{"id":"https://openalex.org/W4220823957","doi":"https://doi.org/10.31086/tjgeri.2022.264","title":"Comparison of the efficacy and safety of direct-acting antiviral agents in the treatment of hepatitis C virus genotype 1 between the Turkish elderly and younger population","display_name":"Comparison of the efficacy and safety of direct-acting antiviral agents in the treatment of hepatitis C virus genotype 1 between the Turkish elderly and younger population","publication_year":2022,"publication_date":"2022-03-23","ids":{"openalex":"https://openalex.org/W4220823957","doi":"https://doi.org/10.31086/tjgeri.2022.264"},"language":"en","primary_location":{"id":"doi:10.31086/tjgeri.2022.264","doi":"https://doi.org/10.31086/tjgeri.2022.264","is_oa":true,"landing_page_url":"https://doi.org/10.31086/tjgeri.2022.264","pdf_url":"https://doi.org/10.31086/tjgeri.2022.264","source":{"id":"https://openalex.org/S2482508668","display_name":"The Turkish Journal of Geriatrics","issn_l":"1304-2947","issn":["1304-2947","1307-9948"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","jufo-1","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4365365834","host_organization_name":"Turkish Geriatrics Society","host_organization_lineage":["https://openalex.org/P4365365834"],"host_organization_lineage_names":["Turkish Geriatrics Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Turkish Journal of Geriatrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.31086/tjgeri.2022.264","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013474817","display_name":"Haydar Adan\u0131r","orcid":"https://orcid.org/0000-0003-1899-5846","observed_orcids":["https://orcid.org/0000-0003-1899-5846"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haydar ADANIR","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1899-5846","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003132821","display_name":"Mete Ak\u0131n","orcid":"https://orcid.org/0000-0003-2393-7990","observed_orcids":["https://orcid.org/0000-0003-2393-7990"]},"institutions":[{"id":"https://openalex.org/I197907453","display_name":"Akdeniz University","ror":"https://ror.org/01m59r132","country_code":"TR","type":"education","lineage":["https://openalex.org/I197907453"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Mete AKIN","raw_affiliation_strings":["Akdeniz University , Facultyof Medicine, Gastroenterology , Antalya , Turkey","Akdeniz University, Facultyof Medicine,","Gastroenterology, Antalya, Turkey","Medical Park Antalya Hospital,"],"raw_orcid":"https://orcid.org/0000-0003-2393-7990","affiliations":[{"raw_affiliation_string":"Akdeniz University , Facultyof Medicine, Gastroenterology , Antalya , Turkey","institution_ids":["https://openalex.org/I197907453"]},{"raw_affiliation_string":"Akdeniz University, Facultyof Medicine,","institution_ids":["https://openalex.org/I197907453"]},{"raw_affiliation_string":"Gastroenterology, Antalya, Turkey","institution_ids":[]},{"raw_affiliation_string":"Medical Park Antalya Hospital,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081420857","display_name":"Erhan ALKAN","orcid":"https://orcid.org/0000-0002-7211-4483","observed_orcids":["https://orcid.org/0000-0002-7211-4483"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erhan ALKAN","raw_affiliation_strings":["Medical Park Antalya Hospital , Gastroenterology , Antalya , Turkey"],"raw_orcid":"https://orcid.org/0000-0002-7211-4483","affiliations":[{"raw_affiliation_string":"Medical Park Antalya Hospital , Gastroenterology , Antalya , Turkey","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003132821"],"corresponding_institution_ids":["https://openalex.org/I197907453"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hcv-genotype-1","display_name":"HCV genotype 1","score":0.8029999732971191},{"id":"https://openalex.org/keywords/direct-acting-antivirals","display_name":"direct-acting antivirals","score":0.8889999985694885},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.8690000176429749},{"id":"https://openalex.org/keywords/ledipasvir-sofosbuvir","display_name":"ledipasvir/sofosbuvir","score":0.9279999732971191},{"id":"https://openalex.org/keywords/ombitasvir-paritaprevir-ritonavir","display_name":"ombitasvir/paritaprevir/ritonavir","score":0.9570000171661377},{"id":"https://openalex.org/keywords/dasabuvir","display_name":"dasabuvir","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ribavirin","display_name":"ribavirin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/sustained-virologic-response","display_name":"sustained virological response","score":0.9509999752044678},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6169999837875366},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.9879999756813049},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.8550000190734863},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9049999713897705},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C2778817970","wikidata":"https://www.wikidata.org/wiki/Q7855390","display_name":"Turkish population","level":4,"score":0.7063935995101929},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7036749124526978},{"id":"https://openalex.org/C2781121862","wikidata":"https://www.wikidata.org/wiki/Q256","display_name":"Turkish","level":2,"score":0.6591446399688721},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6260495781898499},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6183673143386841},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.5650334358215332},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41087862849235535},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.37980401515960693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24393239617347717},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.22553852200508118},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15442630648612976},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07756593823432922},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.31086/tjgeri.2022.264","doi":"https://doi.org/10.31086/tjgeri.2022.264","is_oa":true,"landing_page_url":"https://doi.org/10.31086/tjgeri.2022.264","pdf_url":"https://doi.org/10.31086/tjgeri.2022.264","source":{"id":"https://openalex.org/S2482508668","display_name":"The Turkish Journal of Geriatrics","issn_l":"1304-2947","issn":["1304-2947","1307-9948"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","jufo-1","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4365365834","host_organization_name":"Turkish Geriatrics Society","host_organization_lineage":["https://openalex.org/P4365365834"],"host_organization_lineage_names":["Turkish Geriatrics Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Turkish Journal of Geriatrics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.31086/tjgeri.2022.264","doi":"https://doi.org/10.31086/tjgeri.2022.264","is_oa":true,"landing_page_url":"https://doi.org/10.31086/tjgeri.2022.264","pdf_url":"https://doi.org/10.31086/tjgeri.2022.264","source":{"id":"https://openalex.org/S2482508668","display_name":"The Turkish Journal of Geriatrics","issn_l":"1304-2947","issn":["1304-2947","1307-9948"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","jufo-1","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4365365834","host_organization_name":"Turkish Geriatrics Society","host_organization_lineage":["https://openalex.org/P4365365834"],"host_organization_lineage_names":["Turkish Geriatrics Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Turkish Journal of Geriatrics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4220823957.pdf","grobid_xml":"https://content.openalex.org/works/W4220823957.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1921321055","https://openalex.org/W2000336618","https://openalex.org/W2022693941","https://openalex.org/W2042063943","https://openalex.org/W2042158802","https://openalex.org/W2142660384","https://openalex.org/W2185218296","https://openalex.org/W2258263090","https://openalex.org/W2326752552","https://openalex.org/W2329982221","https://openalex.org/W2333066654","https://openalex.org/W2514340439","https://openalex.org/W2536951822","https://openalex.org/W2546099614","https://openalex.org/W2574959804","https://openalex.org/W2586826494","https://openalex.org/W2587825182","https://openalex.org/W2714779231","https://openalex.org/W2761518106","https://openalex.org/W2791564295","https://openalex.org/W2942777341","https://openalex.org/W2977861016","https://openalex.org/W3107529120"],"related_works":["https://openalex.org/W4289844193","https://openalex.org/W3183218407","https://openalex.org/W3118390037","https://openalex.org/W3123314662","https://openalex.org/W2514340439","https://openalex.org/W3136967961","https://openalex.org/W2579037114","https://openalex.org/W4220857427","https://openalex.org/W4388795175","https://openalex.org/W2746262573"],"abstract_inverted_index":{"Introduction:":[0],"Direct-acting":[1,219],"antiviral":[2,40,67,220],"agents":[3,41],"are":[4,222],"highly":[5,223],"effective":[6,224],"and":[7,36,56,91,109,116,157],"safe":[8],"treatments":[9],"for":[10,127,133],"chronic":[11],"hepatitis":[12,44],"C":[13,45],"infection;":[14],"however,":[15,179],"the":[16,34,43,81,102,119,130,134,146,168,186,214,233],"treatment":[17],"may":[18],"be":[19,207],"more":[20,152,192,210],"problematic":[21],"in":[22,80,140,148,171,185,213,225,232],"elderly":[23,51,187,215,226],"patients":[24,58,84,136,227],"due":[25],"to":[26,32,206],"accompanying":[27],"comorbid":[28],"conditions.This":[29],"study":[30],"aimed":[31],"assess":[33],"efficacy":[35],"safety":[37],"of":[38,104,129,173,200,235],"direct-acting":[39,66],"among":[42],"virus":[46],"genotype":[47],"1":[48,88,142],"infected":[49],"Turkish":[50],"population":[52],"(\u226565":[53,97],"years).":[54],"Materials":[55],"Method:Ninety-six":[57],"older":[59],"than":[60],"18":[61],"years":[62],"old":[63],"treated":[64],"with":[65,137,189,209],"regimens":[68,221],"(sofosbuvir/ledipasvir":[69],"\u00b1":[70,76],"ribavirin":[71],"or":[72,191],"ombitasvir/paritaprevir/ritonavir":[73],"+":[74],"dasabuvir":[75],"ribavirin)":[77],"were":[78,114,125,182],"included":[79],"study:":[82],"48":[83,92],"(50%)":[85,93],"constituted":[86,94],"Group":[87,95,141,149],"(<65":[89],"years)":[90],"2":[96,150],"years).Comorbidities,":[98],"potential":[99,193],"drug-drug":[100],"interactions,":[101],"number":[103],"interacting":[105],"drugs,":[106],"adverse":[107],"events,":[108],"sustained":[110],"virologic":[111,122],"response":[112,123],"rates":[113,124],"evaluated":[115],"compared":[117],"between":[118,167],"groups.Results:":[120],"Sustained":[121],"100%":[126],"both":[128],"groups,":[131],"except":[132],"two":[135,169,190],"substance":[138],"abuse":[139],"who":[143],"dropped":[144],"from":[145],"study.Patients":[147],"had":[151],"cirrhosis":[153],"(p":[154,160,176,196,216],"=":[155,161,177,197,217],"0.005)":[156],"respiratory":[158],"diseases":[159],"0.037).There":[162],"was":[163,203],"no":[164],"significant":[165,230],"difference":[166],"groups":[170],"terms":[172],"side":[174,180,211,236],"effects":[175,181,212],"0.683);":[178],"significantly":[183],"higher":[184],"group":[188],"drug":[194],"interactions":[195],"0.049).The":[198],"presence":[199],"cardiovascular":[201],"disease":[202],"also":[204],"found":[205],"associated":[208],"0.022).Conclusion:":[218],"without":[228],"a":[229],"increase":[231],"risk":[234],"effects.":[237]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2022-04-03T00:00:00"}
