02.001","is_oa":true,"landing_page_url":"https://doi.org/10.36347/sajp.2022.v11i02.001","pdf_url":"https://doi.org/10.36347/sajp.2022.v11i02.001","source":{"id":"https://openalex.org/S4210173594","display_name":"Scholars Academic Journal of Pharmacy","issn_l":"2320-4206","issn":["2320-4206","2347-9531"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scholars Academic Journal of Pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.36347/sajp.2022.v11i02.001","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hikaru Tabuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hikaru Tabuchi","raw_affiliation_strings":["Laboratory of Pharmaceutics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Shido 1314-1, Sanuki, Kagawa 769-2193, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmaceutics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Shido 1314-1, Sanuki, Kagawa 769-2193, Japan","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081917003","display_name":"Rikako Nojima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rikako Nojima","raw_affiliation_strings":["Laboratory of Pharmaceutics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Shido 1314-1, Sanuki, Kagawa 769-2193, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmaceutics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Shido 1314-1, Sanuki, Kagawa 769-2193, Japan","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024239918","display_name":"Takuro Kurita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157960836","display_name":"Nihon Pharmaceutical University","ror":"https://ror.org/039aamd19","country_code":"JP","type":"education","lineage":["https://openalex.org/I157960836"]},{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuro Kurita","raw_affiliation_strings":["Division of Clinical Pharmaceutics, Department of Pharmaceutical Sciences, Nihon Pharmaceutical University, Komuro 10281, Ina-machi, Kitaadachi-gun, Saitama 362-0806, Japan","Laboratory of Pharmaceutics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Shido 1314-1, Sanuki, Kagawa 769-2193, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmaceutics, Department of Pharmaceutical Sciences, Nihon Pharmaceutical University, Komuro 10281, Ina-machi, Kitaadachi-gun, Saitama 362-0806, Japan","institution_ids":["https://openalex.org/I157960836"]},{"raw_affiliation_string":"Laboratory of Pharmaceutics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Shido 1314-1, Sanuki, Kagawa 769-2193, Japan","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043310274","display_name":"Tadakazu Tokumura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadakazu Tokumura","raw_affiliation_strings":["Laboratory of Pharmaceutics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Shido 1314-1, Sanuki, Kagawa 769-2193, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmaceutics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Shido 1314-1, Sanuki, Kagawa 769-2193, Japan","institution_ids":["https://openalex.org/I89098413"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0884,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.21689331,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"11","issue":"2","first_page":"37","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candesartan-cilexetil","display_name":"candesartan cilexetil","score":1.0},{"id":"https://openalex.org/keywords/hplc-method-validation","display_name":"HPLC method validation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/powder-production","display_name":"powder production","score":0.4869999885559082},{"id":"https://openalex.org/keywords/drug-content-determination","display_name":"drug content determination","score":0.5109999775886536},{"id":"https://openalex.org/keywords/drug-addiction-recovery","display_name":"drug recovery","score":0.38999998569488525},{"id":"https://openalex.org/keywords/accuracy-and-precision","display_name":"precision and accuracy","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C2780036600","wikidata":"https://www.wikidata.org/wiki/Q415970","display_name":"Candesartan","level":4,"score":0.8745198249816895},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7911241054534912},{"id":"https://openalex.org/C23531484","wikidata":"https://www.wikidata.org/wiki/Q3196863","display_name":"Calibration curve","level":3,"score":0.5975590348243713},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.5811498761177063},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5485523343086243},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.5163768529891968},{"id":"https://openalex.org/C202799725","wikidata":"https://www.wikidata.org/wiki/Q272035","display_name":"Accuracy and precision","level":2,"score":0.46049100160598755},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.39655235409736633},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.38037925958633423},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.29000574350357056},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.24060606956481934},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.36347/sajp.2022.v11i02.001","doi":"https://doi.org/10.36347/sajp.2022.v11i02.001","is_oa":true,"landing_page_url":"https://doi.org/10.36347/sajp.2022.v11i02.001","pdf_url":"https://doi.org/10.36347/sajp.2022.v11i02.001","source":{"id":"https://openalex.org/S4210173594","display_name":"Scholars Academic Journal of Pharmacy","issn_l":"2320-4206","issn":["2320-4206","2347-9531"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scholars Academic Journal of Pharmacy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.36347/sajp.2022.v11i02.001","doi":"https://doi.org/10.36347/sajp.2022.v11i02.001","is_oa":true,"landing_page_url":"https://doi.org/10.36347/sajp.2022.v11i02.001","pdf_url":"https://doi.org/10.36347/sajp.2022.v11i02.001","source":{"id":"https://openalex.org/S4210173594","display_name":"Scholars Academic Journal of Pharmacy","issn_l":"2320-4206","issn":["2320-4206","2347-9531"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scholars Academic Journal of Pharmacy","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4220841007.pdf","grobid_xml":"https://content.openalex.org/works/W4220841007.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W2009514283","https://openalex.org/W2316664853","https://openalex.org/W2316898738","https://openalex.org/W2320962428","https://openalex.org/W2322118080","https://openalex.org/W2330327526","https://openalex.org/W2740375005"],"related_works":["https://openalex.org/W2351343692","https://openalex.org/W7212380052","https://openalex.org/W2375137522","https://openalex.org/W2617874143","https://openalex.org/W3207928061","https://openalex.org/W2946512706","https://openalex.org/W7094946236","https://openalex.org/W2380904208","https://openalex.org/W2314263130","https://openalex.org/W7219378385"],"abstract_inverted_index":{"The":[0,58,102,124,160,175],"aim":[1],"of":[2,39,45,61,75,83,142,145,152,162,177],"the":[3,36,72,76,81,143,150,183,187,195],"present":[4],"study":[5],"was":[6,56,63,78,108,130,154,167],"to":[7,85,147,156,197],"develop":[8],"and":[9,48,90,95,97,100,112,117,119,122,189,192,207],"validate":[10],"a":[11,32,42,49],"HPLC":[12],"method":[13,77],"for":[14],"assaying":[15],"candesartan":[16],"cilexetil":[17],"(CAND)":[18],"in":[19,80,179],"powder":[20,180],"preparations":[21],"prepared":[22],"from":[23,182],"Blopress\u00ae":[24,163],"Tablets":[25,164],"2":[26,165],"mg.":[27],"A":[28,67],"chromatographic":[29],"system":[30],"comprising":[31],"YMC":[33],"AM12S05-1506WT":[34],"column,":[35],"mobile":[37],"phase":[38],"CH3CN:H2O:HClO4:NaClO4=700:300:1:5":[40],"(V/V/V/W),":[41],"flow":[43],"rate":[44],"1":[46],"mL/min,":[47],"UV":[50],"detector":[51],"set":[52],"at":[53,105,127,137],"254":[54],"nm":[55],"used.":[57],"retention":[59],"time":[60],"CAND":[62,178],"approximately":[64],"8.8":[65],"min.":[66],"regression":[68],"analysis":[69],"revealed":[70],"that":[71],"calibration":[73],"curve":[74],"linear":[79],"range":[82,144],"0.10":[84,106,128,138,158],"80":[86],"\u00b5g/mL.":[87,159],"Intra-day":[88],"precision":[89,111],"accuracy":[91,103,113,125,135],"ranged":[92,114],"between":[93,98,115,120],"0.1":[94],"1.6%":[96],"-0.4":[99],"20.9%.":[101,109],"value":[104,126],"\u00b5g/mL":[107,129,139],"Inter-day":[110],"0.2":[116],"3.0%":[118],"-0.3":[121],"20.6%.":[123,131],"In":[132],"both":[133],"cases,":[134],"values":[136],"were":[140,200],"out":[141],"-10%":[146],"10%.":[148],"Therefore,":[149],"limit":[151],"quantification":[153],"established":[155],"be":[157],"content":[161],"mg":[166],"99.20":[168],"\u00b1":[169,172,202,205,209],"0.81%":[170],"(mean":[171],"SD,":[173],"n=3).":[174],"ratios":[176],"removed":[181],"mortar,":[184],"remaining":[185],"on":[186,194],"mortar":[188],"pestle":[190],"surface,":[191],"scattered":[193],"paper":[196],"total":[198],"recovery":[199],"85.48":[201],"3.50,":[203],"14.27":[204],"3.53,":[206],"0.30":[208],"0.02%,":[210],"respectively.":[211]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-04-03T00:00:00"}
